Fatima T Husain

Fatima T Husain
University of Illinois, Urbana-Champaign | UIUC · Department of Speech and Hearing Science

PhD

About

76
Publications
7,106
Reads
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1,850
Citations
Introduction
Additional affiliations
January 2008 - August 2014
University of Illinois, Urbana-Champaign
Position
  • Professor (Assistant)
August 1999 - December 2007
National Institute on Deafness and Other Communication Disorders
National Institute on Deafness and Other Communication Disorders
Position
  • IRTA Fellow; Research Fellow

Publications

Publications (76)
Article
Objective: To investigate the effect of tinnitus and/or hyperacusis on distortion product otoacoustic emission (DPOAE) measures in adults with normal hearing thresholds from 0.25 to 8 kHz, while accounting for extended high-frequency (EHF) thresholds.Design: A behavioural study consisted of comprehensive audiological assessment, validated tinnitus...
Article
Full-text available
Background : Growing evidence suggests changes in cognitive control in persons with age-related hearing loss (ARHL), however, the nature of these alterations especially in those with mild ARHL needs further investigation. Methods : This study examined group differences in cognitive control between 20 older adults with unaided mild ARHL and 20 age-...
Article
Full-text available
Subjective, chronic tinnitus, the perception of sound in the absence of an external source, commonly occurs with many comorbidities, making it a difficult condition to study. Hearing loss, often believed to be the driver for tinnitus, is perhaps one of the most significant comorbidities. In the present study, white matter correlates of tinnitus and...
Article
Brain imaging studies have revealed neural changes in chronic tinnitus patients that are not restricted to auditory brain areas; rather, the engagement of limbic system structures, attention and memory networks are has been noted. Hearing aids (HA) provide compensation for comorbid hearing loss and may decrease tinnitus-related perception and annoy...
Article
Objective: To investigate the association between the highly comorbid tinnitus and hyperacusis conditions using standard questionnaires. Design: A cross-sectional internet-based survey consisted of general demographic questions, questions about hearing and emotional status, Tinnitus Primary Function Questionnaire (TPFQ), and Hyperacusis Question...
Preprint
Full-text available
Fine-grained understanding of dynamics in cortical networks is crucial in unpacking brain function. Here, we introduce a novel analytical method to characterize the dynamic interaction between distant brain regions, and apply it to data from the Human Connectome Project. Resting-state fMRI results in time series recordings of the activity of differ...
Article
Functional magnetic resonance imaging has been increasingly used to understand the mechanisms involved in subjective tinnitus; however, researchers have struggled to reach a consensus about a primary mechanistic model to explain tinnitus. While many studies have used functional connectivity of the BOLD signal to understand how patterns of activity...
Article
Full-text available
Growing evidence suggests alterations in cognitive control processes in individuals with varying degrees of age-related hearing loss (ARHL); however, alterations in those with unaided mild ARHL are understudied. The current study examined two cognitive control processes, cognitive flexibility, and inhibition, in 21 older adults with unaided mild ARH...
Article
In the present study, we used an innovative music-rest interleaved fMRI paradigm to investigate the neural correlates of tinnitus distress. Tinnitus is a poorly-understood hearing disorder where individuals perceive sounds, in the absence of an external source. Although the great majority of individuals habituate to chronic tinnitus and report few...
Chapter
Tinnitus, the perception of sound in the absence of an external source, has been noted for millennia in historical medical and other texts. It affects between 10% and 15% of adults in the general population. Tinnitus can be considered to be both the perceived sound itself and the psychological reaction to it. Variability in both these factors drive...
Article
Purpose Difficulties in speech-in-noise understanding are often reported in individuals with tinnitus. Building on our previous findings that speech-in-noise performance is correlated with subjective loudness of tinnitus, this study aimed to investigate the effect of tinnitus pitch on consonant recognition in noise. Method Pure-tone audiometry and...
Article
Full-text available
Objective: Tinnitus has been shown to be associated with specific cognitive deficits. Contemporary models of tinnitus, based primarily on human behavior, emphasize the influence of the cognitive response to tinnitus in tinnitus manifestation and level of associated annoyance. The models and hypotheses proposed thus far have (a) focused on the cogni...
Preprint
Full-text available
Background: Military service personnel are at increased risk for developing tinnitus due to heightened exposure to acoustic trauma. The auditory disorder is a leading service-connected disability among veterans and is highly comorbidly diagnosed with posttraumatic stress disorder (PTSD). The biopsychosocial model illustrates that chronic health con...
Article
Tinnitus is the perception of a self-generated sound and an individual's psychological reaction to it. This article discusses one element of the reaction: depression. Epidemiologic studies have noted high comorbidity of tinnitus and depression. Findings from recent brain imaging studies have noted shared neural networks in depression and severe tin...
Article
Full-text available
The resting state fMRI time series appears to have cyclic patterns, which indicates presence of cyclic interactions between different brain regions. Such interactions are not easily captured by pre-established resting state functional connectivity methods including zero-lag correlation, lagged correlation, and dynamic time warping distance. These m...
Article
Purpose: The tinnitus patient population is inherently heterogeneous. Although tinnitus often co-occurs with hearing loss and is more frequent among elderly people, it affects all age groups with varying hearing sensitivity. In addition, tinnitus severity and patients’ reaction to tinnitus vary across individuals. Regardless of the metrics used to...
Article
Full-text available
Mindfulness-based therapies have been introduced as a treatment option to reduce the psychological severity of tinnitus, a currently incurable chronic condition. This pilot study of twelve subjects with chronic tinnitus investigates the relationship between measures of both task-based and resting state functional magnetic resonance imaging (fMRI) a...
Article
Objective: We used a minimally-modified version of Mindfulness-Based Cognitive Therapy (MBCT) to treat symptoms of distress associated with tinnitus. Design: Audiological screening (establishing a baseline) was conducted prior to treatment and at three time-points: pre-intervention, post-intervention and follow-up, 8 weeks after completion of train...
Article
Purpose In the past decade, resting-state functional connectivity, acquired using functional magnetic resonance imaging (fMRI), has emerged as a popular measure of tinnitus, especially as related to self-reported handicap or psychological reaction. The goal of this study was to assess replicability of neural correlates of tinnitus, namely, resting-...
Article
Full-text available
Objective: We conducted a retrospective review of medical records of tinnitus patients at a tertiary ENT clinic in Groningen, Netherlands. Our goal was to identify factors that differentiated the intermittent subgroup from the larger continuous group with chronic tinnitus. Design: Tinnitus-related factors such as hearing loss, emotional aspects, an...
Article
Previous fMRI studies have shown tinnitus-related changes in resting-state functional connectivity (rs-fc) and have the potential for serving as biomarkers of tinnitus. In this study, we further investigated the effect of tinnitus on three intrinsic neural networks—the auditory network, the dorsal attention network (DAN), and the default mode netwo...
Article
Although we know tinnitus can cause concentration problems, its contribution to communication difficulties has not been well-studied. In a series of experiments, we have investigated Speech-in-noise (SiN) performance, in those with tinnitus and normal hearing sensitivity using a variety of methods, including behavioral, otoacoustic emissions, struc...
Article
Full-text available
Self-reported difficulties in speech-in-noise (SiN) recognition are common among tinnitus patients. Whereas hearing impairment that usually co-occurs with tinnitus can explain such difficulties, recent studies suggest that tinnitus patients with normal hearing sensitivity still show decreased SiN understanding, indicating that SiN difficulties cann...
Article
Full-text available
Chronic tinnitus is a common and sometimes debilitating condition that lacks scientific consensus on physiological models of how the condition arises as well as any known cure. In this study, we applied a novel cyclicity analysis, which studies patterns of leader-follower relationships between two signals, to resting-state functional magnetic reson...
Article
Despite having normal hearing sensitivity, patients with chronic tinnitus may experience more difficulty recognizing speech in adverse listening conditions as compared to controls. However, the association between the characteristics of tinnitus (severity and loudness) and speech recognition remains unclear. In this study, the Quick Speech-in-Noise...
Article
In this study, we investigated gray and white matter changes in subgroups within the larger tinnitus population related to differences in severity or duration of tinnitus symptoms. Tinnitus is the illusory perception of sound in the absence of an external source, most often experienced as a chronic condition. The psychological reaction to the sound...
Data
Supplementary tables depict the results of the ANOVA analysis of the Default Mode and Dorsal Attention networks, and contrast all six participant groups. Figure 1 contains the visual depictions of these results.
Article
Full-text available
Resting state functional connectivity studies of tinnitus have provided inconsistent evidence concerning its neural bases. This may be due to differences in the methodology used, but it is also likely related to the heterogeneity of the tinnitus population. In this study, our goal was to identify resting state functional connectivity alterations th...
Article
Background: Roughly 10-15% of the general population is affected by tinnitus and this percentage is estimated to rise in future. Because there is currently no cure for tinnitus, treatment is limited and is primarily achieved through management of symptoms and counseling. Purpose: This study compared audiologists' and patients' responses to relat...
Article
In this brief review, we describe the latest research on the emotional underpinnings of an individual's reaction to chronic tinnitus. We elucidate evidence for interventions that are beginning to show promise in alleviating the distressing aspects of this reaction. Such therapies do not rely on the traditional sound-based approaches, instead they f...
Article
Full-text available
Hearing loss is one of the most prevalent chronic health conditions in older adults. Growing evidence suggests that hearing loss is associated with reduced cognitive functioning and incident dementia. In this mini-review, we briefly examine literature on anatomical and functional alterations in the brains of adults with acquired age-associated hear...
Article
Full-text available
Objectives: The overall goal of the study was to identify functional and behavioral differences between individuals with higher tinnitus distress and individuals with lower tinnitus distress. Subsequent exploratory analyses were conducted to investigate the role physical activity may have on the observed results between high and low distress group...
Data
Pearson’s correlational analysis. THI = Tinnitus Handicap Inventory, TFI = Tinnitus Functional Index, GLTEQ = Godin leisure time exercise questionnaire, BAI = Beck anxiety inventory, BDI-II = Beck depression inventory. (DOCX)
Article
The article reviews current data about the neural correlates of an individual's reaction to tinnitus, primarily from studies that employ magnetic resonance imaging (MRI). Human studies employing brain imaging remain the most commonly used method to understand neural biomarkers of the reaction to tinnitus, a subjective hearing disorder. Evidence fro...
Article
Full-text available
Objectives . The aim of the study was to compare differences in neural correlates of tinnitus in adults with recent onset and others who had the disorder for longer than a year. Design . A total of 25 individuals with tinnitus were divided into groups based on the amount of time for which they had experienced tinnitus: 1 year (LTIN). Subjects under...
Article
Full-text available
Generation and persistence of tinnitus following hearing loss may be due to aberrant engagement of attention. Here, functional MRI was used to determine differences in auditory and visual attention processing in adults with tinnitus and hearing loss compared to two age-matched control groups, one with matched hearing loss and the other with normal...
Article
The objective of this study was to examine the effects of tinnitus severity on quality of life (QOL) and the benefits physical activity may have on tinnitus severity and QOL. The authors hypothesized that (1) QOL would be negatively correlated with tinnitus severity, (2) physical activity would be negatively correlated with tinnitus severity, (3) t...
Article
Full-text available
Brain imaging data were acquired from three subject groups—persons with hearing loss and tinnitus (TIN), individuals with similar hearing loss without tinnitus (HL) and those with normal hearing without tinnitus (NH)—to test the hypothesis that TIN and control subjects use different functional brain networks for short-term memory. Previous studies...
Article
Although alterations of the limbic system have been linked to tinnitus persistence, the neural networks underlying such alteration are unclear. The present study investigated the effect of tinnitus on emotional processing in middle-aged adults using functional magnetic resonance imaging and stimuli from the International Affective Digital Sounds da...
Article
Full-text available
We investigated the impact of hearing loss (HL) on emotional processing using task- and rest-based functional magnetic resonance imaging. Two age-matched groups of middle-aged participants were recruited: one with bilateral high-frequency HL and a control group with normal hearing (NH). During the task-based portion of the experiment, participants...
Article
Full-text available
We investigated auditory, dorsal attention, and default mode networks in adults with tinnitus and hearing loss in a resting state functional connectivity study. Data were obtained using continuous functional magnetic resonance imaging (fMRI) while the participants were at "rest" and were not performing any task. Participants belonged to one of thre...
Article
Full-text available
Resting state functional connectivity (rs-fc) using fMRI has become an important tool in examining differences in brain activity between patient and healthy populations. Studies employing rs-fc have successfully identified altered intrinsic neural networks in many neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia,...
Article
Full-text available
Neural mechanisms that detect changes in the auditory environment appear to rely on processes that predict sensory state. Here we propose that in tinnitus there is a disparity between what the brain predicts it should be hearing (this prediction based on aberrant neural activity occurring in cortical frequency regions affected by hearing loss and u...
Article
The aim of this study was to measure the effect of tinnitus, while accounting for the effect of hearing loss and aging, on distortion product otoacoustic emissions (DPOAEs). DPOAEs were measured twice in both ears in 5 groups of participants: young adults with normal hearing, middle-age adults with normal hearing, adults with high-frequency sensori...
Article
Emblems are meaningful, culturally-specific hand gestures that are analogous to words. In this fMRI study, we contrasted the processing of emblematic gestures with meaningless gestures by pre-lingually Deaf and hearing participants. Deaf participants, who used American Sign Language, activated bilateral auditory processing and associative areas in...
Article
Full-text available
We investigated auditory perception and cognitive processing in individuals with chronic tinnitus or hearing loss using functional magnetic resonance imaging (fMRI). Our participants belonged to one of three groups: bilateral hearing loss and tinnitus (TIN), bilateral hearing loss without tinnitus (HL), and normal hearing without tinnitus (NH). We...
Article
The effect of increasing the number of scans in the "cluster" of an interleaved silent steady state (ISSS) fMRI imaging scheme from 1 to 2, and then to 3 was examined by a fixed-effects analysis of an auditory short-term memory task with four subjects. Compared to a cluster size of 1, a cluster of 2 scans improved sensitivity at detecting brain act...
Article
Full-text available
In this study, we focus our investigation on task-specific cognitive modulation of early cortical auditory processing in human cerebral cortex. During the experiments, we acquired whole-head magnetoencephalography data while participants were performing an auditory delayed-match-to-sample (DMS) task and associated control tasks. Using a spatial fil...
Article
Subjective tinnitus is the perception of sound in the absence of an external source. Tinnitus is often accompanied by hearing loss but not everyone with hearing loss experiences tinnitus. We examined neuroanatomical alterations associated with hearing loss and tinnitus in three groups of subjects: those with hearing loss with tinnitus, those with h...
Article
Previously, a standard theory of systems level memory consolidation was developed to describe how memory recall becomes independent of the medial temporal memory system. More recently, an extended consolidation theory was proposed that predicts seven changes in regional neural activity and inter-regional functional connectivity. Using longitudinal...
Article
Manual gestures occur on a continuum from co-speech gesticulations to conventionalized emblems to language signs. Our goal in the present study was to understand the neural bases of the processing of gestures along such a continuum. We studied four types of gestures, varying along linguistic and semantic dimensions: linguistic and meaningful Americ...
Article
Full-text available
Language perception comprises mechanisms of perception and discrimination of auditory stimuli. An important component of auditory perception and discrimination concerns auditory objects. Many interesting auditory objects in our environment are of relatively long duration; however, the temporal window of integration of auditory cortex neurons proces...
Article
An important goal of research on the cognitive neuroscience of decision-making is to produce a comprehensive model of behavior that flows from perception to action with all of the intermediate steps defined. To understand the mechanisms of perceptual decision-making for an auditory discrimination experiment, we connected a large-scale, neurobiologi...
Chapter
In this paper we review the relatively recent effort on the part of cognitive neuroscientists to use computational neural modeling in conjunction with functional brain imaging, especially the hemodynamic-based methods such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). The reason why such a review is in a bo...
Poster
A Zwicker tone is an illusory tone. This is the perception of sound in the absence of physical sound. A signal detection analysis on previously collected data found that although the Zwicker tone was perceived by adults in all of our groups, the tone did not reliably differentiate between adults’ hearing status.
Article
Full-text available
In this chapter we review the relatively recent effort on the part of neuroscientists to use computational neural network modeling to investigate the neural basis of subjective tinnitus. There are advantages and challenges in using a modeling framework to understand this complex auditory disorder. The foremost challenge to modeling a subjective con...
Article
Full-text available
Categorization is fundamental to our perception and understanding of the environment. However, little is known about the neural bases underlying the categorization of sounds. Using human functional magnetic resonance imaging (fMRI) we compared the brain responses to a category discrimination task with an auditory discrimination task using identical...
Article
In this article, we review a combined experimental-neuromodeling framework for understanding brain function with a specific application to auditory object processing. Within this framework, a model is constructed using the best available experimental data and is used to make predictions. The predictions are verified by conducting specific or direct...
Article
Using functional connectivity analysis of functional magnetic resonance imaging data, we investigated the role of the inferior frontal gyrus in categorization of simple sounds. We found stronger functional connectivity between left inferior frontal gyrus and auditory processing areas in the temporal cortex during categorization of speech (vowels, s...
Article
We investigated the perception and categorization of speech (vowels, syllables) and non-speech (tones, tonal contours) stimuli using MEG. In a delayed-match-to-sample paradigm, participants listened to two sounds and decided if they sounded exactly the same or different (auditory discrimination, AUD), or if they belonged to the same or different ca...
Article
In this study, we investigated one type of auditory perceptual grouping phenomena--the auditory continuity illusion (also called temporal induction). We employed a previously developed, neurobiologically realistic, large-scale neural network model of the auditory processing pathway in the cortex, ranging from the primary auditory cortex to the pref...
Article
Full-text available
Viewing cognitive functions as mediated by networks has begun to play a central role in interpreting neuroscientific data, and studies evaluating interregional functional and effective connectivity have become staples of the neuroimaging literature. The neurobiological substrates of functional and effective connectivity are, however, uncertain. We...
Article
This commentary focuses on the importance of auditory object processing for producing and comprehending human language, the relative lack of development of this capability in nonhuman primates, and the consequent need for hominid neurobiological evolution to enhance this capability in making the transition from protosign to protospeech to language.
Article
We investigated the neural basis of auditory object processing in the cerebral cortex by combining neural modeling and functional neuroimaging. We developed a large-scale, neurobiologically realistic network model of auditory pattern recognition that relates the neuronal dynamics of cortical auditory processing of frequency modulated (FM) sweeps to...
Article
The neural basis of auditory object processing in the human cerebral cortex was investigated by combining neural modeling and functional neuroimaging. We developed a large-scale, neurobiologically realistic network model of auditory pattern recognition that relates neuronal dynamics of cortical auditory processing of frequency-modulated (FM) sweeps...
Article
Transcranial magnetic stimulation (TMS) exerts both excitatory and inhibitory effects on the stimulated neural tissue, although little is known about the neurobiological mechanisms by which it influences neuronal function. TMS has been used in conjunction with PET to examine interregional connectivity of human cerebral cortex. To help understand ho...
Conference Paper
Formidable conceptual problems exist in interpreting human functional neuroimaging data in terms of the underlying neural activity. To surmount these difficulties, we have developed two neurobiologically realistic models (one for vision, one for audition) of the object recognition pathway in human neocortex in which data at multiple spatiotemporal...
Article
Full-text available
Psychophysical phenomena such as categorical perception and the perceptual magnet effect indicate that our auditory perceptual spaces are warped for some stimuli. This paper investigates the effects of two different kinds of training on auditory perceptual space. It is first shown that categorization training using nonspeech stimuli, in which subje...