Fahad Akhtar

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• Doctor of Philosophy
• PhD Student at China Pharmaceutical University

Oxidative stress (OS) is a result of the imbalance between reactive oxygen species (ROS) and antioxidants in the body that can cause tissue damage. Oxidative stress has a significant involvement in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and male infertility. CP/CPPS is a major risk factor for male infertility...

A wide range of diseases have been treated using low-molecular-weight heparins (LMWHs), the drug of choice for anticoagulation. Owing to their better pharmacokinetic features compared to those of unfractionated heparin (uFH), several systems incorporating LMWHs have been investigated to deliver and improve their therapeutic outcomes, especially thr...

The aim of this research was to specifically assess an alternate formulation for the treatment of leishmaniasis by making microparticulate forms of amodiaquine and quinine sulphate for use in the treatment of leishmaniasis. Using bovine serum albumin as the polymer matrix, amodiaquine and quinine sulfate microparticles were formulated using the spr...

Low molecular weight heparin is a Heparin derivative, produced from commercial-grade Heparin through Chemical or enzymatic depolymerization. LMWH has remained a favored regimen for anticoagulation in cancer patients. Evidence from several studies has suggested that LMWHs possess antitumor and antimetastatic activity aside from their anticoagulant a...

Antiviral peptides (AVPs) represent a novel and promising therapeutic alternative to conventional antiviral treatments, due to their broad-spectrum activity, high specificity, and low toxicity. The emergence of zoonotic viruses such as Zika, Ebola, and SARS-CoV-2 have accelerated AVP research, driven by advancements in data availability and artific...

Many studies have indicated that histone deacetylase inhibitors (HDACis) have a significant antitumor effect in cancer. Here we report a compound named LT-548-133-1 that not only acts as an HDAC inhibitor but also interferes with microtubule assembly to inhibit MCF-7 cell proliferation and induce apoptosis. Consistent with Chidamide, LT-548-133-1 i...

Phosphatidylinositol 4-kinase (PI4K) is a lipid kinase that can catalyze the transfer of phosphate group from ATP to the inositol ring of phosphatidylinositol (PtdIns) resulting in the phosphorylation of PtdIns at 4-OH sites, to generate phosphatidylinositol 4-phosphate (PI4P). Studies on biological functions reveal that PI4K is closely related to...

For cancer therapy, the usefulness of mesoporous silica nanoparticles (MPSNPs) has been widely discussed, likely due to its inorganic nature and excellent structural features. The MPSNPs‐based chemotherapeutics have been promisingly delivered to their target sites that help to minimize side effects and improve therapeutic effectiveness. A wide arra...

Mesoporous silica nanomaterials (MSNs) have made remarkable achievements and are being thought of by researchers as materials that can be used to effect great change in cancer therapies, gene delivery, and drug delivery because of their optically transparent properties, flexible size, functional surface, low toxicity profile, and very good drug loa...

This study was aimed at the investigation of therapeutic as well as pharmacological effects of metoprolol (Met, β-blocker) and losartan (Los, angiotensin-converting enzyme inhibitors, ARBs) on isoprenaline (Iso)-induced left ventricular hypertrophy (LVH) in mice model. The Kunming mice (21-24 g) were randomly divided into six groups (n = 30), namel...

The objective of this research was to determine the uptake of different elements (K, Mg, Ca, Na, Fe, Co, Mn, Pb, Cu, Zn and Ni) which are used as nutrients by the rice crop. Different types of rice seeds KSK-282, KSK-134, BAS-515, IR6, BAS-2000, KSK-133 and super-BAS were collected from National Agricultural Research Centre (NARC) Islamabad Pakista...

The objective of this study was to isolate different organic fractions of the Glycyrrhiza root extract using TLC employing different experimental methodologies and solvent systems. In method A, the powdered drug was heated under reflux for 1 hour with 0.5 M H2SO4 and then fractionated with chloroform. In method B, powdered drug was extracted by hea...

Passive ventricular restraint is non-transplant surgical option for the management of end stage dilated heart failure (HF). The objective of this work is to expand the therapeutic techniques of current medicine , for this purpose we design a novel ventricle restraint device (ASD) which has ability to deliver a therapeutic drug directly to the heart...

Capsicum annuum L. is a rich source of capsaicin, an alkaloid, which is a very pungent compound. Due to ever growing need of capsaicin, an extensive research on its efficient cultivation as well as chemical synthesis is underway. Owing to the pungent nature of capsaicin, its analogous molecules without pungent effect are being explored. The objecti...

Over the past few years, considerable attention has been focused on carrageenan based bionanocomposites due to their multifaceted properties like biodegradability, biocompatibility, and nontoxicity. Moreover, these composites can be tailored according to the desired purpose by using different nanofillers. The role of ferromagnetic nanoparticles in...

Background: Cardiovascular diseases (CVD) are considered to be the foremost basis of mortality and transience in the developing world. CVD risk factors such as diabetes, asthma, anemia, smoking, obesity and the metabolic syndrome, may reverse downward trends in CVD mortality. Methodology:A prospective cross-sectional study was conducted at ATH on p...

The medicinal plants Melilotus indicus and Spinacia oleracea were collected from herb dealer in order to check antibacterial activity in opposition to different Gram-positive and Gram-negative bacterial strains. These medically important bacterial strains including Pseudomonas aeroginosa, Bacillus subtilis, Microccocus luteus and Escherichia coli....

The antibacterial activity of aqueous and ethanol extracts of Balsamodendron myrrha and Viola oderata were evaluated for anti-microbial activity using the agar well diffusion method against six pathogenic bacteria (Klebsiella pneumoniae, Escherichia coli, Pseudomonas, Salmonella typhi, Stapylococcus epidermidis and Enterococcus). These plants are c...