Felix Kluge

Felix Kluge
Friedrich-Alexander-University of Erlangen-Nürnberg | FAU · Department of Artificial Intelligence in Biomedical Engineering

Doctor of Engineering

About

55
Publications
14,153
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520
Citations
Introduction
Felix Kluge currently works at Machine Learning and Data Analytics Lab at the Department of Computer Science, Friedrich-Alexander-University of Erlangen-Nürnberg.
Additional affiliations
July 2012 - present
Friedrich-Alexander-University of Erlangen-Nürnberg
Position
  • Researcher

Publications

Publications (55)
Article
Full-text available
Developing machine learning algorithms for time-series data often requires manual annotation of the data. To do so, graphical user interfaces (GUIs) are an important component. Existing Python packages for annotation and analysis of time-series data have been developed without addressing adaptability, usability, and user experience. Therefore, we d...
Preprint
Background: Measuring mobility in daily life entails dealing with confounding factors arising from multiple sources, including pathological characteristics, patient specific walking strategies, environment/context, and purpose of the task. The primary aim of this study is to propose and validate a multi-task and multi-phase protocol for simulating...
Article
Full-text available
Introduction Rheport is an online rheumatology referral system allowing automatic appointment triaging of new rheumatology patient referrals according to the respective probability of an inflammatory rheumatic disease (IRD). Previous research reported that Rheport was well accepted among IRD patients. Its accuracy was, however, limited, currently b...
Article
Falls are among the leading causes of injuries or death for individuals from the age of 65 and the prevalence of falls is especially high for patients suffering from neurological diseases like Parkinson's disease (PD). Due to advancements in wearable sensor technology, inertial measurement units (IMUs) can be integrated unobtrusively into patients'...
Article
Full-text available
Gait analysis using foot-worn inertial measurement units has proven to be a reliable tool to diagnose and monitor many neurological and musculoskeletal indications. However, only few studies have investigated the robustness of such systems to changes in the sensor attachment and no consensus for suitable sensor positions exists in the research comm...
Preprint
Gait analysis using foot-worn inertial measurement units has proven to be a reliable tool to diagnose and monitor many neurological and musculoskeletal indications. However, only few studies have investigated the robustness of such systems to changes in the sensor attachment and no consensus for suitable sensor positions exists in the research comm...
Article
Full-text available
Indoor localization and human activity recognition are two important sources of information to provide context-based assistance. This information is relevant in ambient assisted living (AAL) scenarios, where older adults usually need supervision and assistance in their daily activities. However, indoor localization and human activity recognition ha...
Article
Purpose We assess feasibility of wearable gait analysis in geriatric wards by testing the effectiveness and acceptance of the system. Methods Gait parameters of 83 patients (83.34 ± 5.88 years, 58/25 female/male) were recorded at admission and/or discharge to/from two geriatric inpatient wards. Gait parameters were tested for statistically signifi...
Article
Full-text available
Recent years have witnessed a strongly increasing interest in digital technology within medicine (sensor devices, specific smartphone apps) and specifically also neurology. Quantitative measures derived from digital technology could provide Digital Biomarkers (DMs) enabling a quantitative and continuous monitoring of disease symptoms, also outside...
Article
Background: Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system, affecting more than 2.3 million people worldwide. Fatigue is among the most common symptoms in MS, resulting in reduced mobility and quality of life. The six-minute walking test (6MWT) is commonly used as a measure of fatigability for the...
Article
Full-text available
Introduction Existing mobility endpoints based on functional performance, physical assessments and patient self-reporting are often affected by lack of sensitivity, limiting their utility in clinical practice. Wearable devices including inertial measurement units (IMUs) can overcome these limitations by quantifying digital mobility outcomes (DMOs)...
Article
Full-text available
Digital technologies provide the opportunity to analyze gait patterns in patients with Parkinson’s Disease using wearable sensors in clinical settings and a home environment. Confirming the technical validity of inertial sensors with a 3D motion capture system is a necessary step for the clinical application of sensor-based gait analysis. Therefore...
Article
Full-text available
Patient-centered health care information systems (PHSs) enable patients to take control and become knowledgeable about their own health, preferably in a secure environment. Current and emerging PHSs use either a centralized database, peer-to-peer (P2P) technology, or distributed ledger technology for PHS deployment. The evolving COVID-19 decentrali...
Article
Full-text available
The world of healthcare constantly aims to improve the lives of people while nurturing their health and comfort. Digital health and wearable technologies are aimed at making this possible. However, there are numerous factors that need to be addressed such as aging, disabilities, and health hazards. These factors are intensified in palliative care (...
Conference Paper
Digital gait measures derived from wearable inertial sensors have been shown to support the treatment of patients with motor impairments. From a technical perspective, the detection of left and right initial foot contacts (ICs) is essential for the computation of stride-by-stride outcome measures including gait asymmetry. However, in a majority of...
Conference Paper
Driven by the advancements of wearable sensors and signal processing algorithms, studies on continuous real-world monitoring are of major interest in the field of clinical gait and motion analysis. While real-world studies enable a more detailed and realistic insight into various mobility parameters such as walking speed, confounding and environmen...
Conference Paper
Full-text available
As global life expectancy is constantly rising, the early detection of age-related, neurodegenerative diseases, such as Parkinson's disease, is becoming increasingly important. Patients suffering from Parkinson's disease often show autonomic nervous system dysfunction which is why its examination is an important diagnostic tool. Measuring the respo...
Article
Full-text available
Gait tests as part of home monitoring study protocols for patients with movement disorders may provide valuable standardized anchor-points for real-world gait analysis using inertial measurement units (IMUs). However, analyzing unsupervised gait tests relies on reliable test annotations by the patients requiring a potentially error-prone interactio...
Article
Full-text available
Physical mobility is essential to health, and patients often rate it as a high-priority clinical outcome. Digital mobility outcomes (DMOs), such as real-world gait speed or step count, show promise as clinical measures in many medical conditions. However, current research is nascent and fragmented by discipline. This scoping review maps existing ev...
Article
Full-text available
Climbing stairs is a fundamental part of daily life, adding additional demands on the postural control system compared to level walking. Although real-world gait analysis studies likely contain stair ambulation sequences, algorithms dedicated to the analysis of such activities are still missing. Therefore, we propose a new gait analysis pipeline fo...
Article
Full-text available
Digital mobility assessment using wearable sensor systems has the potential to capture walking performance in a patient’s natural environment. It enables monitoring of health status and disease progression and evaluation of interventions in real-world situations. In contrast to laboratory settings, real-world walking occurs in non-conventional envi...
Article
Full-text available
Background To objectively assess a patient’s gait, a robust identification of stride borders is one of the first steps in inertial sensor-based mobile gait analysis pipelines. While many different methods for stride segmentation have been presented in the literature, an out-of-lab evaluation of respective algorithms on free-living gait is still mis...
Preprint
Full-text available
Background: To objectively assess a patient's gait, a robust identification of stride borders is one of the first steps in inertial sensor-based mobile gait analysis pipelines. While many different methods for stride segmentation have been presented in the literature, an out-of-lab evaluation of respective algorithms on free-living gait is still mi...
Conference Paper
Full-text available
Patient-centered health care information systems (PHSs) on peer-to-peer (P2P) networks promise decentralization benefits. P2P PHSs, such as decentralized personal health records or interoperable Covid-19 proximity trackers, can enhance data sovereignty and resilience to single points of failure, but the openness of P2P networks introduces new secur...
Preprint
Full-text available
Digital mobility assessment using wearable sensor systems has the potential to capture walking performance in a patient's natural environment. It enables the monitoring of health status and disease progression and outcome evaluation of interventions in real-world situations. In contrast to laboratory settings, real-world walking occurs in non-conve...
Article
Full-text available
Background Multiple sclerosis (MS) is a disabling disease affecting the central nervous system and consequently the whole body’s functional systems resulting in different gait disorders. Fatigue is the most common symptom in MS with a prevalence of 80%. Previous research studied the relation between fatigue and gait impairment using stationary gait...
Article
Full-text available
Analyzing human gait with inertial sensors provides valuable insights into a wide range of health impairments, including many musculoskeletal and neurological diseases. A representative and reliable assessment of gait requires continuous monitoring over long periods and ideally takes place in the subjects’ habitual environment (real-world). An inco...
Preprint
BACKGROUND Patient-centered health care information systems (PHSs) enable patients to take control and become knowledgeable about their own health, preferably in a secure environment. Current and emerging PHSs use either a centralized database, peer-to-peer (P2P) technology, or distributed ledger technology for PHS deployment. The evolving COVID-19...
Article
Full-text available
Indoor location estimation is crucial to provide context-based assistance in home environments. In this study, a method for simultaneous indoor pedestrian localization and house mapping is proposed and evaluated. The method fuses a person’s movement data from an Inertial Measurement Unit (IMU) with proximity and activity-related data from Bluetooth...
Conference Paper
The analysis of gait data is one approach to support clinicians with the diagnosis and therapy of diseases, for example Parkinson's disease (PD). Traditionally, gait data of standardized tests in the clinic is analyzed, ensuring a predefined setting. In recent years, long-term home-based gait analysis has been used to acquire a more representative...
Article
Full-text available
Introduction Advances in wearable sensor technology now enable frequent, objective monitoring of real-world walking. Walking-related digital mobility outcomes (DMOs), such as real-world walking speed, have the potential to be more sensitive to mobility changes than traditional clinical assessments. However, it is not yet clear which DMOs are most s...
Article
Mobile gait analysis using wearable inertial measurement units (IMUs) provides valuable insights for the assessment of movement impairments in different neurological and musculoskeletal diseases, for example Parkinson's disease (PD). The increase in data volume due to arising long-term monitoring requires valid, robust and efficient analysis pipeli...
Article
Full-text available
The evaluation of trajectory reconstruction of the human body obtained by foot-mounted Inertial Pedestrian Dead-Reckoning (IPDR) methods has usually been carried out in controlled environments, with very few participants and limited to walking. In this study, a pipeline for trajectory reconstruction using a foot-mounted IPDR system is proposed and...
Thesis
Full-text available
Knee osteoarthritis (OA) is a progressive disease characterized by the degeneration of articular cartilage of the knee joint. Symptoms include pain, functional limitations and specifically gait dysfunction, all of which severely affect quality of life. In order to understand the causes and effects of pathological gait symptoms and to optimize inter...
Article
Background: Individuals with chronic ankle instability (CAI) demonstrate altered ankle kinematics during running compared to uninjured individuals; however, little is known about differences between individuals with CAI and those who recover successfully from an index sprain (copers). Methods: Thirty-two young male athletes with prior ankle sprain...
Article
Background: Despite the general success of total knee arthroplasty (TKA) regarding patient-reported outcome measures, studies investigating gait function have shown diverse functional outcomes. Mobile sensor-based systems have recently been employed for accurate clinical gait assessments, as they allow a better integration of gait analysis into cl...
Conference Paper
Einleitung: Distorsionen des oberen Sprunggelenks zählen zu den häufigsten Sportverletzungen der unteren Extremität, mindestens ein Drittel aller Betroffenen entwickelt chronische Ge-lenkinstabilitäten (CAI) (Gribble et al., 2016). Veränderungen der Sprunggelenkskinema-tik beim Laufen konnten im Vergleich zu unverletzten Probanden (Moisan et al, 2...
Article
Full-text available
Mobile gait analysis systems based on inertial sensing on the shoe are applied in a wide range of applications. Especially for medical applications, they can give new insights into motor impairment in, e.g., neurodegenerative disease and help objectify patient assessment. One key component in these systems is the reconstruction of the foot trajecto...
Article
Full-text available
Background In the running community, a forefoot strike (FFS) pattern is increasingly preferred compared with a rearfoot strike (RFS) pattern. However, it has not been fully understood which strike pattern may better reduce adverse joint forces within the different joints of the lower extremity. Purpose To analyze the 3-dimensional (3D) stress patt...
Article
Full-text available
The purpose of this study was to assess the concurrent validity and test–retest reliability of a sensor-based gait analysis system. Eleven healthy subjects and four Parkinson’s disease (PD) patients were asked to complete gait tasks whilst wearing two inertial measurement units at their feet. The extracted spatio-temporal parameters of 1166 strides...
Article
Laterally wedged insoles have been shown to be effective for the reduction of the knee adduction moment and other biomechanical variables that are associated with the pathogenesis of knee osteoarthritis. However, inconclusive results such as adverse effects in individual subjects or even no group-wise wedge effects have been presented in different...
Article
Background: While treatment monitoring of healthcare interventions is mainly conducted at the hospital, most information on a patient’s health status could be obtained from his everyday life activities. Therefore, there is a great interest in methods for long term (home) monitoring applications. However, there is still a lack of quantitative method...
Article
Full-text available
Objective: Many different marker sets have been used in marker trajectory based gait classification approaches. Little knowledge exists about the effects of specific marker sets on the subsequent statistical modeling. Such analysis is often based on principal component analysis. The aim of this study was to test the effect of marker set choice on m...
Article
Full-text available
EEG involves the recording, analysis, and interpretation of voltages recorded on the human scalp which originate from brain gray matter. EEG is one of the most popular methods of studying and understanding the processes that underlie behavior. This is so, because EEG is relatively cheap, easy to wear, light weight and has high temporal resolution....
Conference Paper
Full-text available
Motion analysis has become an important tool for athletes to improve their performance. However, most motion analysis systems are expensive and can only be used in a laboratory environment. Ambulatory motion analysis systems using inertial sensors would allow more flexible use, e.g. in a real training environment or even during competitions. This p...
Conference Paper
Full-text available
Muscular movement artifacts constitute a major problem in studies involving electroencephalography (EEG) measurements. EEG measurements are used in a variety of different fields like diagnosing epilepsy and other brain related diseases or in biofeedback for athletes. A major drawback is that EEG is susceptible to artifacts of neck muscles due to th...
Article
Full-text available
Electromyogenic or muscle artifacts constitute a major problem in studies involving electroencephalography (EEG) measurements. This is because the rather low signal activity of the brain is overlaid by comparably high signal activity of muscles, especially neck muscles. Hence, recording an artifact-free EEG signal during movement or physical exerci...

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Projects

Projects (2)
Project
To evaluate various patient-centric eHealth applications in Rheumatology.
Project
In this research project, we aim to i) investigate the possible and inherent security and privacy issues for future patient-centered health care information systems like the emerging Bluetooth-based SARS-CoV-2 (or Covid-19) contact trackers ii) design security models such as Identity-Based Authentication Protocols, Trust Reputation Systems, etc. to provide additional security, and iii) finally evaluate the effectiveness of our security models