Felix Zörgiebel

Technische Universität Dresden | TUD · Institute of Materials Science

Conjunction of miniature nanosensors and droplet-based microfluidic systems conceptually opens a new route towards sensitive, optics-less analysis of biochemical processes with high throughput, where single device can be employed for probing of thousands independent reactors. Here we combine droplet microfluidics with the compact silicon nanowire b...

In this study we demonstrate the sensing capabilities of a portable multiplex measurement system for FET-based (bio)chemical sensors with an integrated microfluidic interface. We therefore conducted pH measurements with Silicon Nanoribbon FET-based Sensors using different measurement procedures that are suitable for various applications. We have sh...

One dimensional nanowire field effect transistors (NW-FETs) are a promising platform for sensor applications. The transport characteristics of NW-FETs are strongly modified in liquid environment due to the charging of surface functional groups accompanied with protonation or deprotonation. In order to investigate the influence of surface charges an...

In this study we present packaging techniques for SD-card form factor test adapters. Our test adapters consist of FET-based biochemical sensors and a CMOS integrated analog multiplexer connected to a printed circuit board (PCB). Protection of the test adapter is required for long term stability and reliable measurements of the biochemical sensor in...

Synergy between biochemistry, medicine, and material science during last decade has led to a tremendous scientific progress in the fields of biodetection and nanomedicine. This tight interaction led to the emergence of a new class of bioinspired systems. These systems are based upon utilizing nanomaterials such as nanoparticles, carbon nanotubes, o...

For the development of ultra-sensitive electrical bio/chemical sensors based on nanowire field effect transistors (FETs), the influence of the ions in the solution on the electron transport has to be understood. For this purpose we establish a simulation platform for nanowire FETs in the liquid environment by implementing the modified Poisson-Boltz...

We demonstrate a pH sensor based on ultrasensitive nanosize Schottky junctions formed within bottom-up grown dopant-free arrays of assembled silicon nanowires. A new measurement concept relying on a continuous gate sweep is presented, which allows the straightforward determination of the point of maximum sensitivity of the device and allows sensing...

Here we propose a platform for the detection of unlabeled human α-thrombin down to the picomolar range in a fluorescence based aptamer assay. In this concept, thrombin is captured between two different thrombin binding aptamers, TBA1 (15mer) and TBA2 (29mer), each labeled with a specific fluorescent dye. One aptamer is attached to the surface, the...

The aim of this study is the development of a portable measurement system that simplifies the analysis of bio-sensitive silicon nanowire field effect transistors (SiNW - FETs). In order to obtain the pH - dependent transfer characteristics of the Schottky barrier (SB) FETs, Id = f (Vg), a measurement unit and two biochip adapters are proposed. For...

We present a multi channel Schottky-barrier (SB) field effect transistor (FET) based platform for chemical sensor applications and investigate its sensitivity on channel length. Designed transistors consist of parallel assembled bottom up grown silicon nanowires with a mean diameter of 20 nm. Focusing on investigations of devices with different cha...

Enzyme rates are usually considered to be dependent on local properties of the molecules involved in reactions. However, for large molecules, distant constraints might affect reaction rates by affecting dynamics leading to transition states. In single-molecule experiments we have found that enzymes that relax DNA torsional stress display rates that...

The characterization of nanostructures with spectroscopic methods is a fundamental tool in nanoscience. For novel nanostructures, the interpretation of spectral features is a challenging task. To address this issue, we present the “Symmetry-Filtered Molecular Dynamics (SFMD)” method to calculate Raman and infrared wavenumbers from molecular dynamic...

We present a theoretical framework for the calculation of charge transport through nanowire-based Schottky-barrier field-effect transistors that is conceptually simple but still captures the relevant physical mechanisms of the transport process. Our approach combines two approaches on different length scales: (1) the finite element method is used t...