Fahad Almughem

Fahad Almughem
King Abdulaziz City for Science and Technology | KACST · National Centre for Pharmaceutical Technology

PhD

About

20
Publications
4,407
Reads
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96
Citations
Citations since 2016
20 Research Items
96 Citations
2016201720182019202020212022010203040506070
2016201720182019202020212022010203040506070
2016201720182019202020212022010203040506070
2016201720182019202020212022010203040506070

Publications

Publications (20)
Article
Full-text available
Neurodegenerative and neuronal-related diseases are major public health concerns. Human vulnerability to neurodegenerative diseases (NDDs) increases with age. Neuronal hormones and neurotransmitters are major determinant factors regulating brain structure and functions. The implications of environmental and climatic changes emerged recently as infl...
Article
Full-text available
Magnetite Fe3O4 and spinel (2:1) and (4:1) NiFe2O4 magnetic nanoparticles (MNPs) were prepared by simple and affordable co-precipitation methods using an extract of star anise (Illicium verum) as a green reducing agent. The morphology and chemical composition of these MNPs were confirmed by field-emission scanning electron microscopy, energy-disper...
Article
Full-text available
Mitochondria are double-membraned cytoplasmic organelles that are responsible for the production of energy in eukaryotic cells. The process is completed through oxidative phosphorylation (OXPHOS) by the respiratory chain (RC) in mitochondria. Thousands of mitochondria may be present in each cell, depending on the function of that cell. Primary mito...
Article
Full-text available
The inadequate eradication of pulmonary infections and chronic inflammation are significant complications in cystic fibrosis (CF) patients, who usually suffer from persistent and frequent lung infections caused by several pathogens, particularly Pseudomonas aeruginosa (P. aeruginosa). The ability of pathogenic microbes to protect themselves from bi...
Article
Full-text available
Geriatric patients are more likely to suffer from multiple chronic diseases that require using several drugs, which are commonly ingested. However, to enhance geriatric patients’ convenience, the electrospun nanofiber system was previously proven to be a successful alternative for the existing oral dosage forms, i.e., tablets and capsules. These na...
Article
Full-text available
Chronic obstructive pulmonary disease (COPD) is a progressive lung dysfunction caused mainly by inhaling toxic particles and cigarette smoking (CS). The continuous exposure to ruinous molecules can lead to abnormal inflammatory responses, permanent damages to the respiratory system, and irreversible pathological changes. Other factors, such as gene...
Article
Full-text available
The emergence of phytosome nanotechnology has a potential impact in the field of drug delivery and could revolutionize the current state of topical bioactive phytochemicals delivery. The main challenge facing the translation of the therapeutic activity of phytochemicals to a clinical setting is the extremely low absorption rate and poor penetration...
Chapter
The number of anticancer agents that have been developed has increased dramatically in the last few decades. However, due to their severe toxicity, high production cost, and low patient compliance, the development of alternative antitumour approaches is urgently needed to minimize these limitations. Several synthetic nanoparticles (NPs), such as po...
Chapter
Multidrug-resistant organisms (MDROs) such as viruses, bacteria, fungi, and parasites have caused significant mortalities worldwide. The continuous misusing of antimicrobial drugs is menacingly emerging infectious diseases that are resistant and difficult to treat. Many mechanisms of resistance have evolved in pathogens to avoid the bioactivities o...
Chapter
Metal nanosized particles are recognized as the notable category among different nanoparticles that has played wide roles like antimicrobial, biomedical appliances, etc. In which there are huge path to extract MNPs that brings bio (green), physical, and chemical methods. The major backlog in chemical or physical technique is its perilous and virule...
Article
Full-text available
High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy among women. Several obstacles impede the early diagnosis and effective treatment options for ovarian cancer (OC) patients, which most importantly include the development of platinum-drug-resistant strains. Currently, extensive efforts are being put into the develo...
Article
Full-text available
In this work, we report a simple method of silica coating of upconversion nanoparticles (UCNPs) to obtain well-crystalline particles that remain small and not agglomerated after high-temperature post-annealing, and produce bright visible emission when pumped with near-infrared light. This enables many interesting biological applications, including...
Article
Full-text available
Hand hygiene is an essential factor to prevent or minimize the spread of infections. The ability to prepare an alcohol-free hand sanitizer (AFHS) with antimicrobial properties is crucial, especially during pandemics, when there are high demands and a low supply chain for ethanol and isopropanol. The objective of this study was to prepare AFHS gels...
Article
Chromium-doped aluminum oxide (ruby) micro- and nanocrystals have shown a sharp and strong fluorescence emission that linearly depends on pressure and temperature. They also have an exceptional photostability and a high quantum efficiency. In spite of their widespread use as pressure sensors, only a few earlier studies have used ruby nanocrystals a...
Article
Full-text available
Sialic acid that presents on the surface of lung epithelial cells is considered as one of the main binding targets for many respiratory viruses, including influenza and the current coronavirus (SARS-CoV-2) through the viral surface protein hemagglutinin. Gold nanoparticles (Au NPs) are extensively used in the diagnostic field owing to a phenomenon...
Article
Full-text available
The exceptional optical properties of lanthanide-doped upconversion nanoparticles (UCNPs) make them among the best fluorescent markers for many promising bioapplications. To fully utilize the unique advantages of the UCNPs for bioapplications, recent significant efforts have been put into improving the brightness of small UCNPs crystals by optimizi...
Chapter
A tremendous number of therapeutic molecules and vaccines have been generated in the last few decades. This level of production necessitates an effective and safe drug delivery system (DDS). Designing a DDS for the specific targeting of organs and for passing through the blood-brain barrier remains a challenge. Several drug carriers have been teste...
Article
Full-text available
Cystic Fibrosis (CF), an autosomal recessive genetic disease, is caused by a mutation in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). This mutation reduces the release of chloride ions (Cl−) in epithelial tissues, and hyperactivates the epithelial sodium channels (ENaC) which aid in the absorption of sodium ions...
Conference Paper
Introduction: Recent researches have focused in exploiting the high affinity nature of streptavidin as a bridge moiety between biotinylated molecules and ligands. This can perform a high affinity non-covalent conjugation of ligands to the surface of nanoparticles as a novel approach (1). In this work, we aim to investigate the effect of streptavidi...

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