Fernando Galan

Universidad de Sevilla | US · Medicine

Aunque alguna vez la enfermedad mitocondrial se consideró rara, la evidencia acumulada sugiere que estas enfermedades son relativamente comunes. La prevalencia total de la enfermedad mitocondrial en adults, incluidas las mutaciones patogénicas de los genomas mitocondrial y nuclear es ≈1 en 4.300, y se encuentra entre las formas adultas más comunes...

En nuestro estudio, sobre la prevalencia de burnout en estudiante de medicina de los cursos 3º y 6º, encontramos que la prevalencia se duplicó desde el tercer año hasta el sexto año También en otro estudio, investigamos la prevalencia del burnout, la depresión y la ideación suicida entre los estudiantes de odontología de 2º, 4º y 5º año de carrera....

El origen de esa falta de profesores numerarios - según mi opinión - fue la aparición de esa “rara figura jurídica” de “Profesor Vinculado”. En esos términos se nos definió por la Asesoría Jurídica de la Universidad, a nuestro escrito pidiendo nos aclararan dicha figura jurídica. Sin aclararnos nuestros derechos y obligaciones con respecto a esa v...

1.- La definición de fibromialgia según el Centros para el Control y Prevención de Enfermedades (CDC). 2.- ¿Enfermedad o síndrome? 3.- Prevalencia de la Fibromialgia. 4.- ¿Dónde situar la fibromialgia? 5.- Datos que demuestran una alteración mitocondrial en la FM. 6.- ¿Cuál es la relación entre los síntomas del estrés oxidativo y FM?

COMMENT FROM DR CHARLES SHEPHERD, MEDICAL ADVISER, ME ASSOCIATION ________________________________________ This interesting case report from Spain links in with a discussion currently taking place on MEA Facebook:

En la práctica clínica, no es raro encontrar pacientes con la superposición de síntomas de algunas condiciones comunes, incluyendo, entre otros, síndrome de fatiga crónica, la fibromialgia, la depresión y la enfermedad psicosomática. Y, más recientemente, también se puede incluir la enfermedad mitocondrial, aunque menos común, pero no muy rara.

MELAS syndrome is a mitochondrial disorder that is caused mainly by the m.3243A>G mutation in mitochondrial DNA. Here, we report on how the severity of pathophysiological alterations is differently expressed in fibroblasts derived from patients with MELAS disease. We evaluated mitophagy activation and mitochondrial biogenesis which are the main mec...

Introduction: Symptoms of mitochondrial diseases and chronic fatigue syndrome (CFS) frequently overlap and can easily be mistaken. Methods: We report the case of a patient diagnosed with CFS and during follow-up was finally diagnosed with mitochondrial myopathy by histochemical study of muscle biopsy, spectrophotometric analysis of the complexes of...

The AMP-activated protein kinase (AMPK) has emerged as an important sensor of signals that control cellular energy balance in all eukaryotes. AMPK is also involved in fatty acid oxidation, glucose transport, antioxidant defense, mitochondrial biogenesis and the modulation of inflammatory processes. The numerous roles of AMPK in cell physiological a...

Objectives: To investigate the prevalence, gender influence, and relationships between burnout, depression and suicidal ideation within the last year among second, fourth and fifth-year dental students. Study Design: A cross-sectional study was carried out in 212 dental students enrolled in the second, fourth and fifth years at the School of Dentis...

There is growing awareness that vitamin D sufficiency is required for overall optimal health. Most experts agree that 25-hydroxyvitamin D levels of at least 75 nmol/L, as sufficient vitamin D status. Our aim was to investigate the serum 25-hydroxyvitamin D concentration required in mid-October to ensure vitamin D sufficiency in early February, and...

It is questionable whether the Maslach Burnout is suitable for studying burnout prevalence in preclinical medical students because many questions are patient-centered and the students have little or no contact with patients. Among factors associated with burnout in medical students, the gender shows conflicting results. The first aim of this study...

Measurements of the proximal femur by dual X-ray absorptiometry (DXA) are assuming increasing importance in clinical and epidemiological studies. However, different DXA manufacturers have adopted varying approaches to measuring the femoral neck and trochanter regions with the result that there is as yet no agreement on normal ranges and how to cros...

In the European Prospective Osteoporosis Study (EPOS), a past spine fracture increased risk of an incident fracture 3.6 - 12-fold even after adjusting for BMD. We examined the possibility that biochemical marker levels were associated with this unexplained BMD-independent element of fracture risk. Each of 182 cases in EPOS of spine or non-spine fra...

Background: In the European Prospective Osteoporosis Study (EPOS), a past spine fracture increased risk of an incident fracture 3.6–12-fold even after adjusting for BMD. We examined the possibility that biochemical marker levels were associated with this unexplained BMD-independent element of fracture risk. Methods: Each of 182 cases in EPOS of spi...

Bone density measurements by dual X-ray absorptiometry (DXA) of the spine can now be made precisely, but there is no uniformity in reporting results and in presenting reference data. A European Union Concerted Action therefore devised a uniform procedure for cross-calibrating and standardizing instruments, using the European spine phantom (ESP) pro...

Up to now it has not been possible to reliably cross-calibrate dual-energy X-ray absorptiometry (DXA) densitometry equipment made by different manufacturers so that a measurement made on an individual subject can be expressed in the units used with a different type of machine. Manufacturers have adopted various procedures for edge detection and cal...

Hip fractures in elderly people are an important public health problem. The incidence varies with ethnic group and shows wide geographical variation. To examine the effect of body mass index, dietary calcium intake, fertile period, physical activity, and years of education on the risk of hip fracture, a case-control study was undertaken, as part of...

The defect of the sodium pump of the blood cell membrane in patients with essential blood hypertension, can induce changes in the metabolic use of ATP, especially at glucolytic pathway level. We studied the blood levels of ATP (32.51 +/- 10.80 mg/100 ml), 2,3-DPG (0.82 +/- 0.47 mumol/ml), piruvate (0.36 +/- 0.16 mg/100 ml) and lactate (18.88 +/- 4....

We evaluate the levels of intra-erythrocytes glucose-6-phosphate-dehydrogenase (G6PD) in a group of 50 patients with essential blood hypertension (EBH) (214.76 +/- 38.31 mU/ml) and in a group of 50 healthy persons (130.11 +/- 49.50 mU/ml) (p minor of 0.0005). At the same time, we have analysed the intraerythrocyte levels of G6PD of 34 healthy sons...

A deficit of immunoreactive calcitonin (iCT) has been found in women with postmenopausal osteoporosis (PM-OP), however, recent studies assessing the monomeric fraction of calcitonin (exCT) do not seem to confirm these findings. We have measured serum levels of iCT by radioimmunoassay (RIA) and exCT (chromatography and RIA) at 0, 5, 10, and 20 minut...

Estrogens retard bone loss after menopause and constitute the most logical therapy for the prevention of postmenopausal osteoporosis. Estrogens are contraindicated in some circumstances and some postmenopausal women are unwilling to accept them. We have used ADFR therapy as an alternative in the prevention of postmenopausal bone loss. One hundred w...

Bone loss after menopause results from an increased bone reabsorption, whereas calcitonin (CT) inhibits osteoclastic activity. We have evaluated physiologic CT reserve in a group of 25 women, with postmenopausal osteoporosis (PMO) and in 18 age-matched control women, by measuring plasma CT levels at 09.00 h and 12.00 h. We have also measured basal...

Calcitonin (CT) and ionic calcium (Ca++) were measured in paired serum samples from the umbilical artery and vein of 47 normal term babies (28 females and 19 males). In the whole group, we found higher CT levels in the vein than in the artery (P less than 0.01). Considered by sex, significant CT (P less than 0.01) and Ca++ (P less than 0.05) gradie...

In mammals and submammalian vertebrates the main sources of calcitonin are the thyroid and ultimobranchial gland, respectively; in lizars, however, calcitonin is isolated from lung. Immunochemical studies have also shown a calcitonin-like material in lizard lung and in bronchial and bronchiolar Kulchitsky cells of man. In our study patients with ch...

To investigate whether human calcitonin (hCT) is preserved during the evolution of vertebrates, we studied extracts of avian (pigeon and chicken) thyroid and ultimobranchial glands (UBG) which have previously been reported to contain salmon calcitonin (sCT)- like molecules. A sensitive and specific radioimmunoassay for hCT, employing two antisera r...

Summary As assessed by radioimmunoassay, and high performance liquid chromatography (HPLC), frog ultimobranchial calcitonin was found to be similar to synthetic human calcitonin but completely different from synthetic salmon calcitonin.

Immunological and chromatographic methods were used to investigate the distribution of calcitonin (CT) in various tissues of Lacerta muralis, a common wall lizard. Salmon CT-like immunoreactivity was found in high concentration in extracts of ultimobranchial gland (UBG) and in significant amounts in lung and brain extracts, but not in other tissues...

To determine whether calcitonin (CT) is present in avian central nervous system (CNS), as it has been recently found in the CNS of other species, we studied extracts of pigeon (Columbia livia) brain by immunochemical methods. A sensitive and specific radioimmunoassay for salmon CT was used together with gel filtration and high performance liquid ch...

A molecule very closely resembling human calcitonin immunologically and chromatographically was extracted from the nervous systems of several protochordates and a cyclostome, Myxine. The presence of human calcitonin-like molecules in the nervous systems of primitive chordates suggests that they have some function in the nervous system of these spec...