Falk Lüsebrink

Falk Lüsebrink
Otto-von-Guericke-Universität Magdeburg | OvGU · Institute of Physics (IfP)

PhD

About

34
Publications
4,056
Reads
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542
Citations
Introduction
I am working on the acquisition and processing of structural ultrahigh resolution in vivo MRI data and prototyping of layer fMRI in humans.
Additional affiliations
October 2021 - present
Otto-von-Guericke-Universität Magdeburg
Position
  • Research Associate
September 2018 - June 2021
Otto-von-Guericke-Universität Magdeburg
Position
  • Research Associate
Description
  • Clinical standardized MR imaging; Automated quality control
January 2018 - September 2019
Otto-von-Guericke-Universität Magdeburg
Position
  • Research Associate
Description
  • Teaching; Acquisition and processing of ultrahigh resolution imaging data
Education
November 2013 - June 2020
October 2010 - May 2013
Otto-von-Guericke-Universität Magdeburg
Field of study
  • Medical Systems Engineering
October 2006 - September 2010
Hochschule Koblenz
Field of study
  • Medical Technology and Sports Medical Technology

Publications

Publications (34)
Article
Subject motion in MRI is a relevant problem in the daily clinical routine as well as in scientific studies. Since the beginning of clinical use of MRI, many research groups have developed methods to suppress or correct motion artefacts. This review focuses on rigid body motion correction of head and brain MRI and its application in diagnosis and re...
Article
Full-text available
We present an ultrahigh resolution in vivo human brain magnetic resonance imaging (MRI) dataset. It consists of T1-weighted whole brain anatomical data acquired at 7 Tesla with a nominal isotropic resolution of 250 μm of a single young healthy Caucasian subject and was recorded using prospective motion correction. The raw data amounts to approximat...
Conference Paper
Full-text available
Denosing of MR data during image reconstruction in complex domain prior to channel combination gives better results compared to denoising magnitude images after reconstruction. In this study we compare 'BM4D' with two settings and the pre-trained neural network 'DnCNN'. The reconstruction pipeline is shared on Github.
Article
Full-text available
Here, we present an extension to our previously published structural ultrahigh resolution T 1 -weighted magnetic resonance imaging (MRI) dataset with an isotropic resolution of 250 µm, consisting of multiple additional ultrahigh resolution contrasts. Included are up to 150 µm Time-of-Flight angiography, an updated 250 µm structural T 1 -weighted re...
Article
The noradrenergic locus coeruleus (LC) in the brainstem shows earliest signs of protein pathologies in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Its small size (about 3‐4mm in width and 15 mm in length) makes it less suitable for Positron Emission Tomography (PET) investigations, so the past decade has seen a steep ris...
Preprint
Full-text available
The noradrenergic locus coeruleus (LC) in the brainstem shows early signs of protein pathologies in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. As the LC’s small size (approximately 2.5 mm in width) presents a challenge for molecular imaging, the past decade has seen a steep rise in structural and functional Magnetic Res...
Article
Full-text available
Primary visual cortex (V1) in humans is known to represent both veridically perceived external input and internally-generated contents underlying imagery and mental rotation. However, it is unknown how the brain keeps these contents separate thus avoiding a mixture of the perceived and the imagined which could lead to potentially detrimental conseq...
Data
Here, we present an extension to our previously published structural ultrahigh resolution T1- weighted magnetic resonance imaging (MRI) dataset with an isotropic resolution of 250 µm, consisting of multiple additional ultrahigh resolution contrasts. Included are up to 150 µm Time-of-Flight angiography, an updated 250 µm structural T1-weighted recon...
Data
Here, we present an extension to our previously published structural ultrahigh resolution T1- weighted magnetic resonance imaging (MRI) dataset with an isotropic resolution of 250 µm, consisting of multiple additional ultrahigh resolution contrasts. Included are up to 150 µm Time-of-Flight angiography, an updated 250 µm structural T1-weighted recon...
Preprint
Full-text available
Primary visual cortex (V1) in humans is known to represent both veridically perceived external input and internally-generated contents underlying imagery and mental rotation. However, it is unknown how the brain keeps these contents separate thus avoiding a mixture of the perceived and the imagined which could lead to potentially detrimental conseq...
Article
The locus coeruleus‐norepinephrine system (LC‐NE system) supports the process of encoding of emotionally salient events. LC integrity varies in healthy elderly and is associated with altered cognitive functions in aging. Post‐mortem as well as structural indicators suggest that the modulation of the LC‐NE system is reduced in elderly. This reductio...
Article
Postmortem studies show that the locus coeruleus (LC), the major source of cortical noradrenergic projections, exhibits evidence of neurodegeneration early in Alzheimer’s disease (AD). Indeed, the noradrenergic system is more affected than the dopaminergic or cholinergic ones. Albeit to a smaller extent, neuronal loss in the LC is also seen in cogn...
Conference Paper
Full-text available
Following the DOI, you can download the entire dataset: https://doi.org/10.24352/UB.OVGU-2020-145 Here, we present an extension to our previously published structural ultrahigh isotropic resolution T1-weighted magnetic resonance imaging (MRI) dataset, consisting of multiple additional high quality contrasts. Included are up to 150 μm Time-of-Fligh...
Article
Full-text available
Purpose Publicly available data provision is an essential part of open science. However, open data can conflict with data privacy and data protection regulations. Head scans are particularly vulnerable because the subject’s face can be reconstructed from the acquired images. Although defacing can impede subject identification in reconstructed image...
Thesis
Full-text available
To quantify brain structures, usually in vivo T1-weighted magnetic resonance imaging data is usually acquired with an isotropic resolution of 1 mm and occasionally of up to 500 μm in clinical and neuroscientific studies. Based on these data the orthological development of the brain or the progression of neurodegenerative as well as psychiatric diso...
Conference Paper
Full-text available
Here, we present a reconstruction pipeline written in MATLAB® to reconstruct raw MRI data. Image reconstruction at the scanner’s console is to some extend a black box and no offline out-of-the-box image reconstruction pipeline is publicly available. While e.g. Gadgetron1 and BART2 exists, they do offer a set of tools to reconstruct data rather than...
Article
Full-text available
Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. In combination with neuropathological bi...
Article
Purpose Recent literature has shown the potential of high‐resolution quantitative susceptibility mapping (QSM) with ultra‐high field MRI for imaging the anatomy, the vasculature, and investigating their magnetostatic properties. Higher spatial resolutions, however, translate to longer scans resulting, therefore, in higher vulnerability to, and like...
Conference Paper
Full-text available
In this work we investigate potential pitfalls in processing high and ultra-high resolution MRI data with FreeSurfer at two important stages of its processing pipeline: the skull stripping and surface generation.
Article
Purpose: Higher magnetic field strengths enable time-of-flight (TOF) angiography with higher resolution to depict small-vessel pathologies. However, this potential is limited by the subject's ability to remain motionless. Even small-scale, involuntary motion can degrade vessel depiction, thus limiting the effective resolution. The aim of this stud...
Conference Paper
Full-text available
Bias field correction is an essential prerequisite for image analysis, especially at high field strength. In this study multiple correction methods – based on acquisition of a reference image and computational approaches are compared. The results indicate that acquisition of an MPRAGE corrected by SPM yields comparable results to acquiring a refere...
Article
Full-text available
Scientific Data 4:170032 doi: 10.1038/sdata.2017.32 (2017); Published 14 March 2017; Updated 9 May 2017 The original HTML version of this Data Descriptor incorrectly included Oliver Speck’s name in the Data Citations as ‘Speck, C.’ instead of ‘Speck, O.
Data
We present an ultrahigh resolution in vivo human brain magnetic resonance imaging (MRI) dataset. It consists of T1-weighted whole brain anatomical data acquired at 7 Tesla with a nominal isotropic resolution of 250 μm of a single young healthy Caucasian subject and was recorded using prospective motion correction. The raw data amounts to approximat...
Data
We present an ultrahigh resolution in vivo human brain magnetic resonance imaging (MRI) dataset. It consists of T1-weighted whole brain anatomical data acquired at 7 Tesla with a nominal isotropic resolution of 250 µm of a single young healthy Caucasian subject and was recorded using prospective motion correction. The raw data amounts to approximat...
Conference Paper
Full-text available
During magnetic resonance imaging (MRI), information about the cardiac activity is required for gating in cardio-vascular MRI (CMR) and for patient monitoring. This can be achieved using electrocardiogram (ECG) signals. However , ECG signals are affected by the different magnetic fields of the MR scanner which can hamper the R-peak detection. Balli...
Article
The amygdala and the hippocampus are two adjacent structures in the medial temporal lobe that have been broadly investigated in functional and structural neuroimaging due to their central importance in sensory perception, emotion, and memory. Exact demarcation of the amygdalo-hippocampal border (AHB) is, however, difficult in conventional structura...
Conference Paper
With increasing field strength a suitable inhomogeneity correction is becoming inevitable to perform for example an accurate structural analysis. It has been shown by Sled et al. that their proposed N3 algorithm is able to significantly improve segmentation and surface extraction. Van de Moortele et al. proposed a method for correcting the inhomoge...
Article
Purpose: The analysis of the human cerebral cortex and the measurement of its thickness based on MRI data can provide insight into normal brain development and neurodegenerative disorders. Accurate and reproducible results of the cortical thickness measurement are desired for sensitive detection. This study compares ultra-high resolution data acqu...
Conference Paper
The analysis of the human cerebral cortex and the measurement of its thickness based on MRI data provide insight into normal brain development and neurodegenerative disorders. Accurate and reproducible results of the cortical thickness measurement are desired. In addition to data processing tools, the quality (i.e. resolution) of the imaging data i...

Projects

Project (1)
Project
Utilizing an ultra-high field strength MR system in combination of prospective motion correction to acquire images beyond high resolution. Currently, we have acquired the highest resolution T1-weighted in vivo full brain MRI as well as time of flight angiography. Data with more contrasts will be acquired within this project.