
Fawzi M. MahomoodallyUniversity of Mauritius | UoM · Faculty of Medicine and Health Sciences; Department of Health Sciences
Fawzi M. Mahomoodally
PhD [Professor- (Extraordinary)]- Alumni: 1. Harvard Kennedy School Executive Education, 2. Young Affiliate to The World Academy of Sciences (TWAS); 3. Fellow of the African Science Leadership Programme; 4. Member of the Global Young Academy
Dean of Faculty of Medicine & Health Sciences, Ranked for 5th consecutive year in the world’s top 2% of Scientists List
About
571
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Introduction
Currently serving as Dean of Faculty of Medicine and Health Sciences, Fawzi is a Harvard University Alumni, Distinguished Visiting Professor for many international Universities, and ranked 104th Worldwide in the field of medicinal Biomolecular chemistry. Keen interest in Biopharmaceuticals/biomedical sciences, Fawzi is the author of >613 publications, >50 keynote/plenary speaker and coached >150 undergrad + 15 PhD/Postdocs. For collaboration mail: f.mahomoodally@uom.ac.mu
Additional affiliations
May 2009 - September 2023
Publications
Publications (571)
Objectives:
Five solvent extracts (n-hexane, ethyl acetate, ethanol, ethanol/water (70%), and water) of Gladiolus italicus Mill. from Turkey were evaluated for chemical and biological properties.
Methods:
Antioxidant activities, inhibitory properties against key enzymes involved in the etiology of chronic diseases were tested, as well as cytotox...
Halophytic plants possess a huge range of active constituents and medicinal benefits. In this study, extracts (water, ethanol, ethyl acetate, dichloromethane, and n-hexane) of two halophytes of the genus Petrosimonia (P. brachiata and P. nigdeensis) were investigated for their phytochemical profiles and pharmacological properties. The phytochemical...
Gout, or hyperuricemia is a multifactorial and multi‐faceted metabolic disease that is quite difficult to manage and/or treat. Conventional therapies such as non‐steroidal anti‐inflammatory drugs (NSAIDs) such as allopurinol, corticosteroids and colchicine amongst others, have helped in its management and treatment to some extent. This study aimed...
In the present study, we aimed to investigate the chemical profiles and biological activities of different extracts (ethyl acetate, dichloromethane, ethanol, and water) of Pelargonium endlicherianum parts (aerial parts and roots). Free radical scavenging, reducing power, phosphomolybdenum, and metal chelating were assayed for antioxidant properties...
BACKGROUND
Parkia biglobosa stem bark extracts were prepared using methanol, methanol 80%, water and ethyl acetate to investigate their phytochemical contents, as well as antioxidant and enzyme inhibitory properties.
RESULTS
Liquid chromatography (LC) quadrupole time‐of‐flight mass spectrometry (MS) and LC‐MSⁿ revealed the presence of flavonoids,...
The genus Stachys L., one of the largest genera of the Lamiaceae family, is highly represented in Turkey. This study was conducted to determine the bio-pharmaceutical potential and phenolic contents of six different extracts from aerial parts of Stachys tundjeliensis. The obtained results showed that the ethanol extract exhibited the highest antiox...
Antibiotics are recognized widely for their benefits when used appropriately. However, they are often used inap-propriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment
is an essential component of universal healthcare, and it is a global responsibility to ensure appropriate use. Currently...
Obesity as a global public health burden has experienced a drastic growing trend recently. The management of obesity is challenging because of its complex etiology, and various factors are involved in its development, such as genetic and environmental factors. Different approaches are available to treat and/or manage obesity, including diet, physic...
Glaucosciadium cordifolium (Apiaceae) is traditionally used against stomach ailments, as aphrodisiac and appetizer. This study endeavored to characterize several extracts of G. cordifolium aerial parts (prepared by various isolation procedures (ASE: Accelerated solvent extraction; HAE: homogenizer-assisted extract; MAE: Microwave-assisted extractio...
Apigenin (4,’5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and abundantly present phenolic compound in the plant kingdom. The main sources of apigenin are fruits, vegetables, nuts, herbs, honey, and plant-based drinks like tea. Numerous plants produce apigenin as a secondary metabolite and its intake is strongly rel...
In this study, the total phenolic and flavonoid contents, HPLC‐DAD detected phytochemicals, antioxidant and enzyme inhibitory potential of methanolic and aqueous (as infusion) extracts of the medicinal plant, Anthocleista djalonensis (leaf and stem bark) collected from two locations, Mafiblé and Prikro, in Ivory Coast, were investigated. The ranges...
Six extracts (water, ethanol, ethanol-water, ethyl acetate, dichloromethane, and n-hexane) of Astragalus caraganae were studied for their biological activities and bioactive contents. Based on high-performance liquid chromatography-mass spectrometry (HPLC-MS), the ethanol-water extract yielded the highest total bioactive content (4242.90 µg g-1 ),...
Asiatic acid (AA) is a natural aglycone of pentacyclic triterpenoids and is abundantly present in many edible and medicinal plants, including Centella Asiatica, which is a reputed herb for wound healing and neuropsychiatric disorders in many traditional medicine formulations. Asiatic acid has various pharmacological functions such as antioxidant an...
Asiatic acid (AA) is a natural aglycone of pentacyclic triterpenoids and is abundantly present in many edible and medicinal plants, including Centella Asiatica, which is a reputed herb for wound healing and neuropsychiatric disorders in many traditional medicine formulations. Asiatic acid has various pharmacological functions such as antioxidant an...
Food packaging material is the primary element of the food industry; therefore, its consideration to sustain food quality and food safety is crucial. Several food-grade materials have been utilized for packaging food commodities for a long time. Still, these materials negatively influence safety, shelf life, texture, quality, and flavors of the foo...
Background
Zingiber officinale Roscoe (Ginger) belongs to the Zingiberaceae family, which is renowned for its rich nutritional and phytochemical composition, and has been validated for its anti-diabetic and anti-inflammatory properties via in vitro, in vivo, and clinical studies. Nonetheless, a comprehensive review of these pharmacological studies,...
Appraised for being one of the oldest staple nutritive foods mainly in the Arabian Peninsula, the date palm tree (Phoenix dactylifera L.), is a crop native to the subtropical and tropical regions of Southern Asia and Africa. Different parts of the date tree have been extensively studied for their nutritional and therapeutic properties. Despite an a...
Arum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain, arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study investigated the antioxidant properties, individual phenolic compounds, total phenolic and total flavonoid contents (HPLC-MS analysis), reducing power and metal chelating effects...
Nature has given us yet another wild card in the form of Zika virus (ZIKV). It was found in 1947, but has only recently become an important public health risk, predominantly to pregnant women and their unborn offspring. Currently, no specific therapeutic agent exists for ZIKV and treatment is mainly supportive. Natural products (NPs) can serve as a...
Paliurus spina-christi Mill., a member of the Rhamnaceae family, is a traditionally used medicinal plant in the management of a panoply of human ailments. The current research focused on its phytochemical profile and biological properties evaluated by its antioxidant and enzyme inhibitory properties. The methanol extract was found to be the most ef...
Ravenala madagascariensis is a widely known ornamental and medicinal plant, but with a dearth of scientific investigations regarding its phytochemical and pharmacological properties. Hence, these properties were appraised in this study. The DPPH (154.08 ± 2.43 mgTE/g), FRAP (249.40 ± 3.01 mgTE/g), CUPRAC (384.57 ± 1.99 mgTE/g), metal chelating (29....
The recent appearance of Zika virus (ZIKV) in Brazil should serve as a wake-up call to international authorities, as it poses a threat to global public health. In the present study, we investigated whether a mangrove plant, Rhizophora mucronata Lam. (R. mucronata) collected in Mauritius, possesses anti-ZIKV activity at the non-cytotoxic doses. ZIKV...
This study documents for the first time the phytochemical composition and biological activities of Tambourissa peltata Baker, an endemic plant from Mauritius. Phytochemical extraction was performed using ethyl acetate, methanol and distilled water as solvents. The phytochemical composition was determined through HPLC-MS and other standard assays. T...
Sepsis is a severe inflammatory response to systemic infection and is a threatening cause of death in intensive care units. In recent years, a number of studies have been conducted on the protective effect of natural products against sepsis-induced organ injury. However, a comprehensive review of these studies indicating the mechanisms of action of...
In this study, the methanolic and infusion extracts of two species, Thymbra capitata and Thymus sipyleus subsp. Rosulans, were tested for their chemical composition and biological abilities (antioxidant, enzyme inhibitory and anti-inflammatory effects). The extracts yielded total phenolic and flavonoid contents in the range of 83.43–127.52 mg GAE/g...
Nepeta leucolaena grows worldwide and is being used in folk medicine system without any scientific evidence. The present study was carried out to unveil the metabolic picture, biological potential and to valid the medicinal uses of N. leucolaena. The flowers and leaves of this plant were separately extracted with n-hexane, chloroform, ethyl, acetat...
In this study, 10 essential oils (EOs), from nine plants (Cinnamomum camphora, Curcuma longa, Citrus aurantium, Morinda citrifolia, Petroselinum crispum, Plectranthus amboinicus, Pittosporum senacia, Syzygium coriaceum, and Syzygium samarangense) were assessed for their antimicrobial, antiaging and antiproliferative properties. While only S. coriac...
The genus Paeonia has gained great interest from the scientific community for exploration as a source of bioactive compounds. The current work focused on the chemical characterisation and biological properties of Paeonia mascula L. from Turkey. The chemical characterisation of the extracts was analysed by LC-DAD-ESI and LC-APCI-MS. The antioxidant,...
The current research was conducted to investigate and compare the role of functional foods such as probiotics and prebiotics alone or in combinations on the markers of liver damage, oxidative stress markers and inflammatory markers in the nonalcoholic fatty liver disease (NAFLD) induced rats. According to the results, G3, G4 and G6 gained significa...
Buxus papillosa C.K. Schneid, (common name: Shamshad) is one of the most common plants of the family Buxaceae, having various folklore uses to treat common ailments. Despite the prospective health benefits, this plant still it is not yet well-recognized in the modern medicinal system. The present review article is directed to furnish a systematic o...
In the quest for novel therapeutic agents from plants, the choice of extraction solvent and technique plays a key role. In this study, the possible differences in the phytochemical profile and bioactivity (antioxidant and enzyme inhibitory activity) of the Alstonia boonei leaves and stem bark extracted using water, ethyl acetate and methanol, and d...
Despite existing conventional hypoglycemic drugs to manage diabetes, their non-availability and cost in low-income countries coupled with the associated side effects remain a major concern. Consequently, exploring for alternative treatments to manage diabetes has been a continuous priority. Nigella sativa L. (NS) (Family: Ranunculaceae) is regarded...
Lumnitzera racemosa is a shrub widely distributed in Madagascar, Australia, Papua New Guinea, Indonesia, Malaysia, the Philippines, Thailand, and India. It is traditionally used to treat snake bites, rheumatism, skin allergies, blood purifier, asthma, and diabetes. It possesses antioxidant, cytotoxicity, and anticoagulant properties. Alkaloids, phe...
Bruguiera parviflora is mostly distributed in Malaysia, Indonesia, and Papua New Guinea. Traditionally used to treat constipation in India. It is a poorly explored mangrove plant in terms of pharmacological properties, phytochemical profiling and fungal endophytes.
Ceriops tagal is a 25 m tall plant largely distributed in North Australia, Indonesia, Malaysia, Madagascar, and East Africa. Traditionally used to treat sores, haemorrhages and malignant ulcers and malaria in China. It possessed antitumor and antioxidant activities. This mangrove species is host to the fungal endophyes Cytospora sp., Penicillium sp...
Heritiera fomes is a 15- to 25-m tall plant scarcely distributed across the globe and traditionally used to treat cardiovascular diseases, gastrointestinal disorders, and skin diseases. Alkaloids, cardiac glycosides, tannins, steroids, saponins, gums, carbohydrates, proteins, amino acids, terpenoids, anthraquinone glycoside, and proanthocyanidins w...
Rhizophora apiculata is a 30 m tall plant distributed in Papua New Guinea, Indonesia, Malaysia, and India. Traditionally used to treat colitis, inflammatory and bowel disease. Aliphatic alcohols, hydrolysable tannins, steroids, triterpenoids, phenolic compounds were identified in this mangrove species. It possesses antioxidant, antimicrobial and an...
Convolvulus arvensis L. is an evergreen herb growing in various regions of Pakistan. Despite of several medicinal properties associated to this herb, it was not investigated scientifically for its bioactive compounds and detailed pharmaceutical properties. Therefore, its methanolic extract was divided into hexane (CA‐H), chloroform (CA‐C), ethyl ac...
Pelliciera rhizophorae is a 20 m tall plant scarcely distributed across the globe. It is a poorly explored mangrove in terms of its pharmacological properties, phytochemical profile and fungal endophytes.
Mangroves are inhabited by an astronomical number of fungal communities responsible to produce a diverse array of extracellular degradative enzymes, namely, cellulase, xylanase, pectinase, cholesterol oxidase. Such enzymes can be isolated from the mangrove fungi and harnessed for different biotechnological applications, namely, as chemical catalyst...
Rhizophora racemosa is 30 m tall plant distributed along the West coast of Africa, Brazil, and Central America. In Nigeria, it is traditionally used to alleviate toothache and dysmenorrhea. It is poorly explored in terms of its pharmacological properties, phytochemical profiling and fungal endophytes.
Rhizophora mucronata is a 20–25 m tall plant widely distributed across the globe and is present in various countries, namely, North America, East Africa, Madagascar, Mauritius, India, Malaysia, Indonesia, Papua New Guinea, Solomons Island. Traditionally used to treat many diseases including amoebiasis, diarrhoea, nausea, and vomiting. It possesses...
Aegialitis rotundifolia is a 2-3 m tall plant mainly found in Bangladesh. Traditionally used as a pain reliever, anti-inflammatory and anti-ache agent. There is a dearth of knowledge on its pharmacological properties, phytochemical profile and fungal endophytes.
Obesity and osteoporosis are two important problems affecting global health with a high impact on both mortality and morbidity. There are complex interactions between metabolic factors and regulatory pathways influencing both obesity and osteoporosis. The long -term prevention of skeletal damage hinges on obesity prevention.
The riches of mangroves have attracted people on every continent over the course of thousands of years. Mangroves have been exploited in many countries, including Vietnam, Malaysia, East Africa, Madagascar, for their wood to produce charcoal, poles, wood vinegar, to construct houses and boats, to make handicrafts, amongst others. Despite mangrove e...
Aegiceras corniculatum is a 6-m tall plant found in Bangladesh, India, Indonesia, South Thailand, and in many regions in Australia and traditionally used to treat rheumatism, painful arthritis, and inflammation. It possessed antinociceptive, antibacterial, and antioxidant activities. Phytochemicals such as amino acids, benzoquinones, tannins, couma...
The relationship between endophytes and their host plants has fascinated researchers especially for their ability to produce structurally unique phytocompounds of significant biopharmaceutical and biomedical importance. It was found that mangrove endophytic fungi are capable to produce an impressive panoply of metabolites with promising biological...
Nypa fruticans, commonly known as mangrove palm, is found in Northern Australia, Papua New Guinea, Indonesia, Malaysia, and the Philippines. Traditionally used to treat snake bites and diabetes. It possesses antimicrobial and antioxidant activities. Compounds from different phytochemical classes alkaloids, cardiac glycosides, anthranoids, polypheno...
Avicennia officinalis is a 30-m tall plant scarcely distributed across the globe. It is traditionally used to treat snakebites, dyspepsia, and smallpox. It possesses antimicrobial, antiulcer, antioxidant, antiinflammatory, and neuropharmacological properties. Host to fungal endophytes originate from different genera including Aspergillus, Penicilli...
Avicennia marina is a 14-m tall plant distributed in Australia, Indonesia, India, and Madagascar, along the coastlines of Saudi Arabia and southeast of Africa and scarcely distributed in north of America and traditionally used to treat small pox, skin diseases, ulcers, and throat pains. Biomolecules from different phytochemical classes, namely, alk...
Avicennia germinans is a 30-50 m high plant widely distributed along the coastlines of United States, Mexico, Central America, Colombia, Venezuela, Guyana, Cayenne, Brazil, and Ecuador. Traditionally used to treat malaria, haemorrhoids, rheumatism, swellings, throat pains, and haemorrhage. This mangrove species is poorly explored in terms of its ph...
Acanthus ilicifolius is a a small tree of height up to 2 m distributed in Bangladesh, India, Australia, Indonesia and South Thailand. Traditionally used to treat rheumatism, relief for asthma, diabetes, diuretic, dyspepsia, leprosy, hepatitis, blood purifier, cure for cold, gangrenous wounds, skin allergies, snake bites, pain reliever, or as an aph...
Sonneratia apetala is a 15-20 m tall plant scarcely distributed across the globe. Traditionally used to treat gastrointestinal disorders, intestinal parasites, cough, dysentery, sprain, bruises, cataract, and sores in the ear. Its fruit contains polyphenols, flavonoids, anthocyanins, ascorbic acid (vitamin C), alkaloids, reducing sugar, tannins, st...
Bruguiera gymnorhiza is a 15-m tall plant widely distributed in Malaysia, Indonesia, Thailand, East Australia, Papua New Guinea, and Madagascar And traditionally used to treat diabetes, fever, eye disease, malaria, shingles, and diarrhea. Phytochemicals present in the leaves, stems, flowers, roots, and fruits include flavonoids, saponins, reducing...
Bruguiera cylindrica is a 20-m tall plant scarcely distributed and traditionally used to treat hemorrhages and ulcers. It is a poorly explored mangrove species in terms of pharmacological properties, phytochemical profile, and fungal endophytes.
Kandelia candel is a 10-m tall plant scarcely distributed across the globe and traditionally used to treat cardiovascular diseases, cancer, and neurodegenerative disorders. It is poorly explored in terms of pharmacological properties and phytochemical profile and hosts fungal endophytes Sporothrix sp., Pestalotiopsis sp., Botryosphaeria sp., Phomop...
Mangroves are ecologically important plants in marine habitats that occupy the coastlines of many countries. In addition to their key ecological importance, various parts of mangroves are widely used in folklore medicine and claimed to effectively manage a pile of diseases. Out of 84 mangrove species, only 27 species were found to be traditionally...
Xylocarpus granatum is a 3-8 m tall plant distributed in Papua New Guinea, Indonesia, Malaysia, Vietnam, Thailand, Madagascar, and East Africa. Traditionally used to treat many diseases including cholera, diarrhea, fever, and malaria. It possesses antioxidant, anticancer, antidiarrheal, and antimicrobial activities. Host to fungal endophytes Tricho...
Ceriops decandra is scarcely distributed across the globe. Traditionally used to treat hepatitis, ulcers, viral infections, gastrointestinal disorders, liver disorders, diarrhoea and amoebiasis. This mangrove species possessed antioxidant, anti-inflammatory and antidiabetic activities. Different parts of the plant are rich with various phytoconstit...
Rhizophora mangle is a 24 m tall plant mostly distributed in Brazil, Colombia, Mexico, Central America, United States, and West Africa. Traditionally used to treat diabetes, sores and swellings. It possesses antioxidant and anti-ulcer activities. Tannins, triterpenes, flavonoids, glycosides, quercetin, myricetin, and kaempferol diglycosides were fo...
Mangroves with Therapeutic Potential for Human Health: Global Distribution, Ethnopharmacology, Phytochemistry, and Biopharmaceutical Applications explores, for the first time in a book, the exciting potential of mangroves for therapeutic applications in medicine and pharmacology. This authoritative, illustrated and clearly written book pairs the fa...
Artemisia verlotiorum Lamotte is recognized medicinally given its long-standing ethnopharmacological uses in different parts of the world. Nonetheless, the pharmacological properties of the leaves of the plant have been poorly studied by the scientific community. Hence, this study aimed to decipher the phytochemicals; quantify through HPLC-ESI-MS a...
In the present study, the extracts of Cytinus hypocistis (L.) L using both traditional solvents (hexane, ethyl acetate, dichloromethane, ethanol, ethanol/water, and water) and natural deep eutectic solvents (NADESs) were investigated in terms of their total polyphenolic contents and antioxidant and enzyme-inhibitive properties. The extracts were fo...
The aim of the present study was to identify/quantify bioactive compounds and determine the antioxidant activity and enzyme inhibitory effects of various solvent extracts (n-hexane, ethyl acetate, methanol, and water) of Prangos heyniae H. Duman and M.F. Watson, Prangos meliocarpoides var. meliocarpoides, and Prangos uechtritzii Boiss. and Hausskn....
Flueggea virosa (Roxb. ex Willd.) Royle is a plant with several traditional uses in tropical countries. To study the potential usefulness, extracts from stem barks and leaves of F. virosa were obtained with different solvents. The phytochemical composition was assessed using LC-MS and NMR. Triterpenes, as oleanolic (0.05–88.09 mg/g extract), and ur...
The bioactive content, antioxidant properties, and enzyme inhibition properties of extracts of Alcea fasciculiflora from Turkey prepared with different solvents (water, methanol, ethyl acetate) and extraction methods (maceration, soxhlet, homogenizer assisted extraction, and ultrasound assisted extraction) were examined in this study. UHPLC-HRMS an...
The biological activity of the aerial part and rhizomes of Primula auriculata were assessed for the first time. The biological activities (antioxidant properties, enzyme inhibition, and AGE inhibition) as well as the phenolic and flavonoid contents of the ethyl acetate, ethanol, hydro-ethanol and water extracts of P. auriculata aerial parts and rhi...
Berry-derived polyphenols are bioactive compounds synthesized and secreted by several berry fruits. These polyphenols feature a diversity of chemical compounds, including phenolic acids and flavonoids. Here, we report the beneficial health effects of berry-derived polyphenols and their therapeutical application on gut-microbiota-related diseases, i...
Withania somnifera (L.) Dunal has been identified as a miracle herb, thus the present study was carried out to investigate W. somnifera growing in Cholistan Desert for its secondary metabolic profile and various biological activities. The WS-C fraction of methanolic extract (WS-M) of W. somnifera was found rich in phenolics (39.96±0.90 mg GAE/g ext...
In this study, six extracts of Arabis carduchorum prepared from solvents of varying polarity (water, methanol, ethyl acetate, dichloromethane, and n-hexane) were investigated for their chemical profiles and total phenolic and flavonoid contents (TPC/TFC) using HPLC–MS/MS and spectrophotometric/colorimetric assays, respectively, along with the asses...
In this study, six extracts of Arabis carduchorum prepared from solvents of varying polarity (water, methanol, ethyl acetate, dichloromethane, and n‐hexane) were investigated for their chemical
profiles and total phenolic and flavonoid contents (TPC/TFC) using HPLC–MS/MS and spectrophotometric/colorimetric assays, respectively, along with the asses...
Piliostigma thonningii (Fabaceae) is a versatile medicinal plant used as a traditional remedy, especially in African countries. In the present study, ethyl acetate, methanolic and water extracts of different parts of (fruits, leaves, stem barks) P. thonningii were evaluated for their bioactive contents, enzyme inhibitory, antioxidant and antimicrob...
Alteration of insect growth regulators by the action of inhibitors is becoming an attractive strategy to combat disease-transmitting insects. In the present study, we investigated the larvicidal effect of 1,2,3-triazolyl-pyrimidinone derivatives against the larvae of the mosquito Anopheles arabiensis, a vector of malaria. All compounds demonstrated...
Dioscorea hispida Dennst. locally known as “ubi gadung” has been used as a traditional remedy and source of carbohydrate among Malaysians. To assess the effect of Dioscorea hispida aqueous extract (DHAE) on the production of reactive oxygen species (ROS) and their effects on DNA damage in Sprague Dawley rat’s placental tissues, pregnant rats were r...