Felix Bermpohl

Felix Bermpohl
Charité Universitätsmedizin Berlin | Charité · Department of Psychiatry and Psychotherapy

Prof. Dr.

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187
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Publications

Publications (187)
Article
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Background: Virtual reality (VR) enables immersion in an interactive digital world with realistic experiences, that can be applied for controlled and personalized interventions. This review summarizes the current research on VR in the treatment of mental disorders. Methods: Selective literature search in PubMed and Google Scholar. Results: An...
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Parenting requires mothers to read social cues and understand their children. It is particularly important that they recognise their child's emotions to react appropriately, for example, with compassion to sadness or compersion to happiness. Despite this importance, it is unclear how motherhood affects women's ability to recognise emotions associat...
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Importance: Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic on AC need to be informed by real-world evidence. Objective: To examine whether lockdown measures are associated with AC and consumption-related temporal and psychological within-person mechanis...
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Gambling problems are often associated with homelessness and linked to elevated psychiatric morbidity and homelessness chronicity. We performed a systematic review and meta-analysis on prevalence rates of problem gambling (PG) and gambling disorder (GD) in homeless people. Following PRISMA guidelines, we searched databases Medline, Embase and PsycI...
Preprint
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Individuals with bipolar disorder are commonly correctly diagnosed a decade after the onset of first symptoms. Machine learning techniques may aid in early recognition and reduce the disease burden. As both individuals at risk and those with a manifest disease display structural brain markers, structural magnetic resonance imaging (MRI) may provide...
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Coercive measures (CM) and involuntary admission to psychiatric treatment can have detrimental consequences for patients. Past research shows that certain clinical, treatment and admission-related characteristics put patients at a higher risk of experiencing CM and involuntary admission. Although of high societal importance, the association between...
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Empathy allows us to share emotions and encourages us to help others. It is especially important in the context of parenting where children’s wellbeing is dependent on their parents’ understanding and fulfilment of their needs. To date, little is known about differences in empathy responses of parents and non-parents. Using stimuli depicting adults...
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Successful parenting requires constant inferring of affective states. Especially vital is the correct identification of facial affect. Previous studies have shown that infant faces are processed preferentially compared to adult faces both on the behavioural and the neural level. This study specifically investigates the child‐evoked neural responses...
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Background Adverse events can occur after antipsychotic discontinuation but evidence from antipsychotic drug trials is scarce. We aimed to estimate the occurrence of adverse events after discontinuing antipsychotics. Methods For this two-stage individual participant data meta-analysis, we searched the Yale University Open Data Access Project's dat...
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Objective: Cognitive down-regulation of craving involves a neural network within the prefrontal cortex. Tobacco use disorder (TUD) and trait impulsivity have been associated with prefrontal cortex impairments and down-regulation deficits. However, general deficits in down-regulation of craving (regarding non-drug-related cues) compared to never-sm...
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Background: Mothers with borderline personality disorder (BPD) often show altered emotional availability toward their own child and heightened stress vulnerability. The aims of the present study were (1) to examine total cortisol output in saliva during mother-child interaction in mothers with BPD and their children and (2) to test whether materna...
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Objective: The aim of the present study was to analyze the effects of the implementation of the Recovery-orientated psychiatric care concept “Weddinger Modell” on the incidence of forced medication, the total number of forced medication incidents per affected case, the maximum dose of a singular forced medication and the maximum voluntary daily dru...
Preprint
Objectives: Impairments in social cognitive processes are discussed as a vulnerability factor for bipolar disorder (BD). Previous studies demonstrated aberrant neural activation in brain areas related to theory of mind (ToM) and impaired affective ToM (aToM) task performance in BD. However, it is yet unknown whether successful psychotherapy of BD i...
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The study was designed to investigate the impact of the Coronavirus Disease 2019 (COVID-19) pandemic on mental health and perceived psychosocial support for elderly psychiatric patients in a longitudinal design. n = 32 patients with affective or anxiety disorders aged ≥60 years were included. Telephone interviews were conducted in April/May 2020 (T...
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Full-text available
Empathy allows us to share emotions and encourages us to help others. It is especially important in the context of parenting where children’s wellbeing is dependent on their parents’ understanding and fulfilment of their needs. To date, little is known about differences in empathy responses of parents and non-parents. Using stimuli depicting adults...
Article
Full-text available
Background Bipolar disorder is one of the most severe mental disorders. Its chronic course is associated with high rates of morbidity and mortality, a high risk of suicide and poor social and occupational outcomes. Despite the great advances over the last decades in understanding mental disorders, the mechanisms underlying bipolar disorder at the n...
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Background Exposure to parental suicide has been associated with increased risk for suicide and suicide attempts, although the strength of this association is unclear as evidence remains inconsistent. Aims To quantify this risk using meta-analysis and identify potential effect modifiers. Method A systematic search in PubMed, PsycInfo and Embase d...
Preprint
Successful parenting requires constant inferring of affective states. Especially vital is the correct identification of facial affect. Previous studies have shown that infant faces are processed preferentially compared to adult faces both on the behavioural and the neural level. This study aims to specifically investigate the child-evoked neural re...
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Introduction: Abrupt discontinuation of antipsychotics is associated with an increased risk of adverse events such as extrapyramidal symptoms in humans. In animal models, vacuous chewing movements may occur after antipsychotic discontinuation. We aim to assess vacuous chewing movements after the discontinuation of second-generation antipsychotics...
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Despite growing evidence on effects of parenthood on social understanding, little is known about the influence of parenthood on theory of mind, the capacity to infer mental and affective states of others. It is also unclear whether any possible effects of parenthood on theory of mind would generalise to inferring states of adults or are specific to...
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Background Identifying predictors for treatment outcome in patients with posttraumatic stress disorder (PTSD) is important in order to provide an effective treatment, but robust and replicated treatment outcome predictors are not available up to now. Objectives We investigated predictors of treatment outcome in a naturalistic sample of patients wi...
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In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite a similar disease burden, the populations at risk of bipolar disorder have not been sufficiently characterized. Within the BipoLife consortium, we used...
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Background Sexual minorities such as lesbian, gay, and bisexual (LGB) people have an increased risk for suicide, whose reasons are not sufficiently understood. We aimed to test if differences in LGB acceptance explain variations in general suicide rates on a country level.Methods We used linear regression models to explain the variation in age-stan...
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Objective Post-coercion review is increasingly regarded as a mean to reduce the negative consequences of coercive interventions, including the development of posttraumatic symptoms. However, the efficacy of this intervention in preventing posttraumatic symptoms or PTSD has not been sufficiently studied. The objective of this study is to examine the...
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Aversive drug cues can be used to support smoking cessation and create awareness of negative health consequences of smoking. Better understanding of the effects of aversive drug cues on craving and the processing of appetitive drug cues in abstinence motivated smokers is important to further improve their use in cessation therapy and smoking-relate...
Preprint
Infant and child faces receive more attention than adult faces, especially when they are portraying emotions. This preferential treatment is increased in mothers. It is unclear how this affects the ability to recognise child emotions and at which age children lose this preferential treatment. Using morphed videos where a neutral face continually an...
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Background and aims Several aspects of how quitting motivated tobacco use disorder (TUD) subjects and never-smokers differ in terms of reward and threat processing remain unresolved. We aimed to examine aberrant reward and threat processes in TUD and the association with smoking characteristics. Design A between- and within-subjects fMRI experimen...
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Major depressive disorder (MDD) has been linked to elevated inflammation markers. It remains unclear whether the elevation of C-reactive protein (CRP) and interleukin-6 (IL-6) levels are not only observable in acute MDD but also in patients after remission. MDD is a common sequela of early life maltreatment (ELM), which has also been associated wit...
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Empathy as the capacity to feel with others is a vital human response. It is especially important in the context of parenting. To date, little is known about differences in empathy responses of parents and non-parents to children and adults. Therefore, in this study functional magnetic resonance imaging was used to shed further light on the interac...
Preprint
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There is growing evidence that parenthood changes how people face the specific needs and requests of infants and children, especially their own. However, little is known about the influence of parenthood on theory of mind, the capacity to infer mental and affective states of others and derive action predictions based on these states. It is also unc...
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Many determinants leading to the use of different coercive measures in psychiatry have been widely studied and it seems that staff attitudes play a crucial role when it comes to the decision-making process about using coercion. However, research results about staff attitudes and their role in the use of coercive measures are inconsistent. This migh...
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Background: Withdrawal symptoms of lithium have not been systematically assessed to date. Aim: Systematic review of withdrawal symptoms after discontinuation of pharmacological treatment with lithium. Methods: Systematic literature search in PubMed and reference lists of relevant articles. We included clinical trials and case reports. Results...
Preprint
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Background: Bipolar disorder is one of the most severe mental disorders. Its chronic course is associated with high rates of morbidity and mortality, a high risk of suicide and poor social and occupational outcomes. Despite the great advances over the last decades in understanding mental disorders, the mechanisms underlying bipolar disorder at the...
Article
Full-text available
Background/aim: Kambô is a name for the secretion of the Giant Maki Frog (Phyllomedusa bicolor), which has been used by indigenous cultures from the Amazonas basin and has recently become popular in alternative healing circles in Western countries, with a certain overlap with psychedelic self-exploration. Methods: We carried out an online-based...
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Kambô, the secretion of the Amazonian Giant Leaf Frog (Phyllomedusa bicolor) contains a plethora of bioactive peptides and was originally used by indigenous communities from the Amazon basin as medicine for improving hunting capacities. In the last 20 years, Kambô has spread to Western urban healing circles. To date it is still controversial whethe...
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Zusammenfassung Ziel der Studie Untersuchung der Wohnsituation, Nutzung des Versorgungssystems und des Substanzgebrauchs bei Patienten1 mit Substanzgebrauchsstörungen in (teil-)stationärer psychiatrischer Behandlung in der Psychiatrischen Universitätsklinik der Charité im St. Hedwig-Krankenhaus. Methode Strukturiertes Interview von 540 Patienten. E...
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Background Previous studies among the general population indicated an association between mental illnesses and different forms of financial difficulties, such as indebtedness.Objective Investigation of the financial burden and associated factors among inpatients and day clinic patients in psychiatric care.Material and methodsA total of 488 patients...
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A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries. We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative moo...
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Obstetric complications (OC) may have implications for later health outcomes. However, there is a lack of research examining the association between OC and behavior problems or quality of life (HRQoL). We aimed to close this gap and further investigate functioning of the hypothalamus-pituitary-adrenal (HPA)-axis as a potential physiological vulnera...
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Background Computational linguistic methodology allows quantification of speech abnormalities in non-affective psychosis. For this patient group, incoherent speech has long been described as a symptom of formal thought disorder. Our study is an interdisciplinary attempt at developing a model of incoherence in non-affective psychosis, informed by co...
Preprint
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Kambô is the name for the secretion of the Giant Leaf Frog (Phyllomedusa bicolor) containing a plethora of bioactive peptides. Originally, it is ritually used by different ethnicities from the Amazon basin as a remedy against bad luck in hunting. In the last twenty years, Kambô has spread to Western urban centers, often associated with the use of a...
Article
Full-text available
Background: Bipolar disorders (BD) belong to the most severe mental disorders, characterized by an early onset and recurrent, severe episodes or a chronic course with poor psychosocial functioning in a proportion of patients. Many patients with BD experience substantial symptomatology months or even years before full BD manifestation. Adequate dia...
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Coercive measures in psychiatry are associated with negative consequences for both patients and staff. When it comes to preventing coercive measures, innovative models of care like the Weddinger Modell focusing on recovery, participation and supported decision-making have proven successful. However, observations from clinical practice show that eme...
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Background: Access to a bank account is critical for overall participation in social life and an indicator for social integration. Worldwide about 1.7 billion people remain with no access to banking facilities as a form of financial exclusion which represents 31% of the world's general population. In contrast, in Western countries like Germany, 99...
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Zusammenfassung Ziel Die Auswirkung des Recovery-orientierten psychiatrischen Behandlungskonzepts „Weddinger Modell“ wurde auf den Einsatz von mechanischen Zwangsmaßnahmen (ZM) untersucht. Methodik Mittels einer retrospektiven Fallkontrollstudie wurden zwei Patientengruppen analysiert: Eine wurde nach dem Weddinger Modell behandelt (Interventionsgr...
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Primary aim of this study was to determine the extent and type of self-reported interpersonal problems in patients with non-affective psychoses and their impact on psychosocial functioning. Furthermore, we aimed to explore potential links with the psychodynamic construct of Stavros Mentzos' "psychotic dilemma", which describes an insufferable inner...
Preprint
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Background Bipolar disorders (BD) belong to the most severe mental disorders, characterized by an early onset and recurrent, severe episodes or a chronic course with poor psychosocial functioning in a proportion of patients. Many patients with BD experience substantial symptomatology months or even years before full BD manifestation. Adequate diagn...
Preprint
Full-text available
Background Bipolar disorders (BD) belong to the most severe mental disorders, characterized by an early onset, predominantly recurrent/chronic course and poor psychosocial functioning. Many patients with BD experience substantial symptomatology months or even years before full BD manifestation. Adequate diagnosis and treatment is often delayed, whi...
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One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still...
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Objective To determine the housing situation among people seeking psychiatric treatment in relation to morbidity and service utilisation. Design Cross-sectional patient survey. Setting Psychiatric centre with a defined catchment area in Berlin, Germany, March–September 2016. Participants 540 psychiatric inpatients including day clinics (43.2% of...
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Das Weddinger Modell ist ein aus der stationären Praxis heraus entwickeltes Recovery-orientiertes Behandlungsmodell, das im Rahmen eines komplexen „Change-Projektes“ 2010 in der Psychiatrischen Universitätsklinik der Charité im St. Hedwig-Krankenhaus implementiert wurde. Alle stationären Strukturen wurden hinsichtlich konsequenter Transparenz, Part...
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Previous research revealed experiences of childhood adversity (CA) to be related to less favorable parenting behavior. It can further be expected that maternal oxytocin receptor (OXTR) genes may influence parenting behavior and moderate relationships between CA and parenting behavior. Moreover, associations between the OXTR gene and plasma oxytocin...
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Background: Early life maltreatment (ELM), borderline personality disorder (BPD), andmajor depressive disorder (MDD) have been associated with empathy deficits in differentdomains. Lack of maternal empathy has also been related to child behavioral problems. As ELM, BPD, and MDD often co-occur, we aimed to identify dissociable effects on empathydue...
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The study addresses the impact of maternal early life maltreatment (ELM) and maternal history of depression (HoD) on offspring’s mental health. Maternal sensitivity was examined as a potential mediator explaining the relationship between maternal ELM, maternal HoD and child psychopathology. Participants were 194 mothers with and without HoD and/or...
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Early life maltreatment (ELM) has long-lasting effects on social interaction. When interacting with their own child, women with ELM often report difficulties in parenting and show reduced maternal sensitivity. Sensitive maternal behavior requires the recognition of the child’s emotional state depicted in its facial emotions. Based on previous studi...
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Background The “empathy hormone” oxytocin (OXT) is associated with social interaction and parent-child interaction. Mothers with mental stress factors, e.g., history of depression, borderline personality disorder or early life maltreatment in their own childhood often show distinct maternal behavior. The objectives of the study were (1) to examine...
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Frühe Gewalterfahrungen können schwerwiegende und lang anhaltende Auswirkungen auf die direkt Betroffenen, aber auch auf die nächste Generation haben. Anhand vorliegender Daten unserer Untersuchungen von Heidelberger und Berliner Mutter-Kind-Dyaden konnten wir zeigen, dass frühe Gewalterfahrungen zu Veränderungen auf behavioraler und neuronaler Ebe...
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Background: Oxytocin (OXT) is critically involved in the regulation of attachment and interpersonal function. In this study, emotional children's movies were used to stimulate OXT secretion in patients with schizophrenia and healthy controls. Furthermore, associations of OXT levels with measures of attachment style (Psychosis Attachment Measure),...
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Major-depressive-disorder (MDD) and alexithymia have both been associated with empathy deficits. We examined whether depression and alexithymia show dissociable or interacting effects on cognitive and emotional trait and state empathy. Healthy controls with high and low alexithymia and MDD-patients with high and low alexithymia were assessed. We us...
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Background: Patients suffering from panic disorder and agoraphobia are significantly impaired in daily life due to anxiety about getting into a situation due to apprehension about experiencing a panic attack, especially if escape may be difficult. Dysfunctional beliefs and behavior can be changed with cognitive behavioral therapy; however, the neu...
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Background: Suicide is one of the four most common causes of death in adolescence worldwide. Although it is well known that suicidal people often have insufficient communication strategies, the importance of family communication for adolescent suicidality has not yet been sufficiently explored. Objective: The aim of this study was to provide a s...
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Background Early life maltreatment (ELM), borderline personality disorder (BPD) and major depressive disorder (MDD) have been shown to increase the potential of abuse. Emotion regulation is an identified mediator for the association of ELM and BPD with abuse potential. Until now, there has been no study to account for the co-occurrence of these ris...
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Background: Early-life maltreatment has severe consequences for the affected individual, and it has an impact on the next generation. To improve understanding of the intergenerational effects of abuse, we investigated the consequences of early-life maltreatment on maternal sensitivity and associated brain mechanisms during mother-child interaction...
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The hypothalamus-pituitary-adrenal axis (HPAA) and its end product, the glucocorticoid cortisol, has been shown to be associated with psychopathology. Determining cortisol concentrations in hair (HCC) allows the investigation of long-term HPAA-activity. There is a significant scarcity of studies investigating the link between HCC and psychopatholog...
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Background: Both, maternal borderline personality disorder (BPD) and maternal major depressive disorder (MDD) are often associated with adverse consequences for children, including increased risk for child behavior problems. Reduced maternal emotional availability might play a critical role in transmitting maternal psychopathology on the child. Ou...