Fathi M Sherif- Professor
- Editor in chief of PPIJ and Mediterr J Pharm Pharm Sci at University of Tripoli
Fathi M Sherif
- Professor
- Editor in chief of PPIJ and Mediterr J Pharm Pharm Sci at University of Tripoli
Dean of Faculty of Pharmacy, University of Abusra and
Vice Chairman of Libyan Association for Pharmacists
About
154
Publications
174,592
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853
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Introduction
Neuropsychopharmacologist (PhD) with pharmaceutical background (BPharm). University lecturer and researcher.
Skills and Expertise
Current institution
Additional affiliations
January 2014 - March 2019
October 1992 - August 2017
January 2014 - present
Education
October 1988 - May 1992
Publications
Publications (154)
Lycium schweinfurthii is a shrub belonging to the Solanaceae family which widely grows in North Africa and Mediterranean regions. The plant leaves have traditionally been used for gastrointestinal diseases as peptic ulcer in Libya. This study aimed to investigate the effect of Lycium schweinfurthii extract on the central nervous system in mice incl...
HOW TO CITE THIS Sherif FM (2023) The future of pharmacy in Libya. Mediterr J Pharm Pharm Sci. 3 (1): 1-2. https://doi.org/10.5281/zenodo.7771304
Anemia, iron deficiency and iron deficiency anemia are common blood disorders. The role of vitamin D was agreed to be regulating in calcium and phosphate absorption and bone metabolism and its deficiency is observed as a crucial nutritional problem. Vitamin D is created under the skin by ultraviolet light. It is usually get vitamins from the food;...
HOW TO CITE THIS Gargoum et al. (2022) A human study on the effect of Alhagi Maurorum (camel thorn) on patients suffering from hepatitis B virus. Mediterr J Pharm Pharm Sci. 2 (4): 39-47. https://doi.org/10.5281/zenodo.7479731. Abstract: Hepatitis B virus infection is a major health problem worldwide. More than 400 million people are suffering from...
HOW TO CITE THIS Gargoum et al. (2022) A human study on the effect of Alhagi Maurorum (camel thorn) on patients suffering from hepatitis B virus. Mediterr J Pharm Pharm Sci. 2 (4): 39-47. https://doi.org/10.5281/zenodo.7479731. Abstract: Hepatitis B virus infection is a major health problem worldwide. More than 400 million people are suffering from...
In Libya, pharmacy education and practice have a similar pattern to medical education and practice. Both sectors of public and private pharmacy education and pharmacy practice still significantly unchanged for more than forty years. It is a traditional pharmacy style of education and practice with a limited change of education and practice. Now, th...
HOW TO CITE THIS Saeed et al. (2022) Postpartum depression and associated risk factors in Libya. Mediterr J Pharm Pharm Sci. 2 (2): 79-89. https://doi.org/10.5281/zenodo.6780513. Abstract: Postpartum depression is a major maternal health problem after childbirth. It can start at any time within the first year after delivery and continue for several...
HOW TO CITE THIS Alssageer et al. (2022) Pattern of drug prescribed and drug related problem among hospitalized elderly patients. Mediterr J Pharm Pharm Sci. 2 (2): 66-78. https://doi.org/10.5281/zenodo.6780506. Abstract: Prescribing drugs for elderly patients is not an easy task since elderly patients are frequently with comorbid conditions. In Li...
In health care delivery systems, if you are not part of the solution, then you must be part of the problem. Over the last few decades, clinical pharmacy encourages pharmacists and pharmacy support staff to move their focus from product-oriented role towards new direct engagement with patients, to make the most of the benefits that patients obtain f...
HOW TO CITE THIS Othman et al. (2022) Effect of Alhagi Maurorum or Gloularia Alypum on lipid profile of experimentally induced hypercholesteremic rats and on blood pressure of experimentally induced hypertensive rats. Mediterr J Pharm Pharm Sci. 2 (4): 31-38. https://doi.org/10.5281/zenodo.7479721. Abstract: In some countries, a high percentage of...
Chronic rheumatoid arthritis (RA) is a systemic inflammatory disease that leads to cartilage and bone erosion. Untreated disease is linked with joint deformity and substantial health care related costs. Conventional disease-modifying anti-rheumatic drugs (DMARDs) are the main tool to treat any form of RA. Methotrexate (MTX) is the key conventional...
Abstract: Introduction: The most effective treatment for severe acne is isotretinoin. However, it carries major side effects as teratogenicity, dryness, lipid profile disturbance and constipation. Although it is commonly prescribed with and without prescription in Libya, little date are available regarding patients understanding and awareness of is...
Introduction: Psychological stress is a common psychiatric disorder in medical students and sometimes is associated with depression. Students at university usually met a great pressure that they face in their study life and to the hard circumstances in the everyday life. The aim of this study is to estimate the prevalence of depression and stress a...
The rate of aging is rapidly increasing and the term of geriatric refers to offer a medical care to elderly people. Drug consumption study on geriatric population is a vital issue since this group is totally neglected in Libya. The aim of this study was to assess drug utilization pattern among elderly patients in terms of world health organization...
Abstract: Sitagliptin is a drug used in treatment of type 2 diabetes mellitus. Incretin hormones, including glucagon-like peptide-1 analogue and dipeptidyl peptidase-4 inhibitor have recently been found to regulate glucose metabolism. Thus, the aim of this study was to evaluate the effect of sitagliptin on glycemic control and it is associated side...
Abstract: Introduction: The most effective treatment for severe acne is isotretinoin. However, it carries major side effects as teratogenicity, dryness, lipid profile disturbance and constipation. Although it is commonly prescribed with and without prescription in Libya, little date are available regarding patients understanding and awareness of is...
Chronic rheumatoid arthritis (RA) is a systemic inflammatory disease that leads to cartilage and bone erosion. Untreated disease is linked with joint deformity and substantial health care related costs. Conventional disease-modifying anti-rheumatic drugs (DMARDs) are the main tool to treat any form of RA. Methotrexate (MTX) is the key conventional...
Prof. Haman will never be forgotten and mourn his loss as a beloved colleague and friend. He was a great man and a good scientist. We happily remember his humor, insight, and endless energy. He will deeply be missed by all those privileged to have known this extraordinary man who greatly enriched our lives. There is no doubt that prof. Haman would...
Community pharmacists are front line to citizens for information and services on general health issues. This could be through what is called value-added pharmacy services; these are supplementary services to pharmacy activities which do not include dispensing of medicines and professional consultation. This study aims to evaluate and to discuss the...
Introduction: Psychological stress is a common psychiatric disorder in medical students and sometimes is associated with depression. Students at university usually met a great pressure that they face in their study life and to the hard circumstances in the everyday life. The aim of this study is to estimate the prevalence of depression and stress a...
Tuberculosis is communicable disease which is common and often deadly infectious disease caused by mycobacterium tuberculosis. Tuberculosis continues to be a major public health problem in the world. The aim of this study is to assess prevalence and associated risk factors of pulmonary tuberculosis. Treatment and development of multidrug-resistant...
The practice of pharmacy in health care societies continues to undergo evolutionary and even radical changes. It has changed to a personal health service charged with assuring pharmaceutic and therapeutic appropriateness of all its functions in the care of patients. The purpose of this study is to review and analysis the historical stages of develo...
The practice of pharmacy in health care societies continues to undergo evolutionary and even radical changes. It has changed to a personal health service charged with assuring pharmaceutic and therapeutic appropriateness of all its functions in the care of patients. The purpose of this study is to review and analysis the historical stages of develo...
Introduction: The antimicrobial agents have saved human from several infectious disease. However, bacteria have capability to develop to become resistant to antibiotics and incorrect use of antibiotics is the main determinants of development of antimicrobial resistance which is a public health issue. Attention on medical students and community peop...
Introduction: The antimicrobial agents have saved human from several infectious disease. However, bacteria have capability to develop to become resistant to antibiotics and incorrect use of antibiotics is the main determinants of development of antimicrobial resistance which is a public health issue. Attention on medical students and community peop...
Several plant extracts have recently been reported as inhibitors for metallic materials in corrosive media. Thus, the corrosion inhibition of mild steel in a 3.5% NaCl solution in the presence of different concentrations of Acokanthera oblongifolia extract at a temperature range of 30 to 60 ⁰C and for various immersion times was studied using weigh...
Several studies have been focused on natural products of medicinal plants as a substitute for some pharmaceutical drugs in certain diseases in developing countries. Syzygium cumini L. skeels (S. cumini) belongs to the family Myrthaceae. It is a native plant to subtropical and tropical areas (e.g., India, South China, East Africa and Eastern Austral...
Inhaled drug therapy remains the treatment option of choice for majority of patients with asthma. Asthma is a major chronic inflammatory disease of the respiratory tract. This study is designed to evaluate if the use of 2Tone helps patients maintain the correct inhalation technique after training and can improve their quality of life using AQLQ (As...
There are several studies about the pathology and pharmacology of certain neurological diseases in humans, such as epilepsy, dementia, Parkinson's and Alzheimer's diseases. However, still research studies are going to understand such diseases. Several drugs are available and some are under trails but no clear picture is presented. This presentation...
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Bronchial asthma is a serious chronic inflammatory disease of the respiratory system. Aerosol inhalation as a route of drug delivery has become well-known in therapy of asthma. This study was designed to evaluate if the use of 2Tone helps patients maintain the correct inhalation technique after training and can improve the clinical benefit. 125 Lib...
Background: Cardiac autonomic neuropathy (CAN) is a chronic complication of diabetes mellitus (DM) with possibly life-threatening consequences. Although there are available simple bedside tests for diagnosis, it is often overlooked.
Objective: To determine incidence and risk factors of CAN in DM of Libyan patients.
Method: A case serious descri...
To investigate the anti-Cerastes cerastes venom effect of aqueous olive leaf extract. The mitigation in the mean survival time
of the male Albino Swiss mice were used to deduce the antivenom property of the aqueous olive leaf extract after challenging
with LD99 of snake venom. The aqueous extract of olive leaf significantly increases mean survival...
Anemia is the most common disorders affecting a large number of pregnant women worldwide. Anemia contributes to maternal mortality and morbidity and to low birth weight. To determine the prevalence of anemia and it's relation to birth weight. This method is a retrospective study, carried out by reviewing files of four hundred Libyan pregnant women...
To improve the countries' pharmaceutical situation and to monitor the progress, the World Health Organization (WHO) and member states developed a system of indicators to measure the respective important aspects as a prerequisite step. Level I indicators to assess the country's pharmaceutical situation include the national drug policy; legislation a...
Phospholipase A2 (PLA2), represents a major venom component of snakes and bees and exhibits a broad range of biological effects including myotoxicity, neurotoxicity, hemolysis, cardiotoxicity, anticoagulant and antiplatelet activities. Melittin, is the main component and the major pain producing substance of honeybee venom. The aim of the present s...
Objective: The appearance of resistant bacteria reduces the efficiency of antimicrobial therapies, thereby increasing the need for more efficient drugs for infections treatment. Many studies have shown an enhance in antimicrobial activity after the interaction of many agents with metal ions. Complexes of the metal ions with ligands which are polyde...
Pre-diabetes is the precursor stage before diabetes mellitus. It is not a disease but rather as an increased risk for diabetes and CVD. Pre-diabetes is assocaited with obesity, dyslipidemia and hypertension. Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.Individuals...
Aqueous olive leaf extract of the Mediterranean tree Olea europaea (Libya) was reported to have several therapeutic properties including: antifungal, antimicrobial, hypotensive and hypoglycemic actions as well as to be used in the treatment of certain cancer cases. In experimental setups, the olive leaf extract is capable to protect nuclear calf th...
Preeclampsia is a disorder of uncertain etiology of human pregnancy. It defines by high blood pressure and high protein in urine. If it left without treatment, it will change to eclampsia which leads to high rates of morbidity and mortality. Preeclampsia is associated with multiple maternal and fetal adverse effects. Periodontal disease (PD) is a c...
Diabetes mellitus is a major public health problem and is a primary cause of morbidity and mortality. The state incidence has much increased in the last years but with a major ignorance of the state health authorities. Thus, this study was aimed to explore the frequency of pre-diabetes and its associated risk factors among Libyan people. Data was c...
Background: Previous studies have indicated that major depressive disorder and anxiety disorders are associated with inflammatory progressions. It has also been shown that administration of anti-inflammatory drugs improve the patient’s psychiatric condition. These facts suggest that NSAIDs may be used as an adjunctive therapy in the management of d...
Background: Pharmacovigilance for pediatric drug therapy is lacking among Libyan patients. Hence, pediatric patients are at risk of unpredictable drug effects as a result of prescription fault. Therefore, this study was aimed to determine the drug prescribing errors for
children attending the pediatric outpatient clinic at Tripoli Children Hospital...
Epilepsy is one of the most common chronic neurological disease that characterized by recurrent, spontaneous brain seizures. Anti-epileptic drug is used clinically to control the epilepsy or reduce the frequency of the attacks. Liver is the primary and main organ for drug metabolism and elimination of several drugs such as anti-epileptic drugs (AED...
Hypertension is a chronic disease which is challenge for public health professionals and it has been recognized as a leading and important modifiable risk factor for cardiovascular disease. This study was aimed to explore the prevalence of associated risk factors of hypertension in Libyan patients. 200 patients (M: F, 1: 1) from different areas of...
Research without writing and publishing is not effective and useful. Writing a paper and publishing is not easy job, it needs time and experience. This presentation shows the steps to run a project in different steps from design to publish.
Background: Heart failure is a major cardiovascular disease and public health problem. It is complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of the blood. Trimetazidine is a cardio-protective drug that exerts cytoprotective effects by inhibition of the mitochondrial long-chain 3...
Background: In patients with end-stage renal disease, the need for renal replacement therapy to prolong life represents the final stage of living. Quality of life is one of the concepts that was accepted as a criterion for evaluating the outcome of medical efforts and the situation of patients with mental and somatic disorders. The aim of this cros...
Hepatitis B virus infection is a major challenge health problem worldwide. More than 300 million persons are suffering from this infectious disease. Camel thorn is used in Libyan folk medicine for hepatitis. The aim of this study is to investigate the effect of camel thorn on hepatitis B virus. After pharmacological and toxicological screening of c...
Although the aqueous extract of pituranthos tortuosus (PT) has been used in folk medicine in treatment of hypertension, there is a lack of data concerning the effectiveness of such extract in hypertension. Therefore, the objective of this study is to assess the effects of the extract on blood pressure in hypertensive rats and to investigate the pos...
Type 2 of diabetes mellitus (DM) is associated with progressive failure of
pancreatic B-cells to secrete insulin, decreased insulin action, due to reduced
insulin receptors at the target sites. Dyslipidemia is a common risk of DM and
is responsible to a large extent for cardiovascular disease-related morbidity and
mortality. This study was planned...
There are about one billion smokers in the world and death toll is almost six million people in a year. By 2020, death will increase to more than 70% in some developing countries. The tobacco use is high and is varied from one country to another. Tobacco addiction inhibits any decrease in morbidity and mortality and nicotine dependence is assumed t...
Background: Pulmonary tuberculosis (TB) remains a major global health problem despite the availability
of effi cient treatment over the last decades. TB is the most common opportunistic infection among HIV
patients and complicated the outcome of treatment globally.
Aims: The prevalence of HCV infection among TB patients has not fully been investiga...
The pharmaceutical industry has produced a large number of new antibiotics over the last three decades, but resistance to these antibiotics by microorganisms has increased. Statistically, WHO estimates that medicinal plants are the primary medicine for 2/3 of the world’s population. Recent studies focus on plant research all over the world to extra...
In the central nervous system, several lines of evidence suggest that the well-characterized inhibitory neurotransmitter gamma-aminobutyric acid (GABA) is involved directly and/or indirectly in the pathogenesis of many neuropsychiatric disorders such as Alzheimer's disease, epilepsy, depression, schizophrenia, anxiety and some other disorders. Acco...
Hypertension is a challenge for public health professionals all-over the world. It is the leading and most important modifiable risk factor for coronary heart disease, congestive heart failure, stroke, renal diseases, retinopathy and many other diseases. The aim of the present study is to evaluate and study the most identifiable risk factors for pa...
As a result of the chronic nature of epilepsy, patients often need concurrent therapy for other diseases. The benzodiazepines are frequently prescribed as anxiolytics, sedatives and hypnotics and these agents may interact with other drugs. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as anti inflammatory, analgesic and antipyreti...
This study is aimed to investigated the role of pharmacist in specialized center. Thus, drug pattern use for chronic cardiovascular diseases in National Heart Center in Tripoli Libya was studied. Several WHO guidelines were used to analysis the drug use. The role of Clinical pharmacy practice was also investigated in this study in order to improve...
The summary of the article is to review university pharmaceutical education in Libya and continuous pharmaceutical education after graduation. The role of pharmacist in health care and pharmaceutical care are discussed. What's the present situation and how to improve the future of pharmacy in education and practice.
Abstract: Breast cancer is one of the most widely distributed cancer diseases in women. Breast carcinomas derive from the epithelial lining of the milk ducts and the duct lobules. 1α, 25 dihydroxyvitamin D3 [1, 25(OH) 2D3], the biologically active form of vitamin D that interacts with vitamin D receptor. It prevents and inhibits the growth of breas...
Because of the chronic nature of epilepsy, patients often require concurrent therapy for other underlying conditions, and drug interaction occurs when the effects of one drug are changed by the prior or concomitant exposure to another drug. The benzodiazepines are frequently prescribed anxiolytic and hypnotic drugs and it has been shown that epilep...
The pharmacist plays a key role in providing rational drug use (assistance, advice and information about drugs available for self-medication). Thus, patterns of prescribing, dispensing and availability of drugs were evaluated in healthcare centers of two major cities in Libya, Tripoli and Zawia, for several months using WHO recommended indicators....
Vigabatrin (gamma-vinyl GABA, GVG) is a common anti-epileptic drug that selectively inhibits the enzyme activity of GABA-transaminase (GABA-T) in the brain and in the blood platelets. In the brain, GABA-T is mainly responsible for the catabolism of the major inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA). Vigabatrin causes se...
Salbutamol and formoterol are short and long -acting selective beta-2 agonists, respectively. Both bronchodilators are used in the treatment of asthma and to prevent bronchospasm. Since both are chronically used, the exploratory behavior was studied by different behavioural models; open-field test of spontaneous motor activity, plus-maze model of a...
To investigate pharmacological interactions of diazepam with non steroidal anti-inflammatory drugs.
Non selective cyclooxygenase enzyme inhibitors (100 mg/kg acetylsalicylic acid, 10 mg/kg inhibitors (100 mg/kg acetylsalicylic acid, 10 mg/kg indomethacin, and 10 mg/kg diclofenac), a selective cyclooxygnase-1 inhibitor (10 mg/kg acetylsalicylic acid...
Background: The World Health Organization advocated that the role of health sector must move increasingly in a health promotion direction. The health professionals' role represents a major contribution in community health promotion and education. The aim of this study was to assess the perceptions of Libyan health professionals on their role to pro...
In Libya, cucumbers traditionally and largly consumed among people all over the year growing under various conditions. Thus, cucumbers of greenhosue are tested for free radical scavenging activity using 1, 1 diphenyl-2-picrylhydrazil radical screening assay. Methanolic cucumber extracts of two different sources (greenhouse and natural, 4.5 g each)...
The aim of this study is to assess the perceptions of Libyan health
professionals of their role in the provision of health education to
the general public. It is also to identify barriers to effective health
education and to suggest actions for a more effective role. A closedend
questionnaire was distributed to 500 health professionals in
five Liby...
Interactions between some drugs were found to widely change the quality of pharmacological and therapeutic effects. In certain cases, non steriodal anti-inflammatory drugs are prescribed with benzodiazepines. Thus, the objective of this work was to study the pharmacological interactions of non steriodal anti-inflammatory drugs with diazepam in expe...
Questions
Questions (42)
Contact between pharmaceutical company representatives (PCRs) and medical practitioners is viewed by drug companies as a vital part of their marketing strategy. Studies show that PCRs employ persuasion disguised as information. Because PCRs are keenly involved in competitive marketing, they are more likely to use persuasion than information during their promotional visits. Information increases customer awareness of a particular product without influencing the preferences. Persuasive marketing directly influences a consumer’s brand preference. Positively influencing a prescriber’s attitude towards a product is essential for effective marketing since there is an association between attitude, intention and behaviour. Numerous studies find that pharmaceutical promotional interactions have an impact on physician’s perceptions and their prescribing practices. Yet, many of today's health professionals do not acknowledge their vulnerability to being misled by pharmaceutical marketing. This study demonstrate that Pharmaceutical promotion strategies do not differ greatly from those of other types of marketing, PCRs more likely to use persuasion to highlight the perceived difference of their particular brand. Persuasion often has a subtle influence that is not easy to detect and physicians should receive education regarding the drug promotion techniques used by pharmaceutical companies. Persuasion often has a subtle influence that is not easy to detect. Overconfidence is a major risk factor for being misled. This analysis highlights some critical aspects of persuasive communication by PCRs in promotional visits. It will help prescribers to interpret, evaluate and respond appropriately to manipulative behaviour by PCRs.
Several behavioral studies in healthy animal models can be used as indicators for some brain psychiatric disorders as anxiety and depression, but this models are free from genetic, lifestyle changes and environmental factors, how really reflect diseases in human brain?
