Fatemeh Hashemi

• PharmD, PhD
• University of Newcastle Australia

The increasing prevalence of Alzheimer’s disease (AD) has led to a health crisis. According to official statistics, more than 55 million people globally have AD or other types of dementia, making it the sixth leading cause of death. It is still difficult to diagnose AD and there is no definitive diagnosis yet; post-mortem autopsy is still the only...

Prostate cancer (PCa) is one of the most commonly diagnosed cancers and is the fifth common cause of cancer‐related mortality in men. Current methods for PCa treatment are insufficient owing to the challenges related to the non‐specificity, instability and side effects caused by the drugs and therapy agents. These drawbacks can be mitigated by the...

The biological identity of nanoparticles (NPs) is defined by a protein layer formed on their surface, called protein corona (PC), once they meet the biological milieu. Any change in the PC composition may influence the biological fate of NPs. The PC composition is strongly dependent on several parameters including the physicochemical properties of...

The surface of nanoparticles (NPs) get coated by a wide range of biomolecules, upon exposure to biological fluids. It is now being increasingly accepted that NPs with particular physiochemical properties have a capacity to induce conformational changes to proteins and therefore influence their biological fates, we hypothesized that the gold NP's me...

Hypothesis: It is now being increasingly accepted that cells in their native tissue show different morphologies than those grown on a culture plate. Culturing cells on the conventional two-dimensional (2D) culture plates does not closely resemble the in vivo three-dimensional (3D) structure of cells which in turn seems to affect cellular function....

As an emerging field, nanotoxicology is gaining significant interest from scientists as well as from international regulatory firms in an attempt to build accumulated knowledge on this topic, which will be the basis for regulatory codes and safer nanotechnology. However, conflicting results and findings are abundant in the literature calling for mo...

A rapid and simple liquid chromatography-UV spectrometric assay was developed for the quantitative determination of sorafenib in the presence of cationic and anionic PAMAM dendrimers. PAMAM dendrimer:sorafenib (SFB) admixture was prepared by Higuchi rotating bottle method for different generations (G4, G4.5, G5). Separation was achieved on a C18 co...

This study is the first report of the solubilization of sorafenib (SFB), a water insoluble drug, by polyamidoamine (PAMAM) dendrimers and b-cyclodextrin (b-CD). For this study whole generations (G4 and G5) of PAMAM dendrimers have been used. The aqueous solubility of sorafenib was measured in the presence of dendrimers and b-cyclodextin at 30 • C a...

To take advantages of single-walled carbon nanotubes (SWNTs) for cellular delivery of chemotherapeu-tic agents (e.g. doxorubicin) in order to decrease doxorubicin toxicity and increase its efficacy, we aimed to develop a novel approach to aqueous disperse and stabilize SWNTs through consequent steps of oxidation (oxSWNT) and PEG-PEI complexation (P...

Background and Aims: Single-walled carbon nanotubes (SWNTs) are a kind of nanomaterials with ultrahigh surface area that permits efficient loading of drugs. SWNTs offer advantages including high cargo loading, prolonged circulation time and intracellular transport of their cargo. They have highly hydrophobic surfaces. For biomedical applications, s...

Background and Aims: This study is the first report of the solubilization of sorafenib (SFB) , a water insoluble drug, by polyamidoamine (PAMAM) dendrimers and β-cyclodextrin (β-CD). Methods: For this study whole generations (G4 and G5) and a half generation (G4.5) of PAMAM dendrimers have been used. The aqueous solubility of sorafenib was measured...