Farjah H Algahtani

Farjah H Algahtani
King Saud University | KKUH · Department of Medicine

Master of Public Health -Johns Hopkins University .Global Clinical Scholars Research Training Program Harvard Medical School, USA.Internal Medicne Department.King Saud University

About

121
Publications
20,676
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
550
Citations
Citations since 2017
51 Research Items
387 Citations
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
Introduction
My Clinical research is focused on Lymphomas, CML, Myeloproliferative disorders thromboembolic disease and cancer /Inflammatory bowel disease, sickle cell disease, including screening, prevention, and management. Currently,I am is the Principal Investigator for ongoing trials and numerous industry-sponsored trials.
Additional affiliations
April 2021 - present
King Saud University
Position
  • Managing Director
November 2019 - July 2021
King Saud University
Position
  • Professor (Full)
September 2009 - May 2015
King Saud University
Position
  • Managing Director

Publications

Publications (121)
Conference Paper
Full-text available
Introduction: Calreticulin (CALR) mutations comprise of a significant proportion of essential thrombocythemia (ET) patients. The frequency, types and clinical characteristics of ET patients with CALR mutations have not been widely studied. Moreover, ET patients with calreticulin (CALR) mutations are reported to have different characteristics and co...
Article
Full-text available
Objective Diffuse large B cell lymphoma (DLBCL) is the commonest sub type of non-Hodgkin's lymphoma (NHL) accounting for 30–50 % of NHL cases. Around 2% to 10% of patients with diffuse large B-cell lymphoma (DLBCL) experience central nervous system (CNS) relapse after initial therapy which is associated with a poor prognosis and most often a fatal...
Article
Full-text available
Background Real-world evidence on factor Xa inhibitor (rivaroxaban) prescribing patterns, safety, and efficacy in patients with non-valvular atrial fibrillation (NVAF) and venous thromboembolism (VTE) is rare. Herein, we sought to examine the above outcomes in the largest academic center in the Kingdom of Saudi Arabia (KSA). Methods This is a retr...
Conference Paper
Full-text available
Covid 19 with hematological presentation and complications that may lead to Stem Cell Transplant The coronavirus infection, known as COVID-19, was first presented as an outbreak of atypical Pneumonia in late2019 . Since then, it has spread globally to infect over9 million cases, by the end of June 2020 (2). This pan-demic has impacted health and th...
Poster
Full-text available
This was a retrospective cohort, post-marketing surveillance study. Patients with ‎NVAF/venous thrombosis, arterial thrombosis, and stroke who began treatment with ‎‎rivaroxaban enrolled in the study. Data collected from ‎January 2015 to December 2019 patients’ and analyzed to ‎examine the outcomes.
Conference Paper
Full-text available
This study is a retrospective study conducted at a large university-affiliated tertiary care centerKing Saud University Medical City) between January 2011 and February 2020. All pregnant women with RHD who had heart valve replacements were reviewed. Patient data were extracted for demographic information, baseline characteristics, anticoagulation t...
Conference Paper
Full-text available
Deep vein thrombosis (DVT) and pulmonary embolism (PE) are two manifestations of venous thromboembolism (VTE), and they are having similar predisposing factors. The oral factor Xa inhibitors such as rivaroxaban represent a major advancement in the prevention and treatment of thromboembolic disease. Real-world evidence on factor Xa inhibitor (rivaro...
Conference Paper
Full-text available
In patients with rheumatic heart disease (RHD) and prosthetic valve replacement, the risk of thromboembolic complications is the highest during and immediately after pregnancy. Therapeutic anticoagulation during this period is crucial to minimize the risk of thromboembolic complications.-The use of low-molecular-weight heparin (LMWH) remains an off...
Article
Full-text available
BACKGROUND: Red cell transfusion remains the gold standard in managing sickle cell disease (SCD) with severe complications. Offering red blood cell exchange (RBCX) either manual exchange transfusion (MET) or automated RBCX (aRBCX) can reduce the complications of chronic transfusion and maintain target Hb thresholds. This study audits the hospital e...
Article
Full-text available
Background: In patients with rheumatic heart disease (RHD) and prosthetic valve replacement, the risk of thromboembolic complications is the highest during and immediately after pregnancy. Therapeutic anticoagulation during this period is crucial to minimize the risk of thromboembolic complications. The use of low-molecular-weight heparin (LMWH) r...
Article
Full-text available
A 68-year-old woman with chronic kidney disease receiving dialysis and iron supplementation presented to our hospital with painful blisters, fragile skin, and changes to skin pigmentation on the dorsal side of both upper and lower limbs. Skin biopsy findings and an increase in urine porphyrins confirmed the diagnosis of porphyria cutanea tarda. Upo...
Article
Background: Red cell transfusion remains the gold standard in the management of sickle cell disease (SCD) with severe complications. Offering red cell exchange (RBCX) either manual (MET) or automated (aRBCX), can reduce the complications of chronic transfusion and maintain target Hb thresholds. This study audits the hospital experience of overseein...
Article
Full-text available
Background: The current trends in lymphoma cases from Saudi Arabia and their long‑term survival are unknown. This study was conducted to evaluate the trends of lymphoma diagnoses and survival from a major tertiary care hospital in Saudi Arabia. Methods: This retrospective study included all new cases of lymphoma diagnosed in adults (age ≥18 years)...
Article
Full-text available
Objectives: This study aimed to estimate the incidence of infections among adult patients on chemotherapy for acute myeloid leu-kemia (AML) and determine the most common type of organisms and site of infection(s). Furthermore, we aimed to determine the possible risk factors that enhance the chances of developing infections. Methods: An observationa...
Article
Background: The current trends in lymphoma cases from Saudi Arabia and their long‑term survival are unknown. This study was conducted to evaluate the trends of lymphoma diagnoses and survival from a major tertiary care hospital in Saudi Arabia. Methods: This retrospective study included all new cases of lymphoma diagnosed in adults (age ≥18 years)...
Article
Full-text available
Patients with multiple myeloma are often treated with chemotherapy or a proteosome inhibitor (bortezomib, carfilzomib, or ixa-zomib) plus lenalidomide plus dexamethasone. Data for the appropriate treatment of patients with multiple comorbidities is limited. Dose modification has been explored in older patients with multiple myeloma, who often have...
Article
Full-text available
The von willebrand disease (vWD) accounts to be one of the most common hereditary bleeding ailment that amounts its incidence to almost 1.5% of normal population. It is mostly associated with a defect in primary hemostasis as well as secondary defect in coagulation factor VIII as diagnosis of vwd happened to be challenging with earlier diagnostic c...
Article
Abstract Objective: This article assesses the impact of renal impairment (RI) on the efficacy and safety of anticoagulation in patients with cancer-associated thrombosis from the Comparison of Acute Treatments in Cancer Hemostasis (CATCH) study (NCT01130025). Materials and methods: Renal function was assessed using the Modification of Diet in Rena...
Article
Full-text available
Context: As the COVID-19 was spreading to all countries, its manifestations were identifying gradually, which were related to several organs. Evidence Acquisition: COVID-19 is associated with distinct hematological changes, increased serum inflammatory markers, and coagulopathy. Most of these changes are related to the patients’ prognosis and morta...
Article
Full-text available
Factor XII (FXII) deficiency is a rare genetic blood disorder. It can lead to a higher risk of developing deep vein thrombosis or acquired thrombotic disorders than the general population. This retrospective study evaluated patients who opted for surgery and were found to have abnormal clotting profiles and clotting factors on preoperative routine...
Article
Full-text available
OBJECTIVE To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards.
Article
Full-text available
The coronavirus infection COVID-19 first presented as an outbreak of atypical pneumonia in Wuhan, China on December 12, 2019 [1]. Since then it has spread globally to infect over 6 million cases, by the end of May, 2020. This pandemic has impacted health and the economy worldwide on an unprecedented scale. As the pandemic sweeps all over the world,...
Article
Full-text available
Clinically relevant bleeding in cancer patients treated for venous thromboembolism from the CATCH study. J Thromb Haemost 2018; 16: 1069-77. Essentials • Cancer patients receiving anticoagulants for venous thromboembolism have an elevated bleeding risk. • This secondary analysis of CATCH assessed characteristics of clinically relevant bleeding (CRB...
Article
Full-text available
The dysfunction of left atrial appendage (LAA) is prone to form thrombus when atrial fibrillation (AF) sustained more than 48 h. Traditional 2D-TEE (transesophageal echocardiography) can not accurate evaluate the function of LAA. The purpose of this study is to analyze the relationship of LAA function parameters and thrombus formation in patients w...
Article
Full-text available
The effectiveness of reticulocyte hemoglobin content (CHr) had been reported to detect early functional iron deficiency especially among Chronic kidney disease (CKD) patients. CHr is more superior to classic biochemical indices in reflecting transient iron-deficiency status, therefore improving diagnosis and treatment. This study was conducted to d...
Article
Full-text available
Covid 19 with Hematological presentation and complications that may lead to Stem cell transplant
Article
TITLE: The Clinical and Laboratory Manifestations Profile of Antiphospholipid Syndrome among Saudi Arabia population: Examining the Applicability of Sapporo Criteria AUTHORS: Farjah H AlGahtani 1 , Aynaa Alsharidi4 , AFsar Sayeeda4 ,Hussein AlArfaj4 , Ghada ElGohary 1,3 , , Ahmed Jamal ,1,, Fatima Alqahtany2 AFFILIATIONS: 1Departement Of Medicine...
Article
Full-text available
Antiphospholipid syndrome is a organized autoimmune disease presented with vascular thrombosis and pregnancy morbidity. The Sapporo classification criteria of APS were revised in 2006 and are used as the main diagnosis guideline, which validity as standard measurements is still in debate. This study observe the clinical and laboratory indices of AP...
Article
Full-text available
To estimate and compare the incidence of thromboembolic disease among patients who are clinically suspected for VTE among high and low altitude dwellers in Saudi Arabia. A prospective study conducted over two years (2011 – 2013) conducted in two different geographical areas in Saudi Arabia;Abha City and Riyadh City. Patients clinically suspected wi...
Article
Full-text available
Background: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a known cause of morbidity and mortality after bariatric surgery. However, the data concerning appropriate thromboprophylaxis after bariatric surgery is uncertain. The objective of this study was to evaluate the efficacy and safety o...
Conference Paper
Full-text available
King Saud University Medical City Red Cell Exchange Program for Patients with Sickle Cell Disease: To the Rescue.
Article
Full-text available
A 68-year-old woman with chronic kidney disease receiving dialysis and iron supplementation presented to our hospital with painful blisters, fragile skin, and changes to skin pigmentation on the dorsal side of both upper and lower limbs. Skin biopsy findings and an increase in urine porphyrins confirmed the diagnosis of porphyria cutanea tarda. Upo...
Article
Full-text available
Background: Chronic myeloid leukemia (CML) is a clonal BCR-ABL1-positive myelo-proliferative disorder resulting from an acquired genetic mutation, characterized by the presence of the Philadelphia (Ph) chromosome. CML is associated with significantly high granulocyte numbers in the bone marrow and peripheral blood. Materials and methods: This re...
Article
Full-text available
Tobacco cigarette smoking is assumed to be a key reason of death all over the world. Smoking had both severe as well long-lasting effects on hematological constraints. As per the data available from World Health Organization, every year nearly 5 million individuals die around the world due to the diseases triggered by smoking. Cigarette smoking is...
Article
Full-text available
Thrombotic disorders are one of the most common causes of morbidity and mortality in developing and developed countries. Several well-known genetic traits underlie predisposition to venous thrombosis. In particular, high factor VIII levels are a risk factor for venous thrombosis and coronary artery disease (CAD). However, similar insight into the g...
Article
Full-text available
Evans syndrome (ES), a hematologic disorder defined by autoimmune destruction of at least 2 hematologic cell types. The association of immune thrombocytopenic purpura (ITP) and autoimmune haemolytic anemia (AIHA). Some cases of Evans syndrome (ES) were associated, mainly in adults, with various medical conditions such as autoimmune diseases, common...
Article
Full-text available
Our study aims to observe the levels of knowledge, attitude, and practice (KAP) associated with sickle cell disease (SCD) and premarital genetic counseling (PMGC) in 351 Saudi adults. The relationships between KAP levels and sociodemographic characteristics (age, gender, marital status, and educational level) were observed. The study was conducted...
Article
Full-text available
Thrombotic disorders are one of the most common causes of morbidity and mortality in developing and developed countries. Several well-known genetic traits underlie predisposition to venous thrombosis. In particular, high factor VIII levels are a risk factor for venous thrombosis and coronary artery disease (CAD). However, similar insight into the g...
Article
Full-text available
Background: Sickle cell disease (SCD) is a monogenic disease that has wide variety of phenotypes with both and environmental factors contributing to its severity. Methods: We performed whole-exome sequencing (WES) in 22 Saudi SCD patients to identify variants that could explain differences in disease phenotypes. All variants, except those that w...
Article
Full-text available
Introduction: Venous thromboembolism (VTE) during hospitalization is a serious and potentially fatal condition. Despite its effectiveness, evidence-based thromboprophylaxis is still underutilized in many countries including Saudi Arabia. Objective of the Study: Our objectives were to determine how often hospital-acquired VTE patients received appro...
Article
Full-text available
Purpose Circulating tissue factor (TF) has been studied as a biomarker for predicting initial, but not recurrent, venous thromboembolism (VTE) in cancer, a setting in which predictors are incompletely understood. We evaluated the association of TF, clinical risk factors, and other biomarkers measured at the time of initial VTE with recurrent VTE in...
Article
Full-text available
In response to the high prevalence of atherothrombotic diseases and the residual risks left by the current antiplatelet therapies, the Food and Drug Administration approved the use of vorapaxar as a secondary prevention of cardiovascular events. Vorapaxar is a novel oral antiplatelet agent that antagonizes protease-activated receptor-1 and inhibits...
Article
Full-text available
Background/Aims Inflammatory bowel disease (ulcerative colitis and Crohn's disease) is characterized by a chronic inflammatory condition, and is accompanied by abnormalities in coagulation and a hyper-coagulable state. This study was conducted to examine the risk factors for developing Thromboembolic Events in Inflammatory Bowel Disease (IBD) in a...
Article
Background: Human platelet antigens (HPAs) are involved in the pathogenesis of several clinical conditions, such as platelet transfusion purpura (PTP), refractoriness to platelet transfusion and neonatal alloimmune thrombocytopenia (NAITP). Typing of HPA (1-6 and 15) has not been carried on the Saudi population. This is the first study of all the...
Article
Full-text available
Article
Full-text available
for the CATCH Investigators IMPORTANCE Low-molecular-weight heparin is recommended over warfarin for the treatment of acute venous thromboembolism (VTE) in patients with active cancer largely based on results of a single, large trial. OBJECTIVE To study the efficacy and safety of tinzaparin vs warfarin for treatment of acute, symptomatic VTE in pat...
Article
Full-text available
Amaç: Sepsis sendromuna genellikle kan pıhtılaşma sisteminin aktivasyonu eşlik eder. İlk çalışmalar ana doğal 3 antikoagülan olan antitrombin, protein C ve protein S eksikliği bulmuştur. Bununla birlikte, bu inhibitörlerin hiç biri doku faktörü bloke etmez, sepsis sırasındaki koagülasyon tetiklenişi özelllikle doku faktör yolak inhibitörü (DFYİ) il...
Article
Full-text available
Background and aim: Screening for tuberculosis (TB) is a key strategy for controlling infection. This study aimed to detect latent TB among dialysis patients. Methods: This is a prospective study conducted in King Saud University, Riyadh involving hemodialysis (HD) and peritoneal dialysis (PD) patients aged ≥18 years. Patients were screened for...
Article
Full-text available
OBJECTIVE: Sepsis syndrome is usually accompanied by activation of blood coagulation mechanisms. Earlier studies found deficiencies of the 3 main natural anticoagulants, antithrombin, protein C, and protein S. However, none of these inhibitors block tissue factor, the prime trigger of coagulation during sepsis that is controlled specifically by the...
Article
Full-text available
Objectives: To determine the knowledge, attitudes and practices (KAP) of urban women of Riyadh regarding breast cancer (BC) and its available screening and treatment modalities. Design: cross-sectional descriptive study Subjects: six hundred females in Riyadh city, aged more than 18 years were interviewed during October 2011 to October 2012 with a...
Article
Full-text available
Venous thromboembolism (VTE) including deep vein thrombosis (DVT) and pulmonary embolism (PE) is commonly encountered in daily clinical practice. After diagnosis, its management frequently carries significant challenges to the clinical practitioner. Treatment of VTE with the inappropriate modality and/or in the inappropriate setting may lead to ser...
Article
Full-text available
To determine the frequency of alloimmunization against human platelet antigens (HPAs) and human leucocyte antigen class 1 (HLA1) in multiparous women and multi-transfused patients. This prospective study was conducted between January and August 2013, on 50 multiparous women with no history of previous blood transfusion recruited from the Obstetric...
Article
Full-text available
Objective: Pernicious anemia is the most frequent cause of megaloblastic anemia in our area, few reports are available from the Saudi population with respect to the serious health implications of pernicious anemia. Hence the objective of the current research was to determine the prevalence of pernicious anemia in patients with macrocytic anemia (hi...
Article
Full-text available
Venous thromboembolism (VTE) is commonly encountered in the daily clinical practice. Cancer is an important VTE risk factor. Proper thromboprophylaxis is key to prevent VTE in patients with cancer, and proper treatment is essential to reduce VTE complications and adverse events associated with the therapy. As a result of an initiative of the Minist...
Article
Full-text available
Background and Objectives: Research pertaining to blood donors is ongoing in contributing to evidence-based practice to improve patient safety. This article evaluates publication trends in blood donor studies in Saudi Arabia benchmarked against the United Kingdom (UK), a global leader in transfusion practice and research, to identify research prior...
Article
Full-text available
Objective: The current research evaluated the prevalence of pernicious anemia (PA) in patients with macrocytic anemia (high MCV) and low serum B12 in Riyadh. Methods: Blood testing was done in 77 patients (males: 45.5%, females: 54.5%) with macrocytic anemia; 84 patients; (males: 23.8%, females: 76.2%) with low serum B12 and 30 healthy subjects. Co...
Conference Paper
Full-text available
Background: Mycobacterium tuberculosis infection is the result of large number of morbidity and mortality worldwide. Saudi Arabia has an incidence rate ranged between 8.6 and 12.2/100,000. QuantiFERON-TB Gold in-tube is approved to detect latent tuberculosis infection and TB disease. We conduct this study to estimate the prevalence of latent Tuberc...
Article
Full-text available
Objective: To determine the immune abnormalities and occurrence of infections in transfusion-dependent b-thalassemia major patients receiving oral iron chelator deferasirox (DFX). Study Design: An observational study. Place and Duration of Study: Hematology Clinics, King Khalid University Hospital, Riyadh, Saudi Arabia, from July to December 2010....
Conference Paper
Lisinopril in patients with Sickle Cell Anemia and Proteinuria.EHA 19th Congress of the European Hematology Association,June 12-15,2014 Milan.
Article
Full-text available
Thalassemias (Thal) are forms of inherited autosomal recessive blood disorders arising out of mutations in the chromosomes 11 or 16. These disorders lead to poor oxygen delivery to blood vessels and consequent splenomegaly, bone deformities, and shorter life spans. The most common detection methods for Thal are complete blood count (CBC) followed b...
Article
Full-text available
Background: Thalassemias (Thal) are forms of inherited autosomal recessive blood disorders arising out of mutations in the chromosomes 11 or 16. These disorders lead to poor oxygen delivery to blood vessels and consequent splenomegaly, bone deformities, and shorter life spans. The most common detection methods for Thal are complete blood count (CBC...
Article
Full-text available
Sickle cell disease (SCD) and thalassemia (Thal) are the most common inherited, autosomal, recessive blood disorders which lead to complications such as vasoocclusion and splenomegaly. Patients who suffer from these diseases have poor quality of life and shorter life span. The most common techniques for detection of these diseases are complete bloo...