About
8
Publications
986
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70
Citations
Introduction
Current institution
Additional affiliations
February 2019 - present
Position
- Lecturer
Description
- "Principles of neural information processing" for MSc in Neuroscience program
March 2016 - July 2017
February 2017 - February 2018
Education
June 2018 - June 2021
February 2017 - January 2019
March 2009 - February 2017
Publications
Publications (8)
Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Here, we report the origins of the PTs' ability to respond to a broad range of stimuli with onset latencies that rival or even precede those of their intracortical input neurons. We find that neurons with extensive horizontally projecting axons cluster ar...
Threat conditioning is held as a model of anxiety disorders. However, this approach is focused on implicit responses evaluated in a single day. Here, we evaluated negative-valence, positive-valence and cognitive-systems in order to evaluate the extent to which threat conditioning models anxiety disorders. Subjects underwent threat conditioning and...
The endocannabinoid (eCB) system is involved in the modulation of the reward system and participates in the reinforcing effects of different drugs of abuse, including alcohol. The most abundant receptor of the eCB system in the central nervous system is the CB1 receptor (CB1R), which is predominantly expressed in areas involved in drug addiction, s...
Bidirectional communication between neurons and glial cells is crucial to establishing and maintaining normal brain function. Some of these interactions are activity-dependent, yet it remains largely unexplored how acute changes in neuronal activity affect glial-to-neuron and neuron-to-glial dynamics. Here, we use excitatory and inhibitory designer...
Cortical layer 6 (L6) neurons uniquely respond to orexin – a neuropeptide influencing arousal and emotion. We show that Drd1a-Cre+ neurons in the prefrontal cortex are selectively sensitive to orexin and regulate prefrontal network activation in vitro and in vivo. Chronically silencing these neurons impairs orexin-induced prefrontal activation and...
The FOXP2/Foxp2 gene is involved in fine motor control in many vertebrate species; in humans, it is one of the candidate genes thought to play a prominent role in language production. Several studies suggest that in the neocortex, Foxp2 is exclusively expressed in a subset of corticothalamic (CT) pyramidal cells (PCs) in layer 6 (L6). However, the...
Objective: To summarize the state of research in the whisker-to-barrel sensorimotor system based on presentations at the Barrels meeting.
Methods: Host the 34th annual Barrels meeting was hosted virtually due to the ongoing Covid-19 pandemic.
Results: The Barrels meeting annually focuses on the latest advances in the rodent sensorimotor research. T...
Questions
Question (1)
Hello. My issue is the following, i'm doing some work that involves the filling and posterior staining of neurons on the living animal. The cells are filled with biocytin, and after perfusion and everything i stain them with ABC protocol and reveal them with DAB. I'm trying to de-mount the brain slices and re-stain with Antibody-Alexa for receptors in the membrane.
Can it be done or will the DAB mess everything? (I tried already and ANYTHING intracellular cannot be re-stained because of the DAB strong signal)
Thanks!
