Fajar Sofyantoro

Universitas Gadjah Mada | UGM · Faculty of Biology

Antiviral peptides (AVPs) are small molecules that inhibit the replication of viruses in living cells. AVPs are being investigated as potential alternatives to traditional antiviral drugs. The development of novel antiviral agents is of the highest concern because some traditional antiviral medications can be ineffective and lead to resistant virus...

Objectives: This study aimed to analyze the global profile of the nucleotide/nucleoside analogs (NAs) for chronic hepatitis virus therapy-related research. Background: NAs, which closely resemble the structure of naturally occurring nucleotides/nucleosides, function by disrupting the elongation of the nascent DNA strand. These compounds are conside...

Dengue virus (DENV) constitutes a formidable public health threat within tropical and subtropical regions. The escalation of cases in Southeast Asia, notably Indonesia, is a matter of considerable concern. Timely identification of DENV infection remains imperative for efficient disease management. The non-structural protein-1 (NS1), distinguished b...

TOR complex 1 (TORC1) is a multi‐protein kinase complex that coordinates cellular growth with environmental cues. Recent studies have identified Pib2 as a critical activator of TORC1 in budding yeast. Here, we show that loss of Pib2 causes severe growth defects in fission yeast cells, particularly when basal TORC1 activity is diminished by hypomorp...

Zebrafish (Danio rerio) have emerged as valuable models for investigating viral infections, providing insights into viral pathogenesis, host responses, and potential therapeutic interventions. This review offers a comprehensive synthesis of research on viral infections using zebrafish models, focusing on the molecular mechanisms of viral action and...

Abstrak: Sebagian besar masyarakat Kulon Progo bekerja sebagai petani dan peternak. Padukuhan Gegunung di Kulon Progo memiliki tanah yang subur. Tanaman kelor kaya akan nutrisi, memiliki akar yang kuat, dan dapat dimanfaatkan sebagai alternatif pakan ternak. Program pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman masyarakat terkait...

Animal venoms and toxins hold promise as sources of novel drug candidates, therapeutic agents, and biomolecules. To fully harness their potential, it is crucial to develop reliable testing methods that provide a comprehensive understanding of their effects and mechanisms of action. However, traditional rodent assays encounter difficulties in mimick...

The burgeoning population of Indonesia has led to a heightened demand for animal protein, particularly within the broiler industry. However, the commercial broiler feed tends to be costly due to its reliance on imported ingredients. Therefore, the potential utilization of Nile tilapia gills as an additional protein source for broiler feed has been...

Aim: This study aimed to evaluate the trends in organoid culture research within the field of regenerative medicine from 2002 to 2022. Methods: The worldwide distribution of organoid research in regenerative medicine articles indexed in the Scopus database was analyzed. Result: A total of 840 documents were analyzed, averaging 42 publications annua...

Ethnobotany is a scientific approach used to explore the potential of plant species traditionally utilized by communities. This study aims to analyze the utilization of plant types and parts, as well as their phytochemical contents, for skin and hair care among the Indonesian population. The data from this research enriches the understanding of the...

Globally, the most frequent cause of serious and prolonged impairment of bodily function is brain disease. Specifically, people with brain ischemia, which alters the physiological functions of the central nervous system (CNS), display irreversible behavioural, cognitive, and emotional alterations. Furthermore, progressive neurodegenerative conditio...

Stress has been associated with various diseases and physiological disruptions. Chlorella vulgaris is known for its antioxidant properties. This study examined the effects of C. vulgaris on the hematological profile of stress-induced Wistar rats. Stress significantly impacted various hematological parameters, including erythrocyte count, hemoglobin...

Obesity increases the risk of various diseases. Black rice, renowned for its high anthocyanin content, is considered a potential functional food for preventing metabolic disorders. The current study investigated the effects of black rice crunch (BRC) on body weight and haematological profiles in obese rats. Rats were fed with high-fat diet to induc...

Palm sugar, derived from coconuts, holds longstanding cultural significance in Indonesian society, offering substantial economic value. The hamlet of Nganti in Yogyakarta thrives on coconut farming and palm sugar production. Despite its potential, the palm sugar industry grapples with challenges such as limited market access and a lack of technolog...

Cells cease to proliferate above their growth-permissible temperatures, a ubiquitous phenomenon generally attributed to heat damage to cellular macromolecules. We here report that, in the presence of rapamycin, a potent inhibitor of Target of Rapamycin Complex 1 (TORC1), the fission yeast Schizosaccharomyces pombe can proliferate at high temperatur...

The misuse of paracetamol is becoming more prevalent worldwide. Due to non-compliance with recommended dosage and regulations, paracetamol consumption can result in serious health issues such as liver necrosis, kidney damage, heart damage, and hematological changes. This study sought to investigate the impact of paracetamol on the development of ze...

The use of peptide drugs to treat cancer is gaining popularity because of their efficacy, fewer side effects, and several advantages over other properties. Identifying the peptides that interact with cancer proteins is crucial in drug discovery. Several approaches related to predicting peptide-protein interactions have been conducted. However, prob...

Ulva lactuca is a functional food ingredient with high antioxidant content. The presence of heavy metal contaminants in natural Ulva lactuca needs to be eliminated. Ulva lactuca was investigated for its potential as a nephroprotector in female Wistar rats. The study assessed Blood Urea Nitrogen (BUN) levels, creatinine levels, and kidney histopatho...

Objectives: Yellow rasbora (Rasbora lateristriata) exhibits potential as a novel animal model for research purposes. Nevertheless, the process of embryonic development of this fish species remains inadequately comprehended. This study aimed to characterize the embryonic development stages of yellow rasbora. Methods: The embryonic development was do...

The current study observed the histological differences of the swim bladder of the tropical eel, Anguilla bicolor bicolor, as an adaptation resulting from hydro-static change. A total of 15 eels were collected from Pasir Puncu, Keburuhan, Purworejo and Segara Anakan, Cilacap, Indonesia in June 2017, September 2020, and April 2021. The eels were gro...

Excessive consumption of paracetamol may lead to hepatic necrosis, nephrotoxicity, extra-hepatic lesions, and even fatality in humans and animals. The objective of this study was to examine the histological changes in the hepatocytes of yellow rasbora (Rasbora lateristriata) exposed to paracetamol. The fish were subjected to varying concentrations...

Objectives: This study aimed to analyze the global profile of the literature in non-alcoholic fatty liver disease (NAFLD) research. Background: Non-alcoholic fatty liver disease is a clinically heterogeneous condition characterized by fat accumulation in the liver and the absence of significant alcohol consumption or underlying genetic disorders...

The current study was conducted to investigate the homogeneity of gonad maturity in Anguilla bicolor bicolor, and whether Gonado-Somatic Index (GSI) is a reliable indicator of this maturity. Eel samples were obtained from fishermen at Segara Anakan, Cilacap, Central Java, Indonesia in December 2015, and May 2017. Fourteen specimens were analyzed ba...

Cells cease to proliferate above their growth-permissible temperatures, a ubiquitous phenomenon generally attributed to protein denaturing and heat damage to other cellular macromolecules. We here report that, in the presence of the macrolide compound rapamycin, the fission yeast Schizosaccharomyces pombe can proliferate at high temperatures that n...

Abstrak: Desa wisata Manding terletak di Yogyakarta dan mengusung usaha kerajinan kulit sebagai pilar utama perekonomian. Berkaca dari kendala yang dialami selama pandemi COVID-19, UMKM di Manding membutuhkan pendampingan terkait adopsi penggunaan teknologi informasi untuk sarana promosi. Program pengabdian masyarakat ini bertujuan untuk memberikan...

N-asetil-p-aminophenol atau parasetamol merupakan analgesik dan antipiretik yang mudah didapat tanpa resep. Penyalahgunaan dan kesalahan dosis konsumsi dapat menyebabkan kerusakan hepar. Fucoidan memiliki aktivitas hepatoprotektif yang dapat menstimulasi regenerasi hepatosit. Studi ini bertujuan untuk mengamati struktur histologis hepar ikan zebra...

Background ASEAN (Association of Southeast Asian Nations) is composed of ten Southeast Asian countries bound by socio-cultural ties that promote regional peace and stability. South Asia, located in the southern subregion of Asia, includes nine countries sharing similarities in geographical and ethno-cultural factors. Chikungunya is one of the most...

Indonesia is well-known for having a vast and rich endowment of unique and genetically diverse biodiversity resources. Currently, initiatives are taking place around the world to generate DNA barcode libraries to make these data available to better understand biodiversity. The objectives of this study are to document DNA barcode research trends and...

The recent monkeypox or mpox outbreak has been a global concern. The present study evaluated the global research outputs, research trends, and topics of published research on monkeypox using a bibliometric approach. The Scopus database was searched for terms associated with "monkeypox" or "monkey pox" up until 19 November 2022. Maps and bibliometri...

Abstract: Fish cultivation in rice fields (minapadi) is the main aspect of tourism developed by the Kebonagung tourism village. However, the high price of fish feed is the main obstacle faced by residents in developing minapadi tourism. Maggot-based feed is an inexpensive alternative to feed with high nutritional quality. Our program aimed to provi...

Pondok Pesantren Asy-Syifa' Muhammadiyah (PPAM) in Yogyakarta established several Micro, Small and Medium Enterprises (MSMEs) including production units of tempeh, mineral water, coffee, and donut. The main obstacle experienced by the MSMEs is the traditional marketing system which limits the sales of products. The current program aimed to assist t...

The tourism village of Kalakijo, Yogyakarta, promotes batik and traditional culinary ‘ingkung’ as its main branding strategy. To date, the marketing and promotion of Kalakijo are performed based on conventional strategies. The emergence of the pandemic in recent years further complicates the problems faced by micro, small, and medium enterprises (M...

The emergence of Covid-19 causes an increasing trend of job loss and decreases the source of income for the majority of people in Indonesia, resulting in reduced uptake of nutritious food in their daily life. To overcome these problems, people in Kalurahan Caturtunggal tried to establish food self-sufficiency, one of which is by cultivating catfish...

Abstract: Klayar Tourism Village is an alternative tourist destination in Gunungkidul, Yogyakarta. The Tourism Awareness Group (POKDARWIS) Klayar Manunggal seeks to develop the traditional culinary of wader fish as a tourist attraction. The current program aimed to provide assistance to POKDARWIS to be able to independently spawn and cultivate wade...

Snake envenomation is a severe economic and health concern affecting countries worldwide. Snake venom carries a wide variety of small peptides and proteins with various immunological and pharmacological properties. A few key research areas related to snake venom, including its applications in treating cancer and eradicating antibiotic-resistant bac...

The SARS-CoV-2 virus, which caused the COVID-19 infection, was discovered two and a half years ago. It caused a global pandemic, resulting in millions of deaths and substantial damage to the worldwide economy. Currently, only a few vaccines and antiviral drugs are available to combat SARS-CoV-2. However, there has been an increase in virus-related...

Pondok Pesantren Asy-Syifa’ Muhammadiyah (PPAM), located in Yogyakarta, aims to become an independent and benevolent institution for the community. To realize its noble missions, PPAM initiated the Tempe Production Unit (TPU) as an alternative source of financial incomes and to provide nutritional foods for its students. The TPU at PPAM was establi...

TOR complex 1 (TORC1) is a multi-subunit protein kinase complex that controls cellular growth in response to environmental cues. The regulatory subunits of mammalian TORC1 (mTORC1) include RAPTOR, which recruits mTORC1 substrates, such as S6K1 and 4EBP1, by interacting with their TOR signaling (TOS) motif. Despite the evolutionary conservation of T...

Mammalian target of rapamycin complex 1 (TORC1) is controlled by the GATOR complex composed of the GATOR1 subcomplex and its inhibitor, the GATOR2 subcomplex, sensitive to amino acid starvation. Previously, we identified fission yeast GATOR1 that prevents deregulated activation of TORC1 ( Chia et al., 2017 ). Here, we report identification and char...

TOR complex 1 (TORC1) is an evolutionarily conserved protein kinase complex that promotes cellular macromolecular synthesis and suppresses autophagy. Amino acid-induced activation of mammalian TORC1 is initiated by its recruitment to the RagA/B-RagC/D GTPase heterodimer, which is anchored to lysosomal membranes through the Ragulator complex. We hav...