Fatma Afifi

Fatma Afifi
University of Jordan | UJ · Department of Pharmaceutical Sciences

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147
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Publications (147)
Article
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Background From the earliest times, manna has been widely used as a tasty local sweet or folk medicine. The type of manna being investigated in the present study is called Gaz-alafi, a mixture of insect and Quercus brantii leaves secretions from oak forests in the north of Iraq and west of Iran.Methods Aqueous and ethanol extracts were prepared as...
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Traditional knowledge of medicinal plant use in Jordan is poorly described. During the last years, many phytochemists and botanists from Jordan have conducted qualitative and quantitative several studies, to gather information from the local people in the different rural regions where herbal medicine flourishes. To assess the effectiveness of the s...
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Aloysia citrodora (Verbenaceae) is traditionally used to treat various diseases, including bronchitis, insomnia, anxiety, digestive, and heart problems. In this study, this plant’s antioxidant and anti-proliferation effects were evaluated. In addition to volatiles extraction, different solvent extracts were prepared. The GC-MS, LC-MS analysis and t...
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Background Angiogenesis is the formation of new blood vessels from pre-existing ones. It occurs in both physiological and pathological conditions. Objectives We aimed to evaluate the antiangiogenic effect of Elaeagnus angustifolia L. water extract in vivo to determine any anti-proliferative effect of the extract on the A549 lung cancer cell line,...
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In Jordanian folkloric medicine, several medicinal plants–based recipes are used for skin lightening. Local recipes for skin lightening were collected and the tyrosinase inhibitory activity of the plants reported in these recipes, as a potential depigmentation mechanism was evaluated in vitro on both, mushroom and murine melanoma tyrosinase. The s...
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The purpose of the present study was to identify, by gas chromatography (GC) and GC-mass spectrometry (GC-MS), the components of the spontaneously emitted volatile organic compounds (VOCs), obtained by Solid-Phase-Micro-Extraction (SPME) and that of the hydrodistilled oil of the fresh flowers and leaves of Ononis natrix, as well as to compare them....
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The present study deals with the gas chromatography/mass spectrometry (GC/ MS) analysis of the aroma profile of different aerial organs obtained by solid-phase microextraction (SPME) and that of the hydro distilled essential oil of the fresh leaves and flowers of Salvia greggii A. Gray grown in Jordan. Oxygenated sesquiterpenes dominated the hydrod...
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This study aimed to determine the volatile oil composition of the fresh leaves of dill, celery, coriander, and fennel, grown in Jordan, and to evaluate the antimicrobial activity of the essential oils individually and in binary (50:50) and quaternary (25:25:25:25) mixtures. The volatile oils, obtained by hydrodistillation, were analysed by gas chro...
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According to complementary and alternative medicine which is based primarily on traditional or folkloric medicines of different world civilizations there is a constant growing interest on cosmetics and cosmeceuticals using botanical ingredients. Since ancient times, humans used distinctive natural ingredients as medicine or cosmetic products. Cosme...
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Objective Achillea fragrantissima L. (Asteraceae) is a traditionally used medicinal herb in the rural communities of Jordan. Methods The present study evaluated the efficacy of the ethanol extract of this species on angiogenesis in both, ex vivo using rat aortic ring assay and in vivo using rat excision wound model. Results In concentrations of 5...
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Although, Solanum elaeagnifolium Cav. is described as a problematic weed difficult to eradicate, it is used in the traditional medicine of different countries for the treatment of different ailments, such as tooth ache and constipation. Its occurrence in Jordan is widespread. In the present study, the aim was to identify the phytochemical compositi...
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The essential oil of the fresh leaves of Platycladus orientalis (L.), grown in four different biogeographic zones of Jordan,- (the Mediterranean, Irano-Turanian, Saharo-Arabian, and Sudanian penetration) -, were obtained by hydrodistillation and analysed by gas chromatography (GC) and gas chromatography-mass-spectrometry (GC/MS). The actual composi...
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The current investigation reports the chemical composition of volatile organic compounds emitted from the different aerial organs of two populations of Salvia dominica L. from Jordan collected from Mediterranean and Irano-Turanian bio-geographical zones. Oxygenated monoterpenes dominated the emission profiles of most organs from the two populations...
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Colorectal cancer (CRC) is the third most common malignancy diagnosed worldwide and its management is still challenging; necessitating discovery of alternative agents. Natural compounds have historically been used in the treatment of CRC. Pistacia genus has recently received particular interest for its antitumor activity. The present study aimed to...
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The present study aimed at investigating the variation in the chemical composition of emitted volatile organic compounds (VOCs) and essential oils obtained from fresh aerial parts of Inula viscosa (Asteraceae) as affected by growth stage and geographical location zone. VOCs were extracted by solid phase microextraction (SPME) method from whole aeri...
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The aroma emitted from the different organs of two Salvia verbenaca L. populations from Jordan were extracted by Solid Phase Micro-Extraction (SPME) and then analyzed by GC/MS. The emission profile of the stems, leaves and sepals samples from the Mediterranean zone (As-Salt) were dominated by monoterpene hydrocarbons (68.0%, 33.7%, and 42.2%., resp...
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The leaves and unripe and fully‐grown fruits of Schinus molle were collected from three geographical regions of Jordan:Amman (the Mediterranean), Madaba (Irano‐Turanean), and Sahab (Saharo‐Arabian).The hydro‐distilled volatile oils of fresh and driedleaves and fruits were analyzed by gas chromatography‐mass spectrometry (GC/MS).The actual compositi...
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The aim of this work was to determine the composition of the hydro-distilled essential oil of Schinus molle L. (Anacardiaceae) fruits, leaves and flowers grown in Ghor-Jordan (75 mm total precipitation per year) and Izmir-Turkey (725 mm total precipitation per year) by gas chromatography (GC) and gas chromatography-mass-spectrometry(GC/MS) and to r...
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The aim of this work was to determine the composition of the hydro-distilled essential oil of Schinus molle L. (Anacardiaceae) fruits, leaves and flowers grown in Ghor-Jordan (75 mm total precipitation per year) and Izmir-Turkey (725 mm total precipitation per year) by gas chromatography (GC) and gas chromatography-mass-spectrometry(GC/MS) and to r...
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Full-text available
The aim of this work was to determine the composition of the hydro-distilled essential oil of Schinus molle L. (Anacardiaceae) fruits, leaves and flowers grown in Ghor-Jordan (75 mm total precipitation per year) and Izmir-Turkey (725 mm total precipitation per year) by gas chromatography (GC) and gas chromatography-mass-spectrometry(GC/MS) and to r...
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The composition of hydro-distilled oils of Achillea fragrantissima inflorescence (fresh and dry) at the pre- and flowering stages was evaluated by Gas Chromatography/Mass Spectrometry (GC/MS). Additionally, the essential oil and solvent extracts of the dried inflorescence were assayed for their inhibitory effect against acetylcholinesterase (AChE)...
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Correction: After the publication [1] it came to the attention of the authors that one of the co-authors was incorrectly included as Hamza Somrain. The correct spelling is as follows: Hamzeh Sumrein.
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Inula graveolens (L.) Desf. and I. viscosa (L.) Aiton (Asteraceae) are traditional phytomedicine plants from Jordan. Materials and Methods: Both Inula species were evaluated for their antiproliferative activity against MCF7 and T47D breast cancer cell lines by the sulforhodamine B assay. Results: Unlike inactive I. viscosa but comparable to the mar...
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Objective: To assess the antiangiogenic activity of fenugreek. Methods: Different fractions of fenugreek crude extracts were prepared and their antiangiogenic properties were assessed using the ex vivo rat aortic ring assay and in vivo chicken embryo chorioallantoic membrane (CAM) assay. They were investigated for their direct cytotoxic activity in...
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Aqueous extract of Pistacia atlantica leaves is widely used in Jordanian traditional medicine for management of diabetes. The genus Pistaciae serves as obligate host for a group of specialized gall-forming aphids. The present study aimed to identify the aphid attacking P. atlantica trees growing wild in Jordan, to determine the composition of the e...
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This study was performed to determine the chemical composition, antioxidant and anticancer effects of essential oils extracted from the aerial parts of fresh (F-PSEO) and air-dried (D-PSEO) Pallenis spinosa. The composition of the oils was analyzed by GC and GC-MS, the antioxidant activity by free radical scavenging and metal chelating assays, and...
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Phytochemical investigation of the chemical constituents of the aerial parts of Scabiosa prolifera L. led to the isolation of one new flavonol glycoside, kaempferol-3-O-(4″,6″-di-E-p-coumaroyl)-β-D-galactopyranoside (1), along with ten other known compounds including luteolin-7-O-(2″-O-ethyl-β-glucopyranoside), β-sitosterol, β-sitosterylglucoside,...
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ABSTRACT Background: Arum hygrophilum is a traditional medicinal plant indigenous to Jordan. The present study explores its phytochemistry, antioxidative, antidiabesity and antiproliferative potentialities. Materials and Methods: Column chromatography and HPLC-MS analysis were used for its phytochemical evaluation. Using leaf crude water and ethano...
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In the current investigation, Volatile Organic Compounds (VOCs) spontaneously emitted from the different organs of Inula viscosa growing wild in Jordan were extracted by Solid Phase Micro Extraction (SPME) method and then analyzed using GC/MS technique. Oxygenated monoterpenes dominated roots emission (52.39 %) while sesquiterpene hydrocarbons were...
Article
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Echium judaeum Lac.(Boraginaceae) growing wild in Jordan has not been studied before phytochemically and pharmacologically. In this study the hydro-alcoholic extract was analyzed using Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS). Total phenols and flavonoids were determined colorimetrically. Using SRB assay, the anti-prolife...
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The volatiles emitted from the fresh and dry leaves, determined by solid-phase-micro-extraction (SPME), the essential oils obtained by hydro-distillation and supercritical-fluid-extraction (SFE) from the leaves of Origanum syriacum L. (Lamiaceae), grown in Jordan, were analyzed by GC-MS. In all applied methods, oils were rich in monoterpenes, while...
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Context: Adiantum capillus-veneris L. (Adiantaceae) hypocholesterolemic activity is therapeutically praised. Objectives: Pharmacological modulation of pancreatic triacylglycerol lipase (PL) and α-amylase/α-glucosidase by A. capillus-veneris are evaluated. Materials and methods: Recruiting positive controls (acarbose, orlistat, guar gum, atorvasta...
Article
Arum dioscoridis and A. palaestinum (Araceae) are indigenous plant species in Jordan. HPLC-MS analysis of A. dioscoridis revealed the presence of apigenin, luteolin, quercetin, quercetin-3-O-β-glucoside, vitexin, isoorientin, esculin, and caffeic and ferulic acids. Both Arum spp., influenced gastrointestinal carbohydrate and lipid digestion and abs...
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The aim of this work was to determine the composition of the hydro-distilled essential oil of Salvia judaica Boiss. and S. multicaulis Vahl. (Lamiaceae) from Jordan by GC and GC-MS and to report the actual composition of their fresh leaves and flowers using SPME (Solid Phase Micro-Extraction).Their dual alpha-amylase/alpha glucosidase and pancreati...
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Achillea santolina is used in Jordanian herbal traditional medicine for the treatment of diabetes, intestinal disorders, inflammations and for wound healing. Aims: The present study aimed at investigating the variation of the hydro-distilled oil composition extracted from fresh and air dried flowering parts of A. santolina collected at different gr...
Article
Context: National statistical reports in Jordan indicate a decrease in the total fertility rate along with a parallel increase in contraceptive use. The folkloric use of medicinal herbs in gynecological disorders has been growing in Jordan, despite of deficient reports on the evidence-based safety and efficacy of these practices. Objective: The a...
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We are thankful to all contributors of this special issue for their valuable research papers. We are grateful to the reviewers for their constructive criticisms and timely response that made this special issue possible. Our sincere thanks and gratitude go to the Editorial Board of this journal for inviting us to edit this special issue.
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Chemical investigation of Gynandriris sisyrinchium (L.) Parl growing in Jordan resulted in the isolation and characterization of a total of twelve compounds two of which are reported here for the first time in Nature. These new compounds included the isoflavones; 3'-methyl tenuifone (2) and gynandrinone (5). In addition, ten known compounds includi...
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Hypercholesterolemia is a predominant risk factor for atherosclerosis and associated with coronary and cerebrovascular diseases. The global incidence of hypercholesterolemia is rapidly increasing. Adiantum capillus veneris L. (Adiantaceae) has been reported as herbal medicine for diverse ailments in Jordan. However, its alleged benefits and action...
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Aim: To show that Gymnema sylvestre (Roxb.) Asclepiadaceae not only has antidiabetic propensities, but it most likely works by regeneration of pancreatic  cells which is imperative in anti-obesity-diabetes therapeutic applications of medicinal plants. Study Design: The present study design investigated the effects of G. sylvestre leaves crude aque...
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Pancreatic triacylglycerol lipase (PL), α-amylase and α-glucosidase are appealing pharmacological targets for the management of dyslipidemia, atherosclerosis, and obesity-diabetes. Presently, in vitro screening for considerable inhibition of these digestive hydrolases by endemic Sardinian Pistacia lentiscus L. and P. terebinthus L. leaves and fruit...
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Ethanol extracts obtained from two Salvia species, S. triloba and S. dominica, collected from the flora of Jordan, were evaluated for their antiproliferative activity against MCF7 and T47D breast cancer cell lines by the sulforhodamine B assay. The ethanol extracts were biologically active with IC50 values of (29.89 ±0.92) and (38.91 ±2.44) μg/mL f...
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Abstract: Achillea biebersteinii Afan. (Asteraceae) is used as a traditional medicine for healing wounds and in the treatment of abdominal pain and stomach ache. Fresh and air dried flowering parts of A. biebersteinii at different growth stages were subjected to hydro-distillation and the different essential oils obtained were analyzed by GC-MS tec...
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Achillea biebersteinii Afan. (Asteraceae) is used as a traditional medicine for healing wounds and in the treatment of abdominal pain and stomach ache. Fresh and air dried flowering parts of A. biebersteinii at different growth stages were subjected to hydro-distillation and the different essential oils obtained were analyzed by GC-MS technique. Mo...
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Pancreatic triacylglycerol lipase (PL), α-amylase and α-glucosidase are appealing pharmacological targets for the management of dyslipidemia, atherosclerosis, obesity and diabetes. Presently, in vitro screening for considerable inhibition of these digestive hydrolases by crude aqueous extracts (AEs) of eleven Salvia spp. grown and sold in Jordan (L...
Article
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The ability of hesperidin (HP) to form complexes with five metals; cobalt, nickel, zinc, calcium and magnesium was investigated. The complexation was studied using U.V spectroscopic titration, in methanol as well as aqueous buffer solutions (physiological conditions). Potential complexes were studied by IR and NMR spectroscopy, melting point and th...
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The composition of the essential oil isolated from the fresh and dry leaves of Ducrosia flabellifolia Boiss. (Apiaceae) was determined by gas chromatography and gas chromatography–mass spectrometry using hydrodistillation and solid phase microextraction (SPME). The hydrodistilled oil of the fresh leaves yielded 38 components, accounting for 98.67%...
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Pancreatic triacylglycerol lipase (PL), alpha-amylase and alpha-glucosidase are interesting pharmacological targets for the management of dyslipidemia, atherosclerosis, and obesity-diabetes. Limonium spp (Plumbaginaceae) are endemic to Sardinia, Italy. Comparable with acarbose, aqueous extracts (AE) of L. contortirameum and L. virgatum, and their p...
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Pancreatic triacylglycerol lipase (PL) has been reported as an interesting pharmacological target for the management of dyslipidemia, atherosclerosis, and obesity. In the current study, a 4-quinoline-3-carboxylic acid system has been identified as a potent inhibitor of PL. Three new fluoroquinolones (11, 12, and 13) were synthesized and evaluated i...
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Aqueous and hydro-alcoholic extracts of Achil- lea fragrantissima L. (Asteraceae) grown in Jor- dan were screened for their antioxidant, antimi- crobial, antiplatelet, anti-proliferative and ace- tylcholinesterase (AChE) inhibition efficacy. To- tal phenols and flavonoids were determined co- lorimetrically. The radical scavenging activities were ev...
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Angiogenesis is one of cancer hallmarks that are required for both cancer progression and metastasis. In this study we examined the antiangiogenic properties of the ethanolic crude extracts of four Salvia species grown in Jordan. The direct antiangiogenic activity was evaluated using various models: ex vivo rat aortic ring assay, in vitro assessmen...
Article
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Plant species have long been regarded as possessing the principal ingredients used in widely disseminated ethnomedical practices. Different surveys showed that medicinal plant species used by the inhabitants of Jordan for the traditional treatment of diabetes are inadequately screened for their therapeutic/preventive potential and phytochemical fin...
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Volatile oil composition and antiproliferative activity of Laurus nobilis L. (Lauraceae) fruits and leaves grown in Jordan were investigated. GC-MS analysis of the essential oil of the fruits resulted in the identification of 45 components representing 99.7 % of the total oil content, while the leaf essential oil yielded 37 compounds representing 9...
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Geranium graveolens, Sarcopoterium spinosum and Varthemia iphionoides are utilized traditionally for diabetes ethnomedicine in Jordan. Their aqueous extracts (AE) for antidiabetic activity and mechanism of action were investigated in vitro. Insulin secretion and pancreatic proliferation as well as glucose diffusion in vitro bioassays were recruited...
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This study explores the prevalence of herbal medicine use in a cohort of patients with chronic kidney disease (CKD), dyslipidemia and hypertension (HTN) in Jordan. The study took the form of a cross-sectional survey of patients attending the outpatient departments at The Jordan University Hospital (JUH), in Amman. The method was based on semi-struc...
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Hypocholesterolemic activity of Crataegus aronia L. (Rosaceae) is therapeutically praised. Its potent antiobesity (P < 0.001, n = 6-8) as well as marked triacylglycerol-reducing efficacies (P < 0.001, n = 6-8) in 10 weeks-high cholesterol diet (HCD) fed rats are demonstrated. Pancreatic triacylglycerol lipase (PL), α-amylase and α-glucosidase are a...
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In Jordan, Salvia dominica L. is widely distributed while Salvia hormium L. is scarcely found. The objective of this study was to determine the volatile oil composition of the fresh and dried aerial parts of these two species, collected during flowering time. The hydrodistilled volatile oils were analyzed by gas chromatography-mass spectrometry (GC...