Feng He

• Jiangxi University of Traditional Chinese Medicine

Background Periodontitis (PD) is a chronic infectious and inflammatory disease characterized by alveolar bone loss. The distinctive activity of immune cells critically exacerbates bone resorption in PD. Myeloid-derived suppressor cells (MDSCs) are known to contribute to various chronic inflammatory conditions, but their role in the pathogenesis and...

Background IgA nephropathy (IgAN) can cause hypertension, and severe hypertension can exacerbate the progression of IgAN. However, the long-term kidney outcome of malignant hypertension (mHTN)-associated thrombotic microangiopathy (TMA) with IgAN is not well defined. Methods 292 individuals with mHTN-associated TMA confirmed by kidney biopsy were...

Objective Overweight and obesity is a risk factor for hypertension. Malignant hypertension (MHT) is the most severe form of hypertension, and thrombotic microangiopathy (TMA), one of its complications, has been linked to significant renal outcomes. However, the impact of overweight and obesity on renal prognosis in MHT patients with TMA is not well...

Introduction Malignant hypertension (mHTN) is a hypertensive emergency. Thrombotic microangiopathy (TMA) is a widespread complication of mHTN. Few studies have evaluated whether glomerular hematuria provides prognostic information for renal dysfunction in patients with mHTN-associated TMA. Methods This observational cohort study included 292 patie...

Importance Thrombotic microangiopathy (TMA) on kidney biopsy is a pattern of endothelial injury commonly seen in malignant hypertension (mHTN), but treatment strategies are not well established. Objective To evaluate the kidney outcomes of angiotensin receptor-neprilysin inhibitor (ARNI), specifically sacubitril/valsartan, vs angiotensin-convertin...

Background Long non-coding RNAs (LncRNAs) have been implicated as critical regulators of cancer tumorigenesis and progression. However, their functions and molecular mechanisms in colorectal cancer (CRC) still remain to be further elucidated. Methods LINC00460 was identified by differential analysis between human CRC and normal tissues and verifie...

The aeroacoustic feedback loops in high-speed circular jets that impinge on a large flat plate are investigated via acoustic measurements and schlieren visualizations. In the present experiments, the nozzle pressure ratio ranges from 1.39 to 2.20, the corresponding ideally expanded jet Mach number $M_j$ is from 0.70 to 1.12 and the nozzle-to-plate...

Purpose Consensus molecular subtypes (CMS) are mainly used for biological interpretability and clinical stratification of colorectal cancer (CRC) in primary tumors (PT) but few in metastases. The heterogeneity of CMS distribution in metastases and the concordance of CMS between PT and metastases still lack sufficient study. We used CMS to classify...

This paper investigates the processes of droplet condensation and self-propelled jumping on microcolumn-structured superhydrophobic surfaces with various size parameters. Using a three-dimensional (3D) multiphase lattice Boltzmann method, a novel phenomenon of secondary coalescence jumping is identified, and the underlying mechanisms are analyzed i...

Superhydrophobic photothermal surface shows significant potential in the anti/de-icing field. In this work， we focus on the photothermal anti/de-icing performances of superhydrophobic surfaces with various micropatterns. A finite element simulation， coupling the wave optics and heat transfer models， is employed to illuminate the enhanced phototherm...

The mechanical properties (compressibility or deformability) of cells are closely related to their death, migration, and differentiation. Accurate separation and manipulation of bioparticles based on these mechanical properties are still a challenging in the field of acoustofluidics. In this work, based on surface acoustic waves (SAW) and divergent...

In this paper, the acoustic resonance mechanism for different axisymmetric screech modes of the underexpanded jets that impinge on an inclined plate is investigated experimentally. The ideally expanded Mach number of jets ( $M_j$ ) ranges from 1.05 to 1.56. The nozzle-to-plate distance at the jet axis and the impingement angle are respectively set...

Increasingly heart failure patients need to use Ventricular Assist Devices (VADs) to keep themselves alive. During treatment, hemolysis is an inevitable complication of interventional devices. The most common method for evaluating mechanical hemolysis is to calculate Hemolysis Index (HI) by the power-law formula. However, the HI formula still has o...

Superhydrophobic surfaces (SHSs) have shown significant potential in the anti-icing field over the past decade. In this work, we conduct impact experiments of supercooled drops on SHSs with various micropillar arrays and show how micropatterns contribute to efficient anti-icing performances. Here, we found four dynamic-freezing modes: partial penet...

It is important to accurately identify and measure in-focus droplets from shadowgraph droplet images that typically contain a large number of defocused droplets for the research of multiphase flow. However, conventional in-focus droplet identification methods are time-consuming and laborious due to the noise and background illumination in experimen...

The starting processes of under-expanded free jets with nozzle pressure ratios of 2.15, 2.7, and 3.4 are systematically analyzed by large-eddy simulations, and the unified laws of the evolution of the screech frequency and the screech mode in the starting jet are given. Through the development of vortices, the critical time points of the generation...

In this work, a new three-dimensional sessile droplet freezing model, involving the ice fraction and ice distribution after the droplet recalescence, is established based on the many-body dissipative particle dynamics with the energy conservation method for the first time. The proposed model is verified by comparing it with experimental results, an...

This paper describes the mechanism underpinning modal staging behaviour in screeching jets. An upstream-propagating subsonic guided-jet mode is shown to be active in all stages of screech. Axial variation of shock-cell spacing manifests in the spectral domain as a series of suboptimal peaks. It is demonstrated that the guided-jet mode may be energi...

For the shadowgraphy techniques with a single camera, it is difficult to accurately obtain the shape, size and depth location of the droplets out of focus due to the defocus blur. This paper proposed a deep learning-based method to recover the sharp images and infer the depth information from the defocused blur droplets images. The proposed model c...

High-speed jets have wide applications in many directions, such as material cutting, surface cleaning, and rocket launches. The steady situation of free jet has been widely studied, but transient evolution details have not been given, so the analysis of the starting process of the supersonic free jet is the main concern. The large-eddy simulation o...

Aim: The aim of this study was to investigate the role and mechanism of long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3)-205 in renal inflammation and fibrosis in diabetic nephropathy (DN). Materials and methods: lncRNA microarray profiling was used to examine differentially expressed lncRNAs of kidney tissues in db/db mice compare...

In many fluid experiments, we can only obtain low-spatial high-temporal resolution flow images and high-spatial low-temporal resolution flow images due to the limitation of high-speed imaging systems. To solve this problem, we proposed a degradation and super-resolution attention model (D-SRA) using unsupervised machine learning to super-resolution...

This work presents an experimental study on the splashing behaviors of drops impinging on rough solid surfaces. Most prior studies have shown the increase in surface roughness can promote the occurrence of a drop splash. Interestingly, we found two opposite effects of surface roughness on the drop splash that the increase in surface roughness can p...

The dominant resonance mode switch pattern concerning nozzle pressure ratio and impinging distance for under-expanded jets issuing from a convergent nozzle and impacting a flat surface is demonstrated for the first time. Schlieren visualization and acoustic measurements have been carried out to simultaneously capture the dynamic and acoustic proper...

This work investigates the splashing behaviors of droplets impacting on solid surfaces and mainly focuses on the characteristics of secondary droplets. According to the experimental results, two different splashing patterns, corona splash and levitating-lamella breakup, are observed. A new breakup mode, named rim-segmenting, is found during the lev...

Surface acoustic wave-based particle/bioparticle manipulation has emerged as a promising tool for disease diagnosis. The effects of the titled angle of the acoustic field θ and the microchannel aspect ratios β on the particle migration mode, the force of particle, and the three-dimensional focusing behavior are studied by using simulation and high-...

In serval experimental researches, UV-induced hydrophilicity enabled better hemocompatibility in the TiO2 surface, which was considered to be caused by the removal of the carboxylic acid contamination from the surface. In this paper, we altered the surface wetting property by applying the formate contamination on the rutile (110) surface, and syste...

Droplets icing has important applications in real life. The icing process of droplets on microstructure is explored based on the MDPDE method in this study. Firstly, the correctness of the heat transfer model was verified by one-dimensional heat conduction simulation, and then the feasibility of the phase change model was verified by investigating...

The stromal and immune cells crosstalk with cancer cells in tumor microenvironment, but few studies have fully considered the overall landscape of the infiltrating stromal and immune cells in colorectal cancer. We enrolled 1836 colorectal cancer patients and divided them into the training, validation and test cohorts. 64 stromal and immune cells we...

The upstream-propagating waves of feedback loops in under-expanded impinging jets are investigated through several typical flow conditions. Schlieren image capturing and far-field acoustic measurement are applied to the jet. The flow structures related to the discrete tones are extracted through dynamic mode decomposition (DMD), and the standing wa...

There are many practical applications of droplets freezing, and in many cases, it is necessary to prevent the droplets freezing to reduce the loss caused by freezing. Based on the many-body dissipative particle dynamics with energy conservation method, this research proposes an icing model that considers the recalescence process and initial ice mas...

The influence of liquid viscosity on the splashing behavior of a drop impacting a smooth surface is investigated. It is found that the liquid viscosity plays a reversed role on the drop splash, and the liquid viscosity promotes the drop splash in the low-viscosity cases but suppresses the drop splash in the high-viscosity cases. Here, we focus on t...

Acoustic measurements and time-resolved schlieren visualizations are performed on underexpanded jets issuing from a convergent nozzle to investigate the screech feedback loop and the mode staging phenomenon. In the present experiments, the nozzle pressure ratio ranges from 2.00 to 4.00. The instability mode of the jet successively experiences the a...

The phenomenon of droplets impacting fiber has important applications in the recovery of waste liquid, separation of solid and liquid phases, gas and liquid phases, and glass wool manufacturing. This study explored the impact of droplets on fiber based on the many-body dissipative particle dynamics (MDPD) method. First, the impact of droplets on fi...

This study experimentally investigates the dynamic behaviors of water droplets over wide ranges of diameters and velocities (200μm < D0 < 2600μm, 50 < We < 3000) impacting on surfaces with various wettability (ranging from hydrophilic to superhydrophobic), and focuses on the effect of surface wettability on water droplet spreading and splashing. Th...

Strategies to suppress the coffee-ring effect are critical in various applications, such as printing, surface manufacturing, and biochemical analysis. We propose a simple and contactless method based on forced airflow to obtain uniform depositions of drying colloidal droplets in this work. This method eliminates the coffee-ring effect without chemi...

Introduction: Previous studies of coronavirus disease 2019 (COVID-19) have focused on the general population. However, diabetes (DM) as one of the most common comorbidities is rarely studied in detail. This study is aimed at describing clinical characteristics and determining risk factors of ICU admission for COVID-19 patients with DM. Methods:...

Aims: To addresses whether surgical procedure (proximal gastrectomy [PG] vs total gastrectomy [TG]) influences survival outcomes. Methods: Patients were selected from Surveillance, Epidemiology and End Results Program (SEER) database. Survival curve was used to evaluate the differences in overall survival (OS) and cancer-specific survival (CSS). Re...

Background: The pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to prevention and treatment. We aim to describe the clinical characteristics and risk factors of COVID-19 patients needing use assisted ventilation therapy. Methods:...

The flow structures and the acoustic feedback loops of underexpanded round jets are investigated by numerical simulations. The jets have a Mach number of 1 at the nozzle exit and a diameter-based Reynolds number of 2.5 × 10 3. Three nozzle pressure ratios (NPRs) of 2.2, 2.4 and 2.6 are considered. The wavelengths of the screech tones are in good ag...

Background: SARS-CoV-2 has raged around the world since March, 2020. We aim to describe the clinical characteristics and risk factors of severe patients with COVID-19 in Guangzhou. Results: The severity and mortality of COVID-19 was 10.4% and 0.3% respectively. And each 1-year increase in age (OR, 1.057; 95% CI, 1.018-1.098; P=0.004), Wuhan expo...

Titanium dioxide is easily contaminated by carboxylic acid (mainly formate) in ambient environments. Although numerous studies have proven that the removal of contamination will enhance the adsorption of albumin and then the hemocompatibility of the TiO2 surface, recontamination makes further experimental investigation difficult. Previous molecular...

COVID-19 has become a global concern. A large number of reports have explained the clinical characteristics and treatment strategies of COVID-19, but the characteristics and treatment of COVID-19 patient with systemic lupus erythematosus (SLE) are still unclear. Here, we report the clinical features and treatment of the first SLE patient with confi...

Previous studies on coronavirus disease 2019 (COVID-19) have focused on the general population. However, cardiovascular disease (CVD) is a common comorbidity that has rarely been investigated in detail. This study aims to describe clinical characteristics and determine risk factors for intensive care unit (ICU) admission of COVID-19 patients with C...

Developing simple methods to suppress the coffee-ring effect without modifying colloidal suspensions (e.g., inherent properties of the solute or solvent) is critical for related industrial and bio-medical applications. This study experimentally investigates adding air bubbles in droplets as a means of suppressing the coffee-ring effect. The added a...

We present a numerical model to study the dynamic behaviors and heat conduction of freezing liquid droplets based on the MDPDE method (many-body dissipative particle dynamics with energy conservation configurations). In this model, the freezing processes involved in cooling, recalescence, and nucleation are considered. A new scaling method was deve...

Ultrasonic vibration has a wide application prospect in the fields of droplet atomization and aircraft anti/de-icing. The present work experimentally investigates the dynamic behaviors and anti-icing characteristics of droplets, with a wide range of velocities, impacting on ultrasonically vibrating surfaces. Two kinds of splash mode are observed, i...

Facing the gradually increased prevalence of heart failure (HF) and the shortage of donated hearts, the blood pump is widely used to prolong the life of end-stage HF patients: however, the pump generates continuous flow under constant rotational speed, declining the arterial pulsatility and causing related complications. Previous studies show that...

A large-eddy simulation is performed to study the shock motions and flow structures of an underexpanded free jet. The jet is characterized by a nozzle pressure ratio of 3.4 and a fully expanded Mach number of 1.45. At this condition, the dominant instability mode of the jet is the helical (C) mode. The numerical results of mean velocity fields, sho...

This paper investigates the impact behavior between water drops with different velocities and cylindrical superhydrophobic surfaces with various diameters and presents two possible outcomes of drop impact, which are asymmetric rebound and stretched breakup. Due to the special cylindrical topology of the surface, drops undergo an asymmetric spreadin...

Increasing evidence suggests that intestinal microbiota have critical function in the pathogenesis of inflammatory bowel disease. This present study investigated the effects of Escherichia coli (E. coli) in mice with dextran sulfate sodium (DSS)-induced colitis. Furthermore, Toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB) gene expression...

Long noncoding RNAs (lncRNAs) are implicated in human cancer, but their mechanisms of action are largely unknown. In this study, we investigated lncRNA alterations that contribute to colorectal cancer (CRC) through microarray expression profiling in CRC patient samples. Here, we report that the CRC-associated lncRNA PVT1-214 is a key regulator of C...

Introduction: Glomerular filtration rate (GFR) estimation equations using creatinine and Cystatin-C appear to be superior to those based on creatinine or Cystatin-C in older adults. We sought to compare the performances of those based on creatinine and Cystatin-C in Chinese older adults with chronic kidney disease (CKD). Methods: A total of 368...

Genome-scale CRISPR-Cas9 Knockout Screening was applied to investigate novel targets in imatinib-resistant gastrointestinal stromal tumor (GIST). 20 genes and 2 miRNAs have been selected by total reads of sgRNA and sgRNA diversity, which has been further validated in imatinib-resistant GIST cells by CCK8 and qPCR analysis. Our study has finally rev...

The temperature of bypass flow not flowing through the reactor core is obviously lower than that of the main coolant helium in a High Temperature Gas-cooled Reactor (HTGR). In addition, change and deviation of reactor power will introduce higher radial temperature difference of main coolant helium. In order to investigate the effects of bypass flow...

Colorectal cancer (CRC) is the third most common type of cancer; however, the molecular mechanisms underlying colorectal tumor metastasis and growth remain elusive. Recently, accumulating evidence has indicated that long non‑coding RNAs (lncRNAs) play a critical role in CRC progression and metastasis; however, the biological role and clinical signi...

Functional materials with controllable droplet breakup property have extensive application prospects in aircraft anti-icing, spraying cooling, surface coating and so on. Here we show that introducing micro-pillar arrays with various morphology to fabricate superhydrophobic surfaces could either facilitate or suppress droplet splitting. The spacing...

Resistance to oxaliplatin (L-OHP) is a major obstacle to successful chemotherapy in colorectal cancer (CRC). In the present study, the ability of gambogic acid (GA) to reverse L-OHP resistance in CRC LoVo cells was investigated. L-OHP-resistant LoVo/L-OHP cells were established by exposing them to increasing concentrations of L-OHP. GA-reversed L-O...

This paper investigates the impact behaviors between supercooled droplets and various superhydropho-bic surfaces. We analyze the thermodynamic reason of the liquid adhesion at low temperature and discuss the influence of the substrate roughness, temperature and wetting property on the impact dynamics of supercooled droplets both experimentally and...