Felipe López-Saucedo

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Verified

Felipe verified their affiliation via an institutional email.

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• PhD
• PostDoc Position at National Autonomous University of Mexico

This study addresses the modification of poly(vinyl chloride) catheters with N-vinylpyrrolidone and ciprofloxacin to achieve an antimicrobial surface. The copolymer was synthesized using the grafting-from method with gamma rays as a physical initiator and under different reaction conditions (absorbed dose, monomer concentration, and solvent). The m...

High-density polyethylene HDPE is a highly polluting plastic, and its reuse, reprocessing and modification are subjects of current research to mitigate environmental pollution. In recent times, it has been modified for specialized purposes as a harmless and resistant polymer. The present work details the modification of HDPE (obtained from Bonafont...

In this work, we present the modification of a medical-grade silicone catheter with the N-vinylimidazole monomer using the grafting-from method at room temperature and induced by gamma rays. The catheters were modified by varying the monomer concentration (20-100 vol%) and the irradiation dose (20-100 kGy). Unlike the pristine material, the grafted...

Radiation chemistry presents a unique avenue for developing innovative polymeric materials with desirable properties, eliminating the need for chemical initiators, which can be potentially detrimental, especially in sensitive sectors like medicine. In this investigation, we employed a radiation-induced graft polymerization process with N-vinylcapro...

The incorporation of polymer materials into disposable medical devices proves to be valuable due to their chemical and physical properties that make them practically unique. Approximately 25% of hospital waste consists of plastics, prompting various efforts to mitigate their environmental impact, such as reusing or reprocessing. In this study, we a...

Tissue engineering and regenerative medicine have emerged as innovative approaches to enhance clinical outcomes by addressing tissue lesions and degenerations that can significantly impair organ function. Since human tissues have limited regenerative capacity, the field of regenerative medicine aims to restore damaged tissues and their functionalit...

This work proposes the development of a polymer film made up of affordable components for its use as a healthcare material. Chitosan, itaconic acid, and Randia capitata fruit extract (Mexican variation) are the unique ingredients of this biomaterial prospect. Chitosan (from crustacean chitin) is crosslinked with itaconic acid, and in situ added R....

Controlled synthesis of biomaterials with pH-responsive materials by radiation chemistry allows the development of new materials with fine-tuned properties that is affordable for simple production schemes and without potentially harmful chemicals. This work develops new lignocellulose-based materials with antimicrobial properties for wound dressing...

Currently, polyethylene terephthalate (PET) is one of the most widely used polymeric materials in different sectors such as medicine, engineering, and food, among others, due to its benefits, including biocompatibility, mechanical resistance, and tolerance to chemicals and/or abrasion. However, despite all these excellent characteristics, it is not...

Bioelectronics searches for the union between living systems and electronic devices, which would allow understanding, monitoring, stimulating, and controlling electrical signals at a biological level, to advance in the diagnosis, treatment, and prophylaxis of diseases, as well as in the development of devices and tools to study the biological syste...

This chapter discusses the role of sutures, their improvement over time, and their therapeutic value, including general concepts and examples. First, the history of sutures and some of their characteristics are mentioned, followed by their classification and characteristics. current of these. Likewise, the modification of sutures is discussed, as a...

Magnetic nanoparticles (MNPs) represent an advanced tool in the medical field because they can be modified according to biomedical approaches and guided by an external magnetic field in the human body. The first objective of this review is to exemplify some promising applications in the medical field, including smart drug-delivery systems, therapie...

This work presents the modification of Teflon films, formally named polytetrafluoroethylene, with dimethylacrylamide (DMA) through a graft copolymerization reaction initiated by gamma radiation (from Co-60) to endow the material with the capability to deliver hydrophilic drugs. Results suggest the surface of the grafted films is suitable for the lo...

Gamma rays were evaluated as energy source to generate reactive points onto polyvinyl chloride (PVC) catheters, allowing the grafting of stimuli-responsive vinyl monomers that may endow the catheters with the ability to load and release vancomycin. Dual temperature- and pH- responsiveness was achieved in PVC catheters in a two-step route using the...

Surface modification of polypropylene (PP) films was achieved using gamma-irradiation-induced grafting to provide an adequate surface capable of carrying glycopeptide antibiotics. The copolymer was obtained following a versatile two-step route; pristine PP was exposed to gamma rays and grafted with methyl methacrylate (MMA), and afterward, the film...

Surface modification of polypropylene (PP) films is achieved using gamma-irradiation-induced grafting to proffer with antimicrobial activity. The copolymer was obtained through a versatile two-step route; pristine PP is exposed to gamma rays and grafted using methyl methacrylate (MMA), then N-vinylimidazole (NVI) is grafted onto the copolymer PP-g-...

The low reactivity of polytetrafluoroethylene (PTFE) switches up through grafting reactions with acrylic monomers such as methyl methacrylate (MMA) and 2-(diethylamino)ethyl methacrylate (DEAEMA). (PTFE-g-PMMA)-g-PDEAEMA copolymer enhances its hydrophilic behavior through the coating of ZnO. Co-60 is used as the radical initiator source to perform...

This chapter addresses the advances of sonochemistry and its application in the synthesis of inorganic nanomaterials. Sonochemistry is an emerging energy source for inorganic nanomaterial synthesis that is quite affordable by adapting conventional reactions or developing new methods. In this text, in specific cases, sonochemical methods are compare...

This work reviews the fundamentals, synthesis methods, and therapeutic applications of ZnO-based nanomaterials synthesized via green chemistry. ZnO nanoparticles are a very stable compound; when it is nanostructured and incorporated into a material as part of or by itself, its reactivity becomes of interest for medicine due to its therapeutic activ...

In a vast number of medical treatments, the local drug delivery is of prime importance to achieve a favorable therapeutic effect since it enhances drug bioavailability. These systems provide biological and chemical protection for drugs, reduce toxicity, increase the concentration at the site of interest, and avoid systemic exposure. The development...

Cellulose is a widely studied natural polymer due to its availability, biodegradability, non-toxicity, and ease of chemical modification. Currently, cellulose has many applications in science and technology, but it has vast relevance in biomedical applications, such as a protective coating for wound dressing in skin burns, and injuries to avoid bac...

Biofouling is an ongoing problem that decreases the efficiency of membranes used in wastewater treatment. Fortunately, numerous efforts have been dedicated to improving the antibacterial performance. Providing an effective antibacterial membrane includes methods as grafting, coating, and blending. These methods in most cases involve the addition of...

This paper presents two modified copolymeric hydrogel films with thermo‐responsiveness. The final films are hydrogels containing N‐isopropylacrylamide, N‐N‐dimethylacrylamide, methyl methacrylate, and ethoxyethyl methacrylate. The incorporation of Ag and Cu in the smart hydrogel films endowed them with specific properties that could be useful in de...

This chapter shows a brief overview about the principles and the main C-C coupling reactions adapted in aqueous medium. It explains the different types of coupling reactions that can be develop in water, depicted with the latest investigations in the field. The variables that affect the efficiency of the C-C coupling reactions in water, like cataly...

The goal of this work was to synthesize hybrid thin films prepared combining polyamide-6 (N6) and microcellulose (CE) at various weight ratios. Products exhibited improved mechanical properties, temperature-tunable hydrophilicity, and antimicrobial features. The obtained N6@CE films were grafted with N-vinylcaprolactam (NVCL) using gamma-rays, prov...

This chapter reviews the principles of surface modification induced by ionizing radiation, as well as its main applications. Highlighting characteristics and advantages offered using γ‐rays and swift heavy ion but recognizing limitations and challenges that the technique must face. The effects of ionizing radiation on polymers may seem complicated...

We report on the synthesis of new manganese carbonyls-based materials prepared using gamma-rays radiation (at doses of 10 and 40 kGy) as energy source. Characterization was achieved using nuclear magnetic resonance, infrared spectroscopy, elemental analysis, single-crystal X-ray diffraction, differential scan calorimetry, thermogravimetric analysis...

Polytetrafluorethylene, PTFE, films were activated and modified via gamma-rays to graft, in two steps, first methyl methacrylate, MMA, and subsequently N-vinylimidazole, NVI. The modified materials with a more reactive surface, PTFE-g-MMA and (PTFE-g-MMA)-g-NVI, were characterized spectroscopically and thermally; also, the behavior of the films was...

The stimuli-responsive nanoparticles (NPs) can modify reversibly their physical properties in response to an external stimulus or stimuli, causing changes in their particle properties such as dimensions, structure, and interactions, which lead to rearrangements or changes in their aggregation state where the responsiveness is supplied from the enti...

Controlled synthesis of nanostructured materials allows the development of new materials with fine-tuned mechanical, optical, magnetic, electronic, conductive, and catalytic properties that are used in numerous applications for example in medical area as vehicles for drug delivery, in diagnostics or combinations thereof. Advantages of using radiati...

The goal of this work was the modification of silicone rubber (SR) by radiation grafting of glycerol methacrylate (GlyMA) which was limited just on the surface, allowing the control of hydrophilicity and swelling properties. The grafted SRs were activated by derivatization of GlyMA to2-oxoethyl methacrylate using sodium periodate, enabling the chem...

The aim of this work was to implement a radiation-grafting method for the surface functionalization of polypropylene (PP) suture threads with N-vinyl imidazole (NVI) for the subsequent loading of silver (Ag) particles onto the surface. Grafting of NVI required the previous grafting of hydroxyethyl methacrylate (HEMA) or N-isopropyl acrylamide (NIPA...

The goal of this work was to provide antimicrobial activity to polypropylene by covalent immobilization of lysozyme. The first step was the grafting of ethylene glycol dimethacrylate and glycidyl methacrylate through “grafting-from” method by means of γ-rays. Then those chemical groups were activated to allow the immobilization of lysozyme by Schif...

Pyridylthiother-ligated Pd(II) complexes have been synthesized and efficiently applied in Suzuki-Miyaura couplings using microwave irradiation in DMF and water. The pyridylthioether NS (NS1 and NS2) and pyridyldithiother (SNS) ligands and their corresponding palladium complexes Pd-NS1, Pd-NS2, Pd-SNS were easily synthesized and fully characterized...

Harnessing the properties of imidazolium species, antimicrobial activity against Gram-negative and Gram-positive bacteria was attained by binary-grafting 2-hydroxyethyl methacrylate (HEMA) or N-isopropylacrylamide, followed by N-vinylimidazole onto polypropylene (PP) monofilaments (sutures) using 60Co γ-rays. Ulterior functionalization with methyl...

Functionalization of silicone rubber films with lysozyme was achieved by grafting copolymerization and its chemical activation allowing the covalent immobilization of the enzyme. The new materials were characterized by means of Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, contact angle, ato...

Gamma radiation has been shown particularly useful for the functionalization of surfaces with stimuli-responsive polymers. This method involves the formation of active sites (free radicals) onto the polymeric backbone as a result of the high-energy radiation exposition over the polymeric material. Thus, a microenvironment suitable for the reaction...

Silicone rubber (SR) is widely used in medical and food sectors due to its excellent mechanical properties. Either as component of medical devices or surfaces in contact with food, there is a current demand to endow SR with antimicrobial activity. Although promising, covalent immobilization of lysozyme on SR is not an easy task and the yield of cur...

N-isopropylacrylamide (NIPAAm), 2-hydroxyethylmethacrylate (HEMA) and N-vinylimidazole (NVIm) were grafted separately onto polypropylene (PP) monofilament sutures. These grafted copolymers have properties with potential application in the synthesis of new biomedical devices. Co-60 gamma radiation was employed with dose rate of 9.2 kGyh⁻¹ in synthes...

Gamma radiation has been shown particularly useful for the functionalization of surfaces with stimuli-responsive polymers. This method involves the formation of active sites (free radicals) onto the polymeric backbone as a result of the high-energy radiation exposition over the polymeric material. Thus, a microenvironment suitable for the reaction...