Femida gwadry-sridhar

Western University | UWO · Department of Computer Science

Melanoma is a type of skin cancer developed from melanocytes. It is one of the most lethal types of cancer, accounting for approximately 75% of skin cancer deaths. Late stage melanoma is very difficult to treat, since the cancer cells are deranged, may be genetically linked and can be unresponsive to therapy. Therefore, determining how to effective...

Alzheimer's disease (AD) is a genetically complex neurodegenerative disease, which leads to irreversible brain damage, severe cognitive problems and ultimately death. A number of clinical trials and study initiatives have been set up to investigate AD pathology, leading to large amounts of high dimensional heterogeneous data (biomarkers) for analys...

lzheimer's disease (AD) is a genetically complex neurodegenerative disease, which leads to irreversible brain damage, severe cognitive problems and ultimately death. A number of clinical trials and study initiatives have been set up to investigate AD pathology, leading to large amounts of high dimensional heterogeneous data (biomarkers) for analysi...

Alzheimer's disease (AD) is a chronic neurodegenerative disease, which involves the degeneration of various brain functions, resulting in memory loss, cognitive disorder and death. Large amounts of multivariate heterogeneous medical test data are available for the analysis of brain deterioration. How to measure the deterioration remains a challengi...

The diagnosis of Alzheimer’s disease (AD) requires a variety of medical tests, which leads to huge amounts of multivariate heterogeneous data. Such data are difficult to compare, visualize, and analyze due to the heterogeneous nature of medical tests. We present a hybrid manifold learning framework, which embeds the feature vectors in a subspace pr...

Background: Nutritional support is an essential component of critical care. Malnutrition has been associated with poor outcomes among patients in intensive care units (ICUs). Evidence suggests that in patients with a functional gut, nutrition should be administered through the enteral route. One of the main concerns regarding use of the enteral ro...

We tested the diagnostic and prognostic utility of a rapid, visual T1 assessment method for identification of cardiac amyloidosis (CA) in a "real-life" referral population undergoing cardiac magnetic resonance for suspected CA. In patients with confirmed CA, delayed-enhancement cardiac magnetic resonance (DE-CMR) frequently shows a diffuse, global...

This paper describes an approach utilizing both data analysis and visualization to help diabetes patients improve medication compliance. Through information visualization tools, we aim to provide feedback to patients to encourage behavior change. The system has two core building blocks: (1) Data analysis combining several statistical and machine le...

Data Analytics has proven its importance in knowledge discovery and decision support in different data and application domains. Big data analytics poses a serious challenge in terms of the necessary hardware and software resources. The cloud technology today offers a promising solution to this challenge by enabling ubiquitous and scalable provision...

This study aims to systematically review, critically appraise and identify from the published literature, the most effective interventions to improve medication adherence in osteoporosis. A literature search using Medline, EMBASE, Cochrane library, and Cumulative Index to Nursing and Allied Health Literature was undertaken to identify prospective s...

A119 Stimulation (SCS) provides pain relief and improves patients' health. We assessed in a naturalistic context the cost-utility of SCS in FBSS patients unresponsive to conventional medical management (CMM). METHODS: We conducted an observational, multicenter, longitudinal prospective study in which a sample of patients assigned to receive SCS in...

This study describes health-related quality of life (HRQoL) of persons with haemophilia A in the United States (US) and determines associations between self-reported joint pain, motion limitation and clinically evaluated joint range of motion (ROM), and between HRQoL and ROM. As part of a 2-year cohort study, we collected baseline HRQoL using the S...

The use of novel analytical techniques (such as data clustering and decision trees) that can model and predict patient disease outcomes has great potential for assessing disease process and progression in Alzheimer's disease and mild cognitive impairment. For this study, 124 different variables (generated from image data, demographics and data) hav...

Consumers are increasingly turning to the Internet to gather information in making a wide variety of decisions - from the reliability of different brands of automobiles, to product costs. Similarly, many individuals are making use of online sources of information through the Internet and their employers to make health-related decisions - including...

The use of mobile and ubiquitous computing devices is advantageous for collecting and sharing patient data at the bedside or in hospital waiting areas. iPhone web applications - or web apps - combine the power of Internet based solutions with the simplicity of multi-touch and gesture technology, all one portable device. Since many data collection p...

The use of novel analytical techniques (such as data clustering and decision trees) that can model and predict patient disease outcomes has great potential for assessing disease process and progression in Alzheimer’s disease and mild cognitive impairment. For this study, 43 different variables (generated from image data, demographics and clinical d...

The evolving structure and business of health care services and delivery need the functionality and capability offered by electronic health record (EHR) systems. By electronically diffusing the traditional patient record, however, this new model blurs the long-established medical data home, raising concerns about data ownership, confidentiality, ac...

Compliance, adherence, and persistence are outcomes easily measured in pharmacy claims databases. However, these measures are used with differing taxonomies and the calculations are heterogeneous. The results can then lead to spurious interpretations. Therefore, the research community would benefit from a common set of definitions and methods to ca...

Background: In 1975 a partnership among clinicians, consumers and government agencies created a nationwide regional healthcare delivery system that increased access to clinical care and prevention services for individuals with hemophilia, a costly, rare, inherited chronic disorder that has significant physical, social, and financial consequences. P...

In reply Stewart and colleagues wonder why we did not include the study by Gattis et al¹ in our review.² The reason was that because the intervention was delivered exclusively by a clinical pharmacist and our focus was on a multidisciplinary intervention, the study was not eligible. Stewart and colleagues also question our excluding the study by St...

Heart Failure (HF) is a chronic disease syndrome that has become one of the leading causes of hospitalization in Canada. The high mortality, marked disability and subsequent lack of productivity of people with HF weigh heavily on the patient, family and society. ^ In this thesis I conducted a pilot study to determine whether intensive education pro...

Increasingly, hospitals are engaging in continuous quality improvement (CQI) endeavors, aimed at optimizing patient care. Physician involvement is critical to the success of such initiatives. Little is known about any mediating factors that affect physician participation in these projects, though such knowledge may be potentially important for targ...

Approaches to interpretation of quality of life changes in clinical trials have fallen into two camps: those that rely on the distribution of changes and the Effect Size (ES), and those that use some external anchor, such as patient judgments of change, which is then used to compute a Minimally Important Difference (MID), the proportion benefiting...

The objective of this chart review was to determine the frequency of transfusion and prevalence of anemia (hemoglobin result < 100 g/L) in patients receiving chemotherapy. This study was a retrospective review of medical charts. Patients receiving chemotherapy were included from 12 tertiary care comprehensive cancer centres across Canada. The prima...

This study reports the 8- to 10-year follow-up of male and female patients between the ages of 25 and 70, admitted to two Ontario Regional Cancer Centres with newly diagnosed cancers of a number of common sites. Information was gathered by interview on education, occupation, and chronic illnesses other than cancer. Stage of disease at diagnosis, ex...

The objective of this historical prospective review of 12 medical centres across Canada was to determine the prevalence of anaemia and the frequency of transfusion in patients (pts) receiving chemotherapy for the treatment of selected cancers (lung, breast, ovary, sarcoma Hodgkin's/non-Hodgkin's lymphoma, melanoma, bladder, colorectal). The 616 pts...

The objective of this retrospective cohort study was to determine the frequency of red cell transfusion for anemia and risk factors. It was conducted at a regional cancer center and host hospital. All patients receiving chemotherapy in 1989 were studied. Complete data were available on 381; 26 were excluded. Age, diagnosis, baseline and nadir hemog...

Experimental work has shown that, during the development of tumours, host macrophages are triggered to produce high levels of prostaglandin E2 which inactivates natural killer cells and suppresses lymphokine activated killer cell development. Sustained, uninterrupted indomethacin treatment, when combined with interleukin-2 (IL-2), can totally eradi...

Experimental work in murine models has shown that, during the development of tumors, prostaglandin E2 produced by host macrophages inactivates natural killer cells and suppresses lymphokine-activated killer (LAK) cell development. Chronic indomethacin therapy when combined with interleukin-2 (IL-2) can totally eradicate experimental lung metastases...

Preclinical models of advanced melanoma have shown that chronic indomethacin therapy combined with interleukin 2 (IL-2) can eradicate experimental metastases. A phase II trial was done in patients with advanced melanoma. Indomethacin and ranitidine were begun at least one week before IL-2. Of the objective responses in 3 patients, 2 were achieved o...

The formulation of an oral iron tablet may influence its therapeutic efficacy in correcting iron deficiency. In order to determine the oral iron preparations patients in a Canadian urban center were receiving, a questionnaire was circulated to family physicians, internists, surgeons, and obstetrician-gynecologists to determine their prescribing pra...