Feizhou Zhu

Feizhou Zhu
Central South University | CSU · Department of Biochemistry and Molecular Biology

PhD
Being a Guest Scientist in Max Planck Institute for Heart and Lung Research in Germany.

About

15
Publications
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Introduction
Research interests: My research direction is adrenal tumor and secondary hypertension, especially focus on Pheochromocytoma and Paraganglioma (PCPG). We are mainly interesting in the molecular contributing to development and metastasis of PCPG and the targets for diagnosis and therapy of PCPG. Methodology: RNAi and Crispr/cas9 are used to down-regulate the expression of PCPG genes to study the functions of these genes. After KD and KO, PCPG cell lines and PCPG aninal models are generated.

Publications

Publications (15)
Article
Full-text available
Heterozygous germline mutation of the MEN1 tumor suppressor gene is responsible for multiple endocrine neoplasia type 1. Parathyroid and thoracic neuroendocrine tumor specimens and DNA from two Han Chinese MEN1 family patients were analyzed using whole exome and Sanger sequencing. The proband (II-3) was sequentially diagnosed with pituitary adenoma...
Article
Full-text available
Pheochromocytoma, as a neuroendocrine tumor with the highest genetic correlation in all types of tumors, has attracted extensive attention. Von Hipper Lindau (VHL) has the highest mutation frequency among the genes associated with pheochromocytoma. However, the effect of VHL on the proteome of pheochromocytoma remains to be explored. In this study,...
Article
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Importance Large studies investigating long-term outcomes of patients with bilateral pheochromocytomas treated with either total or cortical-sparing adrenalectomies are needed to inform clinical management. Objective To determine the association of total vs cortical-sparing adrenalectomy with pheochromocytoma-specific mortality, the burden of prim...
Article
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Background: The Von Hippel-Lindau (VHL) p.Tyr98His (Y98H) mutation is designated as the "Black Forest" founder mutation and has been previously reported in Western countries. This study reports the first recorded Chinese VHL family with the "Black Forest" mutation in Asia. Methods: Paired whole-exome sequencing (WES), Sanger sequencing and immun...
Article
Full-text available
Pheochromocytoma and paraganglioma (PCC/PGL) are rare tumors that originate from adrenal or extra-adrenal chromaffin cells. A significant clinical manifestation of PCC/PGL is that the tumors release a large number of catecholamines continuously or intermittently, causing persistent or paroxysmal hypertension and multiple organ functions and metabol...
Article
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Background: Macrolides have been widely used to treat moderate-to-severe acne for more than 50 years. However, the prevalent antibiotic resistance of Propionibacterium acnes, along with the absence of clinically available resistance tests, has made macrolide misuse a frequent occurrence around the globe, with serious consequences. Objective: We...
Article
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Shijing Liao,1,* Yapeng Zhang,1,* Xuanhe Pan,1 Feizhou Zhu,2 Congyuan Jiang,3 Qianqian Liu,2 Zhongyi Cheng,4 Gan Dai,1 Guojun Wu,1 Linqian Wang,5 Liyu Chen1 1Department of Medical Microbiology, School of Basic Medical Sciences, Central South University, Changsha 410013, China; 2Department of Biochemistry and Molecular Biology, School of Life Scienc...
Article
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p align="left">Pheochromocytomas (PCCs) are rare neuroendocrine tumors that originate from chromaffin cells of the adrenal medulla, and paragangliomas (PGLs) are extra-adrenal pheochromocytomas. These can be mainly found in clinical syndromes including multiple endocrine neoplasia (MEN), von Hippel–Lindau (VHL) syndrome, neurofibromatosis-1 (NF-1)...
Preprint
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The microbiota in the human gut is not only a complicated microecological system but also plays important roles in both health and disease. In order to understand the roles of these gut bacteria, we determined the distribution of microbiota in different regions of the gut by sequencing the 16S rRNA gene V4 region of the bacteria in the saliva, gast...
Preprint
The microbiota in the human gut is not only a complicated microecological system but also plays important roles in both health and disease. In order to understand the roles of these gut bacteria, we determined the distribution of microbiota in different regions of the gut by sequencing the 16S rRNA gene V4 region of the bacteria in the saliva, gast...
Article
Abstract: Abstract Background Adrenalectomy is standard of care for phaeochromocytomas, but for bilateral phaeochromocytoma, the recommendations are inconsistent. However, large studies systematically investigating long-term outcomes for total adrenalectomies compared to those for patients with adrenalsparing operations are lacking. Methods This pr...
Article
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Single Nucleotide Polymorphism (SNP), not only has been used in genetic research widely, but also has magnificent clinical significance. Scientists have developed many methods to detect SNP, but few of which are available for clinic. Amplification refractory mutation system-quantitative PCR (ARMS-qPCR) has been used for detection of mutations, but...
Article
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Objective: To identify 14 bacteria by sequencing the 16S rRNA gene and establish the basis for clinical application in the future. Methods: DNA samples of the 14 bacteria were extracted. The 16S rRNA genes were amplified by PCR and sequenced with common primers. The sequences of the 16S rRNA genes were aligned by online software Blastn in nucleo...
Article
Full-text available
Parkinson's disease (PD) is the most frequent progressive neurodegenerative movement disorder, and autosomal dominant inherited PD can be caused by LRRK2 mutations. The new findings of LRRK2's function were summarized and described in 10 aspects, such as molecular genetics, expressing distribution and subcellular localization, function of mutants,...

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