Fevzi Bardakci

• PhD
• Professor (Full) at University of Ha'il

Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is marked by the pathological accumulation of amyloid-β plaques and tau neurofibrillary tangles, both of which disrupt neuronal communication and function. Emerging evidence highlights the role of extracellular vesicles (EVs) as key mediators of intercellular communication, particu...

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks targeted therapeutic options due to the absence of estrogen, progesterone and HER2 receptors. The present study explores the anti-cancer potential of Plumbago zeylanica L. (P. zeylanica), a medicinal plant known for its diverse pharmacological properties. Usin...

Background/Objectives: Amyloid-β (Aβ) plaque accumulation, oxidative stress, and cholinergic dysfunction are hallmarks of Alzheimer’s disease (AD), a neurodegenerative disability that progresses over time, ultimately resulting in the loss of neurons. The side effects and limitations of current synthetic drugs have shifted attention toward natural a...

Knowledge of genetic variability within and among types and breeds of dromedary (Camelus dromedarius L.) can be a valuable asset in selective breeding of desirable characteristics and will shed light on their origin, dynamics of domestication, and dispersion. Variability in an 809 bp segment of the mtDNA genome was measured within and among dromeda...

Candidiasis, caused by opportunistic fungal pathogens of the Candida genus, poses a significant threat to immunocompromised individuals. Natural compounds derived from medicinal plants have gained attention as potential sources of anti-fungal agents. Ajwa dates (Phoenix dactylifera L.) have been recognized for their diverse phytochemical compositio...

Introduction: Hyperphosphorylation of tau is an important event in Alzheimer’s disease (AD) pathogenesis, leading to the generation of “neurofibrillary tangles,” a histopathological hallmark associated with the onset of AD and related tauopathies. Microtubule-affinity regulating kinase 4 (MARK4) is an evolutionarily conserved Ser-Thr (S/T) kinase t...

Objective: In the present study, we determined the frequency of D32 allele distribution and its relationship with various carcinomas in a Turkish population. Design and methods: We determined the allelic frequency of CCR5-D32 in 267 healthy individuals as well as 39 breast, 34 laryngeal, 30 thyroid and 20 brain carcinomas in a Turkish population us...

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

The present study aimed to molecularly identify and characterize the hard ticks infesting camels from the northern region (Ha’il province) of Saudi Arabia using the mitochondrial barcoding gene cytochrome oxidase subunit I (COI). The sequences of tick samples from camels in three regions of Ha’il were aligned with those previously reported from dif...

Antimicrobial resistance by pathogenic bacteria has become a global risk to human health in recent years. The most promising approach to combating antimicrobial resistance is to target virulent traits of bacteria. In the present study, a biosurfactant derived from the probiotic strain Lactobacillus acidophilus (L. acidophilus) was tested against th...

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria isolated from the air in the neighborhoods of the city of Hail

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.

Bacteria were isolated from the air in the neighborhoods of the city of Hail.Bacteria were isolated from the air in the neighborhoods of the city of Hail.

The objective of the present investigation was to compare potential differences in cytoplasmic amino acid levels between clinical and ATCC 29213 strains of Staphylococcus aureus (S. aureus). The two strains were grown under ideal conditions to mid-exponential and stationary growth phases, after which they were harvested to analyze their amino acid...

In recent years, bacterial pathogens have developed resistance to antimicrobial agents that have created a global threat to human health and environment. As a novel approach to combating antimicrobial resistance (AMR), targeting bacteria’s virulent traits that can be explained by quorum sensing (QS) is considered to be one of the most promising app...

Malaria and schistosomiasis are two major parasitic diseases that remain leading causes of morbidity and mortality worldwide. Co-infections of these two parasites are common in the tropics, where both diseases are endemic. The clinical consequences of schistosomiasis and malaria are determined by a variety of host, parasitic, and environmental vari...

Homeostasis between protein synthesis and degradation is a critical biological function involving a lot of precise and intricate regulatory systems. The ubiquitin-proteasome pathway (UPP) is a large, multi-protease complex that degrades most intracellular proteins and accounts for about 80% of cellular protein degradation. The proteasome, a massive...

The epidermal growth factor receptor (EGFR) has been shown to be extremely important in numerous signaling pathways, particularly those involved in cancer progression. Many therapeutic inhibitors, consisting of both small molecules and monoclonal antibodies, have been developed to target inflammatory, triple-negative and metastatic breast cancer. W...

Background: Marketed fish and shellfish are a source of multidrug-resistant and biofilm-forming foodborne pathogenic microorganisms. Methods: Bacteria isolated from Sparus aurata and Penaeus indicus collected from a local market in Hail region (Saudi Arabia) were isolated on selective and chromogenic media and identified by using 16S RNA sequencing...

The proteinaceous compounds produced by lactic acid bacteria are called bacteriocins and have a wide variety of bioactive properties. However, bacteriocin’s commercial availability is limited due to short stability periods and low yields. Therefore, the objective of this study was to synthesize bacteriocin-derived silver nanoparticles (Bac10307-AgN...

Listeria monocytogenes (L. monocytogenes) is a serious food-borne pathogen that can cause listeriosis, an illness caused by eating food contaminated with this pathogen. Currently, the treatment or prevention of listeriosis is a global challenge due to the resistance of bacteria against multiple commonly used antibiotics, thus necessitating the deve...

PKP1 has been crucially involved in enhancing the MYC translation leading to lung carcinogenesis via evading numerous tumour-suppressing checkpoint systems. Plakophilin 1(PKP1) is the part of armadillo and plakophilin gene families and it is a necessary component of desmosomes. Several researches reported PKP1 protein as one of the most overexpress...

In this study, a novel polymeric nanomaterial was synthesized and characterized, and it its potential usability in hypertension treatment was demonstrated. For these purposes, a poly(hydroxyethyl methacrylate-methacryloylamidophenylalanine)-based polymeric nanomaterial (p(HEMPA)) was synthesized using a mini-emulsion polymerization technique. The n...

Metabolic reprogramming is a key attribute of cancer progression. An altered expression of pyruvate kinase M2 (PKM2), a phosphotyrosine-binding protein is observed in many human cancers. PKM2 plays a vital role in metabolic reprogramming, transcription and cell cycle progression and thus is deliberated as an attractive target in anticancer drug dev...

16sRNA sequencing and identification of bacteria from fish (Sparus aurata)

16sRNA sequencing and identification of bacteria from fish (Sparus aurata)

16sRNA sequencing and identification of bacteria from shellfish (Penaeus indicus)

16sRNA sequencing and identification of bacteria from fish (Sparus aurata)

16sRNA sequencing and identification of bacteria from shellfish (Penaeus indicus)

16sRNA sequencing and identification of bacteria from shellfish (Penaeus indicus)

Industrial effluents, agricultural runoff, and municipal wastewaters contain unknown substances and complex mixtures that are released into the environment and can lead to contamination of surface and subsurface waters. Such activities have endangered the existence of ecosystems and their inhabitants. Changes in the genome caused by genotoxic agent...

The sharp increase in infections due to Staphylococcus aureus is associated with its ability to adapt to changes in its habitat. This study aimed to investigate the differences in the cytoplasmic amino acid profiles of a clinical strain of S. aureus under five combinations of stress-induced conditions representative of a wound site by varying tempe...

This study investigated the druggability, pharmacokinetics and ethyl acetate extract of Teucrium polium (EA T. polium), from Ha’il, and the protective effect against carbon tetrachloride (CCl4) induced liver cirrhosis in rats. The total antioxidant capacity (TAC) and scavenging activity of the extract were examined. The in vivo protective study was...

Due to advances in molecular biology techniques, large numbers of highly informative DNA markers have been developed for the identification of genetic polymorphism. In the last decade, the random amplified polymorphic DNA (RAPD) technique based on the polymerase chain reaction (PCR) has been one of the most commonly used molecular techniques to dev...

Diabetes is a complicated multifactorial disorder in which the patient generally observes polyphagia, polydipsia, and polyuria due to uncontrolled growth in blood sugar levels. For its management, the pharmaceutical industry is working day and night to find a better drug with no or least toxicity. That’s why nowadays a more focused branch is to use...

Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years. Plants and microbes are the primary and potential sources of natural compounds to fi...

Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years. Plants and microbes are the primary and potential sources of natural compounds to fi...

Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years. Plants and microbes are the primary and potential sources of natural compounds to fi...

Toll-like receptors (TLRs) are one of the major sensors to regulate innate immunity. It is present in inactive form within immune cells. However, after recognizing the conserved region of the foreign body, it gets activated by the foreign body, such as bacteria, viruses, fungus, etc. Recently, it is reported that apart from participating in innate...

Toll-like receptors (TLR) are one of the most-studied receptors for their role in innate immunity. TLRs are reported to binds with conserved pathogen-associated molecular patterns (PAMPS). TLRs and PAMPS interaction leads to several downstream proteins' activation, which further signaled to the various transcription factors. Moreover, these transcr...

A new record of a marble trout mtDNA haplotype known to be restricted to Adriatic basin (called marmoratus lineage within Salmo trutta complex) has been reported from Eşen Stream in the Aegean Sea basin of southeastern Turkey, based on sequence data of the mitochondrial DNA control region. The results of this study showed a single unique haplotype...

Diabetes mellitus is a multifactorial disease that affects both developing and developed countries and is a major public health concern. Many synthetic drugs are available in the market, which counteracts the associated pathologies. However, due to the propensity of side effects, there is an unmet need for the investigation of safe and effective dr...

Genetic predisposition has been always noted in the context of familial hematological malignancies. Epidemiological studies have provided evidence consisting of an increased risk to develop blood cancer in relatives diagnosed with the same pathology and characterized by early age at diagnosis and higher severity compared to sporadic forms. With the...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection inducing coronavirus disease 2019 (COVID-19) is still an ongoing challenge. To date, more than 95.4 million have been infected and more than two million deaths have been officially reported by the WHO. Angiotensin-converting enzyme (ACE) plays a key role in the disease patho...

Acute Respiratory Distress Syndrome (ARDS) is a form of respiratory failure in human. The number of deaths caused by SARS-CoV-2 infection inducing this severe pneumonia (ARDS) is relatively high. In fact, COVID-19 might get worsen in ARDS and provoke respiratory failure. A better understood of ARDS key features and the pathophysiological injuri...

We have investigated the effect of subchronic exposure to tetradifon (TDF), as an endocrine disruptor chemical, on some parameters related to serious metabolomic disorders such as obesity, type2 diabete and hyperlipidemia. TDF promoted significant increases in both duodenal and pancreatic α–amylase and lipase especially in the 12-weeks treated rats...

Little is known about the phylogeographic history of amphibian populations along the western Fennoscandinavian coast. In the present study, we focus on the common toad (Bufo bufo) and document the spatial distribution of mitochondrial DNA (cytb) haplotypes at 20 localities along its coastal Norwegian range. Two common haplotypes (out of eight haplo...

Testudo graeca has a wide distribution under different geographic, climatic and ecological conditions, and shows high morphological differences especially in the Asian (Middle Eastern and Caucasian) parts of the range. This study investigates morphometric and genetic differentiation in the T. graeca complex in Turkey using the densest sampling to d...

Stock structure analysis of anchovy from the Rovinj, Maslenica and Island of Korčulain in the Adriatic Sea was carried out by using 13 microsatellite loci. Overall, 259 alleles were detected in 13 loci, the number of alleles per locus and population ranged from 4 to 28. The allelic richness of overall loci was found to be highest in the Rovinj popu...

Locally printed book with short introduction to phylogeny

Mitochondrial DNA sequences from cytochrome c oxidase subunit I (COI) were used to provide a phylogeny of the Chironomidae (Diptera) from Turkey. Data were obtained from 70 species of Chironomidae belonging to the genera Ablabesmyia, Chironomus, Cladotanytarsus, Conchapelopia, Cricotopus, Cryptochironomus, Dicrotendipes, Endochironomus, Eukiefferie...

Aim In this study population genetic stock structure and genetic diversity of striped red mullet (Mullus surmuletus L.) species distributed in the Aegean Sea, the Mediterranean Sea, the Black Sea and the Atlantic Ocean (The eastern Europe coasts) will be determined by using mitochondrial DNA control region and nuclear DNA microsatellite loci. Mat...

Aim: Mullus barbatus (red mullet) is a commercial fish species naturally distributed from Eastern Atlantic: British Isles to Dakar, Senegal, Canary Islands, Mediterranean and Black Sea. There is no study in our knowledge aimed to determine population genetic structuring and genetic stocks of M. barbatus species in territorial waters of Turkey. Only...

The European anchovy Engraulis encrasicolus (Linnaeus, 1758) is a small pelagic fish included Actinopterygii has considerable economical importance in fisheries. Distribution area of European anchovy is shallow waters (0-400m) of Black and Azov seas, Mediterranean and Atlantic coastline of Europe. In this study we examined 13 microsatellite loci in...