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Felipe Maglietti

Felipe Maglietti
Instituto Universitario de Ciencias de la Salud Fundación H. A. Barceló · Anatomy

MD-PhD
Research in electroporation-based technologies and treatments, mainly electrochemotherapy and gene electrotransfer.

About

27
Publications
4,245
Reads
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353
Citations
Citations since 2017
12 Research Items
275 Citations
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20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
Additional affiliations
June 2009 - present
Universidad de Buenos Aires
Position
  • Research Scientist / PhD. Student

Publications

Publications (27)
Article
Full-text available
Electrochemotherapy (ECT) consists in the application of electric pulses to increase chemotherapeutic drug intake (bleomycin, cisplatin, or calcium) into the tumor cells. It has become a very valuable treatment option in veterinary oncology. It is an effective and safe treatment modality, which is not only beneficial as a palliative treatment, but...
Article
Full-text available
Aim: Cutaneous squamous cell carcinoma (cSCC) is a common disease in patients exposed to UV-light and human papillomavirus. Electrochemotherapy, a well-established treatment modality with minimum side effects in human and veterinary medicine, circumvents chemoresistance to bleomycin by the use of electric fields. However, patients are sensitive to...
Chapter
Electroporation-based treatments have consistently proven their usefulness in the treatment of superficial tumors with high response rates, regardless of the histology and virtual absence of side effects. The natural evolution of the field moves toward extending the applications to internal organs, and for that purpose, novel electrodes are being d...
Chapter
Cancer treatments are based on a combination of different treatment modalities with different mechanisms of action allowing oncologists to improve survival times, maintain a good quality of life, and in many situations, provide long-term control, and sometimes cure. This chapter is provided to educate veterinarians about electrochemotherapy (ECT) a...
Article
Prickly pear fruit is rich in natural pigments and bioactive compounds that contribute to its antioxidant capacity and health-promoting properties. These compounds can be extracted using pulsed electric fields (PEF), a non-thermal technology that is energy efficient and is being increasingly used for food processing. For that end, a novel electropo...
Article
Full-text available
Electroporation is a technology that increases cell membranepermeabilitybytheapplication of electric pulses. Electrochemotherapy (ECT), the best-known application of electroporation, is a very effective local treatment for tumors of any histology in human and veterinary medicine. It induces a local yet robust immune response that is responsible for...
Article
Full-text available
Background Oral malignant melanoma is the most common, but aggressive oral cancer in dogs with poor prognosis. Electrochemotherapy (ECT) has therapeutic potential in such tumors as effective local treatment. Therefore, the aim of this prospective clinical study was to evaluate treatment effectiveness of ECT in as first line treatment for canine ora...
Conference Paper
In electroporation (EP)-based protocols, such as in Gene Electrotransfer (GET), tissue pH-damage and ROS damage underline the EP phenomenon, however, tissue damage due to irreversible EP or thermal damage due to temperature effects may occur owing to the possible appearance of strong electric fields in a zone very close to the electrodes. In the qu...
Presentation
In electroporation (EP)-based protocols, such as in Gene Electrotransfer (GET), tissue pH-damage and ROS damage underline the EP phenomenon, however, tissue damage due to irreversible EP or thermal damage due to temperature effects may occur owing to the possible appearance of strong electric fields in a zone very close to the electrodes. In the qu...
Preprint
Full-text available
Electrochemotherapy is a treatment modality which has been increasingly used in veterinary and human medicine for treating cutaneous and subcutaneous tumors. In this prospective work we evaluated the outcome of using electrochemotherapy as a first-line treatment for canine oral melanoma in different stages, with the aim of determining predictive fa...
Article
Full-text available
Background Nasal cavity tumors are usually diagnosed late, when they already have infiltrated adjacent tissues thus requiring very aggressive treatments with serious side effects. Here we use electrochemotherapy (ECT), a well demonstrated treatment modality for superficial tumors. Materials and methods In the case of deep-seated tumors, the main l...
Article
Gene electrotransfer (GET) protocols, based on the introduction into the cells of genes encoding immunomodulatory molecules, constitute a safe and powerful strategy for inducing an immune response against cancer. But GET efficiency can be significantly affected by damage due to the products of electrolysis, in particular, pH fronts. To elucidate th...
Article
Full-text available
Background: Electrochemotherapy (ECT), a medical treatment widely used in human patients for tumor treatment, increases bleomycin toxicity by 1000 fold in the treated area with an objective response rate of around 80%. Despite its high response rate, there are still 20% of cases in which the patients are not responding. This could be ascribed to t...
Article
Full-text available
Electrochemotherapy (ECT), a medical treatment widely used in human tumor treatment, consists in the administration of bleomycin either systemically or locally followed by the application of an electric field. This procedure increases the toxicity of the bleomycin by 1000 fold in the treated area with an objective response rate of around 80%. Despi...
Article
The electrochemical treatment (ECT) of solid tumors is an electropermeabilization technique firmly established and widely used. In ECT protocols, pulse intensity as well as tissue electric conductivity are of utmost importance for assessing the final electropermeabilized area. Present ECT mathematical modeling based on the solution of the nonlinear...
Article
Full-text available
Optimal gene electrotransfer (GET) requires a compromise between maximum transgene expression and minimal tissue damage. GET in skeletal muscle can be improved by pretreatment with hyaluronidase which contributes to maximize transgene uptake and expression. Nevertheless, tissue damage remains severe close to the electrodes, with a concomitant loss...
Article
Full-text available
Electropermeabilization (EP) based protocols such as those applied in medicine, food processing or environmental management, are well established and widely used. The applied voltage, as well as tissue electric conductivity, are of utmost importance for assessing final electropermeabilized area and thus EP effectiveness. Experimental results from l...
Article
Full-text available
Background: Electrochemotherapy is a novel tumor treatment routinely used for cutaneous and subcutaneous tumors in human patients in the European Union since 2006. Here we used it to treat an amelanotic melanoma of the root of the tongue in a canine patient. Case Presentation: The patient was a 9 year-old, female, Golden Retriever, dehydrated, cach...
Article
Full-text available
A case of a canine oral eosinophilic granuloma in a 14-year-old female crossbred is described. The dog was presented with a history of ptyalism, halitosis, local pain, decreased appetite, and blood staining noted on food and water bowls. Clinical, hematologic, and biochemical examinations, abdominal ultrasonography, and 3-view chest radiographs wer...
Poster
Full-text available
Gene electrotransfer vaccination protocols (GET) constitute a safe and powerful way for introducing foreign antigens into the host for inducing an immune response. Optimal GET requires a compromise between maximum transgene expression and minimal tissue damage. Though GET in skeletal muscle can be improved by pretreatment with hyaluronidase, tissue...
Article
Full-text available
Treatments based on electroporation (EP) induce the formation of pores in cell membranes due to the application of pulsed electric fields. We present experimental evidence of the existence of pH fronts emerging from both electrodes during treatments based on tissue EP, for conditions found in many studies, and that these fronts are immediate and su...
Article
Full-text available
Gliomas are the most common primary brain tumors and yet almost incurable due mainly to their great invasion capability. This represents a challenge to present clinical oncology. Here, we introduce a mathematical model aiming to improve tumor spreading capability definition. The model consists in a time dependent reaction-diffusion equation in a th...
Data
Supplemental video of case 2 tumor growth simulation (anaplastic oligodendroglioma). Simulation was run for 2600 days since tumor onset (one original cell) with a detection level of 1 cell/mm2. (WMV)
Data
Supplemental video of case 1 tumor growth simulation (glioblastoma). Simulation was run for 500 days since tumor onset (one original cell) with a detection level of 1 cell/. (WMV)
Article
Full-text available
We present experimental measurements and theoretical predictions of ion transport in agar gels during reversible electroporation (ECT) for conditions typical to many clinical studies found in the literature, revealing the presence of pH fronts emerging from both electrodes. These results suggest that pH fronts are immediate and substantial. Since t...
Article
Full-text available
Electrochimica Acta j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / e l e c t a c t a a b s t r a c t We have recently shown that in the classical electrochemical treatment (EChT) of tumors, i.e., the pas-sage of a direct electric current through two electrodes inserted locally in the tumor tissue, from an initial un...

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Projects

Project (1)
Archived project
Study of electric field based treatments for solid tumor destruction.