Federica Maruccia

• Institute of Photonic Sciences

Significance A shortcoming of the routine clinical use of diffuse optics (DO) in the injured head has been that the results from commercial near-infrared spectroscopy-based devices are not reproducible, often give physiologically invalid values, and differ among systems. Besides the limitations due to the physics of continuous-wave light sources, o...

Background: Red blood cells transfusions (RBCT) are utilized to restore normal values of hemoglobin concentration and hematocrit percentage in anemic patients. As expected, RBCT often leads to local and global alteration of blood flow (BF) and blood/tissue oxygenation which could have local deleterious consequences. This complicates its use and its...

Hyperventilation (HV) can lower intracranial pressure to prevent secondary injuries in traumatic brain injury patients. Hybrid diffuse optics can detect misery perfusion, precursor of ischemia, to help guiding personalized therapy during HV. 22/27 measurement sessions (18 patients) showed MP risk.

Cerebral autoregulation (CAR) assessment in traumatic brain injury during hyperventilation can be multimodally assessed by hybrid diffuse optical device combined with physiological parameters. Results indicate a heterogeneous and complex response in CAR indices.

Alterations in microvascular cerebral blood flow, oxygenation and metabolism measured by diffuse optical spectroscopies, provide insights into intracranial pressure alterations.

A new hybrid convolutional and recurrent neural network model, trained on data acquired by fast diffuse correlation spectroscopy (DCS) from children and adults with different pathologies is proposed to estimate intracranial pressure from cerebral blood flow time-traces.

[This corrects the article DOI: 10.1117/1.NPh.9.4.045005.].

Hyperventilation (HV) therapy uses vasoconstriction to reduce intracranial pressure (ICP) by reducing cerebral blood volume. However, as HV also lowers cerebral blood flow (CBF), it may provoke misery perfusion (MP) where the decrease in CBF is coupled with increased oxygen extraction fraction (OEF). MP may rapidly lead to the exhaustion of brain e...

Significance: The optical measurement of cerebral oxygen metabolism was evaluated. Aim: Compare optically derived cerebral signals to the electroencephalographic bispectral index (BIS) sensors to monitor propofol-induced anesthesia during surgery. Approach: Relative cerebral metabolic rate of oxygen ( rCMRO 2 ) and blood flow (rCBF) were measu...

Significance: Benign external hydrocephalus (BEH) is considered a self-limiting pathology with a good prognosis. However, some children present a pathological intracranial pressure (ICP) characterized by quantitative and qualitative alterations (the so-called B-waves) that can lead to neurological sequelae. Aim: Our purpose was to evaluate wheth...

PurposeThe management of children with benign external hydrocephalus (BEH) remains controversial. Most BEH children do well in the long-term, but a substantial number have temporary or permanent psychomotor delays. The study aims to assess the prevalence and pattern of neurodevelopmental delay in a cohort of children with BEH.Methods We conducted a...

Background The cortical microvascular cerebral blood flow response (CBF) to different changes in head-of-bed (HOB) position has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS) technique. However, the relationship between these relative ΔCBF changes and associated systemic blood pressure changes has...

Intracranial pressure (ICP) is an important parameter to monitor in several neuropathologies. However, because current clinically accepted methods are invasive, its monitoring is limited to patients in critical conditions. On the other side, there are other less critical conditions where ICP monitoring could still be useful, thus there is a need to...

Intracranial pressure (ICP) is an important parameter to monitor in several neuropathologies. However, because current clinically accepted methods are invasive, its monitoring is limited to patients in critical conditions. On the other side, there are other less critical conditions where ICP monitoring could still be useful, thus there is a need to...

We present a proof-of-principle of a method for non-invasive estimation of intracranial pressure in infants and adults based on the pulsatile cerebral blood flow measured by diffuse correlation spectroscopy and employing a recurrent neural network.

Background and aims Previously, microvascular cerebral blood flow (CBF) response to a mild head-of-bed (HOB) elevation has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS). We have hypothesized that early CBF response is related to the functional outcome. Methods Patients with a non-lacunar AIS in t...

Diffuse correlation spectroscopy monitoring revealed periodic fluctuations in the microvascular cerebral blood flow of acute ischemic stroke patients. A follow-up study revealed that the origin of such fluctuations was due to undiagnosed apneas.

Cerebral blood flow and hemoglobin concentration measured by diffuse correlation spectroscopy and time-resolved spectroscopy in patients with traumatic brain injury show different behaviour during hyperventilation therapy according to the functioning of the treatment.