Farid Ljuca

University of Tuzla | UNTZ · Department of Physiology

The current study aimed to explore whether the level of decrease in platelet distribution width (PDW), platelet large cell ratio (P-LCR), and mean platelet volume (MPV) has prognostic value for major adverse cardiovascular events (MACEs) in acute myocardial infarction without ST-segment elevation (NSTEMI) treated by clopidogrel. In this prospective...

Background Liver X receptor alpha (LXRA) plays important role in cholesterol and lipid homeostasis and lipid metabolism; moreover, it has been investigated as a candidate gene in a number of conditions, including onset and progression of atherosclerosis. We hypothesized that the LXRA gene rs2279238 polymorphism may be associated with the onset and...

The association between urine amylase levels and the development of postoperative complications after Whipple resection is still unknown. Aim of this study was to determine the prognostic value of urine amylase levels for postoperative complications in patients who underwent Whipple resection. In this retrospective cohort study, we analyzed amylase...

The association between urine amylase levels and the development of postoperative complications after Whipple resection is still unknown. Aim of this study was to determine the prognostic value of urine amylase levels for postoperative complications in patients who underwent Whipple resection. In this retrospective cohort study, we analyzed amylase...

Objectives To examine a relationship between protein C (PC) and antithrombin III (AT III) activities with ejection fraction of left ventricle (EFLV), in the early phase of acute ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI), and to investigate whether PC and AT III are associated with majo...

Background Histone deacetylase 9 (HDAC9) plays an important role in transcriptional regulation, cell cycle progression and developmental events; moreover, it has been investigated as a candidate gene in a number of conditions, including the onset and progression of atherosclerosis. We hypothesized that the rs2107595 HDAC9 gene polymorphism may be a...

Background: The aim of this study was to investigate whether the C-reactive protein (CRP) is associated with ejection fraction of left ventricle (EFLV) in the early phase of ST-elevation myocardial infarction (STEMI), treated with the primary percutaneous intervention (pPCI), and to establish whether there exists a relationship between its values a...

ABSTRACT Introduction: Osteoporosis is a chronic progressive bone disease where the bone tissue resorption exceeds its regenerative capacities. Such a process leads to the reduction of bone mineral density (BMD), and distortion of trabecular microarchitectonics, which creates the basis for an increased fracture risk on a “low trauma” for osteoporos...

Objectives: To assess the prognostic value of pentraxin 3 (PTX3) in patients with ST-elevation myocardial infarction (STEMI) after bare-metal stent (BMS) implantation. Methods: In this prospective study, PTX3, interleukin (IL-6), IL-10, high-sensitivity c-reactive protein (hsCRP), and cardiac troponin I (cTnI) plasma values were determined befor...

Introduction Metabolic syndrome (METS) represent a simultaneous presence of multiple metabolic disorders in one person. Prevalence is increasing worldwide, which is probably related to increased obesity and sedentary lifestyle. Non-alcoholic steatosis or “fatty liver” is a metabolic disease caused by fat dysfunction. It can be a sign of some other...

Objective: analysis and monitoring of the effectiveness of beta-blockers (BB) in the treatment and prognosis of acute coronary syndrome (ACS). Background: Heart and blood vessels disease are the most common chronic disease and the leading cause of death in the world. The largest proportion of deaths from cardiovascular disease is coronary ischemic...

Objective: Analysis of application of contemporary therapeutic modalities in patients with ischemic heart disease (IHD). Background: Acute Coronary Syndrome (Acs) Is One Of A Number Of Syndromes In A Range Of Clinical Manifestations Of Atherosclerosis Of The Coronary Arteries Or Ischemic Heart Disease, Along With Other Clinical Manifestations Such...

Objective: Analysis of application of contemporary therapeutic modalities in patients with ischemic heart disease (IHD). Background: Acute Coronary Syndrome (Acs) Is One Of A Number Of Syndromes In A Range Of Clinical Manifestations Of Atherosclerosis Of The Coronary Arteries Or Ischemic Heart Disease, Along With Other Clinical Manifestations Such...

Objective: Analysis of advantages and limitations in the application of ACE inhibitors. Background: ACEI are most frequently used group of antihypertensives. The mechanism of

Objective: Timely recognition and optimal management of atherogenic dyslipidemia (AD) and residual vascular risk (RVR) in family medicine. Background: The global increase of the incidence of obesity is accompanied by an increase in the incidence of many metabolic and lipoprotein disorders, in particular AD, as an typical feature of obesity, metabo...

Aim: The aim of the study was to evaluate efficiency of hypertensive urgency treatment using inhibitors of α1-adrenergic receptors and angiotensin converting enzyme inhibitors–ACE inhibitors in the Emergency Room of Outpatient Hospital and Polyclinic „dr Mustafa Šehovic“ Tuzla in relation to age, duration and severity of hypertension. Methods: The...

Introduction: Diabetes mellitus is characterized by the lack of glycemic control, which may cause damage to the small and large blood vessels and nerves, which could, among the other things, lead to changes in the foot. Most of diabetic foot complications that resulted in amputation begin with the formation of skin ulcers. The most important risk f...

Background: Postoperative infection after posterior spondylodesis of thoracic and lumbal spine is the most common complication, and a reason for revision surgery. Aim of this work is to analyze rate of postoperative spine infections at our institution, and to determine eventual risk factors. Subjects and methods: In our paper we analyze incidenc...

Correction of pediatric spine deformities is challenging surgical procedures. This fragile group of patients has many risk factors, therefore prevention of most fearing complication-paraplegia is extremely important. Monitoring of transmission of neurophysiological impulses through motor and sensor pathways of spinal cord gives us an insight into c...

Growing body of evidence suggests that molecular markers are an important prognostic marker for non-small lung cancer (NSCLC). Using targeted therapy based on these markers leads to improved outcomes in lung adenocarcinoma. However, progress of targeted therapy in squamous lung cancer is still modest. p16(ink) protein acts as tumor suppressor and v...

Aim: To determine the efficiency and safety of talc pleurodesis in treating the malignant pleural effusion and recurrent spontaneous pneumothorax. Methods: The study included 54 patients with malignant pleural effusion and recurrent spontaneous pneumothorax, who underwent talc pleurodesis using the "talc slurry" method of pleural talc obliterati...

The aim of this work is to radiologicaly estimate the width, height and depth of bodies of thoracic and lumbal vertebras. Charts of one hundred and seventeen patients with implanted internal fixateur on the thoracic and lumbal spine, between 01.01.2008. and 31.3.2010. at the Department of Orthopedics and Traumatology – Clinical Centre Sarajevo, wer...

Udžbenik ,,Osnovni principi anestezije i intenzivnog liječenja" autentično je autorsko djelo doc. dr. sc. Alise Krdžalić i saradnika. Napisan je u 35 poglavlja na 334 stranice, s više od 90 ilustracija, 110 tablica te više od 600 literaturnih navoda Tekst je poredan logično i smisleno, čineći cjelinu koja donosi sva dosadašnja znanja iz područja an...

Surgical revascularization of the heart (CABG - coronary artery bypass grafting) is one way of treating coronary heart disease. Bleeding is one of the serious and frequent complications of heart surgery and can result in increased mortality and morbidity. Hemostasis disorder may be secondary consequences of surgical bleeding, preoperative anticoagu...

The objective of this study is to evaluate the incidence and clinical presentation of hypertensive crises in the Emergency medical services of the Community Health Centre "Dr. Mustafa Šehović" Tuzla in relation to age, sex, duration and severity of hypertension, as well as the prevalence of accompanying symptoms and clinical manifestations. The stu...

Many malignancies in elderly population are firstly presented by spine metastases. Taking into account the complexity of metastatic diseases, it is very important to complete tumor staging and determine its pathohistology. In this paper, we present a group of patients on which a percutaneous biopsy of tumor at the Department of orthopedics and trau...

The aim of this study was to evaluate a frequency and clinical presentation of hypertension crises due to age, gender, duration and seriousness at Emergency Medical Service Department of the "Dr Mustafa Šehovic" Health Care Center Tuzla. The research was conducted in the period between November 2009 and April 2010 and involved 180 examinees of both...

nal graft function, there are a number of other risk factors that significantly influence survival of the transplanted kidney. Some of these factors are especially important in the immediate postoperative course, among the factors that are of great importance for graft survival, are donor age, recipient hypertension, immunosuppressive therapy, degr...

Introduction: The aim of this research was to compare specifi city and sensitivity of Color Doppler ultrasonographywith CT angiography.Methods: A total of one hundred patients suffering from carotid artery disease (n=200) were tested in this research in the period from June till October, 2011. Average age of the patients was 61.5 years, and most of...

Introduction: Metabolic syndrome is associated with a significantly increased risk of morbidity and mortality. Objective: To assess incidence of the metabolic syndrome in patients of the Team 1 in the Family Medicine centre in Kalesija through the medical audit. Patients and methods: We have analyzed the medical records of all the patients with Team...

Aim of this study was to recognize differences in long-term clinical outcome after femoral neck fracture and hip endoprosthesis implantation. Total of 145 patients were examined, 32 patients with unipolar, 70 with bipolar and 43 patients with total hip endoprosthesis. The mean values of Harris hip score, after 3.8 ± 1.9 years, were: 72.1 ± 17.8, 74...

This study was aimed at investigating the vascular risk factors in stroke patients. It highlighted unfavorable trends in stroke mortality in the region gravitating towards the general hospital in Doboj. The study included all patients hospitalized with the diagnosis of first stroke and their main vascular risk factors were explored, both in terms o...

This paper documented research revealed unfavorable trends the prevalence of stroke in the region which is linked to the general hospital in Doboj. In a research study conducted in 2010 included all patients who were hospitalized with a diagnosis of acute stroke. Registered epidemiological data were analyzed from the point of incidence between the...

The aim of this work is to measure clinically important dimensions of thoracic and lumbal vertebras. Charts of one-hundred and seventeen patients with implanted internal fixateur on the thoracic and lumbal spine between 01.01. 2008. and 31.3.2010. at the Department for Orthopedics and Traumatology, of the Sarajevo Clinical center were retrieved, an...

From all deceases and injuries of femur, most surgical, medical, social and economical difficulties and problems are created by deceases and fractures of femur neck. Aims of this research lie in the value of surgical approach (Hueter, Mooro and Gibson's) when anchoring hip endoprosthesis. The following parameters were analyzed: Harris Hip Score bef...

Background: Patients with high blood pressure are common problem in everyday practice of family medicine. In the evaluation of patients with high blood pressure, family physician has clearly defined objectives such as: detection and confirmation of hypertension, detection of target organ damage, identification of other risk factors for cardiov...

We read with great interest the editorial article by Meshikhes AWN published in issue 25 of World J Gastroenterol 2011. The article described the advantages of emergency laparoscopic appendectomy compared with interval appendectomy as a new safe treatment modality for the appendiceal mass. The author concluded that the emergency laparoscopic append...

Anatomical variations of veins often play a crucial role in formation of thrombotic changes in superficial and deep veins of lower extremities. THE AIM of this study was to determine the frequency of the dominant type of the lower extremity superficial veins, and to determine the eventual influence of such variations to the formation of superficial...

The aim of this study was to establish Gastrointestinal Life Quality Index scores of patients before and after laparoscopic and open cholecystectomy comparing scores after both operations. The 120 patients were involved in this prospective study, 51 male and 69 female, 59 of patients were underwent by laparoscopic method and rest of them, 61, by op...

Prediction of the need for therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in patients with suspected choledocholithiasis (CDL) remains a challenging task. We aimed to evaluate the predictive value of biochemical and ultrasound parameters and to create a corresponding model for prediction of the need for therapeutic ERCP. 203 cons...

Introduction and aim: Diabetes mellitus type 2 (DM-2) is a major cause of chronic kidney disease (CKD), which is the final stage of kidney failure. In the United States, diabetes is the most common cause and the reason almost half of new cases of kidney failure. To investigate the efficacy of family physicians in assessing the level of risk, p...

Background. Heart failure is a common disease that requires frequent and long hospitaliza-tions, the active participation of health workers and famil/ members in the care of such pa-tients, and it leads to reduction of physical activity and lifest/le changes with the patient, which significantl/ affects the quality of life of patients with heart fa...

Background. Disorder of hemostasis in hemodialysis patients is focused in two directions, towards the development of thrombosis and bleeding. Both complications make it difficult to treat and are life-threatening for the patient. Monitoring of hemostatic parameters, it is possible to detect the first changes in the coagulation system and correct th...

Endothelin 1 (ET-1) is vasoactive peptide that acts via ET-A receptors coupling inducing vascular smooth muscle cell proliferation and contraction. ET-1 is involved in the development and maintenance of hypertension. Aim of this study was to determine the contribution of Ras farnesyl transferase, mitogen activated protein kinase (MAP kinase) and cy...

Introduction Emotional experience of catastrophic trauma reflects itself in form of inability to start and maintain social contact, to cope with stress and sometimes distorted cognitive outages. Objectives To test hypothesis that facially expressed emotions were useful monitor in practice as mediator for understanding nature of emotional difficulti...

Background and aim: Osteoarthritis of the knee is a degenerative rheumatic disease that can lead to major disability, including immobility and dependence on someone else's help. The aim of this study was to determine the effect of physical therapy on functional ability in patients with osteoarthritis of the knee using Womac index. Methods: The stud...

Introduction: Antibiotic prophylaxis is defined as the use of antimicrobials in the absence of symptoms of infection, with the aim of preventing or reducing the incidence of infection after surgery. Aim: We analyzed the incidence of surgical wound infection in patients in whom a protection of hemoprophylaxis conducted using cefazolin and gentamicin...

Introduction: Monitoring of iron is required in HD patients and is based on an assessment of three main factors: the determination of serum ferritin, transferrin saturation, and percentage of hypochromatic erythrocytes. Recent research highlights the importance of hemoglobin content in reticulocytes (CHr) as a sensitive and specifc marker of iron d...

Objective: To determine the quality of life in patients with heart failure in accordance to severity of clinical features. Respondets and methodology: Using a sectional study the quality of life of 120 patients suffering from heart failure was analyzed, both genders and all age groups in accordance with severity of clinical features. Respondents we...

The adolescent idiopathic scoliosis - AIS over 40 degrees measured by Cobb, are treated by surgery. Most frequently are used corrective spondylodesis by Harrington (with hooks), by Luqe (with wires), anterior spondylodesis (with transcorporal screws). In last two decades, the posterior corrective spondylodesis by transpedicular screws is popularize...

Unlabelled: Pancreatic tumor is one with the worst prognosis of all cancers, and the tenth most frequent cancer in Europe, making the 3% of all cancers affecting both sexes. Most patients seek treatment when the disease is in its advanced stage and the level for possible resectability is low. Late presentation of the disease is responsible for the...

Background: Acute abdominal pain is frequent and common problem in the practice of family medicine. It can be, and usually is only transient, but often it is the sign and symptom of a serious and severe disorder, which requires surgical intervention. Objective: To analyze the evaluation efficiency of acute abdominal pain in the practice of family...

Aim(s) or purpose: to examine the diagnostic accuracy with a review, undertaken in the family medicine practice in patients with abdominal pain. Design and method: We retrospectively analyzed two groups of 30 patients of team 1 from Family Medicine health Center Kalesija, who came to a medical examination in the clinic in 2009 due to abdominal...

Aim(s) or purpose: to investigate the spread of certain musculoskeletal problems in women with type 2 diabetes, comparing to women without diabetes. Design and method: during the 2009 we analyzed some musculoskeletal problems in 38 women with type 2 diabetes who were over 50 years old, which have been treated in family medicine team 1 of healt...

The aim of the study was to present and evaluate the long-term results of percutaneous catheter drainage (PCD) in the treatment of symptomatic pancreatic pseudocysts (PPC). We performed a retrospective analysis of 128 patients with 140 PPC treated by PCD from 01/01/1989 to 12/31/2008. All procedures were performed under ultrasound control. Surgical...

Endothelins (ETs) are a family of three peptides (ET-1, ET-2, ET-3) that are implicated in the physiological control of vascular smooth muscle cell (VSMC) and myocardial contractility and growth. ET-1 is vasoactive peptide that acts via ET-A receptors coupling inducing vascular smooth muscle cell contraction. ET-1 is involved in the development and...

Aim: The prognostic value of circulating antibodies to oxidized low-density lipoprotein (anti-oxLDL) in patients with coronary heart disease is not completely clear. We aimed to investigate the association between levels of anti-oxLDL in three groups of patients with different grades of severity of coronary heart disease. Patients and methods: The...

Introduction: Micro-vascular complications of diabetes in men damage urinary bladder function leading to chan- ges in excitability detrusora and contractility damage, and myopathy appearance of urethral obstruction and ir- ritation symptoms and other urological symptoms. Aims and purpose: To investigate the function of the urinary bladder, specifi...

Introduction: couples who experience fertility problems should be treated with a multidisciplinary approach, with team of specialists. Family medicine physician's office, with empathy, approach oriented toward the patient and in one place, makes diagnosis of possible causes of infertility easier and faster, and increases the efficiency and effec...

Background and Purpose: Investigations of the larynxes in thyrty infants during the first year of life of both sexes, randomized trial, were performed by morphological and histologic analysis. Morphometric parameters of the larynx as: length (anterolateral parameter), width (transverse parameter) and thickness (anteroposterior parameter) were deter...

Increasing gap between demand and availability of human kidneys for transplantation has forced a re-evaluation of the limits on donor age acceptability. The present study included 74 patients who underwent kidney transplantation in University Clinical Centre Tuzla. In an observational cohort study we assessed impact of donor age on post transplant...

Urinary tract infections (UTI) cause a great number of morbidity and mortality. These infections are serious complications in pregnancy, patients with diabetes, polycystic kidneys disease, sickle cell anaemia, kidney transplant and in patients with functional or structural anomalies of the urinary tract. The aim of this investigation was to determi...

Increasing gap between demand and availability of human kidneys for transplantation has forced a re-evaluation of the limits on donor age acceptability. The present study included 74 patients who underwent kidney transplantation in University Clinical Centre Tuzla. In an observational cohort study we assessed impact of donor age on post transplant...

Background: The necessity to perform a computed tomography (CT) scan in moderately and severely head-injured patients is well established. When referring to mildly head-injured patients there is a wide variation in the indications for obtaining a CT scan in published series. Aim: The aim of this study is to suggest a set of indications for head CT...

Type 2 diabetes mellitus (DM-2) is a metabolic disorder characterized by relative insulin deficiency, insulin resistance and hyperglycemia. DM-2 is a high risk of thrombosis. In DM there are changes in hemostasis, decreased fibrinolytic activity and increased thrombogenic risk. Aim of this study was to investigate haemostatic parameters in type 2 d...

The aim of the study was to determine serum levels of matrix metalloproteinase 9 (MMP-9) and high sensitivity C reactive protein (hsCRP) in patients with diagnosis of acute coronary syndrome (ACS). The study included 150 patients divided in three groups: patients with significant coronary artery disease (CAD), patients without significant coronary...

The aim of the study was to determine serum levels of matrix metalloproteinase 9 (MMP-9) and high sensitivity C reactive protein (hsCRP) in patients with diagnosis of acute coronary syndrome (ACS). The study included 150 patients divided in three groups: patients with significant coronary artery disease (CAD), patients without significant coronary...

Urinary tract infection (UTI) is one of the most common infections in children, and usually it appears in early childhood. The aim of this study was to find out the incidence and distribution of urinary tract infections in childhood, and to analyze clinical presentation of urinary tract infections in children. In the retrospective study were includ...

Hepatic resection is the accepted treatment for various liver tumors. Increasing evidence suggests that two factors significantly influence outcome and successfulness of the hepatic resection in patients with HCC in cirrhosis. There are liver function recovery and the degree of inflammation during early postoperative period. Aim of this study was t...

Introduction: Pneumonia is a great cause of illness and mortallity, and it costs a lot. In the USA 10 000 000 people visits the doctor due to pneumonia, 500 000 is hospitalised and 45 000 dies. Goal: To examine the efficiency of family care medicine doctor in risk evaluation, possible development, place of treatment and AB (antibiotic) therapy init...