Fei Zhao

Fei Zhao
University of Bristol | UB

About

75
Publications
13,150
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1,290
Citations
Citations since 2017
21 Research Items
589 Citations
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120

Publications

Publications (75)
Article
Full-text available
To investigate the effect of large vestibular aqueduct syndrome (LVAS) on middle ear sound transmission using wideband absorbance immittance (WAI). WAI results from young adult LVAS patients and normal adults were compared. Averaged energy absorbance (EA) at ambient and peak pressure in the LVAS group showed differences to the normal group. Under a...
Article
Full-text available
Objective: To systematically evaluate the development of Machine Learning (ML) models and compare their diagnostic accuracy for the classification of Middle Ear Disorders (MED) using Tympanic Membrane (TM) images. Methods: PubMed, EMBASE, CINAHL, and CENTRAL were searched up until November 30, 2021. Studies on the development of ML approaches fo...
Article
Purpose: Logistic regression analysis was used to explore the factors that influence tinnitus improvement after idiopathic sudden sensorineural hearing loss (ISSNHL) treatment. Materials and methods: In this retrospective study, 137 ISSNHL patients with tinnitus were recruited at the Sun Yatsen Memorial Hospital of Sun Yat-sen University, China....
Article
Importance: Otitis media with effusion (OME) is one of the most common causes of acquired conductive hearing loss (CHL). Persistent hearing loss is associated with poor childhood speech and language development and other adverse consequence. However, to obtain accurate and reliable hearing thresholds largely requires a high degree of cooperation f...
Article
Full-text available
Wideband Absorbance Immittance (WAI) has been available for more than a decade, however its clinical use still faces the challenges of limited understanding and poor interpretation of WAI results. This study aimed to develop Machine Learning (ML) tools to identify the WAI absorbance characteristics across different frequency-pressure regions in the...
Article
Full-text available
Objectives Numerous task-based functional magnetic resonance imaging studies indicate the presence of compensatory functional improvement in patients with congenital cataracts. However, there is neuroimaging evidence that shows decreased sensory perception or cognition information processing related to visual dysfunction, which favors a general los...
Preprint
Full-text available
Wideband Absorbance Immittance (WAI) has been available for more than a decade, however its clinical use still faces the challenges of limited understanding and poor interpretation of WAI results. This study aimed to develop Machine Learning (ML) tools to identify the WAI absorbance characteristics across different frequency-pressure regions in the...
Article
Full-text available
Objectives This study investigated the usefulness and performance of a two-stage attention-aware convolutional neural network (CNN) for the automated diagnosis of otitis media from tympanic membrane (TM) images. Design A classification model development and validation study in ears with otitis media based on otoscopic TM images. Two commonly used...
Article
Full-text available
The objective of this study was to investigate alterations to brain activity and functional connectivity in patients with tinnitus, exploring neural features in the transition from acute to chronic phantom perception. Twenty‐four patients with acute tinnitus, 23 patients with chronic tinnitus, and 32 healthy controls were recruited. High‐density el...
Article
Full-text available
PurposeThe neural bases in acute tinnitus remains largely undetected. The objective of this study was to identify the alteration of the brain network involved in patients with acute tinnitus and hearing loss.Methods Acute tinnitus patients (n = 24) with hearing loss and age-, sex-, education-matched healthy controls (n = 21) participated in the cur...
Article
Objective: The present study investigated the characteristics of visual processing in the auditory-associated cortex in adults with hearing loss using event-related potentials. Methods: Ten subjects with bilateral postlingual hearing loss were recruited. Ten age- and sex-matched normal-hearing subjects were included as controls. Visual ("sound"...
Article
Full-text available
In order to clarify the central reorganization in acute period of hearing loss, this study explored the aberrant dynamics of electroencephalogram (EEG) microstates and the correlations with the features of idiopathic sudden sensorineural hearing loss (ISSNHL) and tinnitus. We used high-density EEG with 128 channels to investigate alterations in mic...
Article
Full-text available
The objective was to investigate the influence of audiovisual training on horizontal sound localization and the underlying neurological mechanisms using a combination of psychoacoustic and electrophysiological (i.e., event-related potential, ERP) measurements on sound localization. Audiovisual stimuli were used in the training group, whilst the con...
Article
Full-text available
Given the importance of central reorganization and tinnitus, we undertook the current study to investigate changes to electroencephalogram (EEG) microstates and their association with the clinical symptoms in tinnitus. High-density (128 channel) EEG was used to explore changes in microstate features in 15 subjects with subjective tinnitus and 17 ag...
Article
Full-text available
Objectives To investigate factors influencing the effectiveness of intensive sound masking therapy on tinnitus using logistic regression analysis. Design The study used a retrospective cross-section analysis. Participants 102 patients with tinnitus were recruited at the Sun Yat-sen Memorial Hospital of Sun Yat-sen University, China. Intervention...
Article
Objective: Although visual processing recruitment of the auditory cortices has been reported previously in prelingually deaf children who have a rapidly developing brain and no auditory processing, the visual processing recruitment of auditory cortices might be different in processing different visual stimuli and may affect cochlear implant (CI) o...
Article
Full-text available
The purpose of this study was to investigate the effect of symmetrical, asymmetrical and unilateral hearing impairment on music quality perception. Six validated music pieces in the categories of classical music, folk music and pop music were used to assess music quality in terms of its ‘pleasantness’, ‘naturalness’, ‘fullness’, ‘roughness’ and ‘sh...
Article
Full-text available
The aims of the present study were to investigate the ability of hearing-impaired (HI) individuals with different binaural hearing conditions to discriminate spatial auditory-sources at the midline and lateral positions, and to explore the possible central processing mechanisms by measuring the minimal audible angle (MAA) and mismatch negativity (M...
Article
Unlabelled: The purpose of this study was to assess functional changes in the cerebral cortex in people with different sign language experience and hearing status whilst observing and imitating Chinese Sign Language (CSL) using functional magnetic resonance imaging (fMRI). 50 participants took part in the study, and were divided into four groups a...
Article
Full-text available
Objectives: To investigate auditory dysfunction in patients with tinnitus and normal hearing thresholds using two sensitive audiological measures. Design: The study was designed to investigate the characteristics of Audioscan and DPOAE tests in tinnitus patients with normal hearing thresholds. Audioscan and DPOAE notches were analysed and compar...
Article
Full-text available
This study investigated real-ear acoustical characteristics in terms of the sound pressure levels (SPLs) and frequency responses in situ generated from golf club drivers at impact with a golf ball. The risk of hearing loss caused by hitting a basket of golf balls using various drivers was then estimated. Cross-sectional study. The three driver club...
Article
The aim of this study was to investigate auditory cortical development using mismatch negativity (MMN) in prelingual severe-to-profound hearing-impaired children from the stage of cochlear implant (CI) power-up to 6 months after power-up. Eighteen children were recruited and examined at the stage of CI initial power-up (M0), as well as several foll...
Article
Objective: This review aims to highlight the key elements of music perception and its mechanisms in normal hearing people and people with hearing impairments. Design: A systematic literature search was conducted using the National Library of Medicine's search service – PubMed (website: http://www.ncbi.nlm.nih.gov/sites/entrez), with the subject hea...
Article
Objective: The present study aims to develop and validate a Chinese music quality rating test (MQRT). Design: In Experiment 1, 22 music pieces were initially selected and paired as a 'familiar music piece' and 'unfamiliar music piece' based on familiarities amongst the general public in the categories of classical music (6), Chinese folk music (...
Article
Full-text available
Introduction: The general consensus on the roles of hearing loss in triggering tinnitus seems not applicable in patients with normal hearing thresholds. The absence of hearing loss on the audiogram in this group of patients poses a serious challenge to the cochlear theories in explaining tinnitus generation in this group of patients. Objective:...
Article
Three pairs of headphones [standard iPod ear buds and two noise-canceling headphones (NCHs)] were chosen to investigate frequency characteristics of noise reduction, together with their attenuation effects on preferred listening levels (PLLs) in the presence of various types of background noise. Twenty-six subjects with normal hearing chose their P...
Article
Full-text available
Objective: Hearing impairment is known to have various effects upon both the person with hearing impairment (PHI) and their communication partners (CPs). In addition, CPs are reported to play an important role in making the decision to seek a consultation and the acceptance of intervention by the PHI. The overall aim of this paper is to provide a c...
Article
The anterior tympanomeatal angle (ATA) blunting is clinically defined as a certain degree of the ATA obliteration due to excessive fibrous tissue formation, which is a relatively common complication of external auditory canal (EAC) related operations. The aim of this study was to examine the effect of ATA blunting on the middle ear transfer functio...
Article
Abstract Objective: To investigate the characteristics of auditory evoked cortical ERP components P1-N1-P2 and MMN and explore a practical way for ERP waveform identification and classification. Methods: Thirty right-handed normally hearing volunteers participated in the present study, age ranging from 20 to 40 years old, 14 males and 16 females. A...
Article
Full-text available
Abstract Objective: With the development of more sophisticated and sensitive measures of auditory dysfunction, both the Audioscan test and Békésy audiometry can provide detailed information on hearing status between the octaves, which has clinical importance. This study investigated the reliability and validity of Audioscan and Békésy audiometry. M...
Article
Auditory neuropathy is a hearing disorder where outer hair cell function within the cochlea is normal, but inner hair cell and/or the auditory nerve function is disrupted. It is a heterogeneous disorder which can have either congenital or acquired causes. Furthermore, the aetiology of auditory neuropathy is vast, which may include prematurity, hype...
Article
The paper using functional magnetic resonance imaging (fMRI), to observe the changes of cerebral functional cortex in prelingual deaf singers for Chinese sign language(CSL). Results: During observing and imitating CSL, the activated areas in all groups include bilateral middle frontal gyrus, middle temporal gyrus, superior parietal lobule, cuneate...
Article
Bone morphogenetic proteins (BMPs), members of the transforming growth factor β cytokine superfamily, elicit various biological effects in different tissues. BMP receptor type II (BMPRII) contains a unique carboxyl-terminal region that interacts with multiple signaling molecules. However, expression of endogenous BMPRII is low in various mammalian...
Article
Type II bone morphogenetic protein (BMP) receptor (BMPRII) is a membrane receptor containing a unique tail domain. This kinase receptor is involved in various biological processes, including bone formation. Recent studies have revealed that novel BMPRII-interacting proteins are involved in the Smad signaling pathway or in the non-Smad signaling pat...
Chapter
Exposure of cells to compressive strain results in rapid induction of bone morphogenetic protein 2 (BMP2). On the other hand, BMP signaling is inhibited by tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, in chronic inflammatory disorders in which the level of TNF-α increases. However, the mechanism underlying this signaling crosstalk i...
Chapter
Extracellular signal-regulated kinase 5 (ERK5) plays an important role in the regulation of cell proliferation and differentiation. Recent data suggest that ERK5 is activated by neurotrophic factors in various types of neurons and induces neurotrophin-mediated neuronal survival. This report provides advanced findings on the mechanism underlying ERK...
Chapter
Bone morphogenetic protein (BMP) signaling is essential for neurogenesis and bone formation. Dullard phosphatase functions as a negative regulator of BMP signaling by promoting the dephosphorylation or degradation of BMP receptors. In contrast, dullard regulates nuclear membrane biogenesis. This report aims to characterize dullard and determine the...
Article
Full-text available
It has been generally accepted that excessive exposure to loud music causes various hearing symptoms (e.g. tinnitus) and consequently leads to a risk of permanent hearing damage, known as noise-induced hearing loss (NIHL). Such potential risk of NIHL due to loud music exposure has been widely investigated in musicians and people working in music ve...
Article
With developments in software and micro-measurement technology, a three-dimensional middle ear finite element (FE) model can now be more easily constructed to study sound transfer function. Many FE models of the middle ear have been constructed to date, and each has its own particular advantages and disadvantages. In this article, we review the lat...
Article
King-Kopetzky syndrome (KKS) is the condition in which an individual complains of having difficulties understanding speech in background noise but has normal hearing thresholds on pure tone audiometry. KKS is a relatively common condition and recognized as a clinically unique group in the audiological or ENT clinics (about 1–10%). The absence of an...
Article
We have systematically tested the peripheral auditory system in 21 late-onset FSHD cases. The pure tone thresholds did not differ significantly at low and mid frequencies in either better ear or worse ear between FSHD subjects and controls. The patients with FSHD had significantly better hearing thresholds at 4 and 6 kHz than the normative data in...
Article
Speech-in-noise audiometry has potential application as a low-cost, self-screening test for sensorineural hearing loss. To realize this potential, the influence of variations in audio equipment and listening environment need assessment. The present study assessed: 1) the frequency response and distortion produced by a wide range of commercially ava...
Article
The aim of this study is to investigate the middle ear dynamic characteristics and their influence on TEOAEs in patients with middle ear disorders. The middle ear dynamic characteristics and TEOAE findings were investigated in 89 patients with middle ear disorders using the sweep frequency impedance (SFI) meter and the 1LO88 system, respectively. T...
Article
To evaluate the changes in self-rated quality of life (QoL) obtained following cochlear implantation in relation to changes in the individual's complaints. We have used repeated responses over a period of at least 4 years following implantation so as to examine within-subject relationships. Twenty-four consecutive post-lingually deafened patients w...
Article
King-Kopetzky syndrome (KKS) is defined as the condition in which an individual complains of difficulties understanding speech in background noise, but has normal thresholds on pure tone audiometry. Various studies have claimed that a number of factors, including peripheral and central auditory function, linguistic, speech processes and psychologic...
Article
Otoreflectance (OR) is a newly developed multifrequency middle ear function test instrument utilizing acoustic signals, which are presented and recorded in the ear canal. It provides an objective measurement of the middle ear transfer function for a frequency range of 0.25 to 8.0 kHz. In the present study, reflectance measurements were performed in...
Article
In the present study, mild impairment of cochlear function in patients with King-Kopetzky syndrome was investigated using DPOAEs. A significant decrease in DPOAE levels in both ears was found in patients with King-Kopetzky syndrome compared with the controls after considering the thresholds as a co-variable. It is noteworthy that the global mean le...
Article
Speech-in-noise audiometry has potential application as a low-cost, self-screening test for sensorineural hearing loss. To realize this potential, the influence of variations in audio equipment and listening environment need assessment. The present study assessed: 1) the frequency response and distortion produced by a wide range of commercially ava...
Article
The condition in which individuals with normal pure tone audiograms complain of hearing difficulties, especially in the presence of background noise, (normal pure tone audiograms), has had a number of different names. The present term King-Kopetzky Syndrome was coined by Hinchcliffe in 1992. This is a common condition reported in 5 - 10% of those a...
Article
Hearing impairment has long been associated with the rarer forms of severe childhood and infantile facioscapulohumeral muscular dystrophy. Recent studies have suggested a high prevalence in classic, adult or adolescent, onset cases as well. We undertook detailed pure tone audiometric examination of 21 adult onset facioscapulohumeral muscular dystro...
Article
To investigate the middle ear dynamic characteristics in patients with otosclerosis using the sweep frequency impedance meter (SFI test) and conventional tympanometry, and also to evaluate the diagnostic efficiency of the SFI test for otosclerosis. The study was designed to collect a total of 25 (36 ears) consecutive patients with otosclerosis. All...
Article
The Audioscan is a form of high definition audiometry based on iso-hearing level frequency sweeps, which was developed by Meyer-Bisch in 1990. Compared with traditional tone audiometry, it sweeps across the preset frequency range at a predetermined sweep rate and provides a continuous audiometric curve. Because the device has a maximum frequency ra...
Article
King-Kopetzky syndrome (Obscure Auditory Dysfunction, OAD) has been recognized as a clinically distinct condition in audiological and ENT clinics. It is characterized by normal hearing thresholds on pure tone audiometry (PTA) but complaints of difficulties in understanding speech in the presence of background noise. In a study on 110 consecutive pa...
Article
King Kopetzky Syndrome (KKS) is a common condition in which individuals with normal audiograms complain of hearing difficulties, particularly in noisy places. Several studies have shown many patients with KKS to have a family history of hearing problems. In 82 consecutive patients with KKS and normal middle ear function, we compared the performance...
Article
In the present study, the test-retest variability of distortion product otoacoustic emissions (DPOAEs) due to various causes has been assessed quantitatively at individual frequencies using the ILO88/92 system. The short-term variance was generally lower than 3 dB2. Changing the position and the fit of the probe may affect the level of background n...
Article
In this study, the Audioscan test has been used to detect early signs of hearing abnormalities in 80 patients with King-Kopetzky syndrome. A significantly higher prevalence of Audioscan notches between 500 and 3,000 Hz was found for each age band and gender in patients with King-Kopetzky syndrome than in control subjects. This indicates that Audios...
Article
Full-text available
In this study, the parameters of notches in the Audioscan have been compared with the distortion product otoacoustic emission (DPOAE) findings in 100 subjects with normal hearing, including 55 normal controls and 45 patients with King Kopetzky syndrome. Of those, 35 subjects had Audioscan notches (11 controls and 24 patients), 96 per cent (53 out o...
Article
For a number of years we have been using open-ended questionnaires in the assessment of hearing disability and handicap, tinnitus complaint behaviour together with shortcomings and benefits of various rehabilitative interventions. More recently we have applied this approach to positive experiences reported by adults who have developed a hearing imp...
Article
Within this study we have examined the particular hearing complaints of patients being considered for a cochlear implant and the specific benefits/shortcomings experienced by implanted patients using open-ended questionnaires. As we expected, the difficulty of hearing general conversation was the most common individual hearing complaint. However, 4...
Article
The hearing complaints in patients with King-Kopetzky syndrome were studied by use of the open-ended hearing problem questionnaire. The main findings are that complaints were commonly focused on the categories of 'live speech' and 'electronic speech' difficulties in patients with King-Kopetzky syndrome, particularly the auditory difficulties of spe...
Article
The use of transient click-evoked otoacoustic emissions (TEOAEs) recorded with and without the presence of contralateral noise stimulation has been proposed as a test of efferent auditory function. In this study, we used this test with two groups of subjects. The first group comprised subjects with normal pure-tone thresholds and no disclosed or ap...
Article
Within this paper we have considered some of the particular disabilities and handicaps commonly experienced by elderly hearing-impaired people as compared with younger individuals. We examined their ratings of their disability and handicap and found that both disability and handicap increased more rapidly with increasing hearing loss in younger tha...
Article
King-Kopetzky syndrome is characterized by auditory disability with a clinically normal hearing threshold. The main reported disability is hearing speech in the presence of background noise. The degrees of speech-hearing disability in patients with King-Kopetzky syndrome have been investigated with the use of the Social Hearing Handicap Index (SHHI...

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