Feng Yu

• Shanghai Jiao Tong University

Empowered by the rapid advancement of digital technologies, including Big Data, artificial intelligence (AI), and virtual reality, human society has transformed from the era of information to the era of digital intelligence. Unlike previous social formations, the digital-intelligent society has disrupted many longheld consensus norms and introduced...

The COVID-19 pandemic has accelerated the deployment of artificial intelligence (AI) across various domains, notably in healthcare, epidemic management, and public sentiment analysis. Focusing on China as a case study, this paper critically examines AI’s societal and individual impacts during the pandemic. Through a synthesis of literature and case...

This paper provides a comprehensive examination of thought analysis as a contemporary practice within philosophical inquiry, exploring its theoretical foundations, methodological approaches, and practical implications. Rooted in classical philosophical traditions yet acutely relevant to modern life, thought analysis—officially conceptualized by Tia...

Philosophical practice, an art of living rooted in ancient traditions, is enriched by modern techniques such as individual counseling, Socratic group dialogues, and organizational consulting. Philosophical counseling, a key aspect of this practice, employs traditional philosophical frameworks and rational reasoning to address clients' concerns, dis...

This paper examines the application and evolution of philosophical practice in China, which employs philosophical principles and methods to facilitate insights and address life’s complexities. We aim to bridge the knowledge gap regarding the trajectory and contemporary landscape of China’s philosophical practice and its impact on individual and soc...

Although global warming is a serious problem that influences numerous people worldwide, individuals are still reluctant to change their behaviours. The present research investigates how local hot temperatures affect climate action in non‐Western groups. In Study 1, an analysis of temperature and information acquisition by Shanghai residents in 122...

Artificial intelligence (AI) and robots have the potential to revolutionize society, with impacts ranging from the broadest reaches of industry and policy to the minutiae of daily life. The extent to which AI-based technologies can bring benefits to human society depends on how people perceive them––folk beliefs of AI and robots. The present paper...

Traditional Chinese philosophy has always paid much attention to the cultivation of one’s body and mind, speeches and behaviors. The contemporary rise of philosophical practice, especially in the context of philosophical counseling, presents an opportunity to integrate the rich legacy of Confucian self-cultivation. This paper endeavors to delineate...

Emotion has long been considered to distinguish humans from Artificial Intelligence (AI). Previously, AI's ability to interpret and express emotions was seen as mere text interpretation. In humans, emotions co-ordinate a suite of behavioral actions, e.g., under negative emotion being risk averse or under positive emotion being generous. So, we inve...

Emotion has long been considered to distinguish humans from Artificial Intelligence (AI). Previously, AI's ability to interpret and express emotions was seen as mere text interpretation. In humans, emotions co-ordinate a suite of behavioral actions, e.g., under negative emotion being risk averse or under positive emotion being generous. So, we inve...

Artificial intelligence has quickly integrated into human society and its moral decision-making has also begun to slowly seep into our lives. The significance of moral judgment research on artificial intelligence behavior is becoming increasingly prominent. The present research aims at examining how people make moral judgments about the behavior of...

Desire is an important philosophical topic that deeply impacts everyday life. Philosophical practice is an emerging trend that uses philosophical theories and methods as a guide to living a eudaimonic life. In this paper, we define desire philosophically and compare different theories of desire in specific Eastern and Western traditions. Based on t...

Background Various therapeutic strategies are available for the first-line treatment of patients with advanced hepatocellular carcinoma (aHCC). But which approach is the most cost-effective remains uncertain. Objectives This study aims to evaluate the cost-effectiveness of first-line strategies in aHCC patients from the perspective of Chinese and...

Will Chinese people change in terms of their character strengths when disasters strike? As far as the most recent COVID-19 pandemic is concerned, we provide an explorative answer from the impacts of positive traits included in the Values in Action Classification of Strengths upon Chinese people. We conducted a large-scale online survey from 1 Janua...

Aristolochic acid I (AA I) is one of the most abundant and toxic aristolochic acids that is reported to cause Aristolochic acid nephropathy (AAN). This paper was designed to assess whether mitochondrial Uncoupling Protein 2 (UCP2), which plays an antioxidative and antiapoptotic role, could protect human renal proximal tubular epithelial (HK-2) cell...

Sepsis is a type of systemic inflammation response syndrome that leads to organ function disorders. Currently, there is no specific medicine for sepsis in clinical practice. Lipopolysaccharide (LPS) is an important endotoxin that causes sepsis. Here, we report an effective two-drug combination therapy to treat LPS-induced liver and kidney injury in...

Along with the increasing development of information technology, the interaction between artificial intelligence and humans is becoming even more frequent. In this context, a phenomenon called “medical AI aversion” has emerged, in which the same behaviors of medical AI and humans elicited different responses. Medical AI aversion can be understood i...

Background: The drug therapy of venous thromboembolism (VTE) presents a significant economic burden to the health-care system in low- and middle-income countries. To understand which anticoagulation therapy is most cost-effective for clinical decision-making , the cost-effectiveness of apixaban (API) versus rivaroxaban (RIV), dabigatran (DAB), and...

Background: Sepsis, a systemic inflammatory disease that leads to life-threatening organ functions disorders, such as liver and kidney injury. Ulinastatin (UTI) and Thrombomodulin (TM) are active macromolecules isolated from human urine. UTI and TM have been found to have therapeutic effects on inflammatory diseases. In this study, we verified prot...

Aristolactam I (AL-I) is the main active ingredient in the Aristolochia plant species, which have been associated with severe nephrotoxicity. In order to investigate the mechanism of AL-I induced renal epithelial-mesenchymal transition (EMT), we established an AL-I induced EMT model in human proximal tubular epithelial cells (HK-2 cells). Biochemic...

This meta‐analysis was performed to compare the safety, efficacy, and pharmacoeconomic of bivalirudin versus heparin in high‐risk patients for percutaneous coronary interventions (PCI). Earlier meta‐analysis comparing bivalirudin and heparin during PCI demonstrated that bivalirudin caused less bleeding with more stent thrombosis. However, little da...

As COVID-19 struck worldwide, we were inspired by behavioral immune system theory and wondered whether there would be changes to public morality brought about by the pandemic. We tracked public reactions through posts on Chinese social media to analyze the dynamics of public moral motivation. Big data analysis shows that the impact of disaster upon...

Previous studies have widely demonstrated that loneliness will increase people’s anthropomorphic tendency on nonhuman agents. This research extends the effect of loneliness to social robots and differentiates them and common nonhuman agents (e.g., gadgets, animals). Remarkably divergent effects have been verified: experimentally induced loneliness...

Cultural capital is defined as the accumulation of knowledge, behaviors, and skills that a person can tap into to demonstrate one's cultural competence and social status (Bourdieu, 1986). Cultural capital has been well‐understood in social sciences such as sociology and economics for the past decades. Little research has examined the psychological...

• First dose prediction is challenging in neonates. Our objective in this proof-of-concept study was to perform a pharmacokinetic (PK) bridging study from juvenile mice to neonates for drugs metabolized by CYP3A. • We selected midazolam and clindamycin as model drugs. We developed juvenile mice population PK models using NONMEM. The PK parameters o...

Despite the development of green products, convincing consumers to engage in green consumption is still a difficult task. This research attempts to help solve this problem from the perspective of brand logo design. Specifically, this research explores how circular and angular logo shapes influence green consumption. Three studies provide support fo...

Aristolochic acid (AA) is a generic term that describes a group of structurally related compounds found in the Aristolochiaceae plants family. These plants have been used for decades to treat various diseases. However, the consumption of products derived from plants containing AA has been associated with the development of nephropathy and carcinoma...

Although there is a flourishing literature on the psychology of globalization and the psychology of morality, respectively, the moral dimension has been largely absent in the discourse of globalization psychology. Our current work attempts to fill this gap by establishing a conceptual and empirical link between global orientations and moral foundat...

Positive education aims to improve students’ academic performance as well as their well-being and character strengths. In contrast to traditional school counseling methods that are typically post hoc and pathological, positive education advocates a preventive and positive approach, which teaches students well-being skills that can reduce the chance...

Prior research shows mixed results on the relationship between well-being and economic growth, and the relationship between well-being and population size, yet consistent associations between well-being and green space. This paper aims to analyse the relationship between city residents’ well-being and three established indicators: economic growth (...

Dramatic cultural change has occurred in Mainland China over the past four decades, yet little is known about how this cultural shift impacts Chinese peoples’ moral values. The present research aims to fill this gap by examining whether Chinese traditional and modern cultures influence young adults’ moral judgments. Study 1 investigated the relatio...

Active hydraulic ventricular attaching support system (ASD) placed around the heart is not only a novel, nontransplant surgical device used for epicardial administration of drugs like lidocaine, but also a promising treatment option for ventricular fibrillation (VF) and arrhythmias. We hypothesize that lidocaine in 5 mg/kg dose released by ASD sign...

Growth mindset and grit have attracted much attention in educational research recently. Yet the underlying mechanisms that relate these variables to each other as well as to other variables remain largely unclear. This study investigates the relationships among growth mindset, learning motivations, and grit. We recruited a total of 1,842 students (...

Aim: To investigate the protective effect of dantonic in ischemic myocardial damage by evaluating the expression of circulating microvesicles (MVs) and microRNA-1 (miR-1) in two animal models. Methods: Two animal models of myocardial ischemia were established that were isoproterenol-induced myocardial ischemia (ISO-AMI) rat model and the acute myoc...

Ventricular restraint therapy is a non-transplant surgical option for the management of advanced heart failure (HF). To augment the therapeutic applications, it is hypothesized that ASD shows remarkable capabilities not only in delivering stem cells but also in dilated ventricles. Male SD rats were divided into four groups (n = 6): normal, HF, HF +...

Over the past decade, major cities in China have suffered from severe air pollution, which is also known as smog. Despite lay considerations that smog might pose risks for psychopathology, it remains unknown whether it is only linked to affective psychopathology or to a broader range of symptomologies. Moreover, whether individual differences in em...

Aristolochic acid I (AA-I), one of the main active components in Aristolochaia herbs, may induce aristolochic acid nephropathy (AAN). Renal interstitial fibrosis is one of the most typical features of AAN. To investigate the mechanism of Aristolochic acid I (AA-I) -induced renal epithelial-mesenchymal transition (EMT) and determine the role of aqua...

The relationship between Socio-economic factors and morality remains controversial. Previous research has found that wealth makes people unethical, while other research suggests that poverty is a good predictor of unethical behavior. The relationship between other social factors is also ambiguous. In the current study, the relationship between soci...

The gene-guided dosing strategy of warfarin generally leads to over-dose in patients at doses lower than 2 mg/kg, and only 50% of individual variability in daily stable doses can be explained. In this study, we developed a novel population pharmacokinetic (PK) model based on a warfarin dose algorithm for Han Chinese patients with valve replacement...

Rhein is one of the main active compounds in total rhubarb anthraquinones (TRAs) that were reported to cause nephrotoxicity. This paper explored the mechanism of how rhein induced apoptosis in human renal proximal tubular epithelial cells (HK-2 cells). In this study, rhein was found to induce apoptosis in HK-2 cells according to the results of anne...

The central hypothesis of Semantic Network Model of Creativity is that creative people, who are exposed to more information that are both novel and useful, will have more interconnections between event schemas in their associations. The networks of event schemas in creative people’s minds were expected to be wider and denser than those in less crea...

Background/aims: Our previous studies have indicated that a novel endothelin receptor antagonist CPU0213 effectively normalized renal function in diabetic nephropathy. However, the molecular mechanisms mediating the nephroprotective role of CPU0213 remain unknown. Methods and results: In the present study, we first detected the role of CPU0213 o...

We investigated the cultural differences in understanding and reacting to the babyface in an effort to identify both cultural and gender biases in the universal hypothesis that the babyfaced individuals are perceived as naïve, cute, innocent, and more trustworthy. Sixty-six Chinese and Sixty-six American participants were required to evaluate Chine...

There are few studies in which the focus is on cognitive determinants of artwork bidding. Using a micro approach, we explored factors that may influence bidders' offering from a psychological perspective. The 157 participants rated 25 paintings on the price they were willing to offer for works by famous Chinese artists executed in the traditional C...

Rhein is an active component of rhubarb; a traditional Chinese medicine reported to induce apoptosis and cause liver toxicity. However, rhein’s apoptotic-inducing effects, as well as its molecular mechanisms of action on hepatic cells need to be further explored. In the present study, rhein was found to trigger apoptosis in primary human hepatic HL...

Moral issues surrounding products are attracting attention of researchers. Fairtrade products bear logos that communicate moral information, which indicates justice for the poor. Studies found that products tagged with Fairtrade logos were believed to taste better. Furthermore, people tend to judge moral acts as more virtuous while moral violations...

By investigating the use of first-person pronouns in nine languages using the Google Ngram Database, we examined the degree to which different cultural values skewed toward individualism or collectivism over a span of 59 years. We found that in eight of nine languages (British English being the exception), first-person singular pronouns (vs. first-...

Background There is uncertainty surrounding the influence of prior antiplatelet agent use on outcomes after intravenous thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke.AimWe performed a systematic review with a final meta-analysis to evaluate the efficacy and safety of prior antiplatelet use before intravenous re...

Western psychology has essentially become an independent discipline, relying on empirical laboratory research. However, the era of big data will dramatically influence the research paradigm of scientific psychology. The characteristics of big data methods coincide with Chinese folk epistemology, which provides Chinese psychology the opportunity to...

Aim: This study was performed to develop an algorithm using polymorphisms of CYP2D6, p-gp, OPRM1, COMT and psychological variables to predict tramadol response in Chinese patients recovering from upper limb fracture internal fixation surgery. Methods: A total of 250 Han Chinese patients recovering from fracture in the upper limb were enrolled. C...

Pharmacokinetics (PK) of argirein might be changed in response to mitochondrial (MITO) dysfunction and activated nicotinamide adenine dinucleotide phosphate oxidase (NOX) on hypoxia. We hypothesized that hypoxic changes in MITO and NOX could alter PK and tissue distribution of argirein. We tested if these changes in PK of argirein by hypoxia could...

To investigate the antihypertensive effects and tolerability of aliskiren in comparison with other antihypertensive drugs and placebo in patients with hypertension, a meta-analysis was performed of studies published between 1950 and 2012. A systematic literature search of MEDLINE and the Cochrane Library was conducted for randomized controlled tria...

Objectives: To establish a new animal model to mimic the clinical condition of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). CP/CPPS is a highly prevalent condition with detrimental effect on the quality of life, but the etiology, pathogenesis, and optimal treatment of CP/CPPS remain unknown. This new animal model would greatly contr...

Few pharmacogenomic dosing regimens of warfarin have been developed for Chinese patients with non valvular atrial fibrillation (NVAF). The objective of this study was to develop a new algorithm by polymorphisms of CYP2C9, VKORC1 and CYP4F2 to predict the daily stable dose of warfarin in Chinese patients with NVAF. A total of 325 Chinese NVAF patien...

Downregulation of androgen biosynthesis genes StAR (steroidogenic acute regulatory) and 3β-HSD (3β-hydroxysteroid dehydrogenase) contributes to low testosterone levels in hypoxic mice and is possibly related to increased expression of pro-inflammatory cytokines in the testis. The aim of this study is to investigate the effects of CPU86017-RS that b...

Hypoxia exposure initiates low serum testosterone levels that could be attributed to downregulated androgen biosynthesizing genes such as StAR (steroidogenic acute regulatory protein) and 3-beta-HSD (3-beta-hydroxysteroid dehydrogenase) in the testis. It was hypothesized that these abnormalities in the testis by hypoxia are associated with oxidativ...

To evaluate the association between polymorphism of 5,10-methylenetrahydrofolate reductase C677T and risk of acute lymphoblastic leukemia (ALL). Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers, according to the inclusion and exclusion criteria. Data on case-control studies on...

The aim of the present study is to investigate the alterations of cardiac hemodynamics, sodium current (I(Na)) and L-type calcium current (I(Ca-L)) in the cardiomyopathic model of rats. The model of cardiomyopathy was established by intraperitoneal injection of L-thyroxine (0.5 mg/kg) for 10 d. The hemodynamics was measured with biological experime...

The aim of this study was to determine if CPU228, a derivative of dofetilide, is more effective than dofetilide in attenuating isoproterenol-induced heart failure by recovering downregulated FK506 binding protein (FKBP12.6), and suppressing oxidative stress, upregulated NADPH oxidase and protein kinase C epsilon (PKC epsilon) hyperphosphorylation i...

Flt4 plays a key role in promoting tumor metastasis by stimulating solid tumor lymphangiogenesis. In this study, mouse Flt4 (mFlt4) was displayed on T4 phage in order to explore the feasibility of breaking immune tolerance to "self-antigens" and to evaluate the phage's antitumor activity. A T4 phage nanometer particle expressing mFlt4 on the surfac...

An increase in reactive oxygen species (ROS) through NADPH oxidase activation frequently follows stress that activates beta-adrenoreceptors, leading to deterioration of cardiovascular disease. We hypothesized that upregulation of NADPH oxidase in the vasculature causes mild vascular spasm subsequent to chronic isoproterenol (ISO) administration, co...

Acute heart failure (AHF) critically affects morbidity and mortality in patients suffering from septic shock. It is hypothesized that AHF is linked to down-regulation of FKBP12.6 (calstabin 2) and SERCA2a (sarco/endoplasmic reticulum Ca2+ ATPase 2a), which may be mediated by an activated endothelin (ET) system in the myocardium. The aim of the stud...

Pulmonary artery hypertension (PAH, PH) is a chronic and progressive disease with high morbidity and mortality and is resistant to vasodilative drugs in the clinic due to remodeling of pulmonary arterioles involved in PAH. The endothelin (ET) receptor antagonist bosentan is an effective oral medication in relieving PAH due to its antiproliferative...

The occurrence of cardiac arrhythmias is related to the abnormality of ion channels not only in sarcolemma but also in the sarcoplasmic reticulum, which regulates the process of calcium release and up-take intracellularly. Patterns of ion channelopathy in the sarcolemma can be divided into single channel disorder from gene mutations and multiple ch...