
Fatouma Mohamed Abdoul-latifCentre d'Étude et de Recherche de Djibouti | CERD · Institut de Recherches Médicinales
Fatouma Mohamed Abdoul-latif
Docteur en Biotechnologie Microbienne et Cellulaire
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143
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Publications (143)
Abstract: This study investigates the innovative use of natural porous clays from the Bejaad Region in Morocco as a support matrix for the encapsulation and controlled release of lemon essential oil (Citrus limonum, EOCL), a natural compound with well-documented insecticidal properties. The research aims to address the inherent challenges of essent...
Le cancer demeure une des principales causes de mortalité mondiale, notamment dans les pays en développement comme Djibouti, où les infrastructures médicales restent limitées et les traitements conventionnels souvent inaccessibles. Dans ce contexte, les substances naturelles issues des écosystèmes terrestres et marins émergent comme des solutions p...
This study provided a thorough evaluation of a Spirulina platensis extract-infused cream, assessing its physical properties, stability, microbial safety, spreadability, irritancy, moisture retention, and bioactive potential. The cream exhibited highly desirable attributes, making it a promising candidate for cosmetics, meeting industry standards. I...
Nanoinsecticides represent a cutting-edge advancement in agricultural pest management, offering targeted, efficient, and environmentally friendly alternatives to traditional chemical pesticides. These nanotechnology-based formulations enhance the bioavailability and stability of active ingredients, resulting in improved pest control with reduced ap...
Les algues présentent une complexité et un immense potentiel à travers une exploration approfondie de leurs caractéristiques, de leurs applications et de leur impact sur divers secteurs. Ce livre met en lumière leur rôle crucial dans les écosystèmes marins, ainsi que leur capacité à offrir des solutions innovantes aux défis environnementaux et écon...
This comprehensive review explores in depth the various aspects of hospital hygiene in Africa, focusing particularly on nosocomial infections, hospital environment, hand hygiene, and aseptic procedures. The fundamental objective of this study is to provide strategic support to the committee for the fight against nosocomial infections by developing...
Boscia coriacea Graells (BC), Grewia erythraea (Schweinf.) Chiov. (GE), Ochradenus baccatus Delile(OB), and Orthosiphon pallidus Royle ex Benth. (OP) are medicinal plants used in Djibouti. They were evaluated to determine their total phenolic content (TPC), flavonoid content (TFC), and phytochemical profile using HPLC-MS/MS. Additionally, their ant...
Les huiles essentielles ont été reconnues comme une source naturelle importante de pesticides. Ils représentent un marché mondial énorme. Plusieurs espèces des plantes sont capables d'élaborer les composés constitutifs des huiles essentielles. Elles sont réparties en un nombre limité de familles avec une gamme limitée d'activités biologiques pour d...
This study provides an in-depth analysis of mpox, encompassing its history, characteristics, epidemiology, diagnostics, treatment options, and the ongoing evolution of the virus and its transmission dynamics. Mpox, though once successfully eradicated, has re-emerged with new modes of transmission and a broader host range. Genomic analyses have reve...
Crop wild relatives (CWR) encompass wild plant species or subspecies closely related to domesticated crops. This study presents the first comprehensive checklist and prioritized inventory of CWR for Sudan and South Sudan. Building on the regional CWR list for Northeast Africa, we identified 499 CWR taxa belonging to 44 families, with 90% of these b...
This study investigates the innovative use of natural porous clays from the Bejaad region in Morocco as a support matrix for the encapsulation and controlled release of lemon essential oil (Citrus limonum, EOCL), a natural compound with well-documented insecticidal properties. The research aims to address the inherent challenges of essential oils,...
This research explored the use of activated carbon derived from chickpea waste infected with anthracnose for the adsorption-based decontamination of methylene blue. The research process was structured around several key steps: the synthesis and characterization of activated carbon, the optimization of adsorption parameters, and the evaluation of ad...
Two new fusarochromanone derivatives, deacetylfusarochromene (1) and deacetamidofusa-rochrom-2 ′ ,3-diene (2), along with the previously reported metabolites fusarochromanone TDP-2 (3), fusarochromene (4), 2,2-dimethyl-5-amino-6-(2 ′ E-ene-4 ′-hydroxylbutyryl)-4-chromone (5), fusarochromanone (6), (−)-chrysogine (7), and equisetin (8), were isolate...
Tisochrysis lutea is a marine microalga of the Haptophyta family, widely exploited in aquaculture due to its diverse chemical composition and potential in bioactive compounds, including its antioxidant activity. In this study, the antioxidant potential of T. lutea culture enriched with different urea-based nanonutrients (urea, methylurea, tetrameth...
L'objectif principal de cet ouvrage est de fournir une base solide pour la compréhension des notions fondamentales en biostatistiques. La maîtrise de ces concepts est essentielle dans des secteurs variés tels que les laboratoires de bioanalyses et de contrôle qualité, la technologie alimentaire, la biotechnologie végétale, le génie de l'environneme...
Le khat (Catha edulis Forsk) est une plante originaire de la péninsule Arabique et de l'Afrique de l'Est, profondément enracinée dans les traditions sociales et culturelles de ces régions. Sa mastication est une pratique courante au Yémen et à Djibouti, perçue comme un moyen de préserver les traditions alimentaires et de s’adapter aux environnement...
Fucoxanthin, a carotenoid with remarkable antioxidant properties, has considerable potential for high-value biotechnological applications in the pharmaceutical, nutraceutical, and cos-meceutical fields. However, conventional extraction methods of this molecule from microalgae are limited in terms of cost-effectiveness. This study focused on optimiz...
Fucoxanthin, a carotenoid widely studied in marine microalgae, is at the heart of scientific research because of its promising bioactive properties for human health. Its unique chemical structure and specific biosynthesis, characterized by complex enzymatic conversion in marine organisms, have been examined in depth in this review. The antioxidant,...
This study examined the effects of khat chewing on oral gingival conditions by adopting a
targeted process which combined physicochemical analyses of the teeth, histopathological examinations of the gums, and bioinformatics modeling. The physicochemical evaluation of teeth in khat
consumers compared to non-consumers was carried out using specific a...
Malaria, according to data from the World Health Organization (WHO), generated 249 million cases and 608,000 deaths worldwide in 2023. Djibouti, like many other African countries, is impacted by this disease, in particular by Plasmodium falciparum, responsible for around 80% of cases, followed by Plasmodium vivax. Hematological and biochemical alte...
This study investigated the anti-leishmanial properties of silver oxide nanoparticles synthesized using environmentally friendly methods from extracts of Ericaria amentacea seaweed. The extracts were obtained via soxhlet extraction using hexane, ether, chloroform, and methanolic solvents. Physicochemical analyses, including UV spectrophotometry, tr...
Aloe djiboutiensis is a native plant in Djibouti, named botanically in 2007. The leaves and the latex are used traditionally used in Djibouti.
Th e present research work was conducted to assess the possible toxic effect and antioxidant the latex and the leave extract, as well as to
detect rapidly the previously characterized known molecules in the...
This study explores the use of olive pomace from olive mill factories as an adsorbent to remove total phenols from olive mill effluent (OME). This approach aims to reduce the environmental impact of OME and offer a sustainable, cost-effective wastewater treatment solution for the olive oil industry. The olive pomace undergoes pretreatment steps inc...
In Morocco, aromatic and medicinal plants (PAM) represent an important category of non-wood forest products. These products encompass a wide range of products that exist spontaneously, in forests and outside forests, or as crops. After having been considered for a long time as secondary products or small products, RTEs have grown considerably in vi...
This study aims to assess the chemical makeup of essential oils extracted from Catha edulis Forsk plants found in the Day forest of the Republic of Djibouti. Additionally, it seeks to evaluate their effects in vivo through toxicity, biochemical, and hematological assessments. Furthermore, an in vitro study will be conducted to gauge the antibacteri...
This study focuses on assessing the insecticidal properties of γ-Al2O3 nanoparticles derived from Mentha pulegium remnants, including essential oil, ethanol extract, and plant waste. The nanoparticles were synthesized using a direct sol-gel method and their crystal structure was confirmed through extensive physicochemical analyses such as UV-Vis, X...
Leishmaniasis in Africa, which has been designated as a priority neglected tropical disease by various global organizations, exerts its impact on millions of individuals, primarily concentrated within this particular region of the world. As a result of the progressively grave epidemiological data, numerous governmental sectors and civil organizatio...
Cancer stands as one of the foremost causes of mortality globally, impacting millions annually. Thankfully, recent decades have seen significant strides in cancer therapy. Researchers have unearthed numerous natural compounds, some derived from plants, exhibiting promising anti-tumor properties. Among these, essential oils (EOs) and their component...
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic viral disease affecting domestic and wild animals as well as humans, primarily in Africa and the Arabian Peninsula, with a proven ability to emerge in new geographic areas. Despite its importance, the mechanisms for maintaining RVFV between epidemics remain unclear. This review highlights...
This study aims to formulate calcium amendments from the shells of Amiantis umbonella and to evaluate their effectiveness in the cultivation of Vicia faba L. The physicochemical properties of these amendments were analyzed using advanced techniques such as scanning electron microscopy coupled with X-ray diffraction (SEM/EDX), X-ray diffraction (XRD...
The Verongida order comprises several sponge families, such as Aplysinellidae, Aplysinidae, Ianthellidae, and Pseudoceratinidae, reported for producing bromotyrosine-derived compounds.
First identified in 1913, bromotyrosine derivatives have since captivated interest notably for their antitumor and antimicrobial properties. To date, over 360 bromot...
This study concentrates on assessing the insecticidal attributes of the γ-Al2O3 nanoparticles derived from the remnants of Mentha pulegium, which include essential oil, ethanolic extract, and plant waste. The synthesis of the γ-Al2O3 nanoparticles was execute dusing a direct sol-gel procedure, affirming the crystal structure according to extensive p...
Ethnopharmacological relevance: Djibouti was a country where malaria has been endemic for centuries. The local population use the plants as repellents or first aid for uncomplicated malaria. Aim of the study: The aim was, for the first time, to collect and identify plants used by the local population to treat malaria and select the most interesting...
This study concentrates on assessing the insecticidal attributes of γ-Al2O3 nanoparticles derived from remnants of Mentha pulegium, which include essential oil, ethanolic extract, and plant waste. The synthesis of γ-Al2O3 nanoparticles was executed via a direct sol-gel procedure, affirming the crystal structure through extensive physicochemical ana...
The analysis of drugs is a priority in public health, particularly antibiotics which develop resistance due, among other things, to bad dosages or poor-quality of the active substance. In this study, we evaluated eight antibiotics available in health centers in Djibouti through qualitative and quantitative analysis. The tests were based on high-pur...
Abstract: Djibouti, a developing economy, grapples with significant socioeconomic obstacles and
the prevalence of infectious pathologies, including certain forms of neoplasms. These challenges
are exacerbated by limited access to affordable medical technologies for diagnosis, coupled with
a lack of preventive interventions, particularly in disadvan...
Abstract: In this study, anti-leishmanial activities were performed on silver oxide nanoparticles green synthesized from hexane, ethereal, chloroform, and methanolic extracts of the Ericaria amentacea seaweed. The extracts were obtained using a soxhlet extraction system, and the silver oxide nanoparticles were synthesized through a simple and envir...
Brevet d’invention
Récépissé de remise des pièces
Loi n° 17/97 relative à la protection de la propriété industrielle telle que modifiée et complétée par la loi 23-13
Brevet d’invention
Récépissé de remise des pièces
Loi n° 17/97 relative à la protection de la propriété industrielle telle que modifiée et completée par la loi 23-13
The analysis of drugs is a priority in public health, particularly antibiotics which develop resistance due, among other things, to bad dosages or poor quality of the active substance. In this study, we evaluated eight antibiotics available in health centers in Djibouti through qualitative and quantitative analysis. The tests were based on high-pur...
Crop wild relatives (CWR) are an important source of genetic diversity useful for crop improvement. This study was conducted to create both a checklist and a priority inventory of CWR in Northeast Africa. A partial CWR regional checklist was obtained by combining the floras of Djibouti, Ethiopia and Eritrea, Somalia, South Sudan, and Sudan for prio...
Livestock farming plays a pivotal role in Djibouti's meat and milk production, but it frequently faces the threat of diseases that significantly impact both food security and public health. Brucellosis, a formidable obstacle to livestock production and public well-being, is one such disease. While Djibouti has witnessed previous epidemiological stu...
Cancer is one of the leading causes of death worldwide, affecting millions of people each year. Fortunately, the last decades have been marked by considerable advances in the field of cancer therapy. Researchers have discovered many natural substances, some of which are isolated from plants that have promising anti-tumor activity. Among these, esse...
Bovine tuberculosis is a persistent animal disease primarily affecting cattle, but
also known to affect other mammalian species. As a significant zoonosis, it can
be transmitted to humans through inhalation of aerosols or consumption of
unpasteurized milk. The causative agent of bovine tuberculosis is Mycobacterium
bovis. Despite its status as a se...
This work investigates olive pomace from olive mill factories as an adsorbent for the removal of total phenols from olive mill effluent (OME). This pathway of valorization of olive pomace reduces the environmental impact of OME while providing a sustainable and cost-effective wastewater treatment approach for the olive oil industry. Olive pomace wa...
This work aimed to evaluate the chemical composition of essential oils from Catha edulis Forsk collected in the Day Forest of the Republic of Djibouti. Additionally, in vivo toxicity studies, biochemical profiling, and hematological tests were conducted to determine the biological activity of the investigated essential oils. Finally, in vitro tests...
Citation: Abdoul-Latif, F.M.; Ejjabraoui, M.; Ainane, A.; Hachi, T.; Mohamed, J.; Oumaskour, K.; Boujaber, N.; El Montassir, Z.; Ainane, T. Correlation of the Diffusion Parameters and the Biological Activities in the Formulation of Pinus halepensis Essential Oil in Phosphogypsum Material. Appl. Sci. 2023, 13, 5358. https://doi. Abstract: The use of...
The main objective of this research was to optimize the biochar production process using olive pomace waste through a comprehensive 3-factor design of experiments with a Full Factorial Design model. The study focused on examining the individual effects of three crucial factors: biomass size, reactor temperature, and pyrolysis reaction time on bioch...
The production of biogas from food waste is a good approach to the minimization of food waste and increase in the production of renewable energy. However, the use of food waste as a feedstock for biogas production currently poses a difficulty due to an ineffective hydrolysis process, which is a pretreatment procedure and the initial step of the bio...
The present study shows the opportunity of using biofilm in the hydrolysis step of food waste (FW) to increase biogas production. Therefore, screened biofilm-producing microorganisms were adopted to facilitate the biodegradation of organic compounds (OCs) and enhance the volume of biogas production. The biofilm-producing microorganisms were first i...
Sepsis could be a life-threatening crisis. Sepsis happens when a patient have an infection that have already triggers a chain reaction. Diseases that lead to sepsis most regularly begin within the lung, urinary tract, skin, or gastrointestinal tract. Therefore, it is crucial to establish an appropriate antibiotic choice and delivery method as the m...
Diarrhea may be present alone or be associated with other symptoms, such as nausea, vomiting, abdominal pain or weight loss. Diarrhea diseases represent a true public health that needs to be considered. On the other hand, Diarrhea was a very prevalent symptom of COVID-19 and other infections. This study objects to find different parasitic diarrhea....
Diabetes is a chronic (lifelong) condition that arises when the pancreas does not secrete adequate insulin or when the body does not utilize the produced insulin. Diabetes can cause serious health complications such as diabetic foot infections. This study aimed to investigate the problem of diabetic foot amputations and to evaluate the prevalence o...
Voluntary depigmentation is a common practice in Djibouti. This practice can cause dermatological complications including, erysipelas. The objective of this study was to evaluate erysipelas or superficial bacterial dermohypodermatitis in hospitals. This is a retrospective study conducted at the Polyvalent Medicine Service of the Peltier Hospital in...
Ziziphora hispanica L. and Mentha pulegium L. are aromatic shrubs known to produce essential oils demanded by food industries. This study reports on the insecticidal activity of these two oils harvested in Khenifra (Morocco) and of its major compound (Pulegone) against the main legume bruchids. Chromatographic analysis revealed the presence of 33 c...
The Covid-19 pandemic is a pandemic of an emerging infectious disease, the 2019 coronavirus disease Covid-19, caused by the SARS-CoV-2 coronavirus. The essential protective measures recommended by WHO (2020) to limit the spread of the Coronavirus (Covid-19) limited in the suppression of travel, quarantine and containment. In the first part of this...
Ruta chalepensis anticancer test data.
Ruta chalepensis L. (Rutaceae) is a tropical medicinal plant traditionally used in the Republic
of Djibouti to treat several diseases, including tumors. In this study, the anticancer activities of this
plant from Djibouti were investigated according to an in vitro evaluation method and statistical modeling.
The results obtained will make it possibl...
In the context of the search for alternatives to synthetic fungicides to limit their environmental impact, this study explores the potential of the essential oil of Juniperus communis L. The objective is to characterize this essential oil and to study its antioxidant activity. And antifungal. The essential oil was extracted from the aerial part of...
Background: Tiger nut milk and soymilk produce locally are usually contaminated with spoilage microorganisms and are not storage at ambient temperature. Objective: The present study aims to ensure the preservation of tiger nut milk and soymilk through the antimicrobial properties of the essential oil (EO) of Cymbopogon citratus under ambient temper...
Innovative adhesive formulations have been developed in the laboratory based on urea-formaldehyde resin by adding medicinal plants to an industrial adhesive formulation containing raw materials: urea-formaldehyde resin, urea, ammonium sulphate and starch. Specifically, Thymus species (Thymus bleicherianus, Thymus capitates, Thymus satureioides, Thy...
Abstract: Innovative adhesive formulations have been developed in the laboratory based on ureaformaldehyde resin by adding medicinal plants to an industrial adhesive formulation containing
raw materials: urea-formaldehyde resin, urea, ammonium sulphate and starch. Specifically, Thymus
species (Thymus bleicherianus, Thymus capitates, Thymus satureio...
Ocimum plants are of great interest to traditional medicine in the history of several civilizations, particularly in terms of chronic human diseases. Essential oils obtained from this genus have also been used as therapeutic agents. In this present work, two plants of the Ocimum species from Djibouti, Ocimum basilicum L. and Ocimum americanum L., w...
The aim of this research was to evaluate the essential oils of two medicinal plants from Djibouti: Cymbopogon schoenanthus (L.) Spreng. and Nepeta azurea R.Br. ex Benth. in cytotoxic activity against thirteen (13) cancer cell lines (A2780, A549, HCT116, HEK-293, JIMT-T1, K562, MIA-Paca2, MRC5, NCI-N87, PC3, RT4, U2OS and U87-MG) and antibacterial a...
Citation: Abdoul-Latif, F.M.; Elmi, A.; Merito, A.; Nour, M.; Risler, A.; Ainane, A.; Bignon, J.; Ainane, T.
Staphylococcus aureus is a major pathogen for humans who are causing infections of the skin, lungs and sepsis. These infections can be treated with appropriate antibiotics. Their selection is mainly based on culture and sensitivity. Moreover, the problem of antimicrobial resistance has grown around the world because of their irrational prescription...
La pandémie actuelle de Coronavirus Disease 2019 (COVID coronavirus SARS-CoV-2 affecte, de manière majeure, la vie quotidienne des individus dans le monde entier depuis le début de l'année 2020. préexistantes, telles que l'hypertension artérielle, les maladies cardiovasculaires, le diabète ou l'atteinte de la fonction rénale, sont associées à un dé...
Staphylococcus aureus est un pathogène majeur de l'homme causant des infections cutanées, pulmonaires et des septicémies. C appropriés. Leur sélection est principalement basée sur la culture et la sensibilité. Le problème de la résistance aux antimicrobiens s'est développé dans le monde entier à cause de leurs prescriptions irrationnelles. L'utilis...
Traditional beers are often assumed to be safe. This study investigated the conservation and quality of this beer using essential oils extracted from four plants. Twenty five samples of local beers were collected from traditional producers. The chemical composition of the essential oils from the barks of Boswellia sacra, the flowers of Jasminum sam...
This study presents a new diet proposal for type 2 diabetics based on vegetables and fruits of the Cucurbitaceae family such as: cucumber, pickle, zucchini, squash, squash, watermelon and melon. The composition of these foods has a low carbohydrate content, this value which is considered acceptable for type 2 diabetics, also the foods used have ver...
This study aims to examine the total phenol and flavonoid contents of the two seaweeds: Cystoseira spinosa and Cystoseira mauritanica from the Atlantic coast of Morocco, as well as to assess the antioxidant activities of their extracts. To perform this experiment, the antioxidant activities was evaluated in vitro spectrophotometrically using four d...
The balanced diet of type 2 diabetics remains an effective recommended solution for the treatment of the disease, but in the case of infection with COVID-19 can complicate the situation and give a new problem of nutritional balance between several carbohydrate compositions, from lipids, proteins, vitamins, oligoelements, ... in this theme, a model...
Rosemary is a medicinal plant, it is interesting to know its therapeutic virtues, in order to replace synthetic products with bioactive molecules which are based on plants. This work consists of evaluating the antibacterial activity of the essential oil of spontaneous Rosmarinus officinalis L. collected in the region of Khenifra (Morocco). After ex...
The Atlas cedar or Cedar Atlasis one of the dominant plants in Morocco, it is interesting to know its therapeutic virtues, in order to replace synthetic products with bioactive molecules which are based on plants. This work consists in evaluating the antibacterial activity of the essen tial oil of spontaneous Cedar Atlas collected in the region of...
This work around the chemical composition and the insecticidal activity of the essential oils of two species of Moroccan pine, Pinus halepensis Mill. and Pinus pinaster Sol., from the region of Khenifra (Morocco), extracted from the dried aerial parts. The chemical composition of the essential oils extracted by hydrodistillation were studied by gas...