Federico Tucci

Federico Tucci
Sapienza University of Rome | la sapienza · Department of Physiology and Pharmacology "Vittorio Erspamer"

Post doc researcher
Exploring the interplay between oculomotor activities, brain rhythms, and neurodegenerative disorders

About

30
Publications
2,785
Reads
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280
Citations
Introduction
My main interest is to study EEG brain rhythms under resting state condition both in healthy patients and in patients suffering from various neurodegenerative diseases. In addition, I am also actively involved in mouse model research. In this field, I investigate the mechanisms regulating the sleep-wake cycle and back translation models.

Publications

Publications (30)
Article
Full-text available
Background Huntington’s disease (HD) is a progressive neurodegenerative disorder phenotypically manifested by motor, cognitive and psychiatric symptoms (Novak and Tabrizi, 2011). These patients are also characterized by vigilance abnormalities. This has been demonstrated by electrophysiological measures (Wiegand et al., 1991). In particular, previo...
Article
Background Previous evidence showed that persons experiencing post‐COVID‐19 with “brain fog” were characterized by abnormal resting‐state electroencephalographic (rsEEG) rhythms reflecting vigilance dysfunctions. In the present exploratory study, we tested the hypothesis that in post‐COVID persons with normal cognitive status, abnormalities in thos...
Article
Background Previous studies have shown that patients with Mild Cognitive Impairment due to Alzheimer’s disease (ADMCI) were characterized by reduced posterior rsEEG alpha rhythms after a 12‐month follow‐up (Babiloni et al., 2013). However, none of them have found an alpha deterioration considering a shorter follow‐up. A promising neurophysiological...
Article
Background Abnormalities in cortical sources of resting‐state eyes closed electroencephalographic (rsEEG) rhythms recorded by hospital settings (10‐20 montage) with 19 scalp electrodes characterized Alzheimer’s disease (AD) from preclinical to dementia stages. An intriguing rsEEG application is the monitoring and evaluating of AD progression in lar...
Article
Background Alzheimer’s Disease (AD) patients present a higher risk of developing epilepsy compared to the age‐matched general population. Neurodegenerative cognitive disorders in general are closely linked with epilepsy and subclinical Epileptiform Electroencephalographic Activity (EEA). Furthermore, AD with Mild Cognitive Impairment (MCI) patients...
Article
Background Patients with dementia due to Alzheimer’s disease (ADD) and Parkinson’s disease (PDD) suffer from vigilance dysregulation. We hypothesized that such dysregulation may be reflected by altered reactivity of posterior resting‐state electroencephalographic (rsEEG) alpha rhythms during the vigilance transition from eyes‐closed to ‐open condit...
Article
Full-text available
Introduction Longitudinal studies of autistic children show that autism symptoms and emotional/behavioral problems vary and change over time. However, the factors that affect this variability remain far from certain and very little is known about what take place in the preschool period and the role of executive functions (EF). Methods Here, we tes...
Article
Background Abnormalities in the neurophysiological oscillatory mechanisms generating dominant resting‐state eyes closed electroencephalographic (rsEEG) rhythms portray the Alzheimer’s disease (AD) continuum, from the preclinical to the dementia stage. Here, we tested whether these abnormalities may be reproducible by analyzing the rsEEG signals acq...
Article
Background The resting state eyes‐closed electroencephalographic (rsEEG) alpha (8‐12 Hz) rhythms reflect cortical neural synchronization mechanisms underpinning the inhibition of sensory, cognitive, and motor areas in parietal, temporal, and occipital cortex during a condition of low vigilance. Here we tested the hypothesis that age may diversely a...
Article
Abnormalities in cortical sources of resting-state eyes closed electroencephalographic (rsEEG) rhythms recorded by hospital settings (10-20 montage) with 19 scalp electrodes characterized Alzheimer's disease (AD) from preclinical to dementia stages. An intriguing rsEEG application is the monitoring and evaluation of AD progression in large populati...
Article
Abnormalities in cortical sources of resting-state eyes-closed electroencephalographic (rsEEG) rhythms recorded by hospital settings (10–20 electrode montage) with 19 scalp electrodes provide useful markers of neurophysiological dysfunctions in the vigilance regulation in patients with Alzheimer's disease dementia (ADD). Here we tested whether thes...
Article
Background: Patients with amnesic mild cognitive impairment due to Alzheimer's disease (ADMCI) typically show a "slowing" of cortical resting-state eyes-closed electroencephalographic (rsEEG) rhythms. Some of them also show subclinical, non-convulsive, and epileptiform EEG activity (EEA) with an unclear relationship with that "slowing." Objective...
Article
Here we tested if the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms from the eye-closed to eyes-open condition may differ in patients with dementia due to Lewy Bodies (DLB) and Alzheimer's disease (ADD), as a functional probe of the dominant cortical neural synchronization mechanisms regulating the vigilance in...
Article
Background Cortical sources of resting state eyes‐closed electroencephalographic (rsEEG) rhythms are abnormal in patients with amnesic mild cognitive impairment due to Alzheimer’s disease (ADMCI). In the present exploratory and retrospective study, we tested whether those abnormalities may be stronger in ADMCI with (ADMCI‐EEA) than without (ADMCI‐n...
Article
Background Here we tested the hypothesis that gender may diversely affect resting state eyes‐closed electroencephalographic (rsEEG) alpha (8‐12 Hz) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer’s disease and mild cognitive impairment (ADMCI). Method Clinical and rsEEG datasets in 69 ADMCI and 57 Nold individuals ‐ m...
Article
Background In normal old (Nold) and Alzheimer’s disease (AD) persons, a high cognitive reserve makes them more resistant and resilient to brain neuropathology and neurodegeneration. Here we tested whether these effects may affect neurophysiological oscillatory mechanisms generating dominant resting state electroencephalographic (rsEEG) alpha rhythm...
Article
In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals wer...
Article
Full-text available
Microglia, the brain's resident macrophages, actively contributes to the homeostasis of cerebral parenchyma by sensing neuronal activity and supporting synaptic remodeling and plasticity. While several studies demonstrated different roles for astrocytes in sleep, the contribution of microglia in the regulation of sleep/wake cycle and in the modulat...
Article
Background: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-called resting state electroencephalographic (rsEEG) rhythms, showing the highest amplitude in posterior areas at alpha frequencies (8-13 Hz). Objective: Here we tested the hypothesis that age may affect rsEEG alpha (8-12 Hz) rhythms recorded in norma...
Article
Full-text available
The Electrophysiology Professional Interest Area (EPIA) and Global Brain Consortium endorsed recommendations on candidate electroencephalography (EEG) measures for Alzheimer's disease (AD) clinical trials. The Panel reviewed the field literature. As most consistent findings, AD patients with mild cognitive impairment and dementia showed abnormaliti...
Article
Vascular contribution to cognitive impairment (VCI) and dementia is related to etiologies that may affect the neurophysiological mechanisms regulating brain arousal and generating electroencephalographic (EEG) activity. A multidisciplinary expert panel reviewed the clinical literature and reached consensus about the EEG measures consistently found...
Article
Background The European PharmaCog study (www.pharmacog.org) has reported a reduction in delta (1‐6 Hz) electroencephalographic (EEG) power (density) during cage exploration (active condition) compared with quiet wakefulness (passive condition) in PDAPP mice (hAPP Indiana V717F mutation) modeling Alzheimer’s disease (AD) amyloidosis and cognitive de...
Article
Full-text available
In the present exploratory and retrospective study, we hypothesized that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might be more abnormal in patients with epileptiform EEG activity (spike-sharp wave discharges, giant spikes) and amnesic mild cognitive impairment not due to Alzheimer's disease (noADMCI-EEA...

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