
Fabrizio PregliascoUniversity of Milan | UNIMI · Department of Biomedical Sciences for Health
Fabrizio Pregliasco
MD
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109
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Introduction
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November 1991 - December 2015
Publications
Publications (109)
Background:
In medical emergencies adherence to standardized clinical protocols is crucial to ensure a better outcome for patients. Newly qualified physicians may play several roles in serving the National Health Service (substituting general practitioners, on-call duty, working in emergency rooms, etc.) in Italy. In these situations, the physicia...
L'arresto cardiaco extra-ospedaliero (OHCA-Out of Hospital Cardiac Arrest) è una delle principali cause di morte a livello mondiale e rappresenta la patologia tempo-dipendente maggiormente sfidante il sistema dell'emergenza sanitaria territoriale (EMS) in termini organizzativi e di interazione con la gestione ospedaliera. Purtroppo, la prognosi del...
Individuals with severe cartilage degeneration of the hip or knee or collapsed vertebrae that cause spine deformities can suffer from joint and neuropathic pain in the back, disuse of the affected limb, and restriction of movements. Surgical intervention is the most widespread and successful solution to date. There is a general belief that eating h...
Unlabelled:
Background and aim During the COVID-19 emergency, the lombardy region (northern Italy) implemented a regional Centralized Discharge Planning Office (CDPO) to promptly manage the discharge requests, rapidly match the needs of discharge hospitals with the availability of admission facilities and ensure the management of the entire discha...
In developed countries, congenital cytomegalovirus (cCMV) infection is the most common congenital viral infection, representing the leading non-genetic cause of sensorineural hearing loss (HL). Diagnosis of cCMV infection can be performed by detection of CMV DNA in urine or saliva within 2–3 weeks after birth, or later in dried blood samples on the...
Background and aim:
Obtaining a degree in medicine in Italy qualifies for the medical profession; this fact has entailed a newly qualified doctor's remarkable involvement on the medical activities of the National Health Service, especially during the Covid-19 pandemic. It is important to understand the knowledge of the newly qualified doctors and...
Residents of long-term care facilities (LTCFs) have been dramatically hit by the COVID-19 pandemic on a global scale as older age and comorbidities pose an increased risk of severe disease and death. The aim of the study was to assess the quantity and durability of specific antibody responses to SARS-CoV-2 after the first cycle (two doses) of BNT16...
Background
The impact of coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on residents of long-term care facilities (LTCFs) has been dramatic on global scale as older age and comorbidities pose an increased risk of severe disease and death.
Methods
Aim of this study was to evaluate SARS-CoV...
Background
We report the results of an e-learning project focused on the progressively acquired knowledge on Coronavirus Disease 19 (COVID-19), targeted to Italian healthcare professionals. and funded by the Italian National Federation of the Associations of Doctors, Surgeons and Dentists (FNOMCeO) and the Federation of Orders of Italian Pharmacist...
Background We report the results of an e-learning project focused on the progressively acquired knowledge on Coronavirus Disease 19 (COVID-19), targeted to Italian healthcare professionals. and funded by the Italian National Federation of the Associations of Doctors, Surgeons and Dentists (FNOMCeO) and the Federation of Orders of Italian Pharmacist...
Introduction
A precise knowledge of the possible Adverse Events (AEs) related to spinal surgical procedures is crucial in clinical practice.
Research Question
Purposes of this study are: to determine the prevalence and severity of perioperative AEs associated with pediatric and adult spine surgery in a high volume center; to estimate the impact of...
Background: The impact of coronavirus disease 2019 caused by Severe Acute Respiratory Syndrome Coronavirus 2 on hosts of Long Term Care Facilities (LTCFs) has been dramatic at global scale as aging and comorbitities pose individuals at increased risk of severe disease and death.
Methods: Aim of this study was to evaluate SARS-CoV-2 S-IgG antibodies...
Psoriasis (PS) is a skin disease with autoimmune features mediated by immune cells, which typically presents inflammatory erythematous plaques, and is associated with many comorbidities. PS exhibits excessive keratinocyte proliferation, and a high number of immune cells, including macrophages, neutrophils, Th1 and Th17 lymphocytes, and mast cells (...
Acute severe respiratory syndrome coronavirus-2 (SARS-CoV-2) infection causes coronavirus disease-2019 (COVID-19) which is associated with inflammation, thrombosis edema, hemorrhage, intra-alveolar fibrin deposition, and vascular and pulmonary damage. In COVID-19, the coronavirus activates macrophages by inducing the generation of pro-inflammatory...
Psoriasis (PS) is an autoimmune skin disease mediated by immune cells that typically presents inflammatory erythematous plaques, and it is associated with many comorbidities. PS exhibits excessive keratinocyte proliferation, and a high number of immune cells including macrophages, neutrophils, Th1 and Th17 lymphocytes, and mast cells (MCs). MCs are...
SARS-CoV-2 is a newly emerging virus that currently lacks curative treatments. Lactoferrin (LF) is a naturally occurring non-toxic glycoprotein with broad-spectrum antiviral, immunomodulatory and anti-inflammatory effects. In this study, we assessed the potential of LF in the prevention of SARS-CoV-2 infection in vitro. Antiviral immune response ge...
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the ongoing global pandemic of coronavirus disease 2019 (COVID-19), which primarily manifests with respiratory distress and may also lead to symptoms associated with the gastrointestinal tract. Probiotics are living microorganisms that have been shown to confer immune...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus that infects humans and a number of animal species causing coronavirus disease-19 (COVID-19), a respiratory distress syndrome which has provoked a global pandemic and a serious health crisis in most countries across our planet. COVID-19 inflammation is mediate...
The Italian Ophthalmological Society (SOI) has developed clinical practice guidelines for the care of ophthalmic patients during the coronavirus disease 2019 (COVID-19) pandemic. The aim of this document is to define guidelines that would help ophthalmologists in their clinical activities through the adoption of recommended procedures to avoid comm...
The coronavirus disease 2019 (COVID-19) pandemic is the most severe global health and socioeconomic crisis of our time, and represents the greatest challenge faced by the world since the end of the Second World War. The academic literature indicates that climatic features, specifically temperature and absolute humidity, are very important factors a...
The coronavirus disease 2019 (COVID-19) pandemic is the defining global health and socioeconomic crisis of our time and represents the greatest challenge faced by the world since the end of the Second World War. The academic literature indicates that climatic features, specifically the temperature and absolute humidity, are very important factors a...
The respiratory condition COVID-19 arises in a human host upon the infection with SARS-CoV-2, a coronavirus that was first acknowledged in Wuhan, China, at the end of December 2019 after its outbreak of viral pneumonia. The full-blown COVID-19 can lead, in susceptible individuals, to premature death because of the massive viral proliferation, hypox...
PurposeThe COVID-19 pandemic is importantly affecting the orthopaedic practice all over the world with Northern Italy being the first European area that faced the worst scenario. In this study, the changes in clinical practice occurred in an orthopaedic center in Milan are described.Methods
Number and type of admissions, outpatients cancelled and p...
The role of soccer referees has grown in importance in the last decades, as has attention to their performance, which may be influenced and improved with specific and evolved training programs. Today, multiple specialists are working as a team in order to develop effective training programs. Moreover, for athletes, it is becoming more and more impo...
Aims:
The aim of this research is to verify the presence of Legionella in human dental plaque.
Methods:
65 adult patients not treated with systemic or local antibiotics at least 2 months before the time of sample collection were enrolled for plaque collection between September 2015 and December 2016. A brief questionnaire about lifestyle and hea...
BACKGROUND/AIM:
Etiopathogenesis of autism spectrum disorders (ASD) remains to be elucidated. Congenital infections, particularly viral infections, have repeatedly been associated with the onset of such disorders. Our study aimed at assessing the prevalence of herpes simplex type 1 and 2 (HSV1/2) congenital infections in patients with ASD.
MATERIA...
Soccer refereeing is a “not-conventional” sport in which aerobic workload is prevalent. Along the years, several studies have attempted to define best markers of referees’ performance. Many studies focused their attention on field tests and their relationship with aerobic power. Instead, in this study, starting by a medical assessment satisfying th...
Introduction: The codes used to report hospital admissions due to influenza viruses are likely to underestimate the real incidence of influenza-related cases. Methods: In order to estimate this burden we ran a negative binomial model, in which the numbers of weekly admissions for respiratory and cardiovascular diseases were regressed based on influ...
Introduction: The codes used to report hospital admissions due to influenza viruses are likely to underestimate the real incidence of influenza-related cases. Methods: In order to estimate this burden we ran a negative binomial model, in which the numbers of weekly admissions for respiratory and cardiovascular diseases were regressed based on influ...
Introduction
Coagulase-negative staphylococci (CoNS) are the main pathogens responsible for prosthetic joint infections (PJIs). As normal inhabitants of human skin, it is often difficult to define if they are contaminants, or if they have an active role in initiating infection. This study aims to evaluate differences in CoNS organisms (Staphylococc...
Background context:
Spine surgery is a multi-faceted sub-speciality requiring a breadth of knowledge and skill from different branches of medicine for the treatment of pathologies varying from degenerative to deformity, oncological, and trauma.
Purpose:
The aim of the study was to investigate the self-perceived competency of spine surgeons in re...
Introduction:
During night and on weekends, in our emergency department there is no radiologist on duty or on call: thus, X-ray examinations (XR) are evaluated by the orthopaedic surgeon on duty and reported the following morning/monday by radiologists. The aim of our study was to examine the discrepancy rate between orthopaedists and radiologists...
Leukemia accepted article preview online, 27 April 2017. doi:10.1038/leu.2017.127.
Objective:
The study aimed to evidence previous cases of legionellosis or proven or suspected pneumonia in seven hospital facilities for the mentally disabled in Northern Italy, where no clinical surveillance had been previously carried out. An additional aim was to highlight the occurrence of strains of Legionella pneumophila of clinical and envi...
Aim. Constipation is a common disorder in western countries; it is estimated that 20% of the general population suffers from it and it is also an important and chronic problem among institutionalized subjects. Particularly in those subjects with severe mental retardation associated with motor deficits, if not adequately addressed, constipation can...
2496
Cases of childhood leukemia very rarely present as a significant time/space cluster. Clusters offer a unique opportunity to identify a point source causal exposure but, in practice, this is extremely difficult. We herewith report an apparent cluster of seven cases of childhood B cell precursor acute lymphoblastic leukaemia (ALL) occurring over...
Classic Kaposi's sarcoma (cKS) is a human herpesvirus-8 (HHV-8)-associated lympho-angioproliferative tumor typically occurring in the elderly. It is associated with HHV-8-driven perturbed balance of peripheral B-cell subsets, which may have an impact on immune responses to antigenic stimulation. We took advantage of the common practice of cKS patie...
The efficacy of a novel vaccine against influenza virus A (H1N1) in patients with hematologic malignancies is largely unknown.
We prospectively evaluated the humoral and cellular immune responses after one injection of monovalent adjuvanted 2009 H1N1 vaccine in 47 adults with hematologic malignancies and 77 controls by hemagglutination-inhibition a...
Objective. Well-being of professional caregivers has a profound impact on the management of elderly patients in nursing homes. Aim of this paper is to investigate how potentially stressful situations affect workers of facilities for dependent patients. Methods. Fifty-one professional caregivers (15 SRN and 36 NA), of three small institutions of the...
The El Niño phenomenon is the Earth’s strongest climatic fluctuation on an interannual timescale and has a quasi-global impact,
although originating in the tropical Pacific Ocean. A very strong El Niño is recognized to cause extreme dryness and wetness
in different parts of the world. We show that all the eight well-documented influenza pandemics,...
The Wolf-Hirschhorn syndrome (WHS) is a rare genetic condition presenting with severe mental disability, growth retardation, muscular hypotonia, seizures, craniofacial abnormalities and defects in the cardiovascular, genitourinary and digestive apparata. To date, few data about oral status of afflicted patients were reported, and this syndrome is s...
Human herpesvirus-8 (HHV-8) is the etiological agent of Kaposi's sarcoma (KS) and of some lymphoproliferative disorders of B cells. Most malignancies develop after long-lasting viral dormancy, and a preventing role for both humoral and cellular immune control is suggested by the high frequency of these pathologies in immunosuppressed patients. B ce...
Background: Between 40 and 50% of elderly people (>65 years old) are vaccinated against seasonal influenza in Italy every year. However active immunization only occurs in a relatively small number of vaccinated people and does not always last for the entire winter season. Oxidative stress might be one of the factors involved in this low antibody re...
In the last ten years, several studies have been performed to evaluate the effects of various probiotics - both alone and in combination - on immune parameters and infectious/inflammatory conditions in humans. The results of these trials suggest that probiotic bacteria might improve both the humoral and cell-mediated immune response, including phag...
The European Paediatric Influenza Analysis (EPIA) project is a multi-country project that was created to collect, analyse and present data regarding the paediatric influenza burden in European countries, with the purpose of providing the necessary information to make evidence-based decisions regarding influenza immunisation recommendations for chil...
The aim of this study was to identify the most effective disinfection protocol to reduce the presence of Legionella pneumophila in the water system of two Italian hospitals. From 2004 to 2009, 271 samplings of hot water were carried out in 11 hospital units to detect the presence of L. pneumophila. Additionally, water samples collected from one boi...
The aim of this study was to identify the most effective disinfection protocol to reduce the presence of Legionella pneumophila in the water system of two Italian hospitals. From 2004 to 2009, 271 samplings of hot water were carried out in 11 hospital units to detect the presence of L. pneumophila. Additionally, water samples collected from one boi...
Vaccines have long been used to boost the immune system and to confer protection against microbial infections. In contrast, immunotherapy based on ribosomal preparations has been proposed to enhance both specific and nonspecific immune responses (in particular, the mucosal immune defense system) against common respiratory tract pathogens. The aim o...
Ribosomal preparations (ribosome-component immune modulators [RCIMs]) do not contain attenuated bacteria and, in contrast to live bacterial extracts, which may induce severe side effects, retain immune stimulating activity without infectious capability. This study was designed to profile the tolerability of RCIM by reviewing narratively all randomi...
In Europe, the 2007-08 winter season was dominated by influenza virus A (H1N1) circulation through week 7, followed by influenza B virus from week 8 onward. Oseltamivir-resistant influenza viruses A (H1N1) (ORVs) with H275Y mutation in the neuraminidase emerged independently of drug use. By country, the proportion of ORVs ranged from 0% to 68%, wit...
9 years after the previous HPH initiative in Milan, the Lombard network has been willing again to host the activities of the XIIth HPH National Conference, in the perspective of enhancing the Quality of organization and contents, to help participants acquire procedures and instruments more and more oriented to health promotion and to the awareness...
The efficacy of probiotics is currently well documented with regard to the improvement of gastrointestinal functions, whereas their potential role in the prevention of infectious respiratory diseases has not been sufficiently analyzed. PURPOSE OF THE STUDY AND METHODS: A 3-stage prospective, randomized, double blind, placebo-controlled study was ca...
We performed an environmental monitoring in an hospital to estimate the level of contamination from Legionella spp., in connection with several treatments of reclamation. In period 2002-2006 we executed 238 samplings in 21 units hospitals (from hot water, biofilm, filter of the conditioning system, instrument for the assisted respiration) for the d...
The aim of this study is to compare the condition of oral hygiene of thirty institutionalized subjects afflicted with mental retardation already in care near the Dental Service, and seventy ones not yet in, in order to value both the efficaciousness of carried out prevention programs and willingness of the operators responsible for oral hygiene in...
The aim of the present study was to evaluate palatal morphology in Down syndrome (Ds) subjects, focusing on the effect of dental formula on the hard palate to assist clinicians when planning dental rehabilitation. Palatal landmarks were digitized with a three-dimensional (3D) computerized digitizer on the dental casts of 47 Ds subjects (23 dentate...
Streptococcus Pneumoniae is the main etiological agent of pneumonia and causes various other pathologies, e.g. meningitis and otitis, following to the uncontrolled replication in the human organism. The problem of treating the infection is tied to aspects that involve, on the one side the micro organism, that often develops resistance to the antibi...
There is considerable evidence that the mucosa associated lymphoid tissues (MALT) of the body play an active part in triggering off and conducting the immune system's response to both viral and bacterial pathogens. Effectors are capable of intercepting the micro-organisms and rendering them harmless before they penetrate through the mucous membrane...
New rapid diagnostic methods are needed to identify influenza infections to improve virological surveillance usually undertaken with conventional time-consuming, complex, and even expensive laboratory methods. Another reason for using a rapid test is to avoid inappropriate therapy, particularly in children, where use of antibiotics inappropriately...
Objective: In elderly people, because of complications, influenza can be a dangerous pathology. In elderly people common vaccination can be less immunogen because of reduction of immunity, and for this reason this study was conducted on an adjuvated vaccine (with MF59) (FLUAD Chiron, Siena) adjuvant), on a population of old people totally or partia...
Influenza is a serious health problem worldwide. It is important to reduce morbidity and mortality from annual influenza epidemics and to prepare for the next influenza pandemic. During the influenza epidemics every year, an estimated half a million people worldwide die. In 2001, only 250 million vaccine doses were used globally, whereas the people...
Influenza is one of major public health problem worldwide. It is important to define longterm priorities to reduce morbidity and mortality from annual influenza epidemics and to prepare for the next influenza pandemic. During the influenza epidemics every year, an estimated half a million people worldwide die. The four pandemics in the last century...
The oral health of 219 residents with mental retardation living in a long-term-care institution near Milan was assessed. The dental and periodontal status, daily habits, oral hygiene, and oral mucosal status were evaluated. Of the sample, 179 (81.7%) were males. The mean age of the residents was 61.3 years, and the degree of cooperation was evaluat...
Influenza is a leading cause of morbidity and mortality in elderly people. This prospective, observed-blind, randomized, multicenter trial compares the immunogenicity and safety of three influenza vaccines in a sample of 635 elderly residents of four nursing homes in Milano (Italy). All vaccines were well tolerated: no serious adverse events were r...
In this paper the functional groups of the protista community of the activated-sludge process were investigated. Ciliate communities colonizing an activated-sludge plant receiving domestic and industrial waste were monitored. The dynamics of the observed ciliate species were studied through the microscopical analysis of the samples collected in the...
Viral hepatitis B remains a major public health problem in many parts of the world in which is still a leading cause of acute and chronic liver disease including chronic active hepatitis, cirrhosis, and hepatocellular carcinoma. WHO estimates that nearly 1 million people die each year from HBV- related diseases, that about 2 billion people in the w...
The spread of influenza is of major public health concern. Community based clinical morbidity data constitute an excellent predictor of when the peak of influenza virus activity will be reached. Surveillance programmes exist in many countries [1, 2]. A voluntary system for the surveillance of acute respiratory infection (ARI) and influenza was esta...
This article surveys the attitudes and perceptions of a random sample of the elderly population in three regions of Italy on the use and efficacy of influenza vaccine. The data were collected by direct interviews using a standard questionnaire. The results show that vaccination coverage against influenza is inadequate (26-48.6%). The major reasons...
To compare the effectiveness of reverse transcription-polymerase chain reaction (RT-PCR), shell vial culture and cytospin assay as laboratory techniques for rapid diagnosis of influenza infections, a retrospective study was carried out on 270 aliquots of oropharyngeal swabs collected from October 1993 to March 1996 and already characterized by stan...