Feng Li

Feng Li
Hampton University | HIU · School of Pharmacy

About

33
Publications
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837
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Introduction
Skills and Expertise

Publications

Publications (33)
Article
The third-generation of EGFR-TKI osimertinib has been approved as a first-line therapy in NSCLC, representing the most successful advance in molecularly targeted therapy. However, the rapid development of osimertinib resistance renders the unsustainable treatment benefit. Plus, brain metastasis (BMs) is a major mortality cause for NSCLC; there is n...
Chapter
Nanotechnology-based drug delivery system is an emerging technology for targeted delivering chemotherapeutic agents in cancer therapy. Nanomedicines exhibit great potential in treating drug-resistant cancers due to their abilities to improve pharmacokinetic profiles, enhance drug accumulation in tumors, and reduce adverse reactions, when compared t...
Article
Background: Ribosome-inactivating proteins (RIPs) are wildly found in multiple species of plants, bacteria and fungi. As a special family of protein toxins, RIPs can inhibit protein synthesis and induce cell death via inactivating ribosome in eukaryotic cells. Thus, RIPs have been applied for anti-tumor therapy in the past two decades. However, be...
Article
Poor tumor-targeted and cytoplasmic delivery is a bottleneck for protein toxin-based cancer therapy. Ideally, a protein toxin drug should remain stealthy in circulation for prolonged half-life and reduced side toxicity, but turn activated at tumor. PEGylation is a solution to achieve the first goal, but creates a hurdle for the second because PEG r...
Article
Micelles have been successfully used for the delivery of anticancer drugs. Amphiphilic polymers form core-shell structured micelles in an aqueous environment through self-assembly. The hydrophobic core of micelles functions as a drug reservoir and encapsulates hydrophobic drugs. The hydrophilic shell prevents the aggregation of micelles and also pr...
Article
Doxorubicin (DOX) is a chemotherapeutic agent widely used in the treatment of various cancers. However, its clinical use is restricted due to serious cardiotoxicity and the development of drug resistance. Many delivery strategies, including the use of liposomes, micelles, and polymer drug conjugates, have been used to improve the therapeutic effica...
Article
Prostate cancer is the second leading cause of cancer related death in American men. Androgen deprivation therapy (ADT) is used to treat patients with aggressive prostate cancers. After androgen deprivation therapy, prostate cancers slowly progress to an androgen-independent status. Taxanes (e.g. docetaxel) are used as standard treatments for andro...
Article
Users of the illicit drug, 3,4-methylenedioxymethamphetamine (MDMA), show signs of neurotoxicity. However, the precise mechanism of neurotoxicity caused by use of MDMA has not yet been elucidated. Synthetic glutathione (GSH) conjugates of MDMA are transported into the brain by the GSH transporter and subsequently produce neurotoxicity. The objectiv...
Article
The objective of this study was to determine the compatibility of amiodarone hydrochloride with vasopressin during simulated Y-site administration. Amiodarone hydrochloride is compatible with vasopressin under simulated-use conditions when administered according to the Advanced Cardiac Life Support Guidelines. A simulated-use approach is a more app...
Article
Our objective was to design a polymeric micelle-based doxorubicin and lapatinib combination therapy for treating multidrug resistant (MDR) breast cancers. Poly(ethylene-glycol)-block-poly(2-methyl-2-benzoxycarbonylpropylene carbonate) (PEG-PBC) polymers were synthesized for preparing doxorubicin and lapatinib loaded micelles using a film dispersion...
Article
Since the advent of induced pluripotent stem (iPS) cells at 2006, a flood of researches have been performed to study the application of iPS-based approaches in generating various types of disease models, personalized regenerative medicine by gene therapy and tissue engineering. In this chapter, we first reviewed the comparisons between the iPS cell...
Article
Organophosphates are chemicals that inhibit cholinesterases and are employed widely as pesticides. Concerns are increasing regarding the relative safety of these chemicals to the environment. Recent studies suggest organophosphate exposure is associated with increased expression of fragile sites and DNA damage at concentrations that are not associa...
Chapter
Promoters are regulatory elements that provide precise control of magnitude, specificity and duration of shRNA expression and gene silencing. The selection of a suitable promoter is therefore critical in the design of a shRNA expression system. We discuss the use of different promoters for shRNA expression, including constitutive promoters, inducib...
Article
Full-text available
Paclitaxel is a potent chemotherapeutic agent for treating refractory prostate cancer. However, its prolonged treatment develops multidrug resistance. Since lapatinib interacts with and inhibits P-gp activity, our objective was to determine whether the combination therapy of these two drugs can synergistically treat resistant prostate cancer. Our r...
Article
Islet transplantation has the potential for treating type I diabetes; however, its widespread clinical application is limited by the massive apoptotic cell death and poor revascularization of transplanted islet grafts. We constructed a surface-modified adenoviral vector with RGD (Arg-Gly-Asp) sequences encoding human X-linked inhibitor of apoptosis...
Article
Our objective was to synthesize an amphiphilic diblock copolymer for micellar delivery of rapamycin. Poly(ethylene glycol)-block-poly(2-methyl-2-benzoxycarbonyl-propylene carbonate) (PEG-b-PBC) with different hydrophobic core lengths were synthesized from methoxy poly(ethylene glycol) and 2-methyl-2-benzoxycarbonyl-propylene carbonate through ring-...
Article
Islet transplantation has the potential to cure type 1 diabetes. Despite recent therapeutic success, it is still not common because a large number of transplanted islets get damaged by multiple challenges including instant blood mediated inflammatory reaction, hypoxia/reperfusion injury, inflammatory cytokines, and immune rejection. RNA interferenc...
Article
The objective of this study was to design lipopolymers for hydrophobic drug delivery. Poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (PEG-PCD) lipopolymers were synthesized and characterized by (1)H NMR, FT-IR, GPC, and DSC. The critical micelle concentration (CMC) of PEG-PCD micelles was around 10(-8) M a...
Article
To investigate the cellular uptake and elimination process of a lipophilic drug loaded in different nanocarriers, emulsions, liposomes and poly (DL-lactide-co-glycolide) (PLGA) nanoparticles loaded with a model drug, coumarin 6, were prepared and their transportation in HeLa cells compared. After 4 h incubation, liposomes and nanoparticles mediated...
Article
Islet transplantation has the potential to treat type I diabetes, however, its clinical application is limited due to the massive apoptotic cell death and other post-transplantation challenges to islet grafts. Therefore, the objective of this study was to determine whether ex vivo transduction of rat insulin producing INS-1E cells and human islets...
Article
A novel microtubule destabilizer, substituted methoxybenzoyl-ary-thiazole (SMART)-100, was synthesized, which showed good anticancer activity in HepG2 cells. SMART-100 was able to circumvent multidrug resistance (MDR) and effectively inhibited the growth of cell lines that overexpress P-glycoprotein (P-gp). SMART-100 inhibited P-gp activity, which...
Article
Although human islet transplantation is a promising approach for treating type I diabetes, its success is limited as a result of the poor survival rate of transplanted islets. Expression of a growth factor gene to promote revascularization and silencing of pro-apoptotic genes before transplantation may improve the outcome of islet transplantation....
Article
Full-text available
To examine the effect of bicalutamide and embelin on the growth of prostate cancer cells in vitro and in vivo Cell viability was determined by MTT assay. Micelles were fabricated with polyethylene glycol-b-polylactic acid (PEG-PLA) copolymer and characterized in terms of particle size, micellar solubilization and drug loading, followed by evaluatio...
Article
The objective was to determine whether bioconjugation of type I collagen specific triplex forming oligonucleotide (TFO) to N-(2-hydroxypropyl) methacrylamide (HPMA) containing tetrapeptide Gly-Phe-Leu-Gly (GFLG) and mannose 6-phosphate (M6P) can provide their targeted delivery to hepatic stellate cells (HSCs). Following bioconjugation, M6P-GFLG-HPM...
Article
Human islet transplantation has great potential as an effective means of treating insulin-dependent diabetes mellitus. Upregulation of inducible nitric oxide synthase (iNOS) and subsequent product of radical nitric oxide (NO) impair islet beta-cell function. Therefore, we hypothesize that iNOS gene silencing will prevent beta-cell death and improve...
Article
In many cases, initial release of drugs from microparticles is undesirable. In the present study, Pluronic®F127, which shows thermosensitive characteristic, was used for controlling both the initial release and the sustained release of insulin from microspheres. Calcium-alginate insulin microspheres were prepared by emulsion technology and disperse...
Article
Full-text available
Insect baculoviruses are capable of infecting mammalian glial cells in the central nervous system. We investigated in the current study the feasibility of using the viruses as toxin gene vectors to eliminate malignant glioma cells in the brain. We first confirmed that glioma cells were permissive to baculovirus infection, with variable transduction...
Article
In order to obtain small microcapsules with high protein encapsulation efficiency and extended release characteristics various processing factors were studied. Bovine serum albumin-loaded alginate microcapsules were prepared by an emulsion method and further incubated in chitosan. Many process factors were tested including the concentration and mol...
Article
Full-text available
Targeted gene expression mediated by a mammalian cellular promoter is desirable for gene therapy in the brain, where there are a variety of different neuronal phenotypes, several types of supportive cells, and blood vessels. However, this approach can be hampered by weak activity of some cellular promoters. In view of the potency of the transcripti...
Article
OBJECTIVE: To investigate the penetration characteristics of finasteride ethosomes as a transdermal vehicle. METHODS: The ethosomes and liposomes of finasteride were prepared by injection and film dispersing method, respectively. Their morphology was observed by transmission electronic microscopy (TEM). The penetration experiments in vitro were per...

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