Federico Ferreres

Federico Ferreres
Spanish National Research Council | CSIC · Centro de Edafología y Biología Aplicada del Segura

PhD

About

392
Publications
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20,219
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Additional affiliations
January 2010 - December 2012
University of Murcia
January 1998 - December 2013

Publications

Publications (392)
Article
Chukrasia tabularis A.Juss. is a canopy tree widely distributed in Asia and commonly used for construction-grade timber. While the residues resulting from the timber exploration constitute the major source of waste, other parts of the plant remain underutilized. Therefore, aiming the valorisation of a major residue resulting from C. tabularis wood...
Article
Among several extracts from species from Guinea-Bissauan flora, the hydroethanol extract obtained from the leaves of gingerbread plum (Neocarya macrophylla (Sabine) Prance ex F. White.) revealed to be one of the most cytotoxictowards human gastric AGS carcinoma cells of the. Considering the increasing use of N. macrophylla in the food industry and...
Article
Full-text available
This work aimed to identify the bioactive compounds present in adult maqui (Aristotelia chilensis) leaves from different stages of development and seasons of the year and compare them with leaves obtained from maqui plants grown in vitro. The qualitative and quantitative analysis of maqui leaf extracts by HPLC-DAD-ESI-MSn showed the presence of dif...
Article
Full-text available
The effect of coffee and cocoa on oxidative damage to macromolecules has been investigated in several studies, often with controversial results. This study aimed to investigate the effect of one-month consumption of different doses of coffee or cocoa-based products containing coffee on markers of DNA damage and lipid peroxidation in young healthy v...
Article
Full-text available
PurposeSeveral studies have demonstrated the properties of hydroxytyrosol, a phenolic compound present in olive oils and olives with a well-characterized impact on human health. Nevertheless, some knowledge gaps remain on its bioavailability and metabolism; overall concerning to the real rate per cent of absorption and biovailability of dietary hyd...
Article
While the fruits of Xylopia aethiopica (Dunal) A.Rich. are important in African countries as a local trade product, their composition remains scarcely investigated. Phenolic fingerprint is herein delivered through HPLC-DAD-ESI(Ion Trap)-MSⁿ and UPLC-ESI-QTOF-MS² analysis, six cinnamoylquinic acid derivatives and twenty-four flavonoid glycosides bei...
Article
Ethnopharmacological relevance . According to ethnobotanical surveys, Cassia sieberiana DC. (1825) is a particularly reputed species in African folk Medicine, namely due to the application of its leaves and roots for the treatment of diseases and symptomatology that appear to be related with an inflammatory background. In contrast with the roots of...
Article
The present study evaluates the removal capacity of microalgae photobioreactors of environmental pollutants present in wastewater from the dry riverbed El Albujón, as a way to minimize the eutrophication process of the Mar Menor. Particularly, the capacity of four autochthonous microalgae consortia collected from different locations of the salty la...
Article
Notwithstanding Gustavia gracillima Miers widespread distribution in neotropical regions, its chemical profile and biological properties remain uninvestigated. A methanol extract obtained from the flowers was characterized through HPLC-DAD-ESI/MSⁿ, nine ellagic acid derivatives and twelve kaempferol 3-O-glycosides being identified and quantitated f...
Article
Caryota urens L. has long been valued as a traditional food, the edible fruits being eaten raw and the inflorescences commonly used on sweet sap and flour production. In the current work, the phenolic profile of methanol extracts obtained from the inflorescences and fruits was unveiled for the first time, nine caffeic acid derivatives being identif...
Article
Pistachio (Pistacia vera L.) is a drought-tolerant specie grown under the semiarid conditions of the Mediterranean basin. For this reason, it is essential to make an exhaustive quantification of yield and quality benefits of the kernels because the regulated deficit irrigation will allow significant water savings with a minimum impact on yield, whi...
Article
Bioprospecting for seaweed-derived multimodal acting products have earned increasing attention in the fight against diseases of multifactorial origin, such as neurodegenerative conditions. This is a pioneer study on the in vitro screening of neuroactive properties of phlorotannin-targeted extracts from edible Fucus species. Phlorotannin extracts ex...
Article
Full-text available
Lipophenols have been stressed as an emerging class of functional compounds. However, little is known about their diversity. Thus, this study is aimed at developing a new method for the extraction, clean-up, and UHPLC-ESI-QqQ-MS/MS-based analysis of the lipophenols derived from hydroxytyrosol (HT): α-linolenic (HT-ALA), linoleic acid (HT-LA), and o...
Article
Background: An array of bioactive compounds with health-promoting effects has been described in several species of macroalgae. Among them, phytoprostanes (PhytoPs) and phytofurans (PhytoFs), both autoxidation products of α-linolenic acid, have been seen to exert immunomodulatory and antiinflammatory activities in vitro. The purpose of this study w...
Article
Phytoprostanes (PhytoPs) and phytofurans (PhytoFs) are plant oxylipins (isoprostane-prostaglandin-like compounds) formed by the free radical-catalyzed oxidation of α-linolenic acid (ALA, C18:3, n-3). These oxylipins have been previously described in an array of plant-based foods with similar concentrations as phenolics in some fruits and vegetables...
Article
Given the growing interest in phytoprostanes (PhytoPs) and phytofurans (PhytoFs) in the field of plant physiology, biotechnology, and biological functions, the present study aimed to optimize a method of enzymatic hydrolysis which utilizes bacterial and yeast esterases that allow the appropriate quantification of PhytoPs and PhytoFs. To obtain the...
Article
Oxylipins such as isoprostanes (IsoPs), prostaglandins (PGs) and thromboxanes (TXs) are lipid mediators derived from the oxidation of polyunsaturated fatty acids, which regulate the magnitude of oxidative stress and inflammation processes and play an important role in pathophysiological processes in the kidney. A total of 36 oxylipins were analyzed...
Article
Full-text available
The economic value of fig trees has been globally acknowledged due to their utilization in the food industry, being also frequently used in traditional medicine. While ubiquitously distributed in Southeast Asia, Ficus curtipes Corner remains uninvestigated concerning its biological properties and chemical profile. HPLC-DAD-ESI/MS n characterization...
Article
Phytoprostanes (PhytoPs) and phytofurans (PhytoFs) occur in higher plants as a result of the non-enzymatic oxidation of α-linolenic acid (ALA, C18:3 n-3), triggered by increased levels of Reactive Oxygen Species in response to biotic and abiotic stress that can constitute relevant biomarkers of oxidative stress. Currently, in the scenario of growin...
Book
Full-text available
Rice plays a key role in the food security of more than half of the world's population. At least 60% of cultivated soils have abiotic stress limitations caused by mineral deficiencies, temperatures, extremes, drought or acidity. Specific technological practices can help to reduce the damage caused. Phytoprostanes and phytofurans (PhytoPs and PhytoF...
Article
The scientific background on the perinatal pathology, regarding both mother and offspring, from the perspective of lipidomics has noticed the chance of identifying new promising clinical markers of oxidative stress and inflammation, closely related with the normal development of unborn and new-born child that gives rise to new and promising perspec...
Chapter
Oxidative stress and inflammatory injury are responsible for a number of diseases, being strongly associated with neurodegenerative disorders, among others. Caffeinated and decaffeinated coffees act as antioxidant and anti-inflammatory agents in therapeutic processes or exert preventive roles in different pathological situations. Coffee's therapeut...
Article
In rice crops, fertilization is a naturalized practice, although inefficient, that could be improved by applying foliar fertilization. Phytoprostanes (PhytoPs) and phytofurans (PhytoFs) are products of α-linolenic acid peroxidation, useful as biomarkers of oxidative degradation in higher plants. The objective was to determine the effect of the foli...
Article
Cocoa has been widely discussed as a bioactive food rich in sensory stimulation and health benefits. However, no information has been provided concerning phytoprostanes (PhytoPs) and phytofurans (PhytoFs) in cocoa. These compounds are of interest because they play a role in the regulation of immune function. The present study included 31 cocoa clon...
Article
Centaurium erythraea Rafin. is a food flavouring used in both food and beverage industries. Despite the existence of some works on this species, only few of them focus their attention on its common form of consumption (infusion). Thus, we intended to explore the chemical composition and the biological properties of infusions from C. erythraea aeria...
Article
Structure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive molecules. This approach initiates with the comparison of a target candidate with a molecule or a collection of molecules and their attributed biological functions to shed some light in the details of one or more SARs and subsequently using that information...
Chapter
Oxidative stress and inflammatory injury are responsible for a number of diseases, being strongly associated with neurodegenerative disorders, among others. Caffeinated and decaffeinated coffees act as antioxidant and anti-inflammatory agents in therapeutic processes or exert preventive roles in different pathological situations. Coffee´s therapeut...
Article
Enhancement of the diffuse solar radiation to which lettuce plants were exposed clearly affected the vitamin C content and the quantitative and qualitative patterns of phenolic compounds and free amino acids (AA) in the leaves. Although the enhanced level of diffuse light was detrimental to the contents of vitamin C and total phenolic compounds, lo...
Article
The small tree Allophylus africanus, widespread in the African continent, has long been considered valuable, as noted by the number of reports on their multiple medicinal uses. With this work, we aimed to extend the current, and so far restricted, knowledge on the chemical composition of the plant, particularly as source of flavonoids, as well as t...
Article
Ethnopharmacological relevance: Ficus exasperata Vahl, commonly known as sandpaper, is a terrestrial Afro-tropical tree used in popular medicine for the treatment of respiratory infections, ulcers and diarrhoea. Previous studies described the antioxidant, antibacterial, anti-inflammatory, antipyretic and antinociceptive properties of this species....
Article
In the present study, we examined whether particular urinary oxylipins (isoprostanes (IsoPs), leukotrienes (LTs), prostaglandins (PGs), and thromboxanes (TXs)) in 16 elite triathletes could alter during 145 days of training. Within this time span, 45 days were dedicated to examining the effects of the intake of a beverage rich in polyphenols (one s...
Article
Several attempts have been made in recent years to fully characterize phlorotannin-rich extracts. Nevertheless, this remains a challenging quest, not only because of seaweed complex chemical composition, but also due to the diverse structural assemblage within phlorotannin molecules (i.e., type of linkage, modification site, and number of additiona...
Article
To date, the capability of altitude training to improve the performance and physiological parameters of athletes has been promoted, although the effect on clinical variables remains underreported. This work deals with the impact of 2-weeks training at moderate altitude (2320 m) relative to sea level (<400 m) on eight elite triathletes, under contro...
Article
Despite the extensive characterization of Hydroxytyrosol (HT), there is a gap on its capacity to modulate the catecholamine pathways. This study deals with the evaluation of HT, hydroxytyrosol-acetate (HTA), and 3,4-dihydroxyphenylacetic acid (DOPAC), as well as their microbial metabolites (homovanillic alcohol and tyrosol), on catecholamines excre...
Article
Full-text available
At present, people with today's busy lifestyle have a general trend of consuming fruit like banana passion fruit (Passiflora tripartita var. mollisima) as juices or smoothies, being an increasing tendency that can generate a large amount of agro-industrial residues. Whereby, food industries have a significant investment to minimize these wastes gen...
Article
At present, people with today's busy lifestyle have a general trend of consuming fruit like banana passion fruit (Passiflora tripartita var. mollisima) as juices or smoothies, being an increasing tendency that can generate a large amount of agro-industrial residues. Whereby, food industries have a significant investment to minimize these wastes gen...
Article
Phytoprostanes and phytofurans (PhytoPs and PhytoFs, respectively) are nonenzymatic lipid peroxidation 12 products derived from α-linolenic acid (C18:3 n-3), considered biomarkers of oxidative degradation in plant foods. The present 13 work profiled these compounds in white and brown grain flours and rice bran from 14 rice cultivars of the subspeci...
Article
Phlorotannins are widely recognized as an inexhaustible family of naturally occurring molecules, with great potential in food and pharmaceutical industries. The present work explores the anti-inflammatory activity of phlorotannins from different Fucus species native from the Northern Atlantic coast, and from Fucus vesiculosus Linnaeus grown in an i...
Article
Oxylipins are lipid mediators involved in the physiopathology of all organs. Moreover, isoprostanes have been established as general and reliable in vivo oxidative stress biomarkers. Red wine has proved to exert several benefits in order to the maintenance of the oxidative organism balance. Antiradical scavenger capacity has been mainly attributed...
Article
Glandora diffusa (Lag.) D. C. Thomas is a medicinal species widely consumed as herbal tea. Despite being commercialized by several herbs distributors, the genuineness of the marketed product is unknown. Among secondary metabolites with proven taxonomic interest, the phenolics profile was herein used as “fingerprint” of three commercial G. diffusa s...
Article
Vitex spp. have been reported as constituents of herbal preparations, namely Vitex peduncularis, commonly used in Asian countries. Unlike other species extensively investigated, reports on the biological activities and chemical profile of V. peduncularis are still scarce. In this work, the polyphenolic profile of V. peduncularis stem bark was unvei...
Article
Despite the wide use of extra virgin olive oil (EVOO) to combat several diseases, the antidiabetic and anti-cholinesterase activity of Spanish EVOO have not been assessed. In order to evaluate which compounds are responsible for these activities of five Spanish EVOOs, in addition to flavonoids, we investigated for the first time the effect of the c...
Article
Studies involving jackfruit tree (Artocarpus heterophyllus Lam.) focus on its fruit. Nevertheless a considerable part of jackfruit weight is represented by its seeds. Despite being consumed in several countries, knowledge about the chemical composition of these seeds is scarce. In this work, the accumulation of primary and secondary metabolites in...
Article
A green mi­crowave-as­sisted ex­trac­tion of high value-added com­pounds from ex­otic fruits’ peels was op­ti­mized by Box-Behnken de­sign us­ing 3 fac­tors: solid/ sol­vent ra­tio, X1, tem­per­a­ture, X2, and ex­trac­tion time, X3. By us­ing Der­ringer’s de­sir­abil­ity func­tion, op­ti­mum ex­trac­tion yields are ob­tained with X1 = 1/ 149.95 g/...
Article
Esca is a destructive disease of complex etiology affecting grapevines worldwide. A major constraint to the study and control of esca is that the disease is not diagnosed until external leaf and/or fruit symptoms are visible; however external symptoms usually appear several years after infection onset. We studied the phenolic content of V. vinifera...
Article
Full-text available
Purpose To date, several in vitro and in vivo studies have shown phenolic compounds occurring naturally in olives and olive oil to be beneficial for human health due to their interaction with intracellular signaling pathways. However, the bioavailability of the most important of these compounds, hydroxytyrosol, and its transformation into derivativ...
Article
Skin aging is a complex process that is strongly affected by UV radiation, which stimulates the production of reactive oxygen species (ROS) in the epidermis and dermis and subsequently causes skin damage. Among the major consequences are increased collagen degradation and reduced collagen synthesis. Previous reports have demonstrated the beneficial...
Article
F4-neuroprostanes, F3-neuroprostanesn-6 DPA, and F2-dihomo-isoprostanes, metabolites of non-enzymatic lipid peroxidation of polyunsaturated fatty acids [docosahexaenoic acid, n-6 docosapentanoic acid, and adrenic acid respectively], have become important biomarkers for oxidative stress in several diseases like epilepsy and alzheimer. These biomarke...
Article
Full-text available
We analyzed biomarkers of lipid peroxidation of the nervous system -F2-dihomo-isoprostanes, F3-neuroprostanes, and F4-neuroprostanes- in urine samples from 158 healthy volunteers ranging from 4-88 years old with the aim of analyzing possible associations between their excretion values and age (years). Ten biomarkers were screened in the urine sampl...
Article
Adrenic acid (AdA) and docosahexaenoic acid (DHA) peroxidation produces F2-dihomo-IsoPs and neuroprostanes, which have been related oxidative damage on the central nervous system. Besides the polyphenols, melatonin (MEL) and hydroxytyrosol (OHTyr) could be partly responsible for the antioxidant benefits of red wine (excluding colon derivatives). In...
Article
The Mediterranean Diet (MD) has been proved to exert benefits with respect to the maintenance of the redox balance, and wine is a representative component. Bioactive compounds such as polyphenols, melatonin and hydroxytyrosol act as radical scavengers and regulate the oxidation status of the organism. Oxidative damage to DNA yields a large range of...
Conference Paper
Date palm (Phoenix dactylifera L.) is an important fruit tree, native to the hot arid regions of the world, mainly grown in the Middle East and North Africa. Since the ancient time, this plant has been widely used as a food and also in the folk medicine, due to its health-promoting properties. In spite of many previous works concerning the phenolic...
Article
The aim of the study was to determinate the cuali-cuantitative metabolic profiling (LC-MSn) of G. madruno biflavonoids and evaluated the antioxidant activity of these compounds using a structure activity relationship (SAR) analysis. A total of 21 biflavonoids and 3 organic acids were identified. The leaves were the most promising source of biflavon...
Article
The effects of polyphenol-rich foods on the iron status of athletes, as well as the effect of physical training on the hormone hepcidin, implicated in iron metabolism, are not clear. We investigated the influence on iron metabolism of a long-term training intervention of 120 days, measuring the hepcidin concentration in the plasma of 16 elite triat...
Article
The aim of the this study was to determine the effect of a polyphenols-rich juice (aronia-citrus juice, ACJ) on F4-neuroprostanes and F2-dihomo-isoprostanes -markers of oxidative stress associated with the central nervous system (CNS) - in 16 elite triathletes under a controlled diet for triathlon training (145 days). In the triathletes, a decrease...
Article
Metabolites of the non-enzymatic lipid peroxidation of polyunsaturated fatty acids (DHA, n-6 DPA, and AdA), neuroprostanes (NeuroPs), and F2-dihomo-isoprostanes (F2-dihomo-IsoPs) have become important biomarkers for oxidative stress (OS) in neurodegenerative diseases, particularly in epilepsy. These biomarkers were measured by UHPLC-QqQ-MS/MS i...
Article
Previously, we reported that alcoholic fermentation enhanced flavanones and carotenoids content of orange juice. The aim of this work was to evaluate the influence of pasteurization on the qualitative and quantitative profile of bioactive compounds and the antioxidant capacity of fermented orange juice. Ascorbic acid (203 mg/L), total flavanones (6...