Femi Morakinyo

• Ph.D.
• Lecturer at University of Lagos

Background: Stress defined as a disruption in the normal homeostatic functions of an organism caused by stressor (a physiological or psychological challenge) is an unavoidable normal component of life. Previous studies suggest that stress hormones have acute adverse effects on glycaemic control. The aim of this study was to assess the effect of chr...

The study investigated the potential alteration in the level of insulin and adiponectin, as well as the expression of insulin receptors (INSR) and glucose transporter 4 GLUT-4 in chronic restraint stress rats. Sprague-Dawley rats were randomly divided into two groups: the control group and stress group in which the rats were exposed to one of the f...

The present study examined the effect of dietary niacin supplementation on fat mass, glucose control, insulin sensitivity, lipid profile, and adiponectin level in diet-induced obese rats. Male Sprague-Dawley rats (n = 21) were initially divided into 2 groups of seven and fourteen rats; the group of 14 rats was fed with a high-fat diet (HFD) and the...

Please cite this article as: Mofolorunso A.M., Oyebanji K. E., Ndubuisi C. N., Samuel T. A., Morakinyo A. O. Beneficial effect of Cellgevity® on metabolic indices, lipid profile, and antioxidant enzymes in cold-restraint stress rat model. Dietary Supplements and Nutraceuticals 2023; 2(10): 41-54. DOI: https://www. ABSTRACT Background: Stress is a s...

Objectives: The mechanism via which genistein, the major isoflavone content of soya, adversely influenced placenta and fetal development was evaluated in pregnant laboratory rats. Materials and methods: There were control, 2 mg/kg and 4 mg/kg genistein groups of rats with five sub-groups based on gestation termination day. At the end of the expe...

Noise pollution remains a pervasive health hazard that people encounter especially in large commercial metropolis and has been implicated in many adverse non-auditory health conditions such as hypertension, atherosclerosis, vascular (endothelial) dysfunction and metabolic disorders. There is a growing body of evidence showing that chronic noise exp...

Background Genistein was reported to adversely influence fetal development although this is yet to be fully understood as a mechanism. Methods In this study, pregnant rats were divided into control (Cont.) and genistein force-fed (2-mg/kg and 4-mg/kg) groups. Each group was divided further into five subgroups: GD-0, GD-6, GD-13, GD-18, and GD-20 b...

Objectives. We aimed to evaluate the effects of a single (acute) and repeated (chronic) exposure to forced-swimming stressor on glucose tolerance, insulin sensitivity, lipid profile and glycogen content in male rats. Methods. Thirty adult male Sprague-Dawley rats (12 weeks old) were divided randomly into five groups: control group, single exposure...

Objective: We investigated the effects of magnesium supplementation on glucose tolerance, insulin sensitivity, oxidative stress as well as the concentration of insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide induced type-2 diabetic (T2D) rats. Methods: Rats were divided into four groups designated as: 1) control (CTR);...

The possible intake of folate in excess of the recommended upper levels is a matter of critical importance. This study was conducted to investigate the effects of prenatal and postnatal high folic acid supplementation (FAS) on glucose tolerance, insulin sensitivity, lipid metabolism, and expression of adiponectin in rats. The study included 20 fema...

To investigate the mechanism by which maternal obesity disrupts reproductive function in offspring, we examined Kiss1 expression in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV) nuclei, and posterodorsal medial amygdala (MePD) of pre-pubertal and young adult offspring. Sprague-Dawley rats were fed either a standard or ener...

Stress defined as a disruption in the normal homeostatic functions of an organism caused by a stressor (a physiological or psychological challenge) is an unavoidable experience of life. Previous studies suggest that stress hormones have acute adverse effects on glycaemic control. The aim of this study was to assess the effect of chronic psychologic...

The study investigated the potential alteration in the level of insulin and adiponectin, as well as the expression of INSR and GLUT-4 in chronic restraint stress rats. Sprague–Dawley rats were randomly divided into two groups: the control group and stress group in which the rats were exposed to one of the four different restraint stressors; 1 h, tw...

Appropriate levels of mineral nutrients are required to maintain optimal health as acute imbalances of these minerals can be potentially fatal. Therefore, dietary intake of micronutrients is of public health importance due to the consequences of the deficiency. This study analysed the selected minerals (Na, K, Mg, Ca, Fe, Zn, Cu, P, Cl and Mn) in t...

Several epidemiological evidences indicate that consumption of coffee is associated with a lower risk of type 2 diabetes mellitus (T2DM) however; there is dearth of experimental data to support these observations. Given that associations do not necessarily infer causality, the present study was designed to investigate the effect of coffee consumpti...

Diabetes Mellitus is associated with significant morbidity and mortality worldwide. The need for enhanced efficacy and safety, and cheaper and more readily available new drugs has increased the search for new antidiabetic drugs from plants. This study was conducted to investigate the antidiabetic activity of the hydroethanolic leaf extract of B. co...

Deficiency of minerals and micronutrients has been reported to impair the process of spermatogenesis. Historically, salt has been used by women on their husbands to increase their libido, however, the role of salt diet on sperm parameters are yet to be ascertained. The present study was designed to determine the effect of low and high salt diet on...

Background: A bidirectional relationship has been established between testosterone deficiency (TD) and type 2 diabetes mellitus (T2DM). Low testosterone level has been reported to be a predisposing factor to T2DM, whereas recent clinical studies have shown a high prevalence of low testosterone in diabetic individuals. However, it is not known if a...

This study investigated the effects of ALA on blood lipids, renal indices, antioxidant activities, glycemic control, and insulin level in streptozotocin (STZ)-induced diabetic in laboratory rats. The rats used were either administered alpha lipoic acid (ALA) (test group) or distilled water (control group) orally for four weeks after being confirmed...

Hypertension remains a major health problem in terms of treatment, management and control despite recent advances in modern medicine. In the face of the prevalence of this major health problem, lack of accessibility to modern health facilities, rising cost of orthodox medical care where available, lack of definitive curative regiment and prolong tr...

Hypertension remains a major health problem in terms of treatment, management and control despite recent advances in modern medicine. In the face of the prevalence of this major health problem, lack of accessibility to modern health facilities, rising cost of orthodox medical care where available, lack of definitive curative regiment and prolong tr...

Mercury is recognized as a hazardous environmental and industrial pollutant; however it is commercially important in many industries/applications. This has therefore led to an increase in occupational and environmental exposures in many parts of the world. The present study evaluated the impact of mercury chloride on glucose homeostasis and the pos...

Carbon tetrachloride (CCl 4) is a well known toxicant and exposure to this chemical is known to induce oxidative stress by the formation of free radicals. The present study investigates the in vivo effects of alpha lipoic acid (ALA) on CCl 4 -induced hepatic and renal toxicities. Twenty-four Sprague-Dawley rats were divided into four groups of 6 an...

The role of oxidative stress on the hepatic damage caused by acetaminophen (APAP) and the possible protective effects of beta-carotene supplement against this damage were investigated. The rats were randomly divided into four groups: control, APAP, beta-carotene, and APAP+beta-carotene. The control group received distilled water while APAP (750 mg/...

Zingiber officinale is used in African traditional medicine to treat diabetes mellitus. Oxidative stress and inflammation are associated with the pathogenesis of diabetes mellitus and its complications. This investigation tested the hypothesis that extracts of Zingiber officinale inhibit oxidative stress and inflammation by enhancing antioxidant en...

Calcium ions are vital in many biological processes and qualify as an almost ubiquitous intracellular second messenger. This indicates the multiplicity of the effects associated with drug actions aimed at interfering with calcium ions. To examine the cellular process involved in the induction of infertility in males by calcium antagonist (CA) even...

Zingiber officinale is used in African traditional medicine to treat diabetes mellitus. Oxidative stress and inflammation are associated with the pathogenesis of diabetes mellitus and its complications. This investigation tested the hypothesis that extracts of Zingiber officinale inhibit oxidative stress and inflammation by enhancing antioxidant en...

Calcium ions are vital in many biologic processes including a variety of enzymatic reactions, activation of excitable cells, coupling of electrical activation to cellular secretion, haemostasis, bone metabolism and sperm functions. Calcium channel blockers (CCB) appear to have a reversible anti-fertility effect on male rats which does not occur thr...

Oxidative stress contributes to the pathogenesis and progression of many diseases. The use of natural antioxidant as a therapeutic option is desirable and increasingly being practiced. The aim of the present study is to evaluate the in-vitro antioxidant property of Zingiber officinale, a known food additive. Aqueous and ethanol extracts of Zingiber...

Rifampicin is an effective first line drug in the management of tuberculosis. It has been documented to have some toxic effects in humans. Thus, this study intends to investigate the modulatory effects of Vitamins C and E on the haematopoietic suppression caused by Rifampicin. A total of 40 Wister albino rats of 10 animals per group were used. Grou...

After life itself, fertility is probably the most highly prized human possession. Yet, while medical treatment of the individual naturally demands priority, relatively little attention is paid to the effects of treatment on reproductive function. To investigate the effect of the calcium channel blocker, nifedipine, on sperm functions and identify t...

To investigate the effects of Zingiber Officinale on male reproductive functions and study the mechanisms underlying these effects, aqueous extract of Zingiber Officinale were administered orally to two groups of male rats at 500mg/kg b.w. and 1000mg/kg b.w. A third group served as control and received the treatment vehicle, distilled water. Treatm...

Arsenite is a major environmental chemical and a known reproductive toxicant via the depression of spermatogenesis and androgenesis in males. The possibility of sodium arsenite reproductive toxicity been caused by auto-oxidation was investigated in this study taking advantage of the anti-oxidant properties of ginger and its androgenic activities. T...

Introduction Drugs have been shown to adversely affect male fertility and recently anti-hypertensive drugs were added to the list. The anti-fertility effects of nifedipine and similar calcium channel blockers are well-illustrated in in vitro experiments but not in vivo. Purpose The present study was designed to experimentally elucidate the sub-chro...

To investigate the effects of Zingiber Officinale on male reproductive functions and study the mechanisms underlying these effects, aqueous extract of Zingiber Officinale were administered orally to two groups of male rats at 500mg/kg b.w. and 1000mg/kg b.w. A third group served as control and received the treatment vehicle, distilled water. Treatm...

AIM: Malaria remains one the most common causes of illness in the world, particularly in Africa and malaria chemotherapy has been linked with infertility. This study was undertaken to examine the effects of Artemether – Lumenfantrine, a potent antimalarial, on testicular functions and its antioxidant defence system. METHODS: Male rats were divided...

A study investigating the effect of diabetes and insuin resistance on oestrous cycle, corpus luteum function and pregnancy in female Sprague-Dawley rats The rats (pregnant and non-pregnant)were made diabetic by a single intravenous injection of alloxan 40mg/kg and insulin resistant by fructose feeding 25% fructose W/W. Blood was obtained for measu...

To investigate the effect of methanol extract of Ricinus communis seed (RCE) on male rats reproductive functions. Thirty-two male albino rats were divided into four groups. Groups 1, 2 and 3 were gavaged with 0.2 mL of 2.5% tween 80 (RCE vehicle; control) or 20 mg/(kg x d) and 40 mg/(kg x d) of RCE, respectively, for 30 days, and group 4 was also g...

This study was carried out to investigate the impact of oral administration of chloroform extract of Carica papaya seed (CPE) on implantation and pregnancy in female albino rats. The study was divided into three experimental sections. Each section was subdivided into 4 groups treated, respectively with 25, 50 and 100 mg kg ¹ b.w CPE and...

The impact of oral administration of 100 mg kg ¹ b.w of chloroform extract of Carica papaya seed (CPE) on oestrous cycle, fertility and serum 17 -oestradiol levels, in female rats was investigated. Ten proestrous rats received 2.5% tween 80 in normal saline (vehicle for CPE) and served as the control in each part of the study. In the oes...

This work was undertaken to investigate the individual effects and probable mechanism of action of chlorpromazine hydrochloride (largactil) and thioridazine hydrochloride (melleril) on male reproductive functions, in albino rats. A total of 45 adult male albino Wistar-strain rats were used. Five rats served as the control while the remaining forty...