Faris Alenzi

Faris Alenzi
Prince Sattam bin Abdulaziz University · Department of Laboratory Medicine

MS.c., DIC, Ph.D., FIBMS

About

100
Publications
41,003
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1,166
Citations
Introduction
I am very much interested in cancer biology, Immunology of hypersensitivity, stem cells and apoptosis
Additional affiliations
January 2007 - present
Prince Sattam bin Abdulaziz University
Position
  • Professor (Full)
Position
  • Immunology & Serology Basic Hematology Blood Banking

Publications

Publications (100)
Article
Full-text available
p> Background & Objective:- BCL-G is a novel protein of Bax (BCL-G associated protein X) that induces caspase-mediated apoptosis. These proteins play important roles in regulating apoptosis in both normal or neoplastic cells, however their cellular and tissue distribution remains to be determined. Thus, the current study objective was to elucidate...
Article
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p> Introduction: Philadelphia chromosome is a cytogenetic marker for chronic myeloid leukemia (CML). The main aims of this study were to assess the positive responses, side-effects and survival of CML patients treated with imatinib mesylate. Methods: All recently diagnosed CML patients who were treated with imatinib were recruited to this study. W...
Article
p>Functional immune cells are required for the prevention or resolution ofimmune-mediated disease , in particular T cells, including helper (CD4+; Th) or cytotoxic (CD8+; T<sub>c</sub>) T cells. Th cells differentiate into Th1 or Th2 type cells, through production of inflammatory (IL-2, IFN-a) or anti-inflammatory (IL-4, TGF-ß) cytokines, respectiv...
Article
p>It is becoming progressively clearer that the three RAS genes, N-. H-and K-RAS, encode 21 kDa proteins which act as intracellular switches, playing important roles in the signal transduction pathway that control cell development and maturation. These three genes are profoundly homologous, yet more recent findings indicate they have important role...
Article
p> Introduction: Purifed CD34+ cells and cultured colony forming unit-granulocyte and macrophage (CFU-GM) from human bone marrow were utilized to examine the role of Fas/FasL and caspase-8interactionsin the regulation of myelopoiesis. Methods: Fas and FasL expression in CD34+ cells and in day 14 CFU-GM were measured by RTPCR and immunofluorescence...
Article
Background: Chronic myeloid leukemia (CML) is characterized by the spread of malignant cells that exhibit resistance to caspase-mediated cell death (apoptosis) and this mechanism is proposed to play an important role in myeloid cell growth. However, the extent to which caspase-mediated cell death plays a crucial role in the regulation of myelopoies...
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Aim The study was designed to assess the possibility of using circulating miRNAs (serum miRNAs) as diagnostic biomarkers in colorectal cancer (CRC) and to identify their possibility as candidates for targeted therapy. Methods The study involved two sample sets: 1- a training set which included 90 patients with colorectal related disease (30 with C...
Data
Differential expression of the studied miRNAs in CP group versus IBD group. (DOC)
Article
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On the basis that the inflammatory effects of TNF (tumor necrosis factor) are predominantly mediated through interaction with the TNF receptor-1 (TNFRSF1A), the current study was designed to establish the prevalence of the mutations, R92Q and P46L TNFRSF1A polymorphisms both in the general healthy Saudi population, and in Saudi patients carrying in...
Article
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Objective: Fungal urinary tract infections due to Candida have increased significantly in recent years. Our research objective was to study Candida species in urine samples of patients with urinary tract infections (UTIs) associated with obstructive uropathy and to investigate the virulence factors of the isolated Candida. Methods: Patients were d...
Article
Role of T Lymphocytes in Leukemia and Allergic Rhinitis Preventing or curing an immune-mediated disease requires functional immune cells, particularly T cells, including helper (CD4+; Th) and cytotoxic (CD8+; Tc) T cells. Th cells differentiate into Th1 and Th2 type cells, which produce inflammatory (IL-2, IFN-g) and anti-inflammatory (IL-4, TGF-β)...
Article
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Posterior dislocation of the shoulder is a rare injury that occurs secondary to trauma and seizures. Diagnosis is often missed and treatment is challenging. Neglected posterior dislocation is associated with Hill-Sachs lesion which leads to locking of dislocation. Correct diagnosis is achieved by history taking, a physical examination and appropria...
Article
Glycosylated hemoglobin (HbA1c) identifies the average plasma glucose concentration over 120 days. HbA1c test measurements can lead to false outcomes in patients with inherited hemoglobin variants as hemoglobin S, which is prevalent in the Middle Eastern population. Our aim was to evaluate four different methods for measuring the blood HbA1c levels...
Article
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Maspin is a protein that belongs to serin protease inhibitor (serpin) superfamily. The purpose of this study was to review the literature concerning the expression of maspin in salivary gland tumours. A literature search was done using MEDLINE, accessed via the National Library of Medicine PubMed interface. Statistical analysis was not done because...
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Oral cancer awareness among future dental practitioners may have an impact on the early detection and prevention of oral cancer. A cross-sectional survey was undertaken to assess the current knowledge of future Saudi dentists on oral cancer and their opinions on oral cancer prevention. A pretested questionnaire was sent to 550 undergraduate dental...
Article
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The cyto-genetic hallmark of chronic myeloid leukaemia (CML), the Philadelphia chromosome (Ph), is the first consistent chromosomal abnormality that has been associated to a certain cancer type. In CML, Philadelphia chromosome is present leading to resistance to cell death and rapid proliferation. The aim of this study is to evaluate the different...
Article
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Background: The importance of specific animal allergy in immuno-pathology of asthma and atopic diseases remained to be defined. Methods: We measured total and specific IgE. Western blotting of some allergens was also characterised. Result: There was a significant elevation of IgE in 3 persons among 15 samples collected. Western blotting showed comm...
Article
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Background: Wheat allergy has been suggested to represent an important allergic disease. This study collates clinical and laboratory aspects in patients with wheat allergy in Al-Kharj city, Saudi Arabia. Methods: Total and specific IgE were measured in 15 suspected cases of wheat allergy. Protein allergenicity was assessed with Western blotting. Re...
Article
Oral cancer awareness among future dental practitioners may have an impact on the early detection and prevention of oral cancer. A cross-sectional survey was undertaken to assess the current knowledge of future Saudi dentists on oral cancer and their opinions on oral cancer prevention. A pretested questionnaire was sent to 550 undergraduate dental...
Article
Full-text available
Apoptosis plays a central role in the pathogenesis of a number of human diseases. Because apop-tosis represents a fundamental process in the response to such infections, it may represent a therapeutic target for their treatment. There is thus likely to be future clinical relevance in harnessing our growing knowledge both of apoptotic mechanisms, an...
Article
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Objective: This study was aimed at characterizing alterations in the immunohistochemical expression of p16 in carcinoma ex-pleomorphic adenomas. Study design: A selected series of 27 cases of carcinoma ex-pleomorphic adenomas were examined. Results: The results showed that p16 expression in non tumour duct cells was strongly positive nuclear s...
Article
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Oral cancer is the sixth most common malignancy worldwide with more than 263,000 patients diagnosed in 2008. Nonspecialists’ negative attitudes and poor working knowledge of oral cancer significantly contribute to suboptimal detection of early-stage disease which leads to delays in diagnosis. We aimed to assess the working knowledge and views assoc...
Article
Published data indicate that an inverse correlation has been identified in some tu-mours such as ovarian cancer and laryngeal squamous carcinoma. This study aimed to characterize alteration in the immunohistochemical expression of p16 and pRb in carcinoma ex pleomorphic adenoma, and to assess the inverse cor-relation between p16 and pRb in carcinom...
Article
Full-text available
Asthma is a chronic inflammatory disorder of the airways characterized by recurring episodes of reversible airway obstruction, hyper-responsiveness, wheezing, breathlessness and coughing. Clinical diagnosis of asthma is based on the pattern of clinical symptoms and pulmonary fuction tests. Asthma affectes 5% - 10% of the population and the number o...
Article
Full-text available
Asthma is a chronic inflammatory disorder of the airways characterized by recurring episodes of reversible airway obstruction, hyper-respon-siveness, wheezing, breathlessness and cough-ing. Clinical diagnosis of asthma is based on the pattern of clinical symptoms and pulmonary fuction tests. Asthma affectes 5% -10% of the population and the number...
Article
Full-text available
Background: The importance of specific animal allergy in immunopathology of asthma and atopic diseases remained to be defined. Methods: We measured total and specific IgE. Western blotting of some allergens was also characterised. Result: There was a significant elevation of IgE in 3 persons among 15 samples collected. Western blotting showed...
Article
Full-text available
Background: Wheat allergy has been suggested to represent an important allergic disease. This study collates clinical and laboratory aspects in patients with wheat allergy in Al-Kharj city, Saudi Arabia. Methods: Total and specific IgE were measured in 15 suspected cases of wheat allergy. Protein allergenicity was assessed with Western blotting....
Article
Full-text available
Objective: This study was aimed at characterizing alterations in the immunohistochemical expression of p16 in carcinoma ex-pleomorphic adenomas. Study Design: A selected series of 27 cases of carcinoma ex-pleomorphic adenomas were examined. Results: The results showed that p16 expression in non tumour duct cells was strongly positive nuclear staini...
Article
Full-text available
MEDICAL EDUCATION With technological advancement and the phenomenal changes in the world of science and medicine it is expected that medical education will change in keeping with the changing times. The advent of the computer, ultrasound, MRI and laser has changed the face of medicine irrevocably. Diagnostic pro-cedures have also seen much progress...
Article
Published data indicate that an inverse correlation has been identified in some tu-mours such as ovarian cancer and laryngeal squamous carcinoma. This study aimed to characterize alteration in the immunohistochemical expression of p16 and pRb in carcinoma ex pleomorphic adenoma, and to assess the inverse cor-relation between p16 and pRb in carcinom...
Article
Full-text available
Abstract Molecular oxygen (O 2) is essential in all species for the production of energy within mitochondria; a process known as oxidative phosphorylation. The end products of this process include adenosine triphosphate (ATP), water (H 2 O) and carbon dioxide (CO 2). In addition, very small amounts of reactive oxygen species (ROS) or free radicals...
Article
Continuous monitoring of specimen acceptability, collection and transport can result in the prompt identification and correction of problems, leading to improved patient care and a reduction in unnecessary redraws and delays in reporting results. This study aims to identify unacceptable blood specimens and to calculate the specimen rejection rate (...
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J Cell Sci Ther ISSN: 2157-7013 JCEST, an open access journal Open Access Editorial Cell Science & Therapy Alenzi et al., J Cell Sci Ther 2012, 3:7
Article
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Goodpasture syndrome, a rare human autoimmune disorder, is characterized by the presence of pathogenic autoantibodies that react with the components of the glomerular basement membrane. The clinical condition of the Goodpasture syndrome is characterized by an acute necrotizing glomerulonephritis, often with accompanying pulmonary hemorrhage. Notabl...
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Stem cell technology has developed rapidly in recent years to the point that we can now envisage its future use in a variety of therapeutic areas. This review seeks to summarize the types and sources of stem cells that may be utilized in this way, their pattern of development, their plasticity in terms of differentiation and transdifferentiation, t...
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Adoptive T cell therapy depends on the harvesting of the cells from the host, their activation in vitro, and their infusion back to the same host. The way of activating the T cells in vitro is a critical factor for their homing, survival and function in vivo. Sustaining T cell homing molecules, particularly CD62L, is benefic for the trafficking of...
Article
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Human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), affects over 33 million individuals all over the world. The majority of the affected individuals (>95%) are living in the developing countries, where appropriate drug treatment may not be available to all infected individuals. Many factors are know...
Article
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Recent preclinical and clinical studies provide evidence that adoptive transfer of in vitro activated T cells can results in significant antitumour responses in vivo upon acquisition of certain survival and homing properties during in vitro activation. Based on recent studies showing in vivo antioxidant effects of thymoquinone (TQ), the active ingr...
Article
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Apoptosis stimulating proteins of p53 (ASPP-l and ASPP-2) are a novel family of proteins that have been found to co-stimulate p53 activation of Bax (Bcl-2 associated protein X) inducing caspase-mediated apoptosis. Therefore, these proteins may play an important role in regulating apoptosis in normal and neoplastic cells. However, their cellular and...
Article
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One of the major functions of academic journals is to contribute to the evaluation of research activities and scientists. Invented more than 40 years ago, the Institute for Scientific Information (ISI) impact factor (IF) became the most significant indicator of the quality of journals,1 despite well-known problems and critics such as the over-repre...
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Both stem cell and gene therapy research are currently the focus of intense research in institutions and companies around the world. Both approaches hold great promise by offering radical new and successful ways of treating debilitating and incurable diseases effectively. Gene therapy is an approach to treat, cure, or ultimately prevent disease by...
Article
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There is a dire need in the Arab world and Middle Eastern countries to reform the higher education, research policy and planning for improving the quality to meet the needs of modern society. The impact factor (IF) was developed in the 1960s by Eugene Garfield of the Institute for Scientific Information (ISI) in the USA. It has been extensively use...
Article
Monoclonal gammopathies reflect conditions of plasma B-cell disorders. Our objective was to identify the prevalence and types of these gammopathies in our population. A 10year retrospective study was conducted. Serum and/or urine protein electrophoresis were performed on 6624 samples. Positive bands were further tested by immunofixation (IFE). Homo...
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There is worldwide concern on the spreading pandemic wave of the new swine influenza virus (S-OIV). The WHO has placed the pandemic threat alert to level 6. World leaders and scientists importantly stress that regulations and pandemic preparedness may lower the morbidity and mortality. This review describes the background, origin, epidemiology, sig...
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Bcl-2 family members can be functionally divided into anti-apoptotic and proapoptotic groups. The balance between these two groups may determine the fate of tumor cells. In hepatocellular carcinoma (HCC), this balance is often tilted towards the anti-apoptotic members in tumor cells, leading to resistance to cell death and rapid proliferation. In t...
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Caspases are key intracellular molecules in the control of apoptosis, but little is known concerning their relative contribution to the cascade of events leading to eosinophil apoptosis. We examined caspase-3, -8, and -9 activities in receptor ligation dependent apoptosis induction in the cultured eosinophils (CE). CE cultured alone for 48 hours ex...
Article
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Constituents of the Nigella sativa seed are reported to possess potent antioxidant effects. Treatment with anticancer drugs such as cyclophosphamide (CTX) is associated with significant toxicity due to over-production of reactive oxygen species, resulting in increased levels of oxidative stress. The aim of this study is to test whether or not N. sa...
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Apoptosis represents a crucial process in modulating organ development in the embryo, in organ homeostasis in the adult, and in fostering appropriate immunological function. Caspases represent two central classes of molecules that are either involved with the stimulation of the apoptotic cascade (initiator caspases), or the various sequential biolo...
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To investigate the performance of hepatitis B virus polymerase chain reaction (HBV PCR) using one of the commercial methods used around the world to screen for HBV in some blood donors where other conventional serological assays have limitations to detect the virus. This study was designed to use Amplicor AmpliScreen for HBV testing to detect the p...
Article
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Helicobacter pylori (H. pylori) is the etiologic agent of a variety of gastrointestinal disorders. The rationale of the current study is to evaluate six enzyme immunoassays for detection of anti-H. pylori immunoglobulin G (IgG) and IgA in Jordanian patients. Biopsy specimens and blood samples were obtained from patients underwent the endoscopy unit...
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Abstract: This review evaluates the various aspects of the academic career with respect to how and why components of entering academic career. The expectations, the short- and long-term benefits, the move from main stream research to commercialization, and other key issues for academics and aspiring academics to consider are covered in this review....
Article
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Preventing or curing an immune-mediated disease requires functional immune cells, in particular T cells, including helper (CD4+; Th) and cytotoxic (CD8+; Tc) T cells. Based on the type of the antigen presenting cells, the nature of antigens, and the cytokine milieu, CD4+ T cells exhibit high plasticity to differentiate into different subsets with s...
Article
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The replacement of diseased organs by transplantation is now an important medical therapy. However, transplantation is limited by organ shortage. One solution to this problem is xenotransplantation, in other words, the use of organs from animal donors.. Although the problem of hyperacute rejection is now largely solved, there is evidence that xenog...
Article
The aim of this descriptive study was to determine the prevalence of Klebsiella pneumoniae from different clinical specimens, their antibiotic susceptibility pattern and the extended-spectrum beta-lactamase (ESBL) production among such isolates at Armed Forces Hospital, Al-Kharaj, Saudi Arabia, from November, 2004 to October, 2007. A total of 328 i...
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Keywords: Antibiotic; Armed Forces Hospital; Methicillin resistant; Saudi Arabia; Staphylococcus aureus Online:Â 22 May 2009 DOI: 10.3329/bmrcb.v35i1.1983 Bangladesh Med Res Counc Bull 2009; 35: 28-30
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Insulin dependent diabetes mellitus (IDDM) results from irreversible loss of beta cells (beta-cells) of the pancreas. A Streptozotocin (STZ)-induced diabetes in animal model mimics, in some aspects, recent onset IDDM. This study was conducted to investigate the effect of nicotinamide on experimentally-induced IDDM. Thirty Spraque Dawley rats were d...
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Self renewal and apoptosis of haemopoietic stem cells (HSC) represent major factors that determine the size of the haemopoietic cell mass. Changes in self renewal above or below the steady state value of 0.5 will result in either bone marrow expansion or aplasia, respectively. Despite the growing body of research that describes the potential role o...
Article
This study aims to investigate which recognition pathways are important in engulfing apoptotic eosinophils. Here, two epithelial cell were selected namely (large airway bronchial epithelial cells) LAECs and A549. The inhibition assay was examined by resting and dexamethasone-stimulated epithelial cells. Confocal microscopy confirmed the engulfment...
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More than 25 million lives have been claimed by AIDS and 33.2 million people are estimated to have HIV, the majority of which are living in the underdeveloped countries. Failed tests on vaccines, virucides and complete virus eradication have caused scientists to refocus on the basic questions of what makes an effective HIV immune response. The "glo...
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Dendritic cells (DC) are professional antigen presenting cells expressing MHC class II, derived from a common marrow precursor. They are motile, diffused and have a spidery shape with many long cytoplasmic processes. The aim of this project was to test the hypothesis that cellular injury induces the activation and functional maturation of DC. To te...
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Lymphocytes and granulocytes from healthy donors and SLE patients were used to investigate the role of Fas/FasL system in the pathogenesis of systemic lupus erythematosus (SLE). Determination of lymphocyte subpopulations was carried out by flowcytometry. Fas and FasL expression in lymphocytes and granulocytes were measured by immunofluorescence. Ap...