Femi Afolabi

National Biotechnology Development Agency · Bioresources Development Centre, Ogbomoso

This study aimed to establish anti-diarrhoea agents, through in vivo and in silico molecular modelling from the phytoconstituents of Citrullus colocynthis ethanol fruit pulp extract (CCEFPE). The crystal structure of µ (mu) opioid and aquaporin 4 (AQP4) receptors were retrieved from the RCSB database, while the identified compounds from C. colocynt...

Chemotherapy-associated side effects significantly contribute to the challenges of cancer treatment, impacting the well-being of patients and complicating existing conditions. Chemotherapy-induced oedema, characterized by abnormal fluid accumulation and swelling, worsens cancer-related issues, such as impaired wound healing. This oedema may result...

Cannabis sativa L. is an annual herbal plant of the family Cannabinaceae and abundant in nature. It is known locally as igbo, taba, blaze, joint, pot, dope, ganja, sensi, kpoli, weed, and morocco on the streets of Nigeria, and used as a medicinal plant for many centuries in many different parts of the world. Although native to Central Asia, Cannabi...

Environmental contamination is increasing on a daily basis as a result of industrial growth and the products it produces. Because the polymeric materials utilized in diverse applications are not biodegradable, the plastic industries have significantly contributed to the current state of environmental devastation. As a result, there is a need for a...

The corona virus disease 2019 (COVID-19) caused by SARS-CoV-2 is characterized by acute respiratory distress syndrome (ARDS) facilitated by cytokine storm and other risk factors that increase susceptibility and complications leading to death. Emerging as a major global public health challenge, the disease has claimed more than 6 million lives and c...

Soil is the topmost layer of the earth which consists of biologically active constituents including enzymes for diverse purposes. Enzymes are produced by different sources in the soil, these could be from microorganisms, plant roots and residues, and soil animals. Soil enzymes usually accumulate, stabilize or form complexes in the soil matrix. Biot...

This chapter examines the occurrence and distribution of microbial enzymes in freshwater. On the basis of solubility, molecular mass, chemical structure, and occurrence, organic matters in water can be broadly classified into four types, namely, bioorganic matter, dissolved organic matter, colloidal organic matter, and aggregate organic matter. How...

Heavy metals are contaminants that cause immense environmental problems as they are harmful to humans, animals, plant health, and the environment at large. The activities of hydrolytic enzymes and ligninolytic oxidases and peroxidases directly affect the rates of conversion of soil biopolymers into compounds that are accessible to microorganisms an...

Ganoderma lucidum is a well-known medicinal mushroom that has been used for the prevention and treatment of different ailments to enhance longevity and health specifically in China, Japan, and Korea. It was known as “God’s herb” in ancient China as it was believed to prolong life, enhance the youthful spirit and sustain/preserve vitality. G. lucidu...

This study was on the assessment of wastewater in three selected abattoir environments in Ekiti State, Nigeria. The selected abattoirs are Atikankan Abattoir, Ikere-Ekiti Abattoir and Iworoko Road Abattoir. Wastewater samples were collected in the three locations. The physicochemical, heavy metal analysis, and microbial analysis of the samples were...

Nanobiotechnology has become a resourceful/crucial research area due to their copious applications in industrial, pharmacological and medical fields. In the current study, silver nanoparticles (OFI-AgNPs), gold nanoparticles (OFI -AuNPs) and bimetallic alloy nanoparticles (OFI-Ag-AuNPs) were mediated with Opuntia ficus indica (OFI) extract. Evaluat...

This study was conducted not just to cultivate Pleurotus tuber-regium to produce sclerotium but also to know the conditions that enhance the production of sclerotium instead of fruit bodies. Supplemented Sawdusts of White Afra (Terminalia superba), Teak tree (Tectona grandis) and Gmalina arborea were used as substrates. Some portions were incubated...

Major problems associated with the study of mushrooms in Nigeria are inaccuracy in identification, low bio-efficiency of commonly used substrate and difficulty in composting of substrates. The current study attempts the identification and characterization of Pleurotus species commonly cultivated in Western region of Nigeria, and evaluates the effec...

The use of plastics has increased in every aspect of our daily activities, they are cheap, durable, and resistant to corrosion, lightweight, degradation and can be readily moulded into various products. Solution to non-renewable source, management of plastics wastes and disposal has posed a great challenge to environments and the researchers on the...

The safety of monosodium glutamate-containing flavour enhancer at 15 ml/Kg (0.6g/Kg) body weight was investigated on the liver and kidney function, antioxidant/lipid peroxidation and lipid profile of albino rats. Twenty eight (28) male albino rats were randomly assigned into four groups, of seven (7) rats each. Animals in group A (the control)were...

Ogi, a fermented cereal porridge made from maize (Zea mays), sorghum (Sorghum vulgare) or millet (Pennisetum typoideum), experiences nutritional loss during traditional method of production. Hence, this study was undertaken to improve the nutritive value of ‘ogi’ by fortification with Bambara nut, a nutritious legume rich in carbohydrate, moderate...

The low nutritive content of ogi is a known major drawback of this cereal based slurry. The aim of the study is to investigate the extent of nutrient loss during traditional production of ogi. The nutritive content of the grains used in its production are not as bad though. Quantitative determination of nutrients contained in the commonly used cere...

Phenobarbitone, is a barbiturate with soporific, sedative and hypnotic properties and most widely used as anticonvulsant worldwide. This study investigated the effect of administration of ascorbic acid on phenobarbitone induced renal and hepatic toxicity. For the study, twenty four adult Wister rats were randomized into three groups of 8 rats each....

In recent times, there has been an astronomical increase in the cases of bacterial resistance to commonly used antibiotics by medical personnel in Akungba Akoko,Ondo State,Nigeria. It is just right for a study of this nature to be carried out in order to provide the important microbiological pieces of information to help medical practitioners to ta...