Fabrizio Fina

Fabrizio Fina
University College London | UCL · School of Pharmacy

PhD in Pharmaceutics

About

11
Publications
4,283
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1,194
Citations
Introduction
3D printing of oral formulations by Selective laser sintering (SLS) and Fused deposition modeling (FDM)

Publications

Publications (11)
Article
Powder bed fusion (PBF) is a 3D printing method that selectively consolidates powders into 3D objects using a power source. PBF has various derivatives; selective laser sintering/melting, direct metal laser sintering, electron beam melting and multi-jet fusion. These technologies provide a multitude of benefits that make them well suited for the fa...
Conference Paper
3D printing is an innovative manufacturing technology that is able to produce bespoke objects by precise deposition of materials in successive layers. Already well recognised in the metal, ceramic and plastic manufacturing industries, recently 3D printing has approached the pharmaceutical field aiming to revolutionise the way medicines are produced...
Article
Full-text available
Zero-order release formulations are designed to release a drug at a constant rate over a prolonged time, thus reducing systemic side effects and improving patience adherence to the therapy. Such formulations are traditionally complex to manufacture, requiring multiple steps. In this work, fused deposition modeling (FDM) 3D printing was explored to...
Article
Pharmaceutical three-dimensional (3D) printing is a modern fabrication process with the potential to create bespoke drug products of virtually any shape and size from a computer-aided design model. Selective laser sintering (SLS) 3D printing combines the benefits of high printing precision and capability, enabling the manufacture of medicines with...
Article
Full-text available
The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of manni...
Article
Full-text available
Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the first time, to produce small oral dosage forms with modified release properties. As such, paracetamol-loaded 3D printed multiparticula...
Chapter
Powder bed fusion (PBF) is an umbrella term for three separate three-dimensional (3D) printing technologies; selective laser sintering (SLS), direct metal laser sintering (DMLS) and selective laser melting (SLM). These processes share the same printing procedure where powder particles are selectively fused by a local thermal process generated from...
Article
Three-dimensional printing (3DP) is gaining momentum in the field of pharmaceuticals, offering innovative opportunities for medicine manufacture. Selective laser sintering (SLS) is a novel, high resolution and single-step printing technology that we have recently introduced to the pharmaceutical sciences. The aim of this work was to use SLS 3DP to...
Article
Selective laser sintering (SLS) is a three-dimensional printing (3DP) technology employed to manufacture plastic, metallic or ceramic objects. The aim of this study was to demonstrate the feasibility of SLS to fabricating novel solid dosage forms with accelerated drug release properties, and with a view to create orally disintegrating formulations....
Article
Selective laser sintering (SLS) 3-dimensional printing is currently used for industrial manufacturing of plastic, metallic and ceramic objects. To date there are no reports on the use of SLS to fabricate oral drug loaded products, hence, the aim of this work was to explore the suitability of SLS printing for manufacturing medicines. Two thermoplast...
Article
The aim of this study was to manufacture 3D printed tablets (printlets) from enteric polymers by single filament fused deposition modeling (FDM) 3D printing (3DP). Hot melt extrusion was used to generate paracetamol-loaded filaments from three different grades of the pharmaceutical excipient hypromellose acetate succinate (HPMCAS), grades LG, MG an...

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Projects

Project (1)
Project
To fabricate 3D printed oral dosage forms (Printlets).