Fanuel Lampiao

Fanuel Lampiao
Kamuzu University of Health Sciences · Biomedical Sciences

BEd (Science) BSc (Hons) MSc PhD PGD (Bioethics)

About

70
Publications
23,975
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
582
Citations

Publications

Publications (70)
Article
Full-text available
Male genital schistosomiasis (MGS) is hypothesized to increase seminal shedding of HIV-1. This prospective pilot study assessed seminal HIV-1 RNA shedding in men on long-term ART with and without a diagnosis of MGS. Study visits occurred at 0, 1, 3, 6 and 12 months. MGS was diagnosed by egg positivity on semen microscopy or PCR of seminal sediment....
Article
Background: Male genital schistosomiasis (MGS) is an underappreciated complication of schistosomiasis, first described in 1911. However, its epidemiology, diagnostic testing and case management are not well understood in sub-Saharan Africa. To shed new light on MGS prevalence in Malawi, a longitudinal cohort study was conducted among adult fisherm...
Thesis
Infectious diseases accounts for approximately one-half of deaths that occurs in tropical countries including Malawi and majority of people in these countries use traditional medicine for PHC. Therefore, the purpose of the present study was to investigate the antimycobacterial and antiviral activities of extracts and compounds isolated from Aeschyn...
Article
Background Dyslipidaemia is a significant risk factor for cardiovascular events but is often neglected in most resource-poor settings. Aim We aimed to investigate the prevalence, biochemical characteristics, screening and management practice for dyslipidaemia among patients with DM, hypertension, and both DM and hypertension at a tertiary teaching...
Article
Background Dyslipidaemia, obesity and vitamin D insufficiency are important risk factors for cardiovascular disease and may increase the risk for severe COVID-19 among individuals with Diabetes mellitus. Objective To investigate the prevalence of dyslipidaemia, obesity and vitamin D insufficiency among patients attending the diabetes clinic at Que...
Article
Full-text available
Schistosome eggs cause granulomata and pathological abnormalities, detectable with non-invasive radiological techniques such as ultrasonography which could be useful in male genital schistosomiasis (MGS). As part of our novel MGS study among fishermen along Lake Malawi, we describe pathologies observed on ultrasonography and praziquantel (PZQ) trea...
Article
Full-text available
Background: The study was aimed at screening phytochemicals and evaluating the effects of aqueous and 50% (v/v) methanol stem bark extracts of Newtonia hildebrandtii on male rat reproductive system. Materials and Methods: Thirty male Wistar rats were divided into five groups and were given different treatments of N. hildebrandtii extracts at 200 an...
Preprint
Full-text available
Background: Male Genital Schistosomiasis (MGS) is hypothesized to increase seminal shedding of HIV-1 RNA. We aimed to assess the impact of MGS on genital HIV-1 RNA shedding by longitudinally measuring HIV-1 RNA levels in men established on long-term ART comparing those with and without a diagnosis of MGS. Methods: Following optimisation of the Gene...
Preprint
Full-text available
Background Male Genital Schistosomiasis (MGS) is hypothesized to increase seminal shedding of HIV-1 RNA. We aimed to assess the impact of MGS on genital HIV-1 RNA shedding by longitudinally measuring HIV-1 RNA levels in men established on long-term ART comparing those with and without a diagnosis of MGS. Methods Following optimisation of the GeneXp...
Article
Full-text available
Background: The aim of this prospective study was to ascertain antimicrobial resistance (AMR) in clinical bacterial pathogens from in-hospital adult patients at a tertiary hospital in Lilongwe, Malawi. Methods: Clinical specimens (blood culture, pus, urine and cerebrospinal fluid) collected during June to December 2017 were examined for bacteria...
Chapter
SARS-CoV-2 is a well-known viral strain that causes COVID-19. The disease became a pandemic in early 2020 and infected millions of people and killed hundreds of thousands of people worldwide. Vaccine development against the disease was accelerated with multiple collaborations among research institutions in order to shorten the duration that vaccine...
Article
Ethnopharmacological relevance: Medicinal plants are used to manage and treat epilepsy in Malawi because of traditional beliefs and barriers to conventional anti-seizure drugs. Among the plants prescribed by traditional medical practitioners are Margaritaria discoidea, Dalbergia boehmii, Dalbergia nitidula, Catunaregam spinosa, and Lannea discolor...
Article
Cervical cancer has limited treatment options and people have been resorting to herbal medicines in Malawi and worldwide. However, there are limited data in the published literature on medicinal plants used for cervical cancer in Malawi. This study documented medicinal plants for managing cervical cancer in Zomba district. This cross-sectional ethn...
Poster
Full-text available
Natural products (NPs) have been at the centre of attention in drug discovery. For the past decade, several NPs databases from the African continent have been compiled and made available to encourage in silico drug discovery. The aim of this work was to characterize the chemical diversity of drug-like NPs from four African natural product databases...
Article
Mycobacterium tuberculosis remains one of the world's contributors to mortality. With the emergence of SARS-CoV-2 coinfections, patients with TB are predisposed to getting COVID-19 disease. The severity of the disease coupled with drug resistance on the currently used drugs warrants for the search for alternative remedies from plants. Africa is ric...
Article
Full-text available
Male genital schistosomiasis (MGS) is an often-overlooked chronic consequence of urogenital schistosomiasis (UGS) associated with Schistosoma haematobium eggs and associated pathologies in the genital system of afflicted men. Despite the first formal description of MGS in 1911 by Madden, its epidemiology, diagnostic testing and case management of t...
Article
Full-text available
Zn2+ is an essential regulator of coagulation and is released from activated platelets. In plasma, free Zn2+ concentration is fine-tuned through buffering by human serum albumin (HSA). Importantly, the ability of HSA to bind/buffer Zn2+ is compromised by co-transported non-esterified fatty acids (NEFAs). Given the role of Zn2+ in blood clot formati...
Chapter
Full-text available
Phytopharmaceuticals are plant-derived compounds that have pharmacological activities. They make up a good part of drugs made from plant-based molecules as opposed to synthetics. Phytopharmaceuticals are accessed in form of whole fruits, purees, vegetables, prepacked fruits, and/or vegetable products and supplements. They play essential roles in th...
Article
Full-text available
Background Anti-retroviral therapy (ART) is associated with low bone mineral density (BMD) among people living with HIV (PLWHIV). Although physical activity is recommended for improving bone health in patients with reduced BMD, data on effects of strength exercises on low BMD among PLWHIV is scarce. This study therefore aimed to determine the effec...
Chapter
Full-text available
Production of functional foods requires ensured food safety and understanding of good manufacturing practices (GMP). Good manufacturing practices provide harmony to all sections of the facility in working towards food safety. There is always a systematic link among food quality, safety and every activity before, during and after processing starting...
Article
Introduction A lot of unsubstantiated claims have been made regarding the ability of Cassia abbreviata Oliv. to promote male reproductive function. The study was aimed at evaluating the effects of aqueous and 50% (v/v) methanol stem bark extracts of Cassia abbreviata Oliv. on hormonal levels, sperm parameters, testicular histo-architecture, mean bo...
Article
Aim The present study was aimed at screening phytochemicals of Dioscorea bulbifera extracts and evaluating its effects on male rat reproductive system. Background Since ancient times, man has found a lot of health benefits from medicinal plants. According to the World Health Organisation (WHO) about 80% of the world population depends on tradition...
Article
Full-text available
Eichhornia crassipes has been reported to have various medicinal properties including anticancer activities. The plant was collected from the Shire river in Malawi, and two cytotoxic compounds, benzene-1,4-diol and nonanedioic acid, were isolated and characterized for the first time in the leaves and roots of the plant. 1H NMR, COSY, HSQC, HMBC, 13...
Article
Full-text available
Background: Seminal hyperviscosity has been shown to be associated with male infertility. The aim of this study was to assess the prevalence of hyperviscosity in semen of Malawian males seeking infertility treatment. Methods: A total of 120 men visiting our laboratory for fertility assessment donated semen samples. The semen samples were assesse...
Article
Full-text available
Introduction Despite increasing life expectancy among people living with HIV (PLWHIV), anti-retroviral therapy (ART) side effects, HIV chronic inflammation and co-morbidities may limit functional abilities and reduced participation in exercises and physical activity (PA). PA improves wellbeing and overall quality of life of PLWHIV. In Malawi, there...
Article
Full-text available
Introduction Use of tenofovir based anti-retroviral therapy (ART) in HIV patients is associated with low bone mineral density (BMD). Low BMD predisposes people living with HIV (PLWHIV) to fractures thereby increasing morbidity and mortality. Since the introduction of tenofovir based ARV regimens in 2011, information on the prevalence of low BMD in...
Article
Full-text available
Cancers remain one of the leading causes of death in the world. However, known conventional cancer medicines remain scarce, expensive and out of reach to many patients. To provide an alternative for the expensive therapies, plants are proving to have potential to lead to the development of more drugs against cancers. In this work, we aimed at isola...
Article
Full-text available
Diarrhoea is one of the most common infections that under-five children suffer from across the world. Antibiotics remains one of the common measures used to treat the infection, which has led to increased usage; nevertheless, the extent to which an individual is prompted to use antibiotics in managing diarrhoea in the Malawian setting is not clearl...
Article
Urogenital schistosomiasis causes morbidity within the genitalia but is underreported and infrequently examined in men. To draw attention to male genital schistosomiasis (MGS), a longitudinal cohort study was conducted among fishermen along the southwestern shoreline of Lake Malawi. A case series of five participants is presented inclusive of quest...
Preprint
Full-text available
Zn ²⁺ is an essential regulator of coagulation and its availability in plasma is fine-tuned through buffering by human serum albumin (HSA). Non-esterified fatty acids (NEFAs) transported by HSA reduce its ability to bind/buffer Zn ²⁺ . This is important as plasma NEFA levels are elevated in type-2 diabetes mellitus (T2DM) and other diseases with an...
Article
Full-text available
We provide an update on diagnostic methods for the detection of urogenital schistosomiasis (UGS) in men and highlight that satisfactory urine-antigen diagnostics for UGS lag much behind that for intestinal schistosomiasis, where application of a urine-based point-of-care strip assay, the circulating cathodic antigen (CCA) test, is now advocated. Ma...
Article
Introduction Medicinal plants and ethnomedicinal studies continue playing a significant role in herbal products development and traditional knowledge conservation. Calls for ethnomedicinal studies have increased recently to unleash the potential in medicinal plants and document verbal traditional knowledge. This study recorded the medicinal plants...
Article
Full-text available
Introduction Medicinal plants and ethnomedicinal studies continue playing a significant role in herbal products development and traditional knowledge conservation. Calls for ethnomedicinal studies have increased recently to unleash the potential in medicinal plants and document verbal traditional knowledge. This study recorded the medicinal plants...
Article
Full-text available
The high burden of disease in Malawi is exacerbated by a lack of healthcare professionals, and the inaccessibility of healthcare services to many Malawians, due to geographical and financial barriers. The World Health Organization commends the contribution that traditional and complementary medicine could make to achieve such coverage through its i...
Article
Full-text available
Antioxidants, as natural compounds have been documented to possess scavenging abilities which helps in fighting body infections.Therefore, the aim of this study was to analyse the phytochemical constituents and antioxidant potential of some medicinal plants reported to possess anti-viral activity in Malawi. The antioxidant potentials of Aeschynomen...
Conference Paper
Full-text available
Medicinal plants and ethnomedicinal studies continue playing a significant role in the discovery of pharmaceuticals, nutraceuticals and cosmeceuticals. Calls for ethnomedicinal studies have increased recently to unleash the potential in medicinal plants and document majorly verbal traditional knowledge. This study was aimed at recording the ethnome...
Article
Full-text available
Male genital schistosomiasis (MGS) is a gender specific manifestation of urogenital schistosomiasis (UGS) first described in 1911 by Madden in Egypt. Today, while affecting millions of men and boys worldwide, MGS receives insufficient attention, especially in sub-Saharan Africa (SSA). To provide a systematic review with an epidemiological update of...
Article
Full-text available
Eichhornia crassipes is reported to have molecules that are active against liver, cervical, breast cancers and melanoma cells. This systematic review was conducted according to Cochrane hand book of systematic review and guidelines for systematic reviews aiming to explore the potential that the plant has in providing drug leads against cancer. The...
Article
Full-text available
Background: The use of traditional remedies in pregnancy has been associated with bad obstetric outcomes including uterine rupture and foetal distress. These outcomes may ultimately lead to maternal and child mortality or morbidity. Few studies have been done to measure the effects of various herbs in pregnant women or a developing fetus. This stu...
Article
Full-text available
Low bone mineral density is becoming more common among people living with HIV following the use of current antiretroviral therapy drugs such as tenofovir. Although pharmacological therapies used to treat low bone mineral density are associated with adverse effects and may increase the pill burden in people living with HIV who are already burdened b...
Article
Full-text available
Background: Kigelia africana fruit powder is being sold in Malawian retail pharmacies for the purported purpose of lowering blood sugar in diabetic patients when there is scant data on its hypoglycaemic activity. This study was aimed at evaluating the hypoglycaemic potential of the Kigelia africana fruit powder being sold in Malawian retail pharmac...
Article
Aim The purpose of this study was to evaluate the semen profiles of bicycle taxi cyclists and healthy controls in Mangochi district, Malawi. Methods Semen samples were collected from young bicycle taxi cyclists after two to three days of sexual abstinence. A control group, comprising young men who were not bicycle taxi operators also submitted seme...
Chapter
Male infertility is caused by a variety of factors including anatomical and genetic abnormalities, but it is estimated that over 30 % of male infertility is of an unknown cause. The most likely contributors to idiopathic male infertility are life style and environmental factors such as poor diet, insufficient physical activity, exposure to toxins,...
Article
Full-text available
Background: Coitus interruptus has been practiced since ancient times. Despite the development of other modern contraceptive methods, coitus interruptus is still practiced by people of all ages but commonly among adolescents. Aim: This mini review highlights recent research findings about coitus interruptus and the debate of whether spermatozoa exi...
Article
AIM: To profile semen parameters of Malawian men seeking fertility testing. METHODS: Semen analysis is a key element in the fertility evaluation of men and permits male reproductive potential to be evaluated. Semen samples were collected from consenting men after 3-5 d of sexual abstinence. The samples were collected from 130 males; 78 were male pa...
Article
Chinese aphrodisiacs have become popular remedy for sexual dysfunction and improvement of libido in men in Malawi. However, selling of these drugs seems not to be well regulated. Probably the aphrodisiacs that are currently on the market have unknown efficacy, potency and safety profiles. The aim of this study was to assess the efficacy of imported...
Article
Full-text available
A bulk of contraceptives on the market is women-oriented today. The aim of this study was to investigate the effect of a medicinal herb, Acacia nilotica on various parameters of male fertility using a rat model. Male Wistar rats (n = 40) were randomly divided in to two groups. One group received Acacia nilotica, while the other acted as controls. T...
Article
Full-text available
Aim This study was aimed at assessing knowledge and attitude to semen donation among male students at the College of Medicine. Methods A semi-structured questionnaire survey of students doing Pre-Medical Sciences, MBBS, Pharmacy, Physiotherapy, and Medical Laboratory Science degrees at the College of Medicine. There were 180 respondents who took pa...
Article
Background: Erectile dysfunction has been found to have strong associations with chronic cardiovascular conditions like hypertension and diabetes. We sought to establish if erectile dysfunction can be used as an early marker of chronic conditions i.e., diabetes mellitus and hypertension in a rural setting in Malawian District of Blantyre. Methods:...
Article
In the past decades, a lot of advances in understanding the biochemistry and physiology of the pineal gland have been made. There is evidence that it interacts with many endocrine as well as non-endocrine tissues to influence their metabolic activity modulating many organs and functions. Melatonin is secreted by the pineal gland in the brain and pl...
Article
Full-text available
Several studies report an increase in both male and female factors in infertility worldwide. In recent years there has been a tremendous increase in couples seeking assisted reproductive technology (ART) procedures in order to have children. However, the success rates of these procedures still remain very low. One of the major contributing factors...
Article
Full-text available
For a very long time, family planning methods have paid little attention to the needs of men, but instead focused primarily on women. A bulk of contraceptives on the market today is women oriented. Probably, many providers assume that women have the greatest stake and interest as far as family planning is concerned. Worst still, there is a misconce...
Article
For a very long time, family planning methods have paid little attention to the needs of men, but instead focused primarily on women. A bulk of contraceptives on the market today is women oriented. Probably, many providers assume that women have the greatest stake and interest as far as family planning is concerned. Worst still, there is a misconce...

Network

Cited By