Federico Dagna

• MD
• Azienda Sanitaria Locale Torino 5

Tracheoesophageal puncture with voice prosthesis placement is used to restore vocal function after total laryngectomy. However, closure of the fistula is sometimes needed. At our department, a simple and effective technique for closure was developed. It does not require interposed tissues or materials. Moreover, our procedure allows for a short reh...

BACKGROUND: Acoustic bimodal stimulation is one of the most debated topics in audiology. Wearing a hearing aid contralaterally to the cochlear implant provides an advantage in noisy environments but benefit in silence is still debated. More importantly it is still unclear why some patients seem to benefit from it and others do not, and in later yea...

Plain-language-summary Platelet-rich plasma (PRP) gel has been used in several conditions to enhance wound healing processes. The aim of this retrospective study was to evaluate clinical outcomes in patients who underwent superficial parotidectomy with and without the use of PRP gel at the surgical field. Fifty-nine patients underwent superficial p...

Aims: In previous decades Menière’s disease (MD) has been classified into four different categories: certain, definite, probable and possible. Recently, in the need to overcome critical issues in the diagnosis, the Bárány Society proposed new diagnostic criteria on MD excluding the certain and possible categories. Nevertheless, this updated classif...

Résumé La ponction trachéo-œsophagienne secondaire (PTO) avec mise en place d’un implant phonatoire est l’une des possibilités pour restaurer la fonction vocale après une laryngectomie totale. Cependant, certains patients ont des comorbidités qui contre-indiquent l’anesthésie générale. Dans notre service, une procédure de PTO en consultation pour m...

Secondary tracheoesophageal puncture (TEP) with voice prosthesis placement represents one of the possibility to restore vocal function after total laryngectomy. However, some patients have comorbidities that contraindicate general anesthesia. In our department, an in-clinic TEP procedure for retrograde voice prosthesis placement was developed. It a...

Objective: To assess the audiological profile in a cohort of children affected by syndromic craniosynostosis. Methods: Eleven children with Apert syndrome (n=4), Saethre-Chotzen syndrome (n=3), Muenke syndrome (n=2), Crouzon syndrome (n=1) and Pfeiffer syndrome type 1 (n=1) were submitted to a complete audiologic evaluation including otoscopy, p...

Objective: To report a rare case of a myeloid sarcoma of submandibular salivary gland. Methods: A 65-year-old woman with a history of successfully treated myelodysplastic syndrome, presenting with periodic painful swelling of her right submandibular area. Results: Physical evaluation, ultrasound and CT scan revealed the presence of a 3-cm mass...

This is a case of successful cochlear implantation in a 50-year-old man who experienced sudden hearing loss and developed ipsilateral severe tinnitus at three years following conservative stage 1 vestibular schwannoma retrosigmoid surgery. After cochlear implantation, tinnitus improved from THI grade 4 to 2. Localisation skills improved. Hearing in...

Objectives/HypothesisTo determine whether speech recognition scores (SRS) differ between adults with long-term auditory deprivation in the implanted ear and adults who received cochlear implant (CI) in the nonsound-deprived ear, either for hearing aid-assisted or due to rapidly deteriorating hearing loss. Study DesignRetrospective study. Methods Sp...

Objective: The first aim was to determine the prevalence, kind, and functional effects on hearing of ossicular chain suffering (OCS) in chronic otitis without cholesteatoma (NCOM) and tympanic perforations (TP). The second aim was to correlate the findings with clinical parameters and hearing level. Materials and methods: The study group compris...

Perineuronal nets (PNNs) are aggregates of extracellular matrix molecules surrounding several types of neurons in the adult CNS, which contribute to stabilising neuronal connections. Interestingly, a reduction of PNN number and staining intensity has been observed in conditions associated with plasticity in the adult brain. However, it is not known...

shows a coronal section of the brainstem of the adult mouse stained by a-NeuN antibodies, in which the LVN (dashed line) is clearly identified thanks to the presence of giant neurons (neurons of Deiters). It is located medially to the inferior cerebellar peduncle (icp) and the spinal trigeminal nerve (sp5), laterally to the medial vestibular nucleu...

are representative images taken from the ventral cochlear nucleus (VCN) of animals sacrificed at 1 dpo (a, b) and at 6 dpo (c, d) after UL. VGLUT1 is intensely expressed in the contralateral side (a, c), but weakly expressed in the ipsilateral side (b, d), due to VIII nerve degeneration. Scale bar: 100 µm in a (also applies to b, c, d)

Objective To present the first reported case of intraneural direct cochlear nerve stimulation in a human being. Study design This is a case report. Results A 23-year-old patient with bilateral progressive hearing loss associated with bilateral complete semicircular canal aplasia and ossified cochleas underwent cochlear implantation. During surger...

Objective: To describe a rare case of middle ear foreign metal body and its management. Patient: A 47 years old male welder presenting to Emergency Department with left othalgia and mild hearing impairment after a metallic spark has entered his ear. The patient underwent clinical evaluation, pure-tone audiometry and HRCT scan, that showed inferior...

Hearing loss in Menière's disease has been described to affect above all low frequencies (upward curve) with a tendency to become irreversible and non-fluctuating at the higher frequencies (peaked curve) over time. The aim of the study was to determine the effects of MD on hearing function on the basis of differences existing between the affected a...

Following injury to the adult mammalian cochlea, hair cells cannot be spontaneously replaced. Nonetheless, the postnatal cochlea contains progenitor cells, distinguished by the expression of nestin, which are able to proliferate and form neurospheres in vitro. Such resident progenitors might be endowed with reparative potential. However, to date li...

The aim of this study was to compare oval and round window vibroplasty. Eighteen (18) patients implanted with Vibrant Soundbridge (VSB) were enrolled. Two groups were formed depending on FMT placement: on round window in ten cases (RW group) and on oval window in eight (OW group). Pre and postoperative audiological tests were performed both under h...

Plasticity, namely the capability of neurons to reorganize their connections in physiological conditions or following injury, depends on the balance between neuronal intrinsic mechanisms and extrinsic regulatory molecules. During postnatal development, extracellular matrix molecules accumulate around neurons, forming perineuronal nets (PNNs), which...

To assess differences in hearing threshold estimation of four different ABR tone-bursts at 1kHz. Twenty-one (21) ears from 11 subjects were tested with pure-tone audiometry (PTA): 5 ears (24%) were normal hearing, 5 (24%) affected by mild hearing loss, 7 (33%) showed moderate hearing loss and 4 (19%) severe hearing loss. After PTA each subject unde...

Aim: Menière's disease (MD) diagnosis is based on the characteristics of vertigo and hearing loss. MD crisis do not present premonitory signs and often determine anxiety and modify significantly the way of life. Methods: The present study was carried out on 236 patients affected by unilateral definite MD according to AAO-HNS. Each patient has fille...

Objective To assess the role of the efferent auditory system by inhibition of contralateral otoacoustic emission in dyslexic children with auditory processing disorders. Methods The study sample was 34 children: 17 with dyslexia and 17 age-matched controls. Sensitive speech tests (low-pass filtered, time-compressed, distorted and dichotic) were pe...

The aim of the study was to describe ossicle resorption in chronic otitis with cholesteatoma and correlate it with clinical parameters such as age, contralateral ear condition, tympanic membrane aspect, cholesteatoma pathogenesis and extension, associated lesions and hearing threshold. Preoperative clinical data were collected for 140 patients with...

To assess the reliability of Blackman windowed tone burst auditory brainstem response (ABR) as a predictor of hearing threshold at low frequencies. Fifty-six subjects were divided in to three groups (normal hearing, conductive hearing loss, sensorineural hearing loss) after pure tone audiometry (PTA) testing. Then they underwent tone burst ABR usin...

Work idoneity in hearing loss must be related to working ability and evolution risks. Working ability is referred to the difficulties found in speech comprehension and in signals perception. As regards hearing loss evolution it is necessary to define if the subject is affected by conductive or neurosensorial hearing loss. In conductive hearing loss...

Non-auditory effects of noise involve several systems and functions, the most important of which are the cardiovascular, the vestibular and the psychic. Although several studies correlated noise exposure to some pathologies, like hypertension and anxiety disorders, and recent analysis carried out on cavy explained part of their pathophysiology, the...

Obstructive sleep apnoea syndrome in a child is characterized by prolonged episodes of obstructive hypopnoea and/or apnoea of upper airway leading to morbidity. The most common risk factor is adeno-tonsillar hypertrophy. Obstructive sleep apnoea syndrome diagnosis is based on clinical ENT evaluation and an instrumental approach, such as pulse oxime...

Objectives Many different grafting materials have been proposed in myringoplasty. The aim of this study was to evaluate the results obtained in transmeatal underlay myringoplasty using bovine and equine pericardium. The results were compared with those obtained by using autologous temporalis fascia. Methods The study group consisted of 52 patients...

Aim. Tympanic perforations can lead to hearing loss which magnitude ranges from negligible to 50 dB. This variability has always been related to location and size of the perforation: the conductive hearing loss is greater as perforation size increases and if the posteroinferior quadrant is involved. However these considerations were suggested by cl...

Oltre agli ovvi effetti sull'organo dell'udito con rela-tiva ipoacusia, è noto che l'esposizione a rumore possa determinare effetti su numerosi altri apparati e sistemi. Benché tali effetti non siano sempre facilmente quantifi-cabili e i dati esistenti conducano talora a risultati ambi-gui, svariati studi condotti su cavie hanno dimostrato l'attiva...