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Farzad Salehpour

Farzad Salehpour
Independent Researcher

Master of Science

About

35
Publications
16,440
Reads
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825
Citations
Citations since 2017
30 Research Items
824 Citations
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2017201820192020202120222023050100150200250

Publications

Publications (35)
Article
Full-text available
Background Neuroinflammation is a response that involves different cell lineages of the central nervous system, such as neurons and glial cells. Among the non-pharmacological interventions for neuroinflammation, photobiomodulation (PBM) is gaining prominence because of its beneficial effects found in experimental brain research. We systematically r...
Article
Full-text available
Sexual dysfunction (SD) is frequently encountered in patients suffering from depression. There is a bidirectional relationship between various types of SD and depression, so the presence or treatment of one condition may exacerbate or improve the other condition. The most frequent sexual problem in untreated depressed patients is declining sexual d...
Article
Full-text available
The glymphatic system is a glial-dependent waste clearance pathway in the central nervous system, devoted to drain away waste metabolic products and soluble proteins such as amyloid-beta. An impaired brain glymphatic system can increase the incidence of neurovascular, neuroinflammatory, and neurodegenerative diseases. Photobiomodulation (PBM) thera...
Chapter
Salehpour et al. for PBM and CoQ10 Brain Ischemia During Aging and CoQ10 treatments. Collectively, the findings of this preclinical study imply that the procognitive effects of NIR PBM and CoQ10 treatments, separately or in combination, are beneficial in a model of transient global brain ischemia superimposed on a model of aging in mice.
Article
Background: Photobiomodulation (PBM) involves the use of red and/or near-infrared light from lasers or LEDs to improve a wide range of medical disorders. Transcranial PBM, sometimes accompanied by intranasal PBM, has been tested to improve many brain disorders, including dementia. Objective: To conduct a systematic review according to PRISMA guide...
Chapter
Major depressive disorder (MDD) is associated with prefrontal hypometabolism and mitochondrial dysfunction. Photobiomodulation (PBM) is a novel treatment under development for MDD. PBM uses near-infrared (NIR) or red light to modulate metabolism and functioning of different tissues and organs, including the brain. NIR and red light are nonionizing...
Chapter
Full-text available
Aging, as a physiological phenomenon, is complicated with secondary problems that cause enormous health, economic, social, and emotional costs. Neuropsychological problems are among the most important health threats in the aged population. Numerous pharmacological and nonpharmacological approaches have been evaluated to boosting of brain function i...
Article
Full-text available
Photobiomodulation (PBM) might be an effective treatment for Parkinson’s disease (PD) in human patients. PBM of the brain uses red or near infrared light delivered from a laser or an LED at relatively low power densities, onto the head (or other body parts) to stimulate the brain and prevent degeneration of neurons. PD is a progressive neurodegener...
Article
Full-text available
The effectiveness of transcranial photobiomodulation (tPBM) and methylene Blue (MB) in treating learning and memory impairments is previously reported. In this study, we investigated the effect of tPBM and MB in combination or alone on unpredictable chronic mild stress (UCMS)–induced learning and memory impairments in mice. Fifty-five male BALB/c m...
Article
Background and objective: Photobiomodulation (PBM) therapy is a promising and non-invasive approach to stimulate neuronal function and improve brain repair. The optimization of PBM parameters is important to maximize effectiveness and tolerability. Several studies have reported on the penetration of visible-to-near-infrared (NIR) light through vari...
Article
Background: Transcranial photobiomodulation (t-PBM) is a noninvasive modality that may improve cognitive function in both healthy and diseased subjects. Objective: This systematic review and meta-analysis addresses the question of whether t-PBM improves cognitive function in healthy adults. Methods: We searched MEDLINE using PubMed, EMBASE, SCOPUS...
Article
The application of photobiomodulation therapy (PBMT) for neuronal stimulation has been studied in different animal models and in humans, and has been shown to improve cerebral metabolic activity and blood flow, and provide neuroprotection via anti-inflammatory and antioxidant pathways. Recently, intranasal PBMT (i-PBMT) has become an attractive and...
Article
Full-text available
The aim of the present study was to investigate the electrophysiological effects of the photobiomodulation (PBM) by the quantitative electroencephalography (qEEG) as a diagnostic method. The neurotherapeutic potential of transcranial PBM has been recently investigated in preclinical and clinical studies. According to the PBM mechanisms of action on...
Article
Brain photobiomodulation (PBM) describes the use of visible to near-infrared light for modulation or stimulation of the central nervous system in both healthy individuals and diseased conditions. Although the transcranial approach to delivering light to the head is the most common technique to stimulate the brain, delivery of light to deeper struct...
Article
Objective: We present a case report of rapid reversal of cognitive impairment, olfactory dysfunction and quality of life measures in a patient with cognitive decline after multi-modality photobiomodulation (PBM) therapy. Background: Transcranial and intranasal PBM has been introduced as a light-based therapeutic technique in which exposure to low-...
Article
Full-text available
Disturbances in mitochondrial biogenesis and bioenergetics, combined with neuroinflammation, play cardinal roles in the cognitive impairment during aging that is further exacerbated by transient cerebral ischemia. Both near-infrared (NIR) photobiomodulation (PBM) and Coenzyme Q10 (CoQ10), administration are known to stimulate mitochondrial electron...
Article
Transcranial photobiomodulation is a potential innovative noninvasive therapeutic approach for improving brain bioenergetics, brain function in a wide range of neurological and psychiatric disorders, and memory enhancement in age-related cognitive decline and neurodegenerative diseases. We describe a laboratory protocol for transcranial photobiomod...
Article
Objectives: Noise is a potential environmental stressor affecting brain function as evidenced by altered stress neurotransmitters and hormone levels and psychobehavioral changes. Here, we explored the effects of noise exposure on the social behavior of mice as well as cerebral oxidative stress and neuroendocrine markers. Materials and Methods: In t...
Article
This study was aimed to evaluate the effects of near-infrared (NIR) photobiomodulation (PBM) combined with coenzyme Q10 (CoQ10) on depressive-like behavior, cerebral oxidative stress, inflammation, and apoptosis markers in mice. To induce a depressive-like model, mice were subjected to sub-chronic restraint stress for 5 consecutive days. NIR PBM (8...
Article
Full-text available
Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide range of neurological and psychological conditions. Red/NIR light is able to stimulate complex IV of the mitochondrial respiratory chain (cytochrome c oxidase) and increase ATP synthesis. Moreover, light absorption by ion channels res...
Article
Full-text available
Objective(s) Chronic stress has been linked to the pathophysiology of mood disorders including anxiety and depression. In this study, we aimed to investigate the effect of troxerutin (TRX), as a flavonol, on stress-induced anxiety and depression. Materials and Methods 56 animals were randomly divided into seven groups (n=8 per group) as follows: c...
Article
Medial prefrontal cortex (mPFC) ischemia affects post-stroke cognitive outcomes. We aimed to investigate the effects of different doses and routes of cerebrolysin (CBL) on the structural synaptic plasticity and cognitive function after mPFC ischemia in mice. Thence, CBL (1, 2.5 ml/kg/i.p./daily) or (1 ml/kg/i.n./daily), were administrated in photot...
Article
Sleep deprivation (SD) causes oxidative stress in the hippocampus and subsequent memory impairment. In this study, the effect of near-infrared (NIR) photobiomodulation (PBM) on learning and memory impairment induced by acute SD was investigated. The mice were subjected to an acute SD protocol for 72 hr. Simultaneously, NIR PBM using a laser at 810...
Article
Sleep deprivation (SD) causes oxidative stress in the hippocampus and subsequent memory impairment. In this study, the effect of near-infrared (NIR) photobiomodulation (PBM) on learning and memory impairment induced by acute SD was investigated. The mice were subjected to an acute SD protocol for 72 hr. Simultaneously, NIR PBM using a laser at 810...
Article
Mitochondrial function plays a key role in the aging-related cognitive impairment and photoneuromodulation of mitochondria by transcranial low-level laser therapy (LLLT) may contribute to its improvement. This study focused on transcranial LLLT effects on the D-galactose (DG) induced mitochondrial dysfunction, apoptosis and cognitive impairment in...
Article
Depression is a common psychiatric disorder that its prevalence has been reported to be 16% among adults. In recent years, transcranial near-infrared laser therapy (NILT) has gained considerable attention as a novel non-pharmaceutical method for depression. The present study was designed to compare the efficacy of two different treatment strategies...
Article
Major depressive disorder is a common debilitating mood disorder that affects quality of life. Prefrontal cortex abnormalities, an imbalance in neurotransmitters, neuroinflammation, and mitochondrial dysfunction are the major factors in the etiology of major depressive disorder. Despite the efficacy of pharmacotherapy in the treatment of major depr...
Presentation
Full-text available
The Orch OR theory suggests conscious experience is strongly connected to the fine-scale structure of space–time geometry, and that consciousness could be deeply related to the operation of the laws of the universe.
Article
Background and objective: The application of transcranial low-level light/laser therapy (tLLLT) in the range of red to near-infrared (NIR) spectrum for psychological disorders is a new area that is attracting growing interest in recent years. The photomodulation effects of NIR and red coherent lights on the activity of cytochrome c oxidase in neur...
Poster
Full-text available
The photoneuromodulation with transcranial low-level light/laser therapy is the non-invasive brain stimulation which use low power light from lasers or LEDs in the red to NIR of the electromagnetic spectrum. Upregulation of neuronal function using LLLT have been shown in some in vitro studies. Furthermore, beneficial in vivo effects of photoneuromo...
Conference Paper
Background: Depression and anxiety disorders are common major sources of mental distress and social disability. Pharmacotherapy for treating depression is effective but 30% of patients with treatment-resistant depression do not show a partial response to any treatments. Transcranial low-level light therapy (tLLLT) using non-invasive lasers, and lig...

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Projects

Projects (3)
Project
The ”Photobiomodulation for Brain” Worldwide Consortium is a network of photobiomodulation professionals, pioneers, researchers, and companies from around the world that focus on potential therapeutic applications of low-level laser/light therapy in the Neuroscience field. Our vision for the ”Photobiomodulation for Brain” Worldwide Consortium is that it will grow into a productive scientific and technological network that will be the knowledge source for the field of Brain Photobiomodulation. It will also become the forum to discuss new discoveries/innovations and major challenges in this field of research.
Project
To present a case of improvement in olfactory function after photobiomodulation therapy
Project
we are working to complete the ABSTRACT on this Case Report by April 1st to present at a conference