Feng Shi

Feng Shi
United Imaging Intelligence · R&D

Doctor of Philosophy

About

527
Publications
56,028
Reads
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17,298
Citations
Additional affiliations
February 2018 - present
United Imaging Intelligence
Position
  • R&D
February 2016 - February 2018
Cedars Sinai Medical Center
Position
  • Professor (Assistant)
October 2013 - February 2016
University of North Carolina at Chapel Hill
Position
  • Professor (Assistant)

Publications

Publications (527)
Article
A novel porous organic polymer catalyst with in situ encapsulated single-site Rh (Rh@CPOL-DPMphos&p-3vPPh3) was developed and employed in heterogeneous hydroaminomethylation of alkenes, affording the corresponding amines in good to excellent regioselectivity and catalytic activity by a one-pot method. The combined actions of hierarchical pore confi...
Article
A new strategy for the enantioselective synthesis of axially chiral 3,3'‐bisindoles was devised by the direct coupling of two indole rings. This strategy makes use of the C3‐umpolung reactivity of 2‐indolylmethanols, which enables the catalytic asymmetric addition reaction of 2‐indolylmethanols with rationally designed 2‐substituted indoles, thus c...
Article
Full-text available
Ischemic stroke is the most common type of stroke, ranked as the second leading cause of death worldwide. The Alberta Stroke Program Early CT Score (ASPECTS) is considered as a systematic method of assessing ischemic change on non-contrast CT scans (NCCT) of acute ischemic stroke (AIS) patients, while still suffering from the requirement of experts...
Article
Background: Exploring the genomic landscape of hepatocellular carcinoma (HCC) provides clues for therapeutic decision-making. Phosphatidylinositol-3 kinase (PI3K) signaling is one of the key pathways regulating HCC aggressiveness, and its genomic alterations have been correlated with sorafenib response. In this study, we aimed to predict somatic m...
Article
Full-text available
PurposeEphA2 is a key factor underlying invasive propensity of gliomas, and is associated with poor prognosis of tumors. We aimed to develop a radiomics-based imaging index for predicting EphA2 expression in diffuse gliomas, and further estimating its value for grading of tumors.MethodsA total of 182 patients with diffuse gliomas were included. All...
Article
An organocatalytic asymmetric construction of hexahydropyrrolo[2,3-b]indole-containing tetrasubstituted allene scaffolds bearing both axial chirality and central chirality has been established via a cascade 1,8-addition/dearomatization-cyclization reaction of para-aminophenyl propargylic alcohols with tryptamines in the presence of chiral phosphori...
Article
The first highly atroposelective construction of N-N axially chiral indole scaffolds were established via a new strategy of de novo ring formation. This strategy makes use of the organocatalytic asymmetric Paal-Knorr reaction of well-designed N-aminoindoles with 1,4-diketones, thus affording high yields for N-pyrrolylindoles with excellent atropose...
Article
The first highly atroposelective construction of N‐N axially chiral indole scaffolds were established via a new strategy of de novo ring formation. This strategy makes use of the organocatalytic asymmetric Paal‐Knorr reaction of well‐designed N‐aminoindoles with 1,4‐diketones, thus affording high yields for N‐pyrrolylindoles with excellent atropose...
Article
The catalytic asymmetric construction of axially chiral indole-based frameworks is an important area of research due to the unique characteristics of such frameworks. Nevertheless, research in this area is still in its infancy and has some challenges, such as designing and constructing new classes of axially chiral indole-based scaffolds and develo...
Article
A new class of axially chiral styrene-based thiourea-tertiary amine catalysts, which have unique characteristics such as an efficient synthetic route, multiple chiral elements and multiple activating groups, has been rationally designed. These new chiral catalysts have proven to be efficient organocatalysts, enabling the chemo-, diastereo- and enan...
Article
A new class of axially chiral styrene-based thiourea-tertiary amine catalysts, which have unique characteristics such as an efficient synthetic route, multiple chiral elements and multiple activating groups, has been rationally designed. These new chiral catalysts have proven to be efficient organocatalysts, enabling the chemo-, diastereo- and enan...
Article
Full-text available
Diminishing fossil fuel resources and calls for sustainability are driving the urgent need for efficient valorization of renewable resources with high atom efficiency. Inspired from the natural goethite mineral with Mn paragenesis, we develop cost-effective MnO 2 /goethite catalysts for the efficient valorization of dihydroxyacetone, an important b...
Article
Full-text available
Purpose: Parkinson’s disease (PD) diagnosis algorithms based on quantitative susceptibility mapping (QSM) and image algorithms rely on substantia nigra (SN) labeling. However, the difference between SN labels from different experts (or segmentation algorithms) will have a negative impact on downstream diagnostic tasks, such as the decrease of the a...
Article
Full-text available
Catalytic asymmetric [2 + 4] cycloadditions of 3-vinylindoles with ortho-quinone methides and their precursors were carried out in the presence of chiral phosphoric acid to afford a series of indole-containing chroman derivatives with structural diversity in overall high yields (up to 98%), good diastereoselectivities (up to 93:7 dr) and moderate t...
Article
Lung cancer is the leading cause of cancer deaths worldwide. Accurately diagnosing the malignancy of suspected lung nodules is of paramount clinical importance. However, to date, the pathologically-proven lung nodule dataset is largely limited and is highly imbalanced in benign and malignant distributions. In this study, we proposed a Semi-supervis...
Preprint
Full-text available
Early and accurate severity assessment of Coronavirus disease 2019 (COVID-19) based on computed tomography (CT) images offers a great help to the estimation of intensive care unit event and the clinical decision of treatment planning. To augment the labeled data and improve the generalization ability of the classification model, it is necessary to...
Article
Full-text available
Background Emerging evidence indicates that iron distribution is heterogeneous within the substantia nigra (SN) and it may reflect patient-specific trait of Parkinson’s Disease (PD). We assume it could account for variability in motor outcome of subthalamic nucleus deep brain stimulation (STN-DBS) in PD. Objective To investigate whether SN suscept...
Article
Full-text available
Early and accurate severity assessment of Coronavirus disease 2019 (COVID-19) based on computed tomography (CT) images offers a great help to the estimation of intensive care unit event and the clinical decision of treatment planning. To augment the labeled data and improve the generalization ability of the classification model, it is necessary to...
Article
Full-text available
Background: It is often tricky to differentiate cystic pituitary adenoma from Rathke cleft cyst with visual inspection because of similar MRI presentations between them. We aimed to design an MR-based radiomics model for improving differential diagnosis between them. Methods: Conventional diagnostic MRI data (T1-,T2-, and postcontrast T1-weighte...
Article
Precisely controlling the regioselectivity with monophosphine ligand is a long-standing challenge in hydroformylation. Herein, we describe the one-pot encapsulation of single-atom Rh catalysts within porous monophosphine polymers for regioselective heterogeneous hydroformylation of alkenes. The optimized catalyst ([email protected]) shows remarkabl...
Chapter
CO 2 is a cheap, abundant, renewable, and nontoxic C 1 resource, and the utilization of CO 2 as carbonyl resource for the synthesis of value‐added carbonyl compounds has attracted increasing interests from the view of environmental protection and sustainable development. The developments and recent advances in conversion of CO 2 to produce useful c...
Chapter
Non‐C 1 carbonyl molecules, including carbonyl metal, formates, formamides, formic anhydride, silacarboxylic acid, n ‐formylsaccharin, acyl chloride, and in situ generated carbonyl resource, have been developed as CO surrogates for synthesis of carbonyl compounds. In this chapter, the recent advances in carbonylation reactions using different carbo...
Chapter
Although CO has been extensively applied in chemical industry, its intrinsic properties such as high toxicity, flammability, and special equipment requirement for handling limit its utilization in organic synthesis and academia. Thus, considerable efforts have been devoted to the development of CO surrogates to avoid the direct use of CO. As cheap...
Chapter
Synthesis and transformation of carbonyl‐containing molecules constitute the core of carbonyl chemistry. These molecules can bridge the whole catalytic process and behave as reactants to provide the carbonyl sources for various carbonyl compounds (aldehydes, ketones, acids, esters, and their derivatives) synthesis; as catalysts for the acid‐catalyz...
Chapter
The transformation of carbonyl molecules is a powerful tool for the synthesis of fine and bulk chemicals as well as pharmaceuticals. Carbon monoxide (CO) represents an indispensable carbonyl reagent in the synthesis of carbonyl‐containing compounds due to its abundance, low price and high reactivity. This chapter will briefly describe the recent ad...
Chapter
Carbonyl molecules including aldehydes and ketones groups can be applied as the active species in many valuable transformations. This chapter mainly focuses on the reactions realized via carbonyl–hydroxyl groups recycling. To be specific, carbon material and related polymers containing aldehydes and ketones group as the catalyst are discussed in de...
Chapter
Carboxyl group (–CO 2 H) can be applied as the active species in many catalytic reactions. This chapter will briefly introduce the progress in the acid‐catalyzed reactions with –CO 2 H. Specifically, carboxylic acid and carboxyl functionalized carbon materials as the catalysts are discussed in this section, which presented several meaningful reacti...
Chapter
As an important class of structural motifs, carbonyl compounds display the robust synthetic utility in functional materials owing to the presence of easily transformable carbonyl group. In this chapter, synthetic applications of carbonyl compounds to produce functional materials will be discussed briefly. Particularly, the synthesis of functional m...
Chapter
Carbonyl compounds serve as key intermediates in the preparation of a variety of functional molecules. In this chapter, synthetic applications of carbonyl compounds to produce versatile chemicals will be described. Particularly, the synthesis of functional molecules is mainly focused on the transformations with carbonyl compounds as starting materi...
Article
Full-text available
The shift from fossil carbon sources to renewable ones is vital for developing sustainable chemical processes to produce valuable chemicals. In this work, value‐added formamides were synthesized in good yields by the reaction of amines with C2‐C3 biomass‐based platform molecules such as glycolic acid, 1,3‐dihydroxyacetone and glyceraldehyde. These...
Article
With the advance of medical imaging technologies, multimodal images such as magnetic resonance images (MRI) and positron emission tomography (PET) can capture subtle structural and functional changes of brain, facilating the diagnosis of brain diseases such as Alzheimers disease (AD). In practice, multimodal images may be incomplete since PET is of...
Article
Based on the experimental and DFT calculation results, here for the first time we built preferential adsorption sites for nitroarenes by modification of the supported Cu catalysts surface with 1,10-phenathroline (1,10-phen), by which the yield of aniline via reduction of nitroarene is enhanced three times. Moreover, a macromolecular layer was in-si...
Article
Enantioenriched indole derivatives are widely found in natural products, pharmaceuticals and bioactive compounds. Therefore, developing efficient methods for the synthesis of enantioenriched indole derivatives has become an important goal in the community of organic chemistry. To this end, chemists have designed and developed a variety of indole-co...
Article
Atroposelective construction of axially chiral alkene‐heteroaryl scaffolds is highly desired but challenging. In this work, we established an atroposelective construction of axially chiral alkene‐indole scaffolds via the strategy of catalytic enantioselective addition reaction of 3‐alkynyl‐2‐indolylmethanols with bulky nucleophiles. In this strateg...
Article
Full-text available
Background Spatial and temporal lung infection distributions of coronavirus disease 2019 (COVID-19) and their changes could reveal important patterns to better understand the disease and its time course. This paper presents a pipeline to analyze statistically these patterns by automatically segmenting the infection regions and registering them onto...
Article
The worldwide spread of coronavirus disease (COVID-19) has become a threatening risk for global public health. It is of great importance to rapidly and accurately screen patients with COVID-19 from community acquired pneumonia (CAP). In this study, a total of 1658 patients with COVID-19 and 1027 CAP patients underwent thin-section CT. All images we...
Article
Full-text available
Background and aims: Even though the Compulsive Sexual Behavior Disorder (CSBD) was added to the ICD-11 under the impulse control category in 2019, its neural mechanisms are still debated. Researchers have noted its similarity both to addiction and to Obssesive-Compulsive Disorder (OCD). The aim of our study was to address this question by investi...
Preprint
How to fast and accurately assess the severity level of COVID-19 is an essential problem, when millions of people are suffering from the pandemic around the world. Currently, the chest CT is regarded as a popular and informative imaging tool for COVID-19 diagnosis. However, we observe that there are two issues -- weak annotation and insufficient da...
Article
The coronavirus disease, named COVID-19, has become the largest global public health crisis since it started in early 2020. CT imaging has been used as a complementary tool to assist early screening, especially for the rapid identification of COVID-19 cases from community acquired pneumonia (CAP) cases. The main challenge in early screening is how...
Article
The catalytic dehydrogenation of ethanol to acetaldehytde by releasing hydrogen which is catalyzed by heterogeneous catalysis is an improsing and sustainable approach. Compared with oxidative pathyway, the cataltyic dehydrogeantion of ethanol affords the production of H2 simultaneously which is considered as an efficient, clean, and renewable energ...
Article
How to fast and accurately assess the severity level of COVID-19 is an essential problem, when millions of people are suffering from the pandemic around the world. Currently, the chest CT is regarded as a popular and informative imaging tool for COVID-19 diagnosis. However, we observe that there are two issues – weak annotation and insufficient dat...
Article
Understanding chest CT imaging of the coronavirus disease 2019 (COVID-19) will help detect infections early and assess the disease progression. Especially, automated severity assessment of COVID-19 in CT images plays an essential role in identifying cases that are in great need of intensive clinical care. However, it is often challenging to accurat...
Article
A base-promoted (4 + 2) cyclization of aza-o-quinone methides (aza-o-QMs) in situ generated from N-(o-chloromethyl)aryl amides was established. In this approach, azlactones were utilized as competent two-atom reaction partners to undergo (4 + 2) cyclization with aza-o-QMs, which afforded a series of dihydroquinolinone derivatives in overall good yi...
Article
With the rapidly worldwide spread of Coronavirus disease (COVID-19), it is of great importance to conduct early diagnosis of COVID-19 and predict the conversion time that patients possibly convert to the severe stage, for designing effective treatment plans and reducing the clinicians’ workloads. In this study, we propose a joint classification and...
Article
Full-text available
The ongoing worldwide COVID-19 pandemic has become a huge threat to global public health. Using CT image, 3389 COVID-19 patients, 1593 community-acquired pneumonia (CAP) patients, and 1707 nonpneumonia subjects were included to explore the different patterns of lung and lung infection. We found that COVID-19 patients have a significant reduced lung...
Chapter
Computed Tomography Perfusion (CTP) images have drawn extensive attention in acute ischemic stroke assessment due to its imaging speed and ability to provide dynamic perfusion quantification. However, the cerebral ischemic infarcted core has high individual variability and low contrast, and multiple CTP parametric maps need to be referred for preci...
Preprint
Full-text available
Background: Spatial and temporal lung infection distributions of coronavirus disease 2019 (COVID-19) and their changes could reveal important patterns to better understand the disease and its time course. This paper presents a pipeline to analyze statistically these patterns by automatically segmenting the infection regions and registering them ont...
Article
Axially chiral indole‐based frameworks have been recognized as a class of important five‐membered heterobiaryls and developing catalytic asymmetric approaches for constructing these frameworks in an enantioselective manner is highly desirable. In recent years, synthetic chemists have paid much attention to this research field, and rapid development...
Article
The hydroarylation of alkenes with aromatic amines is recognized as the most atom-economical and straightforward approach to obtain functional aromatic amines, which are versatile building blocks in organic synthesis and material chemistry. However, controllable synthesis of single hydroarylation product is still a significant challenge because hyd...
Article
Chiral indole derivatives such as indolines and indolenines are important heterocyclic frameworks which constitute the core structures of many natural products and bioactive molecules. So, intensive attentions from chemists have been paid to the construction of such frameworks. Among different approaches, organocatalytic asymmetric dearomatization...
Article
The synthesis of N‐substituted amines is one of the key transformations in synthetic chemistry and chemical industry because amines are ubiquitous in the syntheses of agrochemicals, pharmaceuticals, flavorings, fragrances, and advanced materials. In order to realize the clean and economic synthesis of N‐substituted amines, several aspects should be...
Chapter
Infection segmentation is essential for quantitative assessment in computer-aided management of COVID-19. However, clinical CT images are usually heterogeneous, which are reconstructed by different protocols with varying appearance and voxel spacing due to radiologist preference. Most existing infection segmentation models are only trained using sp...
Article
Functional connectivity (FC) matrices measure the regional interactions in the brain and have been widely used in neurological brain disease classification. A brain network, also named as connectome, could form a graph structure naturally, the nodes of which are brain regions and the edges are interregional connectivity. Thus, in this study, we pro...
Article
The coronavirus disease 2019 (COVID-19) is now a global pandemic. Tens of millions of people have been confirmed infection, and more people are suspected. Chest computed tomography (CT) is recognized as an important tool for COVID-19 severity assessment. As the number of chest CT images increase rapidly, manual severity assessment becomes a labor-i...
Chapter
Graph convolutional network (GCN) has shown its potential on modeling functional MRI connectivity and recognizing neurological disease tasks. However, conventional GCN layers generally inherit the original graph topology, without the modeling of hierarchical graph representation. Besides, although the interpretability of GCN has been widely investi...
Article
The regio‐ and enantioselective (3+3) cycloaddition of nitrones with 2‐indolylmethanols has been established under the cooperative catalysis of hexafluoroisopropanol (HFIP) and chiral phosphoric acid (CPA). This approach not only realized the first organocatalytic asymmetric (3+3) cycloaddition of nitrones and the first C3‐nucleophilic asymmetric (...
Article
The regio‐ and enantioselective (3+3) cycloaddition of nitrones with 2‐indolylmethanols was accomplished by the cooperative catalysis of hexafluoroisopropanol (HFIP) and chiral phosphoric acid (CPA). Using this approach, a series of indole‐fused six‐membered heterocycles were synthesized in high yields (up to 98%), with excellent enantioselectiviti...
Chapter
Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging technique used to quantitatively measure the iron content in the brain. Patients with Parkinson’s disease are reported having increased iron deposition, especially in substantia nigra (SN) which is a relatively small gray matter structure located in the midbrain. The automati...
Chapter
Vessel segmentation and anatomical labeling are of great significance for vascular disease analysis. Because vessels in 3D images are the tree-like tubular structures with diverse shapes and sizes, and direct use of convolutional neural networks (CNNs, based on spatial convolutional kernels) for vessel segmentation often encounters great challenges...
Article
A convenient and effective heterogeneous non-noble metal catalytic system for regioselective hydrosilylation of alkynes was successfully developed by the combination of Ni/Al2O3 with a xantphos ligand. The resulting catalytic system displayed excellent catalytic performance in the heterogeneous hydrosilylation of PhSiH3 with a wide range of aromati...
Chapter
The transformation of carbon dioxide (CO2) into value‐added chemicals is very important from the view of environmental protection and sustainable development. The use of heterogeneous catalysts for CO2 transformation is desirable and attractive owing to the convenience of recovering and recycling of the catalysts. The recent advances in the catalyt...
Article
Chest computed tomography (CT) becomes an effective tool to assist the diagnosis of coronavirus disease-19 (COVID-19). Due to the outbreak of COVID-19 worldwide, using the computed-aided diagnosis technique for COVID-19 classification based on CT images could largely alleviate the burden of clinicians. In this paper, we propose an Adaptive Feature...
Article
Atroposelective synthesis of axially chiral molecules has attracted substantial attention from chemists because of the importance of such molecules. However, catalytic asymmetric synthesis of axially chiral styrenes or vinyl arenes is underdeveloped and challenging due to the low rotational barrier and weak configurational stability of such molecul...
Article
The title reaction has been established under the cooperative bimetallic catalysis of iridium and copper catalysts, which afforded indole C3-allylation products with branched selectivity in moderate yields (up to 78%) and good enantioselectivities (up to 97:3 er). This reaction not only represents the first catalytic asymmetric ring-opening reactio...
Article
A catalytic asymmetric substitution of 3-substituted 2-indolylmethanols with 2-naphthols has been established under the catalysis of chiral phosphoric acid. By this approach, a series of structurally diversified triarylmethane derivatives were obtained in moderate to high yields with good enantioselectivities (up to 97% yield, 95:5 er). This approa...
Article
A chiral phosphoric acid‐catalyzed asymmetric 1,4‐addition of benzofuran‐derived azadienes with 3‐substituted indoles has been established, which offered enantioenriched tri(hetero)arylmethane products in generally good yields (up to 98%) and high enantioselectivities (up to 99:1 er). This reaction has not only realized the application of chiral ph...
Article
A catalytic asymmetric synthesis of 3,3’-bisindoles bearing single axial chirality has been established via chiral phosphoric acid (CPA) catalyzed enantioselective addition reaction of 3,3’-bisindoles with ninhydrin-derived 3-indolylmethanols. The selection of ninhydrin-derived 3-indolylmethanols as suitable electrophiles is based on the considerat...
Article
A base-promoted (2+4) annulation of benzofuran-derived azadienes with para-quinone methide derivatives has been established, which afforded spiro-benzofuran derivatives in generally high yields (57–97%) and with good diastereoselectivities (85:15 to >95:5 dr). This reaction not only represents the first application of benzofuran-derived azadienes a...
Article
Background: Pathological diagnosis of glioma subtypes is essential for treatment planning and prognosis. Standard histological diagnosis of glioma is based on postoperative hematoxylin and eosin stained slides by neuropathologists. With advancing artificial intelligence (AI), the aim of this study was to determine whether deep learning can be appl...