Falah Mohammad Aziz

Salahaddin University - Erbil | SUH · Department of Biology

Purpose Since nanoparticles (NPs) are beginning to be introduced in medicine and industry, it is mendatory to evaluate their biological side-effects, among other things. The present study aimed to investigate the pathways by which nickel nanoparticles (NiNPs) enter nephrons and to evaluate their localization and effects on cellular ultrastructure....

Ifosfamide IFO) is a cytotoxic alkylating drug used for the treatment of a variety of cancers but has reported to cause certain hematological, hepatotoxic and nephrotoxic side effects. For protection against these side effects, different antioxidants were used. This study is performed to evaluate the ability of omega-3 fatty acids (Omega-3 FAs) to...

The purpose of the present study was to investigate the protective role of omega-3 oil against the toxic effect of cadmium as cadmium chloride (CdCl2) on the liver of male, dams and weanling rats from the histological, ultrastructural and immunohistochemical points of view. Thirty adult male and thirty adult female rats (dams) were used in the pres...

Intentional abuse of anabolic androgenic drugs (AASs) by athletes has been increased rapidly in many countries. Therefore, investigations are needed for studying the adverse effects of these drugs. Administration of three doses of Sustanon 250mg (3, 5 and 10mg/kg.B.wt) which includes four testosterone derivatives and taken by athletes as body build...

Ficus carica L. latex is used traditionally for many therapeutic purposes. Oxidative stress may be the main reason behind most histological and cellular effects of lead. The aim of this study was to investigate the possible hepatoprotective role of Ficus carica L .latex against lead acetate-induced oxidative stress in rats. In the present investiga...

Development of optical nanobiosensors is one of the important priorities especially in the field of biomedical diagnostics science and technology. The application of nanobiosensors has been accelerated with the introduction of plasmonic NPs, which overcome the most of the limitations in the case of conventional optical nanobiosensors. Since the pla...

The widespread antigenic changes lead to the emergence of a new type of coronavirus (CoV) called as severe acute respiratory syndrome (SARS)-CoV-2 that is immunologically different from the previous circulating species. Angiotensin-converting enzyme-2 (ACE-2) is one of the most important receptors on the cell membrane of the host cells (HCs) which...

The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method and their physicochemical propert...

Urolithiasis is a well-known problem that stones could form in various parts of the urinary system and it is the most common disease of the urinary tract. The current study was planned to investigate the effect of radish juice on ethylene glycol (EG)-induced urolithiasis. Twenty-one rats randomly divided into three groups. The first group was the c...

The utilization of AuNPs in therapeutic applications has been accelerated by discovering their catalytic activity consistent with the activity of natural enzymes. However, to reduce unwanted activities, it is imperative to fully understand their catalytic mechanisms to increase efficiency and safety. Therefore, along with other reports, we aimed to...

Cadmium (Cd) is considered to be one of the major environmental pollutants which have potential threat to human health. Reports of declining male fertility have renewed interest in the role of environmental and occupational exposures in the etiology of human infertility. Cd exposure led to obvious degenerative changes in testicular tissue. This stu...

Background: Gold nanoparticles (AuNPs) with unique physicochemical properties have received a great deal of interest in the field of biological, chemical and biomedical implementations. Despite the widespread use of AuNPs in chemical and biological sensing, catalysis, imaging and diagnosis, and more recently in therapy, no comprehensive summary has...

AuNPs with enzyme-like features have received strong attention in different areas, although limited data is available in literature on their biological/industrial functions. NPs especially Au counterparts have been shown to functionally mimic the activity of antioxidant enzyme. Indeed, due to low cytotoxicity and SPR characteristics of AuNPs, there...

In this study, we formulated silymarin-HSA nanoplex and assayed its ability to reduce LPS-induced toxicity in vitro and in vivo. Silymarin molecules were encapsulated into HSA nanoplex and the loading efficiency and characterization of fabricated nanoplex were performed by using HPLC, TEM, SEM, DLS, FTIR analysis, and theoretical studies. Afterward...

Aims Different kinds of vitamins can be used as promising candidates to mitigate the structural changes of proteins and associated cytotoxicity stimulated by NPs. Therefore, the structural changes of α-syn molecules and their associated cytotoxicity in the presence of SWCNTs either alone or co-incubated with vitamin K1 were studied by spectroscopic...

Herein, the interaction of CeO2 NPs with HSA was explored by fluorescence, CD, UV–vis and molecular docking studies. Afterwards, the antioxidant activity of CeO2 NPs against H2O2-induced oxidative stress in BM-MSCs were explored by MTT, ROS and apoptosis assays. Antibacterial assay was also done on two Gram-positive and Gram-negative bacterial stra...

Nickel oxide nanoparticles (NiO NPs) have received great interests in medical and biotechnological applications. However, their adverse impacts against biological systems have not been well-explored. Herein, the influence of NiO NPs on structural changes, heme degradation and aggregation of hemoglobin (Hb) was evaluated by UV-visible (Vis), circula...

Aim Among therapeutic proposals for amyloid-associated disorders, special attention has been given to the exploitation of nanoparticles (NPs) as promising agents against aggregation. Methods In this paper, the inhibitory effect of cerium oxide (CeO2) NPs against α-synuclein (α-syn) amyloid formation was explored by different methods such as Thiofl...

Aim: It has been indicated that NPs may change the amyloidogenic steps of proteins and relevant cytotoxicity. Therefore, this report assigned to explore the impact of ZVFe NPs on the amyloidogenicity and cytotoxicity of α-synuclein as one of the many known amyloid proteins. Methods: The characterization of α-synuclein at amyloidogenic condition eit...

Aim Nanoparticles (NPs) have been receiving potential interests in protein delivery and cell therapy. As a matter of fact, NPs may be used as great candidates in promoting cell therapy by catalase (CAT) delivery into high oxidative stress tissues. However, for using NPs like SiO2 as carriers, the interaction of NPs with proteins and mesenchymal ste...

Enzymes are one of the foundations and regulators for all major biological activities in living bodies. Hence, enormous efforts have been made for enhancing the efficiency of enzymes under different conditions. The use of nanomaterials as novel carriers for enzyme delivery and regulating the activities of enzymes has stimulated significant interest...

Aim It has been indicated that NPs may change the amyloidogenic steps of proteins and relevant cytotoxicity. Therefore, this report assigned to explore the impact of ZVFe NPs on the amyloidogenicity and cytotoxicity of α-synuclein as one of the many known amyloid proteins. Methods The characterization of α-synuclein at amyloidogenic condition eith...

Nanoparticles (NPs) are increasingly used nowadays for nanomedicine purposes, although they have been found to induce harmful effects on human health and living species in the environment. The current study investigated the impact of different doses of nickel nanoparticles (NiNPs) on the rats liver. Intraperitoneal (i.p.) administration of (0, 5, 2...

An ameliorating effect of vitamin C on the toxic effect of meloxicam, a new non-steroidal anti-inflammatory drug was studied by evaluating biochemical parameters, histopathological changes in liver and kidney of mice. A total of forty male mice were divided in four experimental groups each comprising of ten mice Meloxicam toxicity was induced by or...

The method was developed to detect crystals (calcium oxalate) in plant and animal tissues and stain the bacteria by using silver nitrate solution2%. By adding the prepared solution to the bacterial fixed on the slide and leaving it for 10 minutes at room temperature, then expose the slide to ultraviolet light for 30 minutes. Also expose the slide o...

The present investigation dealt with the study of the effect of two doses of lead nitrate (40mg/kg and 80mg/kg) for three weeks on the liver and kidney of the male toad, Bufo viridis. Lead nitrate caused several histological alterations in the studied organs in a dose dependent pattern. The histological alterations included degeneration of hepatocy...

Methomyl is a carbamate broad spectrum insecticide; quickly paralyze the nervous system of insects by blocking the production and action of cholinesterase. The rapid development and sharp increase of using mobile phones by people has led researchers to concern about diverse effects of mobile phone radiofrequency waves exposure on human health, this...

Renal calculi formation is one of the most common urological disorders. Urinary stone disease is a common disease, which affects 10‑12% of the population in industrialized countries. The objective of this study was to investigate the antiurolithiatic and antioxidant activity of fenugreek on ethylene glycol-induced urolithiasis in rats. Twenty male...

The present investigation included the neurotoxic effect of different doses of uranyl acetate in male rats. Routine light and electron microscopic techniques were used in this study. The histological studies of cerebellum and cerebrum showed a significant increase of died and decrease of healthy pyramidal cells in the 3 rd layer of cerebrum and Pur...

The abusing of anabolic androgenic steroids (AASs) athletes have been increased especially in Iraqi Kurdistan region. The present investigation wu acllieved to study the hepatoto:dcity and nephrotoxicity of sustanon which contains four testosterone derivatives in rats. This investigation induded biochemical, histological and wtrutructural observati...

The abusing of anabolic androgenic steroids (AASs) athletes have been increased especially in Iraqi Kurdistan region. The present investigation wu acllieved to study the hepatoto:dcity and nephrotoxicity of sustanon which contains four testosterone derivatives in rats. This investigation induded biochemical, histological and wtrutructural observati...

Both methomyl (a carbamate insecticide) and di-n-butylphthalate (a plasticizer) were found to induce toxicity, but nothing is known about the toxic effect of their combination, although this combination is environmentally possible due to continuous public use. The present investigation was designed to study the histological effect of orally adminis...

Problem statement: Ifosfamide (IFO) is a cytotoxic alkylating drug used for the treatment of a variety of cancers, although it has been found to induce certain hematological, hepatotoxic and nephrotoxic side effects. This drug is widely used in developing country, especially Iraq, but without caring too much to the storing temperature due to low dr...