Fernando Moreto

Fernando Moreto
São Paulo State University | Unesp · Department of Pathology

PhD in Pathology

About

73
Publications
6,297
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634
Citations
Citations since 2017
29 Research Items
470 Citations
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
Introduction
Biomedical Scientist, PhD in Pathology. Primary focus is biomarkers for redox homeostasis and oxidative stress in metabolic diseases and its complications. Also focused on modulation of pathophysiological processes by bioactive compounds such as histidine-containing peptides. Analytical skills for HPLC (UV, FD and EC detections) and LC-MS/MS.

Publications

Publications (73)
Article
Full-text available
Nonalcoholic fatty liver disease (NAFLD) is the main cause of liver disease. The physiopathological processes involved in the disease are metabolic syndrome (MetS) components (central obesity, dyslipidemia, insulin resistance/type 2 diabetes, hypertension), genetic, and dietary factors, including unsaturated fats and sweetened beverages, which are...
Article
Full-text available
Objectives Non-Alcoholic Fatty Liver Disease (NAFLD) is a silent disease linked to behavioral habits (poor diet and sedentary lifestyle) with inflammatory and oxidative stresses as background, leading to cardiovascular diseases (CVDs) as the worse outcome. These point out to lifestyle modification program(LSMP) as a potential non-pharmacological st...
Article
Full-text available
Purpose This study aimed to evaluate the effect of rice bran (RB) supplementation to a high-sugar fat (HSF) diet on cardiac dysfunction in an experimental obesity model. Methods Male Wistar rats were distributed into three groups: control, high-sugar fat, and high-sugar fat supplemented with 11% RB for 20 weeks. Results HSF diet promoted obesity...
Article
Background Skeletal muscle is the most important organ for whole-body glucose homeostasis. However, it has been suggested that obesity-related inflammation could be involved in insulin resistance and diabetes mellitus type 2 (DM2) development due several mechanisms, among them, the reduced expression of the glucose transporter type 4 (GLUT-4). Gamm...
Article
Full-text available
Background: Obesity is a chronic low-grade inflammation condition related to cardiac disorders. However, the mechanism responsible for obesity-related cardiac inflammation is unclear. The toll-like receptor 4 (TLR-4) belongs to a receptor of the transmembrane family responsible for the immune response whose activation stimulates the production of...
Article
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Introduction: The receptor for AGEs (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface receptors expressed in many organs, among them, the kidneys. When activated, RAGE leads to a sequence of signaling that results in inflammation and oxidative stress, both involved in kidney disease pathogenesis. Gamma-oryzanol (γOz)...
Article
Nonalcoholic steatohepatitis (NASH) is a pathological manifestation with a progressive incidence in response to the epidemic of hepatic steatosis caused primarily by excessive energy intake. The present study unravels affected biological processes and functions by the presence of NASH in rats using a label‐free quantitative proteomic strategy. NASH...
Article
Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The aim of this stu...
Article
The literature has reported a higher prevalence of negative clinical outcomes due to Coronavirus disease 19 (COVID-19) in obese individuals. This can be explained by the cytokine storm, result from the cytokine production from both obesity and viral infection. Gamma-oryzanol (γOz) is a compound with anti-inflammatory and antioxidant activities. How...
Article
Full-text available
Introduction: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The a...
Article
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Purpose The consumption of products containing fructose is associated with metabolic disorders and nonalcoholic fatty liver disease (NAFLD). Several pathways have been described associating the fructose intake and liver damage, among them the reduced peroxisome proliferator-activated receptor alpha (PPAR-α) expression, insulin resistance, inflammat...
Article
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Background/aims: Considering the importance of inflammation on obesity-related disorders pathogenesis, including cardiac dysfunction, the interest in natural anti-inflammatory therapeutic strategies has emerged. The lycopene is a carotenoid presents in tomato and red fruits that displays anti-inflammatory properties. In this sense, we will evaluat...
Article
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The system redox imbalance is one of the pathways related to obesity-related cardiac dysfunction. Lycopene is considered one of the best antioxidants. The aim of this study was to test if the tomato-oleoresin would be able to recovery cardiac function by improving β-adrenergic response due its antioxidant effect. A total of 40 animals were randomly...
Article
Full-text available
Background: The higher consumption of fat and sugar are associated with obesity development and its related diseases such as non-alcoholic fatty liver disease (NAFLD). Lycopene is an antioxidant whose protective potential on fatty liver degeneration has been investigated. The aim of this study was to present the therapeutic effects of lycopene on N...
Article
Full-text available
The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement...
Article
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Background Adipose tissue dysfunction is a condition characterized by inflammation and oxidative stress able to lead metabolic disorders. Curcuma longa L. ( Cl ) is a rhizome commonly used in Indian culinary which presents anti-inflammatory and antioxidant compounds. The aim of this study was to evaluate the effect of in natura Curcuma longa L. on...
Article
Full-text available
The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, such as dyslipidemia, hypertension, and cardiovascular disease. The aim of this study was to evaluate the association between dyslipidemia and cardiac dysfunction induced by western diet consumption. Wistar rats were randomly divided into two experim...
Article
Full-text available
The kidney is an important organ in the maintenance of body homeostasis. Dietary compounds, reactive metabolites, obesity, and metabolic syndrome (MetS) can affect renal filtration and whole body homeostasis, increasing the risk of chronic kidney disease (CKD) development. Gamma oryzanol ( γ Oz) is a compound with antioxidant and anti-inflammatory...
Article
Full-text available
In this study, an acute overloading of methionine (MetLo) was used to investigate the trassulfuration pathway response comparing healthy controls and HIV+ patients under their usual diet and dietary N-acetyl-l-cysteine (NAC) supplementation. MetLo (0.1 g Met/kg mass weight) was given after overnight fasting to 20 non-HIV+ control subjects (Co) and...
Chapter
Taurine (Tau) (2-aminoethanesulfonic acid) is an amino acid, lacking the carboxyl group and messenger ribonucleic acid. As a major intracellular free amino acid, Tau regulates the osmolality and cell membranes stabilization. Moreover, due to its ability to generate conjugates with bile acids, xenobiotics, retinoic acid, and chloramine, Tau is invol...
Article
Full-text available
Abstract Background Phase angle (PhA) value is a useful tool for identifying cell membrane integrity dysfunction. It is known that metabolic syndrome (MetS) increases oxidative stress and inflammation; and consequently can promote cellular damage. We hypothesized that MetS and inflammatory blood markers could be associated with lower PhA values. T...
Article
Full-text available
Background: The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, such as diabetes, and cardiovascular and kidney diseases. Different strategies have been used to prevent these diseases associated with obesity, such as changes in eating habits and/or the addition of dietary components with anti-inflamm...
Article
Full-text available
Purpose High-sugar intake and obesity are strinctly related to oxidative and inflammatory damages which underlie developments of many severe clinical conditions. This study aimed to investigate the effects of a lycopene supplementation (Lyc-suppl) on protein carbonylation, lipid content and inflammatory marker in liver of obese rats treated with a...
Article
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Background: The metabolic syndrome (MS) has been assessed since childhood mainly because of the nutritional and epidemiological transition that has occurred worldwide. Our objectives were to explore the MS and its components according to anthropometric and demographic factors and to assess the relationship among MS components and dietary character...
Chapter
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Viral infections are becoming more common daily around the world, and acquired immunodeficiency syndrome (AIDS) (the end phase of human immunodeficiency virus [HIV] infection) has been one of the most dreaded infectious diseases causing mortality in individuals. The survival of HIV inside the CD4+ lymphocytes depends on cells properly signaling pat...
Article
Metabolic syndrome (MetS) is often accompanied by pro-oxidative and pro-inflammatory processes. Lifestyle modification (LiSM) may act as primary treatment for these processes. This study aimed to elucidate influencing factors on changes of malondialdehyde (MDA) and C-reactive protein (CRP) concentrations after a LiSM intervention. Sixty subjects (5...
Article
The additional effect of omega-3 supplementation in association with lifestyle modification program (LSMP) in free living-adults was evaluated. We studied 39 adults (control group with LSMP (G1, n = 16) and LSMP plus supplementation of 3 g of fish oil per day (360 mg of docosahexaenoic acid and 540 mg of eicosapentaenoic acid) (G2, n = 23)) during...
Article
HIV+ patients present higher plasma levels of pro-oxidant and lower antioxidant markers irrespective of their nutritional status and the presence of HAART [1]. The presence of HAART showed some beneficial effects on β-carotene plasma levels but not on the other antioxidant markers [2]. Among those were glutathione (GSH) and its precursors [3]. GSH...
Chapter
Rationale: Reduction-oxidation reactions determine cell homeostasis and free-radicals productions are invariable components of the aerobic metabolism processes. The cells have an elaborate defense against free-radicals and the imbalance resulting in excessive accumulation of free-radicals, defined as oxidative stress which plays a key role in promo...
Article
Full-text available
This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 ± 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and labora...
Chapter
Human immunodeficiency virus (HIV) replication induces oxidative stress that is produced by the constituent proteins of the virus and is amplified by host-cell immunological defenses. In general, the disease progresses with increased oxidative stress, while the antioxidant defenses, although present, are insufficient for neutralizing the damaging e...
Article
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Metabolic Syndrome (MS) increases the risk of cardiovascular events and the recommended intake of fruits and vegetables (FV) is related to its prevention. The scope of this study is to associate the intake of FV and its relation to MS and its components in an adult population sample. A prospective cross-sectional study was conducted with 636 adults...
Article
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Background High plasma uric acid (UA) is a prerequisite for gout and is also associated with the metabolic syndrome and its components and consequently risk factors for cardiovascular diseases. Hence, the management of UA serum concentrations would be essential for the treatment and/or prevention of human diseases and, to that end, it is necessary...
Article
Metabolic syndrome (MetS) is a complex disorder with definition and prognostic significance still on dispute but representing a growing public health problem. In this chapter by adding personal data to the reviewed literature it is described that MetS is determined by aging, less education and lower income subjects characterized by their obesogenic...
Article
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Background The high blood lipid levels and obesity are one of the main risk factors for cardiovascular diseases, and the atherosclerotic process begins in childhood. Some environmental factors are supposed to be involved in this relationship, such as dietary factors. This study aimed to investigate the relationship between dietary intake and blood...
Article
Full-text available
Low-grade chronic systemic inflammation is often associated with chronic non-communicable diseases, and its most frequently used marker, the C-reactive protein (CRP), has become an identifier of such diseases as well as an independent predictor for cardiovascular disorders and mortality. CRP is produced in response to pro-inflammatory signaling and...
Article
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We aim to investigate the effectiveness of a 10-week lifestyle intervention focusing on physical activity and high fiber intake for reducing indicators for metabolic syndrome in overweight-obese individuals. A prospective study of 50 overweight (OW) adults (22 in the general educational group - G1; 28 in the high fiber nutrition group - G2) was per...
Article
Patients with positivity for the human immunodeficiency virus (HIV⁺) present low concentrations of antioxidant nutrients, including total glutathione (GSH) and its precursors. We investigated the responses of the sulfur-containing amino acid pathway to cysteine and glutamine (Gln) dietary supplements in patients with HIV⁺ compared with healthy cont...
Article
Aim: To correlate the sagittal abdominal diameter (SAD) and waist circumference (WC) with metabolic syndrome-associated abnormalities in adults. Methods: This cross-sectional study included onehundred twelve adults (M = 27, F = 85) aging 54.0 ± 11.2 yrs and average body mass index (BMI) of 30.5 ± 9.0 kg/m2. The assessment included blood pressure, p...
Article
Full-text available
To correlate the sagittal abdominal diameter (SAD) and waist circumference (WC) with metabolic syndrome-associated abnormalities in adults. This cross-sectional study included onehundred twelve adults (M=27, F=85) aging 54.0±11.2 yrs and average body mass index (BMI) of 30.5±9.0 kg/m². The assessment included blood pressure, plasma and anthropometr...
Article
Full-text available
To evaluate the association between the consumption of different dietary fats with the quality of the diet, insulin resistance, and hyperhomocysteinemia in adults. Cross-sectional study conducted with 624 overweight subjects (73.7% females). Assessments of food intake (24h food recall and health eating index-HEI), anthropometry, and biochemical ass...
Article
Full-text available
The metabolic syndrome has been described in children; however, a standard criterion has not been established for its diagnosis. Also, few studies have been conducted to specifically observe the possible existence of agreement among the existing diagnostic criteria. The purpose of the study is to evaluate agreement concerning prevalence rates of th...
Article
To investigate the relationship of dyslipidemia with demographic distribution and patterns of body fat and dietary intakes. From a universe of adults clinically selected for a lifestyle modification program 979 subjects (409 males and 570 females, 52.2 ± 9.6 years) fulfilled the inclusion criteria. Overnight-fasting plasma was assayed (dry chemistr...
Article
Full-text available
To investigate the relationship of dyslipidemia with demographic distribution and patterns of body fat and dietary intakes. From a universe of adults clinically selected for a lifestyle modification program 979 subjects (409 males and 570 females, 52.2 +/- 9.6 years) fulfilled the inclusion criteria. Overnight-fasting plasma was assayed (dry chemis...
Article
Full-text available
Objective: The objective of this study was to investigate changes in inflammatory markers in obese individuals with impaired fasting glucose. Methods: The following data of 125 adult individuals were assessed: body mass index, waist circumference, fasting glucose, high-sensitivity c-reactive protein, uric acid and homocysteine. The groups with norm...
Article
Full-text available
The esophagus cancer-host has a two way close relationship as seen in its sulphur-amino acid metabolism. Taurine one of these compounds has ubiquous role in host defense and other physiological mechanisms related to survival. To study the plasma levels of taurine and its precursors in patients with esophagus cancer. In a sectional design both group...
Article
Full-text available
The purpose of this study is to investigate the association of insulin resistance (IR) with dietary, fitness, anthropometric and other components of Metabolic Syndrome (MS) in adult participants. Cross-sectional study of 80 adult participants (58±8 years old) were clinically and ethically selected. They were all assessed for anthropometry, dietary...

Questions

Questions (2)
Question
What is the difference of these two substances in B6 derivatization?
Question
I'd like to know what are the major determinants for this analysis? pH, water, buffers, gradients?

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