Fatiha Brahmi

Université de Béjaïa · Laboratoire de biomathématique, biophysique biochimie

The aim of this work was to optimize the conventional parameters for the extraction of phenolic compounds from potato (Solanum tuberosum L.) peels (PP). A central composite design (CCD) was used to establish the impacts of ethanol concentration (%), extraction time (min), and liquid/solid ratio (mL/g). The optimal experimental conditions that maxim...

7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well as in subjects concerned with civilization diseases (type 2 diabetes, bowe...

Research studies about the effect of environmental agents on the accumulation of phenolic compounds in medicinal plants are required to establish a set of optimal growth conditions. Hence, in this work, we considered the impact of habitat types, soil composition, climatic factors, and altitude on the content of phenolics in Mentha species [M. puleg...

The propagation of the COVID-19 pandemic in Algeria has pushed the population searching alternative therapies as preventives and treatment selections. The use of medicinal plants is a promising alternative solution to strengthen immunity and chase COVID-19. The aim of this study was to carry out an ethnobotanical survey in the Bejaia department (Al...

Coronavirus illness (COVID-19) is an infectious pathology generated by intense severe respiratory syndrome coronavirus 2 (SARS-CoV-2). This infectious disease has emerged in 2019. The COVID-19-associated pandemic has considerably affected the way of life and the economy in the world. It is consequently crucial to find solutions allowing remedying o...

Citation: Brahmi, F.; Vejux, A.; Ghzaiel, I.; Ksila, M.; Zarrouk, A.; Ghrairi, T.; Essadek, S.; Mandard, S.; Leoni, V.; Poli, G.; et al. Role of Diet and Nutrients in SARS-CoV-2

Opuntia ficus-indica [L.] Mill. (OFI) flower has been studied less than OFI fruit and cladode for the bioactive compounds occurrence. Also, ultrasound-assisted extraction (UAE) technique has been applied less than conventional techniques to extract bioactive compounds, generally. In this work, UAE was developed to extract phenolic compounds from OF...

RESUME: L'objectif de cette étude était de déterminer les effets de diverses doses de rayons gamma sur les paramètres morphologiques et agronomiques de semences de blé (Anza). L’expérimentation a été menée à la station expérimentale de l’Ecole Nationale Supérieure Agronomique, El Harrach (Alger, Algérie), sur une parcelle en bloc aléatoire complet,...

The present work reports an experimental study on the optimization of phenolic compounds extraction from Citrus ✕ paradisi peels and the development of active packaging. Response surface methodology (RSM) was applied to investigate the effect of microwave-assisted extraction (MAE) for the recovery of total phenolic compounds (TPC). The TPC in the o...

Age-related diseases for which there are no effective treatments include cardiovascular diseases; neurodegenerative diseases such as Alzheimer's disease; eye disorders such as cataract and age-related macular degeneration; and, more recently, Severe Acute Respiratory Syndrome (SARS-CoV-2). These diseases are associated with plasma and/or tissue inc...

Grapefruit (Citrus × paradisi, Algerian variety) essential oil obtained by hydro‐distillation was evaluated as a substitute for vitamin E for margarine. The obtained IC50 values were: 39.92 ± 0.18, 15.09 ± 0.02 and 4.42 ± 0.03 mg/mL by the 2,2‐ diphenyl‐1‐picrylhydrazyl method, the reducing power and the β‐carotene/linoleic acid tests, respectively...

Cucurbita species are delicious, nutritious, and delightful products. Cucurbita seeds remain in large quantities as a waste product that could be valorized since they are excellent sources of oil. The aim of this study was to compare the seed oil of two Cucurbita species ( Cucurbita pepo and Cucurbita moschata ) harvested in Bejaia (Algeria). The o...

The present study aims to valorize the apple peels (AP) and grape seeds (GS) by the fortification of the yogurts using their powder. Firstly, the optimization of the extraction parameters for assessing maximum of total phenolic content (TPC) was achieved. Under the optimized conditions, the experimental maximum yields of TPC were 19.33 ± 2.33 and 2...

Many parameters can influence the chemical profiles and the biological activities of seed oils. It was therefore of interest to study Algerian seed oils, whose caharacteristics are not well known. So, the physicochemical properties and nutrient profiles (fatty acids, phytosterols, polyphenols) of seed oils from Pistacia lentiscus L. (PL), Opuntia f...

H-NMR-based metabolomics have been applied to identify potential NMR-markers and biomarkers capable of distinguishing qualifying and classifying three Mentha species:- Mentha pulegium L., Mentha × rotundifolia (L.) Huds., Mentha spicata L., and their ecotypes. Samples of the 3 species were collected in seven different locations in Algeria, with the...

Background This paper presents the uses of Calamintha nepeta , Teucrium flavum and Thymus numidicus in food and in traditional herbal medicines in six districts from Bejaia state, Northern Algeria. Materials A semi-structured interview was conducted to 52 informants, including questions on the demographic data of the informants and uses of the thr...

Argan, olive, and milk thistle seed oils are characterized by high levels of tocopherols, mainly α-tocopherol. They are also rich in oleic acid (C18:1 n-9) and linoleic acid (C18:2 n-6) and contain small quantities of several polyphenols. As tocopherols and polyphenols have antioxidant properties and are able to cross the blood-brain barrier, it is...

This work aims to evaluate the biodegradation potential of petroleum by hydrocarbonoclastic bacteria isolated from Soummam wadi sediments. The chemical-biological properties of their biosurfactants products were also determined. Percentage of petroleum degraded by Rhodococcus ruber, Alcaligenes faecalis and Cellulosimicrobium sp. reached the maximu...

The present study consisted in evaluating the antioxidant, anti-inflammatory and cytoprotective properties of ethanolic extracts from three mint species (Mentha spicata L. (MS), Mentha pulegium L. (MP) and Mentha rotundifolia (L.) Huds (MR)) with biochemical methods on murine RAW 264.7 macrophages (a transformed macrophage cell line isolated from a...

Background The carob ( Ceratonia siliqua L.) is very old edible fruit, flavorful and often used in foods and beverages. In this present study the composition of phenolic compounds, the antioxidant activity and the production locust bean gum (LBG) of seeds grown in Algeria was explored. Methods The phenolic contents (total phenolics, total tannins,...

Cholesterol oxidation products, also named oxysterols, can be formed either by cholesterol auto-oxidation, enzymatically or both. Among these oxysterols, 7-ketocholesterol (7KC) is mainly formed during radical attacks that take place on the carbon 7 of cholesterol. As increased levels of 7KC have been found in the tissues, plasma and/or cerebrospin...

Background The cucurbit fruits are usually used around the world and are seasonal products traditionally used in human food. They are considered as a source of antioxidants which protect human body from several diseases. Objective The aim of this study is to evaluate the antioxidant contents (total phenolics, flavanoids, flavanols, condensed tanni...

The propagation of nerve impulses in myelinated nerve fibers depends on a number of factors involving the myelin and neural axons. In several neurodegenerative diseases, nerve impulses can be affected by the structural and biochemical characteristics of the myelin sheath and the activity of ion channels located in the nodes of Ranvier. Though it is...

The medicinal potential of the ethanol extract of Micromeria graeca (L.) Benth. ex Rchb., harvested in Algeria (MG extract), was evaluated by assessing in vitro its antioxidant, antibacterial, and antityrosinase properties. The total phenolic (= 430 ± 30 mg gallic acid equivalent/100 g of dry weight) and flavonoid (= 190 ± 10 mg quercetin equivalen...

Context: Mints (Lamiaceae) are used as traditional remedies for the treatment of several diseases. Their extracts are recognized as anti-inflammatory compounds. Objective: This study characterized the cytotoxic effects of Mentha spicata L. (MS), Mentha pulegium L. (MP) and Mentha rotundifolia (L). Huds (MR) on macrophage cells (RAW264.7; U937) and...

Background Micromeria species are rich in bioactive compounds such as phenolics which have several medicinal properties. Different solvents are used for extraction of these substances from natural products and solvent type has a major importance in extraction efficiency. In this context, three solvent systems of methanol, ethanol and acetone and th...

Background It is important to consider the optimum conditions and processing factors (like solvent type) influencing activity of plant antioxidants for utilization in food and biological systems. Methods The antioxidant capacity and phenolic content of two Results The efficiency of the used solvents to extract phenols from the two species varied...

Hydrocarbons degrading bacteria were isolated from sediments of the Soummam watershed of Bejaia (Algeria). Eleven bacteria strains were isolated using an enrichment technique, method in mineral salt medium, with various hydrocarbons as the sole carbon source. The biodegradation confirmation of various hydrocarbons by these isolates was tested by ho...

The genus Mentha L. (Lamiaceae) is distributed all over the world and can be found in many environments. Mentha species, one of the world’s oldest and most popular herbs, are widely used in cooking, in cosmetics, and as alternative or complementary therapy, mainly for the treatment of gastrointestinal disorders like flatulence, indigestion, nausea,...

The genus Mentha L. (Lamiaceae) is distributed all over the world and can be found in many environments. Mentha species, one of the world’s oldest and most popular herbs, are widely used in cooking, in cosmetics, and as alternative or complementary therapy, mainly for the treatment of gastrointestinal disorders like flatulence, indigestion, nausea,...

The genus Mentha L. (Lamiaceae) is distributed all over the world and can be found in many environments. Mentha species, one of the world’s oldest and most popular herbs, are widely used in cooking, in cosmetics, and as alternative or complementary therapy, mainly for the treatment of gastrointestinal disorders like flatulence, indigestion, nausea,...

Résumé Les oxystérols sont des formes oxydées du cholestérol ou de ses précurseurs. Certains de ces composés sont biologiquement actifs, et peuvent avoir des effets secondaires, spécialement ceux oxydés en C7 comme le 7-cétocholestérol (7KC). Cet oxystérol est connu pour induire un stress oxydatif et peut contribuer au développement de diverses mal...

Résumé L’objectif de cette étude est de déterminer les propriétés physico-chimiques et de quantifier les composés phénoliques de l’huile fixe d’Opuntia ficus indica L. D’autre part, les activités biologiques de l’huile ont été évaluées. Les paramètres physico-chimiques de notre échantillon sont en accord avec ceux mentionnés par les normes. L’huil...

Medicinal and aromatic plants are the foremost source of life economy drugs for the majority of the world’s population. Secondary plant metabolites are essential for life as drugs, fragrances, pigments and food additives. Botanical study of plants is an inevitable step in the ethnopharmacological approach and it is the reference system since it all...

Some factors related to diet, such as trans fatty acids (TFA), are known to be involved in the progression of atherosclerosis in humans. Thus, the aim of our study was (i) to evaluate the effects of three dietary free fatty acids (FFA) (elaidic (EA), oleic (OA) and palmitic acid (PA)) on U937 human monocytes, and (ii) to study the eventual benefits...

This study is designed to examine the chemical composition and antioxidant activity of Algerian Mentha rotundifolia (L.) Huds essential oil. GC and GC-MS analyses have resulted in the detection of 38 components. The piperitenone oxide (58.7 %) was a major component followed by piperitone oxide (15.9 %), terpinen-4-ol (6.3 %) and pulegone (3.9 %). T...

Air-dried leaves of Mentha spicata L. were collected in Bejaia location (Algeria) during 2013. The plant samples were distillated by Clevenger apparatus and the essential oils obtained were analyzed by GC and GC/MS. Fifty compounds amounting to 98.9% of the oil, were identified. The major components of the oil were carvone (48.5%), limonene (20.7%)...

The impact of the increase in treatment failures of the bacterial resistance to classical antibiotics is increasingly important. It is therefore necessary to discover new bioactive molecules. Bioremediation is a recent technique, which is the voluntary use of spontaneous biological agents to remove or inactivate pollutants from soil, subsoil, groun...

l'objectif de ce travail est d'étudier l'effet de la température du séchage conventionnel (à l'air libre et à l'étuve) des feuilles de la mélisse officinale sur la teneur en composés phénoliques et l'activité antioxydante de leurs extraits. Le meilleur rendement d'extraction a été attribué à l'extrait méthanolique obtenu à partir des feuilles séché...

Objective: To determine the quantitative paremeters of rosmarinic acid in Algerian mints, Mentha spicata L. (M. spicata), Mentha pulegium L. and Mentha rotundifolia (L.) Huds by high performance thin layer chromatography (HPTLC)-densitometric method and screen the effects of these plant extracts on linoleic acid peroxidation. Methods: The analy...

Aqueous and ethanolic extracts of Mentha pulegium L. (Lamiaceae) from two different locations Tizi-Ouzou and Bejaia in Algeria were examined in vitro. Phenolic compounds and antioxidant activity were analyzed. Measurement of total phenolic and total flavonoids contents of the extracts of M. pulegium were achieved by using Folin-Ciocalteu and chlori...

Introduction: The mints are herbs rich in phenolic compounds that appear to be capable of preventing many diseases. This study allowed for quantifation of the levels of total phenolics and flavonoids from Mentha spicata L. harvested in Bejaia (Algeria) using pure solvents (methanol, ethanol, acetone) and their aqueous mixtures at 50 and 75%. Furthe...

In the present work,two plants from the Mentha genus, collected in Algeria (Mentha spicataL. and Mentha pulegiumL.) were examined for radical-scavenging activity (RSA) using2,2’-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) tests. The thanolic extract of M. spicata exhibited the best RSA activity...