Fernando Zegers Hochschild

Fernando Zegers Hochschild
Universidad Diego Portales · Program of Ethics and Public Policies in Human Reproduction

professor

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142
Publications
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Publications

Publications (142)
Article
title International Committee for Monitoring Assisted Reproductive Technologies (ICMART) Preliminary World Report on ART, 2018 Study question In 2018 what was global utilization, effectiveness and safety of ART? Summary answer Globally, ART utilization and data collection continue to increase but with wide variations in utilization, effectiveness...
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Research question: What was the utilization, effectiveness and safety of assisted reproductive technologies (ART) in Latin America during 2019. Design: Retrospective collection of multinational data on ART performed in 196 institutions from 15 countries Results: We report 106,918 initiated cycles, 18,133 deliveries and 21,096 births. ART utilizatio...
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Objective: What are the trends in patient characteristics, effectiveness and safety of assisted reproductive technology (ART) performed in Latin America over the past three decades, as well as the detailed outcomes of procedures initiated in 2018?. Design: Retrospective collection of multinational data including epidemiology and outcomes of ART...
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STUDY QUESTION What were the utilization, effectiveness and safety of practices in assisted reproductive technologies (ART) globally in 2014 and what global trends could be observed? SUMMARY ANSWER The estimated total number of ART cycles conducted in 76 participating countries in 2014 was 1.93 million representing ∼66% of global activity, with 5-...
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Research question What are the trends in patient characteristics, effectiveness and safety of assisted reproductive technology (ART) performed in Latin America over the past three decades, as well as the detailed outcomes of procedures initiated in 2018? Design Retrospective collection of multinational data including epidemiology and outcomes of A...
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Objective To report the utilization, effectiveness, and safety of practices in assisted reproductive technology (ART) globally in 2013 and assess global trends over time. Design Retrospective, cross-sectional survey on the utilization, effectiveness, and safety of ART procedures performed globally during 2013. Setting Seventy-five countries and 2...
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Study question: What was the utilization, effectiveness and safety of practices in ART globally in 2012 and what global trends could be observed? Summary answer: The total number of ART cycles increased by almost 20% since 2011 and the main trends were an increase in frozen embryo transfers (FET), oocyte donation, preimplantation genetic testing...
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Study question: What factors are associated with monozygotic twins (MZT) after autologous IVF/ICSI with fresh and frozen/thawed single embryo transfer (SET) and what is the outcome of MZT? Summary answer: Factors associated with increased MZT were blastocyst transfer and elective single embryo transfer (eSET), with MZT showing a lower gestational a...
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Research question: What was the utilization, effectiveness and safety of assisted reproductive techniques performed in Latin America during 2017. Design: Retrospective collection of multinational data on ART performed in 188 institutions from 15 Latin American countries. Results: We are reporting 93,600 initiated cycles, 16,976 deliveries and...
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This commentary outlines the importance of utilization of assisted reproductive technology as an indicator of access to infertility care and provides a standard way of reporting utilization to facilitate international comparisons. Factors that influence ART utilization as well as underlying inequalities and inequities in access to care are discusse...
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Research question: What was the utilization, effectiveness and safety of assisted reproductive technologies (ART) carried out in Latin America during 2017. Design: Retrospective collection of multinational data on ART carried out in 188 institutions from 15 Latin American countries. Results: In this study, 93,600 initiated cycles, 16,976 deliv...
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Research question: What was the utilization, effectiveness and perinatal outcome of assisted reproductive technologies (ART) performed in Latin America during 2016. Design: Retrospective collection of multinational data on ART performed in 178 institutions from 15 Latin American countries. Results: We are reporting 85,474 initiated cycles, 15,...
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Research question: What was the utilization, effectiveness and perinatal outcome of assisted reproductive technologies (ART) performed in Latin America during 2016? Design: Retrospective collection of multinational data on ART performed in 178 institutions from 15 Latin American countries. Results: This paper reports on 85,474 initiated cycles...
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Research question: What was the utilization, effectiveness and safety of assisted reproductive technologies (ART) performed in Latin American countries during 2015, and what were the regional trends? Design: Retrospective collection of multinational data on assisted reproduction techniques (IVF and intracytoplasmic sperm injection [ICSI], frozen...
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Objective To report the utilization, effectiveness, and safety of practices in assisted reproductive technology (ART) globally in 2011 and assess global trends over time. Design Retrospective, cross-sectional survey on the utilization, effectiveness, and safety of ART procedures performed globally during 2011. Setting Sixty-five countries and 2,5...
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Full-text available
Research question: What was the utilization, effectiveness and safety of assisted reproductive technologies (ART) performed in Latin American countries during 2015, and what were the regional trends? Design: Retrospective collection of multinational data on assisted reproduction techniques (IVF and intracytoplasmic sperm injection [ICSI], frozen...
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PurposeThe purpose of this study is to compare the results of ART treatment in patients with and without endometriosis in a large cohort of patients from different centers over an extented period of time. Methods This retrospective study is using data from patients undergoing 27,294 cycles of IVF/ICSI treatment between 1995 and 2011 that were regis...
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Cambridge Core - Obstetrics and Gynecology, Reproductive Medicine - In-Vitro Fertilization - edited by Gabor Kovacs
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Introducción y objetivos: Aunque la criopreservación embrionaria es frecuentemente utilizada como parte de las técnicas de reproducción asistida, no existe información cuantitativa de cómo las parejas infértiles viven la experiencia de tener embriones criopreservados en Chile. El objetivo del estudio fue examinar las percepciones y creencias que ti...
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Multinational data on assisted reproduction techniques undertaken in 2014 were collected from 159 institutions in 15 countries in Latin America. Treatments included IVF/ ICSI, FET, OD, PGD and fertility preservation (FP). 41.34% of IVF/ICSI cycles were performed in women aged 35 to 39 years and 23.35% in women aged 40 and older. After removing case...
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Study question: Can a consensus and evidence-driven set of terms and definitions be generated to be used globally in order to ensure consistency when reporting on infertility issues and fertility care interventions, as well as to harmonize communication among the medical and scientific communities, policy-makers, and lay public including individua...
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Study question: Can a consensus and evidence-driven set of terms and definitions be generated to be used globally in order to ensure consistency when reporting on infertility issues and fertility care interventions, as well as to harmonize communication among the medical and scientific communities, policy-makers, and lay public including individua...
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Background Although within Latin America Chile has one of the lowest birth rates among adolescents, it has a high rate in comparison to other developed nations. Aim To explore trends in birth rates among adolescents by selected demographics in Chile. Methods The national trend in birth rates was examined for women aged 15–19 years between 1992 an...
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Objective The main objective of this study was to assess the prevalence of overweight and obesity among patients undergoing assisted reproductive technology (ART) in Latin America and its consequences on treatment outcomes. Methods We used the Latin American Registry of ART to obtain women's age and body mass index (BMI), cancellation rate, number...
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Multinational data on assisted reproduction techniques (IVF and intractytoplasmic sperm injection [ICSI], frozen embryo transfer, oocyte donation, preimplantation genetic diagnosis and fertility preservation) were collected from 159 institutions in 15 Latin American countries. A total of 41.34% of IVF–ICSI cycles were conducted in women aged 35–39...
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Background Endometriosis has been described to impair fertility through various mechanisms. However, studies evaluating the reproductive outcomes of women undergoing assisted reproductive technologies show controversial results. The aim of this study is to assess whether the reproductive outcome is impaired among women with endometriosis-associated...
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Objective: To determine whether the addition of either urinary or recombinant LH in patients undergoing routine clinical care improved the outcome in terms of the number of oocytes recovered for insemination or the delivery rate per initiated cycle. Design: Cohort analysis. Patient(s): Couples undergoing IVF/ICSI in 158 institutions in 15 coun...
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Study question: What were utilization, outcomes and practices in assisted reproductive technology (ART) globally in 2008, 2009 and 2010? Summary answer: Global utilization and effectiveness remained relatively constant despite marked variations among countries, while the rate of single and frozen embryo transfers (FETs) increased with a concomit...
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Multinational data on assisted reproduction techniques undertaken in 2013 were collected from 158 institutions in 15 Latin American countries. Individualized cycle-based data included 57,456 initiated cycles. Treatments included autologous IVF and intracytoplasmic sperm injection (ICSI), frozen embryo transfers, oocyte donations. In autologous repr...
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Multinational data on assisted reproduction techniques undertaken in 2013 were collected from 158 institutions in 15 Latin American countries. Individualized cycle-based data included 57,456 initiated cycles. Treatments included autologous IVF and intracytoplasmic sperm injection (ICSI), frozen embryo transfers, oocyte donations. In autologous repr...
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Background: Assisted reproductive technologies still generate debate about ethical moral and religious issues. Aim: To analyze the opinions of the general public about the use of assisted reproduction technology (ART). Material and methods: This analysis used the information gathered in a survey about human reproduction and modern reproduction...
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Embryo cryopreservation is an integral part of assisted reproduction techniques; it allows the sequential transfer of all embryos, thus diminishing the risk of multiple pregnancies and associated perinatal complications. To address concerns about the safety of this procedure, neonatal outcome after 43,070 fresh embryo transfers was compared with 12...
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Multinational data on assisted reproduction technologies were collected from 155 institutions in 14 Latin Amerian countries during 2012. Case-by-case data included 47,326 assisted reproduction technology cycles covering over 80% of cycles carried out in Latin America. Treatments included IVF, intracytoplasmic sperm injection (ICSI), frozen embryo t...
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Objective: This report examines information on Assisted Reproduction Technologies performed in Latin America (LA) during 2012. Methods: Multinational data were collected directly from 155 institutions in 14 countries. Individualized, case-bycase data include 47,326 ART cycles covering more than 80% of cycles performed in LA. Treatments included...
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As part of Assisted Reproductive Technologies (ART), the advent of embryo freezing lowered the number of embryos transferred, decreasing multiple births without jeopardizing pregnancy rates. Using vitrification technology, 90% of embryos survive after thawing, producing clinical pregnancy rates similar to those of fresh embryos (41.6%y 44.3% respec...
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Assisted reproductive technology (ART) is present in almost all Latin American countries. However, it is accessible only to few couples, those who have the economic capacity to cover out of pocket funding. The number of initiated cycles per year in Chile covers less than 4% of the population who would theoretically need treatment. It corresponded t...
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The Inter-American Court of Human Rights has ruled that the Supreme Court of Costa Rica's 2000 judgment prohibiting in vitro fertilization (IVF) violated the human right to private and family life, the human right to found and raise a family, and the human right to non-discrimination on grounds of disability, financial means, or gender. The Court's...
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The Inter-American Court of Human Rights has ruled that the Supreme Court of Costa Rica's 2000 judgment prohibiting in vitro fertilization (IVF) violated the human right to private and family life, the human right to found and raise a family, and the human right to non-discrimination on grounds of disability, financial means, or gender. The Court's...
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To analyze information on assisted reproductive technology (ART) performed worldwide and trends in outcomes over successive years. Cross-sectional survey on access, effectiveness, and safety of ART procedures performed in 53 countries during 2005. A total of 2,973 clinics from national and regional ART registries. Infertile women and men undergoing...
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To systematically quantify the impact of consumer cost on assisted reproduction technology (ART) utilization and numbers of embryos transferred. Ordinary least squared (OLS) regression models were constructed to measure the independent impact of ART affordability-measured as consumer cost relative to average disposable income-on ART utilization and...
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In Chile, as in the majority of countries in Latin America, there are no laws regulating the practice of assisted reproductive technology (ART), and therefore, no official guidelines are available regulating the establishment of new centers, criteria for registering and reporting their data, and, in general, for the provision of this form of medica...
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The Inter-American Court of Human Rights (the Court) has ruled that the Supreme Court of Costa Rica's judgment in 2000 prohibiting in vitro fertilization (IVF) violated the human right to private and family life, the human right to found and raise a family, and the human right to non-discrimination on grounds of disability, financial means, or gend...
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Background: Advances in reproductive medicine and the use of assisted reproductive technologies (ART) have a great impact in the lives of people and the conformation of their families. Aim: To report the results of an opinion survey applied to inhabitants of Santiago, Chile about the use of ART to conceive. Material and Methods: A survey was design...
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Background: Advances in reproductive medicine and the use of assisted reproductive technologies (ART) have a great impact in the lives of people and the conformation of their families. Aim: To report the results of an opinion survey applied to inhabitants of Santiago, Chile about the use of ART to conceive. Material and Methods: A survey was design...
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Introduction: This is the fourteenth report of the European IVF-monitoring (EIM), the ESHRE register on assisted reproductive techniques (ART) organization. This report deals with the results of treatments initiated during 2010. Methods: Data were collected from existing national registries in 30 countries (data sent in at the time of abstract dea...
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Objective: the objective of this study is to evaluate markers of embryo quality, applied on day three of in vitro culture, in their capacity to predict whether embryos will reach blastocyst stage. Methods: a retrospective analysis of embryology database coming from 2772 zygotes obtained in 564 oocyte retrievals was performed; embryos were observed...
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STUDY QUESTION Have changes in assisted reproductive technology (ART) practice and outcomes occurred globally between 2003 and 2004? SUMMARY ANSWER Globally, ART practice has changed with an increasing prevalence of the use of ICSI rather than conventional IVF. In 2004, a small but increasing number of countries are incorporating single embryo tra...
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This study assessed the development of sibling embryos to blastocyst as a prognostic factor for patients undergoing embryo transfer at day 3. A retrospective analysis of a clinical and embryology database including 353 patients who underwent 393 cycles of intracytoplasmic sperm injection with day-3 embryo transfer and excess embryos, maintained in...
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Objective: This study presents the results of polar body genetic diagnosis (PbGD) used as selection tool of euploid oocytes, before their insemination by ICSI. This technique identifies five pairs of chromosomes [13, 16, 18, 21 & 22], in the first polar body of mature oocytes, obtained during an assisted reproductive technology (ART) procedure. Des...
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Multiple birth, due the transfer of more than one embryo, constitutes the most serious complication for both mother and children after assisted reproductive technology. Embryo cryopreservation allows the sequential transfer of the whole cohort of embryos generated in one ART cycle, either by electively transferring one embryo (eSET) or two embryos...
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Background. Reducing the rate in IVF of multiple births and associated perinatal complications has become the major challenge in Latin America, due to is association with a significant increase in the prematurity, and perinatal mortality. Methods. We selected all procedures involving the transfer of IVF embryos, reported to the Latin America Regist...
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Introduction This is the Thirteenth report of the European IVF-monitoring (EIM), the ESHRE register on assisted reproductive techniques (ART) organization. This report deals with the results of treatments initiated during 2009. Methods Data were collected from existing national registries in 30 countries (data sent in at the time of abstract dead...
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Societies in Latin America are not scientifically driven and therefore, the allocation of human and economic resources to research is meager, as a reflection of this as well as other cultural and economic realities.
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Introduction This is the twelfth report of the European IVF-monitoring (EIM), the ESHRE register on assisted reproductive techniques (ART) organization. This report deals with the results of treatments initiated during 2008. Methods Data were collected from existing national registries in 36 countries (3 more than in 2007) and directly entered by...
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To analyze information on assisted reproductive technologies (ART) performed globally. Data on access, efficacy, and safety of ART were collected for the year 2003 from 54 countries. National and regional ART registries globally. Patients undergoing ART globally. Collection and analysis of international ART registry data. Number of cycles performed...
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One injection of corifollitropin alfa replaces the first seven daily FSH injections in controlled ovarian stimulation (COS) cycles. Repeated treatment with therapeutic proteins may cause immune responses or hypersensitivity reactions. We assessed the immunogenicity and safety of corifollitropin alfa treatment in up to three COS cycles. In this mult...
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Introduction: Since 1990, the Latin American Registry of Assisted Reproduction (RLA) has registered ART procedures performed in Latin America. The RLA has increased its regional coverage including to date more than 80% of ART cycles performed. 140 centers enter their data directly on line, and an administrative office collects and analyses the data...
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The type of estrogen and progestin as well as their doses, route and regimens of administration may each affect the benefit-risk profile of postmenopausal hormone therapy. The aim of this study was to evaluate the endometrial effect of progesterone released continuously from a vaginal ring, combined with transdermal estradiol in postmenopausal wome...
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This is the eleventh report of the European IVF-monitoring (EIM), the ESHRE register on assisted reproductive techniques (ART) organization. This report deals with the results of treatments initiated during 2007. Methods Data were collected from existing national registries in 31 countries and directly entered by each national coordinator into the...
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El desafío de cualquier sociedad es construir acuerdos basados en consideraciones éticas y valóricas, que con dinamismo y pragmatismo se renueven según lo que aprendemos día a día a través de la ciencia, de la experiencia y de las realidades sociales. Acuerdos sociales así construidos generan deliberaciones tolerantes, pluralistas y respetuosas de...
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To collect data on the prevalence and reasons for cross-border fertility care (CBFC). Retrospective survey conducted by the International Committee Monitoring Assisted Reproductive Technologies. Forty-nine countries who have previously participated with the International Committee Monitoring Assisted Reproductive Technologies. Number of CBFC patien...
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Many definitions used in medically assisted reproduction (MAR) vary in different settings, making it difficult to standardize and compare procedures in different countries and regions. With the expansion of infertility interventions worldwide, including lower resource settings, the importance and value of a common nomenclature is critical. The obje...