Felix Rizzuto

Felix Rizzuto
UNSW Sydney | UNSW · School of Chemistry

PhD Chemistry

About

51
Publications
4,450
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
989
Citations

Publications

Publications (51)
Article
Full-text available
The self-assembly of block copolymers is often rationalized by structure and microphase separation; pathways that diverge from this parameter space may provide new mechanisms of polymer assembly. Here, we show that the sequence and length of single-stranded DNA directly influence the self-assembly of sequence-defined DNA block copolymers. While inc...
Preprint
Nanoparticle (NP) ripening is a process where energetically favored larger particles grow at the expense of smaller ones: while important in NP synthesis, it is often difficult to control during NP applications. Here, we unveil a new Contact-dependent, Localized Galvanic Ripening (CLGR) mechanism that enables precise control of NP ripening in solut...
Article
Full-text available
Biological systems employ multimetallic assemblies to achieve a range of functions. Here we demonstrate the preparation of metal-organic cages that contain either homobimetallic or heterobimetallic vertices. These vertices are constructed using 2-formyl-6-diphenylphosphinopyridine, which forms ligands that readily bridge between a pair of metal cen...
Preprint
Nanoparticle (NP) ripening is a process where energetically favored larger 8 particles grow at the expense of smaller ones: while important in NP synthesis, it is often difficult to control during NP applications. Here, we unveil a new Contact-dependent, Localized Galvanic Ripening (CLGR) mechanism that enables precise control of NP ripening in sol...
Preprint
Polymers with sequence definition allow access to programmable morphologies and applications, but directly correlating polymer structure to function currently requires case-by-case analysis: high throughput methods that identify promising species from entire chemical families are required. Here, we show that the discovery of effective protein targe...
Article
Full-text available
Biochemical networks interconnect, grow and evolve to express new properties as different chemical pathways are selected during a continuous cycle of energy consumption and transformation. In contrast, synthetic systems that push away from equilibrium usually return to the same self-assembled state, often generating waste that limits system recycla...
Article
Full-text available
DNA tweezers have emerged as powerful devices for a wide range of biochemical and sensing applications; however, most DNA tweezers consist of single units activated by DNA recognition, limiting their...
Article
Full-text available
A three-dimensional Fe II 4 L6parallelogram was prepared from ferrocene-containing ditopic ligands. The steric preference of the bulky ferrocene cores towards meridional vertex coordination brought about this new structure type, in which the ferrocene units adopt three distinct conformations. The structure possesses two distinct, bowl-like cavities...
Article
Full-text available
The diversity of DNA duplex structures is limited by a binary pair of hydrogen-bonded motifs. Here we show that poly(thymine) self-associates into antiparallel, right-handed duplexes in the presence of melamine, a small molecule that presents a triplicate set of the hydrogen-bonding face of adenine. X-ray crystallography shows that in the complex t...
Article
Full-text available
Single molecules can now be visualised with unprecedented precision. As the resolution of single-molecule experiments improves, so too does the breadth, quantity and quality of information that can be extracted using these methodologies. In the field of DNA nanotechnology, we use programmable interactions between nucleic acids to generate complex,...
Article
DNA nanotechnology has generated a wealth of structures uniquely suited for nanoscale patterning; however, scalability, affordability, and recyclability are important preconditions for the industrial production and widespread use of DNA-based materials. In this perspective, we propose that “printing” programmed particles from transient DNA template...
Article
Full-text available
Many useful principles of self-assembly have been elucidated through studies of systems where multiple components combine to create a single structure. More complex systems, where multiple product structures self-assemble in parallel from a shared set of precursors, are also of great interest, as biological systems exhibit this behavior. The greate...
Article
Anion binding by receptor molecules is a central field of modern chemistry which impacts on areas of catalysis as well as biological and materials chemistry. As binding often requires high chemical stability under aerobic and aqueous conditions for practical applications, carbon-based anion receptors have dominated this field, with main group eleme...
Article
In der DNA-Nanotechnologie wird häufig ein Double-Crossover-Motiv verwendet, um Architekturen zu versteifen und die DNA-Konnektivität zu verbessern. Die Funktionalisierung dieser Kacheln mit Metallkomplexen an den Kreuzungspunkten erhöht die thermische Stabilität im Vergleich zu den nicht funktionalisierten Derivaten. Abstract The double crossover...
Article
Full-text available
The double crossover junction (DX) is a fundamental building block for generating complex and varied structures from DNA. However, its implementation in functional devices is limited to the inherent properties of DNA itself. Here, we develop design strategies to generate the first metal-DX DNA tiles (DX M ), by site-specifically functionalizing the...
Article
Modern coordination chemistry is overwhelmingly based on supramolecular interactions involving organic architectures. However, the question of what happens when you depart from this ‘natural’ world to the supramolecular chemistry of ‘unnatural’ structures based on non‐carbon frameworks remains largely unanswered, and is an area that potentially pro...
Article
Modern coordination chemistry is overwhelmingly based on supramolecular interactions involving organic architectures. However, the question of what happens when you depart from this ‘natural’ world to the supramolecular chemistry of ‘unnatural’ structures based on non‐carbon frameworks remains largely unanswered, and is an area that potentially pro...
Article
Full-text available
Herein we present a new strategy to achieve chiral induction and redox switching along the backbone of metallohelicate architectures, wherein a DNA duplex directs the handedness and charge transport properties of a metal-organic assembly more than 60 bonds away (a distance of >10 nm). The quantitative and site-specific binding of copper(I) ions to...
Article
Full-text available
The cavities of artificial receptors are defined by how their components fit together. The encapsulation of specific molecules can thus be engineered by considering geometric principles; however, intermolecular interactions and steric fit scale with receptor size, such that the ability to bind multiple guests from a specific class of compounds rema...
Article
Full-text available
The binding of multiple guests by a single entity can lead to new modes of host–guest interactions and thus new applications in, for example, catalysis and sensing. With the aim of developing modular systems that can promote and adapt to allosteric binding events, this Review explores current strategies used to bind multiple guests in the central a...
Article
Ein fluoreszierender Metall–organischer Käfig mit kationischen Wandflächen ist löslich und stabil in Wasser und bindet selektiv Anionen in Wasser gegenüber ihren neutralen Gegenstücken, wie J. Nitschke et al. in ihrer Zuschrift (DOI: 10.1002/ange.201814149) berichten. Der Zink(II)‐basierte Käfig ermöglicht eine fluorometrische Bestimmung von Mono‐...
Article
A fluorescent metal–organic cage equipped with cationic panels, which is soluble and stable in water and selectively binds anions in water over their neutral congeners, is presented by Nitschke and co‐workers in their Communication (DOI: 10.1002/anie.201814149). The zinc(II)‐based cage detects mono‐ and poly‐phosphoric anions, including nucleotides...
Article
The design of aqueous probes and binders for complex, biologically‐relevant anions presents a key challenge in supramolecular chemistry. Here we report a tetrahedral assembly with cationic faces and corners that is capable of discriminating between anionic and neutral guests in water. Electrostatic repulsion between subcomponents can be overcome by...
Article
The design of aqueous probes and binders for complex, biologically‐relevant anions presents a key challenge in supramolecular chemistry. Here we report a tetrahedral assembly with cationic faces and corners that is capable of discriminating between anionic and neutral guests in water. Electrostatic repulsion between subcomponents can be overcome by...
Article
Full-text available
Herein we elucidate the interplay of chiral, chelate, solvent and hydrogen-bonding information in the self-assembly of a series of new three-dimensional metal-organic architectures. Enantiopure ligands, each containing H-bond donors and acceptors, form different structures depending on the ratio in which they are combined: enantiopure components fo...
Article
Full-text available
We present a method for the directed self-assembly of interlocked structures and coordination complexes in a set of metal-organic hosts. New homo- and hetero-leptic metal complexes – species that cannot be prepared outside – form within the cavities of cuboctahedral coordination cages. When linear bidentate guests and macrocycles are sequentially i...
Article
Oxidation of the P(III) dianion [S-P(µ-NtBu)]22- (1) with elemental sulphur, selenium and tellurium gives the P(V) dianions [(S)(E)P(µ-NtBu)]22- (E = S (6a), Se (6b), Te (6c)). Although 6c proves to be too unstable, the S,S-dianion 6a and ambidentate S,Se-dianion 6b are readily transferred intact to main group and transition metal elements, produci...
Article
The Se-bridged P III /P V phosphazane macrocycle [{( t BuN)P V (μ-N t Bu)} 2 (μ-Se) 2 {P III (μ-N t Bu)} 2 ] 3 is obtained selectively using [Se( t BuN)P(μ-N t Bu)] 2²⁻ as a nucleophilic component.
Thesis
Biomolecular receptors can catalyse reactions, alter their geometry, and inhibit their activity in response to molecules binding around their periphery. Synthetic receptors that can mimic this allosteric binding behaviour extend the potential applications of host-guest chemistry to programmable molecular systems. Modulating the degree and magnitude...
Article
Full-text available
Although a multitude of studies have explored the coordination chemistry of classical tripodal ligands containing a range of main group bridgehead atoms or groups, there has been no clear answer to the question of how underlying periodic trends affect ligand character and reactivity within a single ligand family. In addition to standard steric and...
Article
Although a multitude of studies have explored the coordination chemistry of classical tripodal ligands containing a range of main group bridgehead atoms or groups, there has been no clear answer to the question of how underlying periodic trends affect ligand character and reactivity within a single ligand family. In addition to standard steric and...
Article
Although a multitude of studies have explored the coordination chemistry of classical tripodal ligands containing a range of main group bridgehead atoms or groups, there has been no clear answer to the question of how underlying periodic trends affect ligand character and reactivity within a single ligand family. In addition to standard steric and...
Article
Full-text available
The molecular components of biological systems self-sort in different ways to function cooperatively and to avoid interfering with each other. Understanding the driving forces behind these different sorting modes enables progressively more complex self-assembling synthetic systems to be designed. Here we show that subtle ligand differences engender...
Article
Oxidation of the P(III) dianion [S-P(µ-NtBu)]22- (1) with elemental sulphur, selenium and tellurium gives the P(V) dianions [(S)(E)P(µ-NtBu)]22- (E = S (6a), Se (6b), Te (6c)). Although 6c proves to be too unstable, the S,S-dianion 6a and ambidentate S,Se-dianion 6b are readily transferred intact to main group and transition metal elements, produci...
Article
The unsymmetric PIII/PV cyclodiphosphazane framework [(S=)(H)P(µ-NtBu)2PNHtBu] (2) provides entry into the mixed chalgogenide dianion [(S)P(µ-NtBu)2P(Se)NtBu]2-, and unique insight into the mechanisms of cis/trans isomerism in phosph(III)- and phosph(V)-azanes.
Article
A porphyrin-edged metal-organic tetrahedron was shown to form host-guest complexes containing 1-4 equivalents of fullerene C60, depending on the solvent employed. The molecules of C60 were bound in anti-cooperative fashion within well-defined pockets; an X-ray crystal structure of three fullerenes inside the tet- rahedron was obtained. Electrochemi...
Article
Full-text available
A porphyrin-edged metal-organic tetrahedron was shown to form host-guest complexes containing 1-4 equivalents of fullerene C60, depending on the solvent employed. The molecules of C60 were bound in anti-cooperative fashion within well-defined pockets; an X ray crystal structure of three fullerenes inside the tetrahedron was obtained. Electrochemica...
Article
Self-assembled materials can be designed to express useful optoelectronic properties; however, control over structure is a necessary precondition for the optimization of desired properties. Here we report a simple, metal-templated polymerization process that generates helical metallopolymer strands over 75 repeat units long (28 kDa) from a single b...
Article
Full-text available
Self-assembled materials can be designed to express useful optoelectronic properties; however, control over structure is a necessary precondition for the optimization of desired properties. Here we report a simple, metal-templated polymerization process that generates helical metallopolymer strands over 75 repeat units long (28 kDa) from a single b...
Article
Full-text available
Biomolecular receptors are able to process information by responding differentially to combinations of chemical signals. Synthetic receptors that are likewise capable of multi-stimuli response can form the basis of programmable molecular systems, wherein specific input sequences create distinct outputs. Here we report a pseudo-cuboctahedral assembl...
Article
Full-text available
A new bis-chelating ligand containing a triarylamine electron donor core fused with a thiazolo-thiazole electron acceptor, N,N′-(thiazolo[5,4-d]thiazole-2,5-diylbis(4,1-phenylene))bis(N-(pyridin-2-yl)pyridin-2-amine) (1) has been synthesised. This non-innocent ligand exhibits interesting electronic and spectral properties that can be tuned as a fun...
Article
Full-text available
Zinc(II), a dimolybdenum(II) paddlewheel tetramine A and 2-formylpyridine self-assembled to generate a cubic ZnII8(LA)6 assembly. The paddlewheel faces of this assembly exhibited two distinct conformations, whereas the analogous FeII8(LA)6 framework displayed no such perturbation to its structure. This variation in behavior is attributed to the sub...
Article
Statt fest gebundener Moleküle in einem zentralen Hohlraum nutzten J. R. Nitschke et al. zur supramolekularen Templatbildung ein in schnellem Austausch an die Peripherie eines Assoziats gebundenes Templat, wie sie in ihrer Zuschrift (DOI: 10.1002/ange.201602135) berichten. Damit konnten sie einen pseudooktaedrischen Koordinationskäfig erzeugen, der...
Article
Supramolecular templation usually employs tightly bound molecules that occupy a central cavity. In their Communication (DOI: 10.1002/anie.201602135), J. R. Nitschke et al. report that a template bound in fast exchange at the periphery of an assembly can also be used, as demonstrated by the generation of a pseudo-octahedral coordination cage that ca...
Article
Full-text available
Pseudo-octahedral M(II) 6 L4 capsules result from the subcomponent self-assembly of 2-formylphenanthroline, threefold-symmetric triamines, and octahedral metal ions. Whereas neutral tetrahedral guests and most of the anions investigated were observed to bind within the central cavity, tetraphenylborate anions bound on the outside, with one phenyl r...
Article
Two organic polymers containing alternating electron donating triarylamine and electron accepting thiazolo[5,4-d]thiazole (TzTz) moieties have been synthesized and their redox states investigated. When donor and acceptor units are proximal (polymer 1), electron density is delocalized, leading to a small electrical and optical band gap; these are la...
Article
A ligand containing the thiazolo[5,4-d]thiazole (TzTz) core (acceptor) with terminal triarylamine moieties (donors), N,N′-(thiazolo[5,4-d]thiazole-2,5-diylbis(4,1-phenylene))bis(N-(pyridine-4-yl)pyridin-4-amine (1), was designed as a donor–acceptor system for incorporation into electronically active metal–organic frameworks (MOFs). The capacity for...
Article
The synthesis, as well as the electrochemical, optical and magnetic properties of a sulfate bridged Co(II) dimer, [Co2(DMIM)4(μ2 O2,O,O′ SO4)2]•2MeCN (DMIM = 1,2 dimethylimidazole) (2), are reported. The crystal structure consists of two distorted pseudo octahedral Co(II) centres, each ligated by the μ2-(O O′ sulfato) and μ2-(O2 sulfato) bridging m...

Network

Cited By