Fahimeh Kazeminava

• Post Doc position at Tabriz University of Medical Sciences

This study leverages the Passerini three-component reaction (P-3CR), a novel and efficient method for crosslinking carboxymethyl cellulose (CMC) via carboxamide frameworks, to develop bioactive antibacterial hydrogels for enhanced oral drug delivery. The synthesized Passerini-crosslinked CMC hydrogels (PC-CMC) demonstrated a remarkable ability to p...

Hydrogels containing antimicrobial materials have emerged as attractive platforms for wound treatment in the past decade due to their favorable bio-mimicking properties, excellent modulation of bacterial infection, and ability to minimize bacterial resistance. Herein, a hybrid combination of polyvinyl alcohol (PVA), hyperbranched poly L-lysine (L),...

The blood-brain interface poses formidable obstacles in addressing neurological conditions such as Alzheimer's, Multiple Sclerosis, brain cancers, and cerebrovascular accidents. Serving as a safeguard against potential threats in the blood, this barrier hinders direct drug delivery to affected cells, necessitating specialized transport mechanisms....

The nonspecific nature of cancer drug delivery often results in substantial toxic side effects during treatments for breast cancer. To mitigate these negative outcomes, our approach involves loading methotrexate (MTX) within carbon quantum dots (CQDs) synthesized from folic acid, which are then enveloped in exosomal membranes obtained from breast c...

Aortic valve stenosis is the most common type of heart valve disease in the United States and Europe and calcific aortic stenosis (AS) affects 2–7% of people aged 65 years and older. Aortic valve replacement (AVR) is the only effective treatment for individuals with this condition. Transcatheter Aortic Valve Replacement (TAVR) has been widely accep...

Significant advancements have been noticed in cancer therapy for decades. Despite this, there are still many critical challenges ahead, including multidrug resistance, drug instability, and side effects. To overcome obstacles of these problems, various types of materials in biomedical research have been explored. Chief among them, the applications...

Hydrogels with very interesting properties such as high water content, porosity, swelling, and mimicking the structure of the extracellular matrix (ECM) are promising candidates for a variety of applications. Recently, great efforts are being made to improve the shape and functionality of three-dimensional (3D) hydrogels. One of the most promising...

This study aims to design an innovative flexible nanocomposite film via the integration of MnO2 NPs into the biopolymeric carboxymethyl cellulose (CMC) hydrogel for improving its mechanical, swelling, and antibiotic release profile. To end this, the casting method was utilized to incorporate MnO2 NPs in the biopolymeric CMC matrix (CMC/MnO2) plasti...

Polysaccharides are among the most potent materials for wound dressing construction. In this study, antibacterial flexible hydrogel films were prepared through a novel crosslinking of biopolymeric chitosan (CS) with silver-sulfur doped graphene quantum dots (Ag@S-GQD). To end this, S-GQDs were first synthesized from citric acid and 3-mercaptopropio...

Recently, developing antibacterial wound dressings based on biomaterials display good biocompatibility and the potential to accelerate wound healing. For this aim, we prepared eco-friendly and biodegradable nanofibers (NFs) based on N-(3-sulfopropyl)chitosan/ poly (ε-caprolactone) incorporated by zeolite imidazolate framework-8 nanoparticles (ZIF-8...

This study presents the development and characterization of a nanocomposite material, consisting of thermoplastic starch (TPS) reinforced with bentonite clay (BC) and encapsulated with vitamin B2 (VB). The research is motivated by the potential of TPS as a renewable and biodegradable substitute for petroleum-based materials in the biopolymer indust...

In this work, soy protein isolate (SPI) and N-(3-sulfopropyl) chitosan salt (SPCS) was utilized to synthesize electrospun nanofibers (NFs) for the first time. Polycaprolactone (PCL) was also added in the formulation of SPI/SPCS NFs to optimize and improve the SPI/SPCS electrospinnability, surface morphology, and mechanical stability. To confer exce...

Thermoplastic starch (TPS) attracted great interest in the biopolymer industry due to its obvious advantages, such as biodegradability and renewable resources, as substitutes for petroleum-based materials. This study is focused on designing TPS/bentonite clay (BC) nanocomposite (TPS/BC) reinforced with vitamin B2 (VB). The TPS nanocomposites loaded...

Background To provide effective healing in the wound, various carbohydrate polymers are commonly utilized that are highly potent platforms as wound dressing films. In this work, novel antibacterial flexible polymeric hydrogel films were designed via crosslinking polymeric chitosan (CS) with folic acid-based carbon quantum dots (CQDs). To end this,...

A new species of catalysts that are prepared from biocompatible materials is demonstrated. Sulfonated magnetic sugarcane bagasse has been synthesized as a novel biodegradable and robust heterogeneous catalyst for organic transformations. The catalyst was characterized by different techniques. Next, the efficiency of this acid catalyst was examined...

In this work, citric acid-based quantum dots (CA-QDs) as a novel and safe crosslinked agent was applied in different feeding ratios (5–15 wt%) to synthesize carboxymethyl cellulose/polyvinyl alcohol (CMC/PVA) nanofibers (NFs) for the first time. Colistin (CL) as an antibacterial agent was also loaded (2 w/w%) during the synthesizing process of CMC/...

Healing of injured tendon is a major clinical challenge in orthopaedic medicine, due to the poor regenerative potential of this tissue. Two-dimensional nanomaterials, as versatile scaffolds, have shown a great potential to support, trigger and accelerate the tendon regeneration. However, weak mechanical properties, poor functionality and low biocom...

The dramatically increasing levels of antibiotic resistance are being seen worldwide, and is a significant threat to public health. Antibiotic and drug resistance is seen in various bacterial species. Antibiotic resistance is associated with increased morbidity and mortality and increased treatment costs. Antisense-relevant technologies include the...

For stopping long-time harmful bacterial infection, designing a drug carrier with a highly prolonged release profile is a promising approach that is of interest to different biomedical areas. The subject of this work is to synthesis a novel carrier system through coordination of MIL-88(Fe) to carboxymethyl cellulose (CMC) for enhancing interaction...

The aim of this work was to immobilize silver nanoparticles with catalytic and antibacterial activity (AgNPs) inside of the PEG-based hydrogel through a facile and green design. First, the hybrid hydrogels were prepared under solvent-free conditions based on dianhydride ethylenediamine tetraacetic acid, poly(ethylene glycol) of different molar mass...

Objective The microbial, physico-chemical and optical corruptions threaten a variety of foods and drugs and consequently the human biological safety and its accessible resources. The humanbeing’s tendency towards bio-based materials and natural plant-extracts led to an increase in the usage of antimicrobial biocomposites based on medicinal herbs. M...

The synthesis is reported of novel hybrid hydrogels based on ethylenediaminetetraacetic acid dianhydride and poly(ethylene glycol) (PEG) with octa‐aminopropyl polyhedral oligomeric silsesquioxane hydrochloride salt (OA‐POSS) as a nano‐crosslinker under solvent‐free conditions. The molecular weight of PEG was varied between 600 and 1000 Da. The synt...

Silver nanoparticles supported on polyhedral oligomeric silsesquioxane (OA‐POSS) nanocrosslinked poly (ethylene glycol)‐based hydrogels (PEG600‐POSS/Ag NPs) as novel nanohybrid catalysts were synthesized for the first time. The as‐prepared nanohybrid hydrogels were fully characterized by FT‐IR, SEM, EDX, XRD, TEM and TGA. PEG600‐POSS/Ag NPs exhibit...