Ferdinando Paternostro

Ferdinando Paternostro
University of Florence | UNIFI · Dipartimento di Scienze Biomediche, Sperimentali e Cliniche

Professor

About

63
Publications
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523
Citations
Introduction
Analysis of the biomechanics of the body through anatomical networks. Physical activity and prevention of complications of chronic diseases. Development and analysis of IT support for teaching. Macroscopic anatomy of vascular trunks. In vivo anatomical and functional evaluation of organs and systems using the most recent imaging techniques. Neurotoxic effects of Cadmium and Oxaliplatin Study of the effects on pulmonary mechanics of oxidative stress induced by different treatments. History of Medicine, with particular attention to the study of anatomical collections and the history of Anatomy. Cell biology in vivo and in vitro.

Publications

Publications (63)
Article
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Introduction: For many years, anatomical studies have been conducted with a shattered view of the body. Although the study of the different apparatuses provides a systemic view of the human body, the reconstruction of the complex network of anatomical structures is crucial for the understanding of structural and functional integration. Aim: We u...
Article
The foot has 28 bones, 30 joints, and more than 100 muscles, ligaments, and tendons. These structures work together to carry out two main functions: weight-bearing and propulsion. Plus, the foot must be flexible to adapt to uneven surfaces and remain stable. In this article, we briefly illustrate the anatomy of the foot and its various structures
Article
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Cadmium (Cd) is a well-known occupational and environmental pollutant worldwide, and its toxicity is widely recognised. Cd is reported to increase the permeability of the blood–brain barrier (BBB) and to penetrate and accumulate in the brain. Although many lines of evidence show that Cd toxicity is induced by different mechanisms, one of the best k...
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Background: The “classic” thyroid gland arterial vascularization takes into account two superior thyroid arteries (STA), two inferior thyroid arteries (ITA) and, occasionally, a thyroid ima artery (TIMA). The present review focuses on exploring the available data concerning thyroid gland arterial vascularization and its variations. Methods: Here, w...
Article
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Oxaliplatin is a third-generation chemotherapy drug mainly used for colorectal cancer treatment. However, it is also known to trigger neuropathy whose underlying neurobiological mechanisms are still under investigation and currently available treatments show limited efficacy. It is now established that neurons are not the only cell type involved in...
Article
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ABSTRACT Soccer practice can induce marked changes in the lower limbs with dreaded short and long term consequences. We evaluated the possible effects of sport practice on lower limb posture and their relationships with ankle joint mobility (AJM). In 61 male Soccer players mean age 11.6±1.8 years, and in 50 Volleyball and Basketball players match...
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In recent years, alcohol abuse has dramatically grown with deleterious consequence for people’s health and, in turn, for health care costs. It has been demonstrated, in humans and animals, that alcohol intoxication induces neuroinflammation and neurodegeneration thus leading to brain impairments. Furthermore, it has been shown that alcohol consumpt...
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Hyaluronic acid fillers indisputably represent an important tool for face rejuvenation and volume restoration. The temporal area has recently been considered as a potential site of injection. As it happens in the middle face and in other regions of the face, the temporal fossa changes according to the aging process. In a young person, the temple pr...
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Cadmium (Cd), a category I human carcinogen, is a well-known widespread environmental pollutant. Chronic Cd exposure affects different organs and tissues, such as the central nervous system (CNS), and its deleterious effects can be linked to indirect reactive oxygen species (ROS) generation. Since Cd is predominantly present in +2 oxidation state,...
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The study of the relationships between the different structures of the human locomotor system still raises great interest. In fact, the human body networks and in particular the "myofascial system network" underlie posture and movement and new knowledge could be useful and applied to many fields such as medicine and prosthetics. The hypothesis of t...
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Although modern anatomy is commonly retained to begin in the XVI century, the roots of anatomical study in the Western world may be identified beforehand. An anatomical practice was present in the Western world well before the Middle Ages, starting in ancient Greece. Hippocrates of Cos (V-IV centuries B.C.) provided descriptions of the heart and ve...
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Michelangelo's marble sculpture of David is one of the most admired works of art in the world. It is the most iconic symbol of the Florentine Renaissance, and a representation of the idealized human form in its perfection and proportion. The statue was examined in 2004 by two anato-mists who observed the apparent absence of a single muscle. Our re-...
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Introduction: vascular anatomy variations are important in academic, clinical and surgical areas as well as nephrology, urology, oncological and vascular surgery, among others. The main objective of this review is to know the real prevalence of multiple renal arteries in a wide, mul-tiethnic population. Secondary objectives are to establish the pre...
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Cadmium (Cd) is a highly toxic environmental pollutant released from the smelting and refining of metals and cigarette smoking. Oral exposure to cadmium may result in adverse effects on a number of tissues, including the central nervous system (CNS). In fact, its toxicity has been related to neurological disorders, as well as neurodegenerative dise...
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Even if physical activity (PA) plays a key role within diabetic foot treatment its use and the results obtained from this treatment seem to be still limited. Nowadays, new and even more advanced technologies for the long term daily physical activity monitoring (DPAM) are available and they are radically changing some aspects of physical activity su...
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Variations in the branching pattern of the aortic arch are clinically relevant because of the direct influence that their presence can have on the success of cardio-vascular procedures, neck or thorax surgery, trauma management or intensive care. In most cases these anatomical variations are asymptomatic and considered clinically benign, but some p...
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The anatomical illustration of the human body is a topic rich in epistemological elements in the course of medical history. Since ancient times concerns about the real correspondence of the scientific and/or artistic representation of human anatomy with the original one arose. First of all, a static two-dimensional representation, the one typical o...
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Oxaliplatin is a key drug in the treatment of advanced metastatic colorectal cancer. Despite its beneficial effects in tumor reduction, the most prevalent side-effect of oxaliplatin treatment is a chemotherapy-induced neuropathy that frequently forces to discontinue the therapy. Indeed, along with direct damage to peripheral nerves, the chemotherap...
Poster
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Considering that the knowledge and control of the daily physical activity performed (PAP) is an important element in the management of patients with history of foot ulcers, peripheral neuropathy and/or peripheral vascular disease (at risk), the analysis of the social network map (SNM) perceived by themselves directly could also provide useful infor...
Article
Cadmium (Cd), a worldwide occupational pollutant, is an extremely toxic heavy metal, capable of damaging several organs, including the brain. Its toxicity has been related to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. The neurotoxic potential of Cd has been attributed to the changes induced in the brain enzyme network...
Poster
Full-text available
DISTRIBUZIONE DELLE FORZE DURANTE L’APPOGGIO PLANTARE TRA LE COMPONENTI MIO-OSTEO-ARTICOLARI DEL PIEDE. SIMULAZIONI E ANALISI SU UN MODELLO DI NETWORK ANATOMICO
Article
Growing evidence has shown the promise of mesenchymal stromal cells (MSCs) for the treatment of cutaneous wound healing. We have previously demonstrated that MSCs seeded on an artificial dermal matrix, Integra® enriched with platelet rich plasma (EmatrixTM) have enhanced proliferative potential in vitro as compared to those cultured on the scaffold...
Article
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Objective: It is well known that limited joint mobility of the ankle and foot level, impaired muscular performance and reduced gait speed are risk factors for ulceration in diabetic foot. The aim of this study was to evaluate the effect of an experimental protocol of exercise therapy on joint mobility, muscular strength and gait speed in a group of...
Article
Background. Overall, the comparative data available on the timing of metopic suture closure in present-day and fossil members of human lineage, as well as great apes, seem to indicate that human brain evolution occurred within a complex network of fetopelvic constraints, which required modification of frontal neurocranial ossification patterns, inv...
Article
Microglia act as a first line of defence against pathogen invasion, by recognizing, sequestering and processing antigens. Once microglia become activated, they produce and release many substances that activate nearby astrocytes, microglia and neurons (Martin et al., 2005). In this study we compare two microglial cell lines: the human cell line c13-...
Article
Oxaliplatin-based regimens are effective in metastasised advanced cancers. However, a major limitation to their use is represented by neurotoxicity leading to peripheral neurophaty (Wolf et al., 2008). In this study we evaluate the effects of an immunotherapeutic agent (Gc protein-derived macrophage activating factor, GcMAF) in preventing oxaliplat...
Article
It is well known that limited joint mobility of the ankle and foot, impaired muscular performance and reduced gait speed are risk factors for ulceration in diabetic foot. The aim of this study was to evaluate the effect of an experimental protocol of exercise therapy on joint mobility, muscular strength and gait speed in a group of longterm diabeti...
Article
Full-text available
In diabetic patients the evaluation of how ankle joint mobility (AJM) can be useful in the identification of connective tissue alteration and risk of foot ulcer (FU). Plantar and dorsal flexion of foot were evaluated using an inclinometer in 87 patients (54 type 2 and 33 type 1), and 35 healthy sex- and age-matched control subjects. Patients with d...
Article
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Oxaliplatin-based regimens are effective in metastasized advanced cancers. However, a major limitation to their widespread use is represented by neurotoxicity that leads to peripheral neuropathy. In this study we evaluated the roles of a proven immunotherapeutic agent [Gc-protein-derived macrophage activating factor (GcMAF)] in preventing or decrea...
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Aim: Regular and structured physical activity is known to be effective in preventing and/or reducing the physical and mental decline associated with aging. Indeed, such usefulness of physical activity has been associated with the concept of "successful aging". The aim of the present study was to evaluate the possible physical and cognitive effects...
Article
Quality by Design (QbD) is a new paradigm of quality to be applied to pharmaceutical products and processes, recently encouraged by International Conference on Harmonisation guidelines. In this paper QbD approach was applied to the development of a CE method for the simultaneous assay of metformin hydrochloride (MET) and its main impurities. QbD st...
Article
Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised certain expectations in the past decade as an effective cell-based-therapy for this devastating condition. We argue that the first requirement for successful transplantation is defining the window of plasticity for the striatum during development when the...
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Polymerized resin-based materials are successfully utilized in medical applications. One draw- back is the release of monomers from the matrix due to an incomplete polymerization or degradation processes. Released monomers can diffuse in the systemic circulation and induceadverse effects to biological tissues. Although there are many hypotheses abo...
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Macrocystic pancreatic tumors seem to play an important role among neoplastic lesions of the pancreas as they sometimes either show a malignant potential or they already have neoplastic foci inside the cystic tumor. Differential diagnosis is a key factor in comparison with other cystic tumors which are not malignant as Serous Cystic Tumors (SCTs) a...
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Together with race, stature and age, sex is a main component of the biological identity. Thanks to its proportional correlation with parts of the human body, sex can be evaluated form the skeleton. The most accurate approach to determine sex by bone size is based on os coxae or skull. After natural disaster their presence can never be guaranteed, t...
Article
Creating new organs from the correspondent primordia is the goal of organogenesis in transplantation medicine (Hammerman, 2005). Unlike embryonic stem cells, primordia differentiate along defined organ-committed lines and steered differentiation is unnecessary. Rebuilding human brain structures through in situ organogenesis is a real clinical worki...
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Pancreatic cystic tumors represent an heterogeneous group of neoplasms with a various clinical outcome. The incidence of these neoplasia is growing if compared with the past and this is mainly due to the larger use of more and more performing imaging techniques. The role of MRI and in particular of Cholangio-Pancreato Magnetic Resonance (CPMR) seem...
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This study demonstrates the existence of a linear correlation between Body Mass Index (BMI) and waist circumference in Italian school aged children and suggests an indirect method (from weight and height) to estimate waist circumference, whose increase may be indicative for the diagnosis of the metabolic syndrome.
Article
Natural surfactant combined with beclomethasone decreases pulmonary oxidative stress in preterm lambs with respiratory distress syndrome (RDS). To test the hypothesis that this occurs through a decrease in pulmonary inflammation. Preterm lambs received 200 mg/kg of natural surfactant or 200 mg/kg of natural surfactant combined with 400 or 800 μg/kg...
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At the Anatomical section of the Department of Anatomy, Histology and Forensic Medicine, University of Florence, a software for the administration of multiple-choice tests has been designed and developed in 2002. The program, called ATOL (Anatomy Test on Line), allows the integration, by web interface, into the same system of both the verification...
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The 17th century was characterized by a real revolution in the field of scientific research due to the introduction of the experimental method, promoted by Galileo Galilei who was the most representative scientist of this period. Therefore, medical disciplines, particularly Anatomy, underwent innovative and deep changes shattering traditional cultu...
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We performed a randomized study in preterm lambs to assess the hypothesis that the treatment with natural surfactant combined with beclomethasone might decrease pulmonary oxidative stress in an animal model of respiratory distress syndrome (RDS). Animals received 200 mg/kg of porcine natural surfactant or 200 mg/kg of natural surfactant combined wi...
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It was the aim of this pilot study to investigate effects of motor activity on psychosocial and functional-physical conditions (using an assisted multidimensional questionnaire) of 53 (39 female, 14 male) free living elderly and old subjects in Florence, Italy. In addition, ADL (test of Activities of Daily Living) and Pfeiffer test (short portable...
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Membrane-cytoskeleton interaction regulates transmembrane currents through stretch-activated channels (SACs); however, the mechanisms involved have not been tested in living cells. We combined atomic force microscopy, confocal immunofluorescence, and patch-clamp analysis to show that stress fibers (SFs) in C2C12 myoblasts behave as cables that, ten...
Article
Our aim was to evaluate if the combined inhalation of both nitric oxide (iNO) and aerosolized prostacyclin or iNO and adrenomedullin (ADM) is more effective in lowering pulmonary arterial pressure (PAP) and improving oxygenation than nitric oxide alone in an animal model with pulmonary hypertension (PH). Moreover, we studied the effect on pulmonary...
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The life, activity and specimens of Girolamo Segato (Sospirolo 1792--Firenze 1836), as well as the mystery still surrounding his petrifaction method are outlined in this paper with the aim of shedding some light on one of the most controversial naturalists of the 19th century. Even if after his death many preparations became scattered or even destr...
Article
NAPOR-3 is a central nervous system RNA binding protein that is associated with downstream mRNA targets and has been demonstrated to be selectively overexpressed during apoptotic cell death. In this study, we first examined the regional distribution of NAPOR-3 mRNA in the adult rat brain by in situ hybridization: the transcript was abundantly expre...
Article
Sphingosine-1-phosphate (S1P) is a lipid mediator, which affects many essential processes such as cell proliferation, differentiation and contraction in many cell types. We have previously demonstrated that the lipid mediator elicits Ca(2+) transients in a myoblastic cell line (C2C12) by interacting with its specific receptors (S1PR(s)). In the pre...
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Chronic injuries of the locomotor apparatus represent the main cause of drop-out among top level gymnasts. The aim of the present paper was to verify whether the postural control, investigated by using an integrated approach and accordingly optimized, could be an effective tool for the secondary prevention of training-related disorders of the locom...
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To investigate the effects of physical activity not only on morphometric left ventricular parameters, but also on the abdominal aorta diameter and on blood pressure, we enrolled 100 healthy subjects, 50 males and 50 females, aged between 63 and 91 years (mean 73.3 +/- s.d. 7.7), each divided into two subgroups, sedentary and non sedentary, come to...
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Several papers have shown that in young people sports activity is associated with a higher prevalence of cardiac valves incompetence, that can be detected, though to a lesser extent, even in healthy subjects randomly selected from the population. Aim of the present study was to analyse the effects of physical activity not only in young subjects but...
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The main anatomical resources found on the Internet are listed and discussed here, concerning the topics of gross anatomy, neuroanatomy, microscopic anatomy and anatomical museums. The search is updated to September 2000, and all the listed Web sites can be used to build a multimedial anatomical lab.

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Projects

Projects (3)
Project
Obtain current clinical elements from the lessons of History