Farah Wahida Ibrahim

Universiti Kebangsaan Malaysia | ukm · Center for Toxicology & Health Risk Studies (CORE)

Lysosome is a primary degradative organelle and is crucial in cellular homeostasis. A reduction in its function due to ageing has been associated with the development of Alzheimer's disease (AD), a common neurodegenerative disorder characterised by the deposition of neurotoxic amyloid plaque in the brain and cerebral vessel walls. The breakdown of...

Objectives Lysosomal dysfunction could lead to a failure in the degradation process of waste materials, especially for the elimination of aggregated, misfolded and senescence proteins or organelles. Human brain endothelial cells (HBECs) are a part of the blood-brain barrier and any disruption of lysosomal functions could affect the cellular functio...

Objectives: Listening to or memorizing the Quran has been suggested to affect the psychosocial health and well-being of Muslims. Muslims who memorized Quran have a higher quality of life (QoL) and lower anxiety and stress. Hence, this systematic review was conducted to evaluate the studies that assessed the effect of listening to, reciting, or memo...

The increase in the number of Tahfiz schools in Malaysia indicates a high demand from the community for Tahfiz education. Tahfiz schools provide a Quran memorization syllabus as the main part of the curriculum at the primary and secondary levels. There is no holistic module that combines learning and health for Tahfiz students in Malaysia. Huffaz P...

Humans have 24 different types of chromosomes and each chromosome can be identified by its unique characteristics. In a cytogenetics laboratory, analyzing chromosomal characteristics is crucial because it is performed on real patient samples, allowing diseases to be diagnosed directly. However, identification of these chromosomes is difficult to pe...

Asian Conference on Biomedical Research and Laboratory Medicine was organized by three associations: Malaysian Association of Clinical Biochemists (MACB), Association of Scientific Officers Ministry of Health (ASOMH), and Malaysian Biomedical Science Association (MyBIOMED). The conference was held on 24th-25th August 2021 and a workshop on 26th Aug...

Background: In Malaysia, the increasing prevalence of physical inactivity is alarming. The effects of adopting a sedentary lifestyle have led to health problems such as coronary heart disease and type II diabetes mellitus, as well as increased mortality rates. Young adults, including tahfiz students, tend to be physically inactive due to much time...

Background: The process of memorizing various reading materials enhances the brain capacity to process, store, and assemble memories and increases the intelligence quotient (IQ) level. However, the connection between the memorization of Quran and the enhancement of memory level is not fully understood. Hence, a cross-sectional study was conducted t...

Numerous attempts have been made to control leptospirosis by using chemoprophylaxis, but with limited success. The present study was done to investigate the antileptospiral potential of hexane, ethyl acetate and methanol extracts of Zingiber zerumbet rhizomes. The extracts were assayed for antileptospiral activity using broth microdilution method a...

Understanding the molecules that are essential for severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) entry can provide insights into viral infection and dissemination. Recently, it has been identified from several studies that angiotensin‐converting enzyme 2 receptor and transmembrane serine protease 2 are the main entry molecules for th...

The aim of the study is to investigate the potential of Ficus deltoidea aqueous extract in protecting the vital organs of female rats against ovariectomy-induced oxidative stress. The rats were grouped into control intact (normal saline), ovariectomized control (OVX), and ovariectomized rats fed orally with 500 mg/kg F. deltoidea extract (OVX+T). U...

Amalan perubatan tradisional terutamanya dari tumbuh-tumbuhan kini diterokai secara saintifik bagi menyelami dan membongkar rahsia alam. Layari : http://ukmpress.ukm.my/index.php?route=product/product&path=93&product_id=1263

Background: Human brain endothelial cells (HBECs) are part of the blood-brain barrier (BBB). BBB acts as a barrier to control the passage of molecules or materials from the blood into the brain. Identification of specific proteins changes in their expressions that are related to disease state is important in order to understand the disease mechanis...

Autofagi adalah proses fisiologi yang terlibat dalam penggantian komponen sel dan berfungsi sebagai mekanisme kelangsungan hidup sementara semasa kebuluran sel akibat kekurangan sumber makanan. Proses ini melibatkan tapak jalan lisosom yang menguraikan bahan yang terdapat dalam sitoplasma seperti organel dan makromolekul. Keberlangsungan proses aut...

Ficus deltoidea var. deltoidea is used as traditional medicine for diabetes, inflammation, and nociception. However, the antimutagenic potential and cytoprotective effects of this plant remain unknown. In this study, the mutagenic and antimutagenic activities of F. deltoidea aqueous extract (FDD) on both Salmonella typhimurium TA 98 and TA 100 stra...

Functional foods such as pomegranate, dates and honey were shown by various previous studies to individually have a neuroprotective effect, especially in neurodegenerative disease such as Alzheimer’s disease (AD). In this novel and original study, an 1H NMR spectroscopy tool was used to identify the metabolic neuroprotective mechanism of commercial...

Kesihatan dan pendidikan merupakan salah satu matlamat utama yang ditetapkan oleh Pertubuhan Bangsa-Bangsa Bersatu (PBB) yang perlu dicapai menjelang tahun 2030. Usaha perlu dilaksanakan bagi memastikan kehidupan yang sihat dan menggalakkan kesejahteraan pada semua peringkat umur. Maka adalah menjadi tanggungjawab kita sebagai masyarakat Malaysia m...

This study aimed to determine the effects of tropical fruit juice mixture (pomegranate, white guava, and Roselle) on biochemical, behavioral, and histopathological changes of β-amyloid- (Aβ-) induced rats. Formulation 8 (F8) of tropical fruit juice mixture was chosen for this present study due to its high phenolic content and antioxidant capacity....

Alzheimer's disease (AD) is a progressive neurodegenerative disease which impairs memory and cognitive function. Currently, AD has no cure and treatments are focused on relieving its symptoms. Several functional plants and foods, such as pomegranate, date fruits, honey, black seeds and figs, possess nutritious properties which alleviate AD. In vitr...

Gout is the most common inflammatory arthritis worldwide. Untreated gout causes severe pain and affects the quality of life. Zingiber zerumbet is a well-known traditional plant with anti-inflammatory and antioxidant properties. This study was conducted to evaluate the effects of Z. zerumbet extract in gout-induced rats. In this study, 30 male Sprag...

ABSTRAK Hafazan Al-Quran merupakan salah satu amalan keagamaan dalam kalangan umat Islam yang dilaporkan dapat memberi impak positif di dalam diri seseorang. Namun pembuktian secara saintifik berkaitan impak hafazan Al-Quran masih belum menyeluruh. Oleh itu, kajian ini bertujuan untuk mengenalpasti impak hafazan Al-Quran terhadap kesejahteraan fizi...

Zingiber zerumbet is a plant that is traditionally consumed in many countries, including Malaysia due to its therapeutic properties. Previously it has been proven to inhibit migration and proliferation of cancer cells. However, its effects on normal cells are still unknown and would be the main focus of this study. The cytotoxicity along with proli...

Zingiber zerumbet has been traditionally used as an anti-inflammation and antioxidant agent. The present study investigates the neuroprotective effects of ethyl acetate extract of Z. zerumbet against oxidative stress on paraquat (PQ)-induced Parkinsonism in rats. Forty male Sprague-Dawley rats were divided into five groups: Negative control (normal...

Abstract Background Zingiber zerumbet (L.) Smith belongs to the Zingiberaceae family that is widely distributed throughout the tropics, particularly in Southeast Asia. It is locally known as ‘Lempoyang’ and traditionally used to treat fever, constipation and to relieve pain. It is also known to possess antioxidant and anti-inflammatory activities....

Ficus deltoidea is traditionally consumed by Malay woman to augment labour and hastening parturition. This study was to investigate the phytochemical present and uterotonic activity of F. deltoidea var. Deltoidea (FDD) and F. deltoidea var. Angustifolia (FDA) leaves aqueous extract. FDD and FDA were qualitatively analysed. In uterine contraction ac...

Recently, molecular testing for GJB2 mutations has become the standard of care for the diagnosis of patients with non syndromic hearing impairment of unknown cause. The aims of this study are to determine the association between GJB2 mutation and GJB6 and to report the variation of mutations in deaf students who have heterozygous GJB2. This retrosp...

Hearing loss is one of the most frequent sensory disorders in humans. Haplotype reconstruction is one of the methods used in linkage studies, which can be applied to search for the deaf genes in small families. New mutations will arise on a specific chromosomal haplotype, making it easier to track down the genes involved. Thus, haplotype-based meth...

A Malaysian family with congenital insensitivity to pain with anhydrosis was diagnosed based on clinical symptoms of chronic ulcers, joint deformities, malunited fractures, anhydrosis, and learning disabilities. We detected a compound heterozygous mutation in exon 16: V709L from the mother and G718S from the father. Two novel mutations were identif...

Recent development in tissue engineering has enabled a new approach in tissue repair and reconstructive surgery using patient's own cells. Human nasal septum cartilage is an optimum candidate as a starting material for this purpose. It is essential to understand the basic requirements for monolayer culture expansion of human nasal septum chondrocyt...

Hearing loss is a common sensory deficit in humans. The hearing loss may be conductive, sensorineural, or mixed, syndromic or nonsyndromic, prelingual or postlingual. Due to the complexity of the hearing mechanism, it is not surprising that several hundred genes might be involved in causing hereditary hearing loss. There are at least 82 chromosomal...

Twenty percent of all childhood deafness is due to mutations in the GJB2 gene (Connexin 26). The aim of our study was to determine the prevalence and spectrum of GJB2 mutations in childhood deafness in Malaysia. We analyzed the GJB2 gene in 51 deaf students from Sekolah Pendidikan Khas Alor Setar, Kedah. Bidirectional sequencing indicates that 25%...

This study was to assess collagen type II and collagen type I gene expression in tissue-engineered human auricular: cartilage formed via tissue engineering technique. Large-scale culture expansions were transformed into 3D in vitro construct and were implanted subcutaneously on the dorsal of athymic mice. After 8 weeks, explanted construct was proc...