Fabricio Zambom Ferraresi

• PhD
• Navarrabiomed, Hospital Universitario de Navarra (HUN)-Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona (Spain)

Olfactory dysfunction impacts quality of life, safety, and nutrition. Despite its relevance among older adults, the role of medications in influencing olfactory performance remains understudied. This research investigates whether olfactory alterations in older adults are associated with the type or number of medications prescribed. An observational...

Background Hospital-associated functional decline affects nearly one-third of the hospitalized older adults. The aim of this trial is to investigate the effect of a cognitive stimulation intervention provided via immersive virtual reality (IVR), with or without a multicomponent physical exercise intervention (ME) in hospitalized patients aged 75 or...

Background Hospitalization exacerbates sarcopenia and physical dysfunction in older adults. Whether tailored inpatient exercise prevents acute sarcopenia is unknown. This study aimed to examine the effect of a multicomponent exercise programme on muscle and physical function in hospitalized older adults. We hypothesized that participation in a brie...

Background This study aimed to determine the threshold of muscle power and strength enhancements that lead to functional gains after exercise intervention in an acute care unit. Methods A total of 302 older patients (intervention: 169, control: 133) from two randomized clinical trials were included (mean age 86.7 years). We measured maximal streng...

Postoperative delirium (POD) is a common and serious neuropsychiatric syndrome that leads to higher morbidity and mortality. We investigated the association between serum C-reactive protein (CRP) and the occurrence of POD in older hip fracture patients, and whether CRP predicted POD better than a clinical model. Patients aged ≥ 75 years admitted fo...

Background The progressive aging of the population has meant the increase in elderly patients requiring an urgent surgery. Older adults, especially those with frailty, have a higher risk for complications, functional and cognitive decline after urgent surgery. These patients have their functional and physiological reserve reduced which makes them m...

Background and Objectives Exercise may reverse functional decline in hospitalized older adults, but the optimal duration is unclear. This study examined the potential relationship between in-hospital multicomponent exercise program duration and changes in physical function, cognition, and muscle function to maximize exercise-related health benefits...

Postoperative delirium (POD) is a common neuropsychiatric complication in geriatric inpa- tients after hip fracture surgery and its occurrence is associated with poor outcomes. The purpose of this study was to investigate the relationship between pre- operative biomarkers in serum and cerebrospinal fluid (CSF) and the development of POD in older hi...

Postoperative delirium (POD) is a common neuropsychiatric complication in geriatric inpatients after hip fracture surgery and its occurrence is associated with poor outcomes. The purpose of this study was to investigate the relationship between preoperative biomarkers in serum and cerebrospinal fluid (CSF) and the development of POD in older hip fr...

Background The progressive aging of the population has meant the increase in elderly patients requiring an urgent surgery. Older adults, especially those with frailty, have a higher risk for complications, functional and cognitive decline after urgent surgery. These patients have their functional and physiological reserve reduced which makes them m...

Introduction: Hip fractures are the most common fracture leading to hospitalization and are associated with high costs, mortality rates and functional decline. Although several guidelines exist for preventing new fractures and promoting functional recovery, they tend to focus on osteoporosis treatment and do not take into account the complexity of...

Background Bed rest during hospitalization can negatively impact functional independence and clinical status of older individuals. Strategies focused on maintaining and improving muscle function may help reverse these losses. This study investigated the effects of a short‐term multicomponent exercise intervention on maximal strength and muscle powe...

Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture risk, particularly in older adults. Thus, new technologies are necessary to improve the accuracy of fracture risk estimation. In th...

Cancer mostly affects older adults, causing a wide variety of diagnostic and therapeutic dilemmas. One of the most important moments in cancer patients is the hospitalization period, in which older patients usually remain bedridden for many hours and this may lead to the appearance of sarcopenia and disability. We present the research protocol for...

Purpose: Hip fracture is a public health problem worldwide. Traditional prognostic models do not include blood biomarkers, such as those obtained by proteomics. This study aimed to investigate the relationships between serum inflammatory biomarkers and frailty in older adults with hip fracture as well as adverse outcomes at one and three months af...

Background Postoperative delirium (POD) after hip fracture surgery is a common and serious neuropsychiatric syndrome that leads to higher morbidity and mortality. Current predictive models of delirium are based on clinical factors that can be subjective and imprecise. In this study we investigated the association between serum C-reactive protein (C...

Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two authors independently and systematically searched...

Objective: Hip fracture is a public health problem worldwide. Traditional prognostic models do not include blood biomarkers, such as those obtained by proteomics. In this prospective cohort study, we aimed to explore the role of a targeted proteomic approach in better characterizing frailty in older adults with hip fractures. Moreover, we sought to...

Objective: The clinical screening of hip fracture risk is complicated due to the limitations of the reference tools (i.e., bone turnover markers, BMD, FRAX) but with new biomarkers could provide better information for this risk. The present study described emerging biomarkers of the risk of hip fractures with different biomarkers in serum and compa...

Background Different multimorbidity patterns present with different prognoses, but it is unknown to what extent they may influence the effectiveness of an individualized multicomponent exercise program offered to hospitalized older adults. Methods This study is a secondary analysis of a randomized controlled trial conducted in the Department of Ge...

Delirium is an important cause of morbidity and mortality in older adults admitted to hospital. Multicomponent interventions targeting delirium risk factors, including physical exercise and mobilization, have been shown to reduce delirium incidence by 30–40% in acute care settings. However, little is known about its role in the evolution of deliriu...

Background: Postoperative delirium (POD) is a common complication in geriatric patients after surgery and its occurrence is associated with poor outcomes. The aim of this study was to evaluate and compare the quality of life (QOL) and the functional and cognitive status of patients with and without POD after hip fracture surgery in a study with 1-a...

Background: Delirium is a common and severe neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to identify predictive biomarkers of delirium in older patients through a systematic review and metaanalysis. Materials and Methods: A systematic review of literature published up to Au...

Delirium is a transient neurocognitive disorder. Nonpharmacological measures can be efficient in reducing the incidence and intensity of delirium, but there is a paucity of evidence when using a physical exercise program exclusively. This was a secondary analysis of a randomised clinical trial that provided evidence on the functional and cognitive...

Objetivos: Mostrar los resultados preliminares obtenidos de la utilización de Optipharm, una herramienta de formación digital basada en simulación y gamificación dirigida a profesionales clínicos y estudiantes del sector Salud para la mejora de la optimización farmacológica de pacientes mayores. Método: Se ha desarrollado una herramienta tecnológi...

Introducción: Existe un interés continuo y creciente por desarrollar intervenciones multicomponente para prevenir y revertir problemas funcionales, cognitivos, emocionales y de autocuidado en las personas mayores. Métodos: Este estudio enmarcado dentro del proyecto APTITUDE presenta los resultados de las evaluaciones basales previas a una intervenc...

La disminución de la capacidad olfativa es muy común en la población mayor. La disfunción olfatoria puede causar un impacto significativo en el bienestar físico, calidad de vida, estado nutricional y en la seguridad de las personas mayores, asociándose con el aumento de la mortalidad. Asimismo, una reducción del sentido del olfato puede considerars...

OBJETIVOS Dada la complejidad clínica, funcional, cognitiva y social de los pacientes ancianos diagnosticados de fractura de cadera, una intervención mediante un programa multidisciplinar y multicomponente consistente en ejercicio físico con tele-rehabilitación, valoración nutricional y de otras variables relacionadas con la valoración geriátrica i...

Background The increase in life expectancy has led to profound changes in disease prevention and health maintenance. Because of the impact of dysbiosis on the host's health, it is worth considering microbiome-targeted therapies to attenuate or delay age-related perturbations. Aim The aim of the present review was to systematically evaluate the imp...

Background Acute care hospitalization increases the likelihood of developing cognitive impairment and delirium in older adults. Objective To summarize evidence about the effectiveness of exercise and physical rehabilitation interventions on the incidence of delirium and cognitive impairment in acutely hospitalized older patients. Methods Relevant...

Background Physical exercise is an effective strategy for preserving functional capacity and improving the symptoms of frailty in older adults. In addition to functional gains, exercise is considered to be a cornerstone for enhancing cognitive function in frail older adults with cognitive impairment and dementia. We assessed the effects of the Vivi...

Background: Hospitalisation-associated disability due to reduced physical activity levels and prolonged bedrest episodes are highly prevalent in older adults. Objective: To assess the effect of gamified interventions on functional capacity in hospitalised older adults. Methods: A three-armed non-randomised controlled trial with two experimental int...

This randomized clinical trial examines the effectiveness and generalizability of implementing a multicomponent exercise program for treating functional decline associated with acute hospitalization in very old patients.

This is a reply to the comment by Inzitari et al. [...]

Identifying serum biomarkers that can predict physical frailty in older adults would have tremendous clinical value for primary care, as this condition is inherently related to poor quality of life and premature mortality. We compared the serum lipid profile of physically frail and robust older adults to identify specific lipid biomarkers that coul...

The aim of this article is to present the research protocol for a prospective cohort study that will assess the olfactory function and the effect of an intervention based on olfactory training in healthy very old adults (≥75 years old). A convenience sample of 180 older people (50% female) will be recruited in three different environments: hospital...

This study framed within the APTITUDE project presents the results of the baseline evaluations prior to a multicomponent intervention in community patients. The objective is to promote skills related to five different domains (physical exercise, nutrition, psychosocial problems, prevention of cognitive impairment and medication review). The study i...

Modelos de atención en salud a las personas mayores basados en el valor: Diseño del estudio participativo en la Eurorregión Abstract Los modelos de atención a las personas mayores presentan limitaciones que pueden ser abordadas mediante un enfoque basado en valor. Estos modelos tienen como objetivo generar resultados en salud que sean realmente imp...

Background: Lung cancer is the second most prevalent common cancer in the world and predominantly affects older adults. This study aimed to examine the impact of an exercise programme in the use of health resources in older adults and to assess their changes in frailty status. Design: This is a secondary analysis of a quasi-experimental study wi...

The World Health Organization has developed the Integrated Care of Older People (ICOPE) strategy, a program based on the measurement of intrinsic capacity (IC) as "the composite of all physical and mental attributes on which an individual can draw". Multicomponent interventions appear to be the most effective approach to enhance IC and to prevent f...

The purpose of this study was to examine the effects of a 12-month physical activity (PA) programme consisting in walking on muscle function in patients with COPD (Chronic Obstructive Pulmonary Disease). Forty-four men (70.3 ± 6.7 years old) diagnosed with moderate-severe COPD were recruited. The intervention group (PAG) completed a physical activi...

Introduction: The inverse association between cardiorespiratory fitness and all-cause mortality in apparently healthy populations has been previously reported; however, the existence of this association among adults diagnosed with cancer is unclear. Aim: To determine the association between cardiorespiratory fitness and all-cause mortality in ad...

The World Health Organization has developed the Integrated Care of Older People (ICOPE) strategy, a program based on the measurement of intrinsic capacity (IC) as “the composite of all physical and mental attributes on which an individual can draw”. Multicomponent interventions appear to be the most effective approach to enhance IC and to prevent f...

The World Health Organization has developed the Integrated Care of Older People (ICOPE) strategy, a program based on the measurement of intrinsic capacity (IC) as “the composite of all physical and mental attributes on which an individual can draw”. Multicomponent interventions appear to be the more effective approach to enhance IC and to prevent f...

There is emerging evidence that emphasizes RDW as an optimal prognostic biomarker for cardiovascular diseases. However, there is hardly any evidence of interventions that are capable of modifying RDW. Our aim was to investigate the association of RDW levels and the response to an individualized exercise program in hospitalized older adults. To our...

https://blogs.bmj.com/bjsm/2021/03/06/vivifrail-a-multi-component-physical-training-program-to-prevent-weakness-and-falls-in-people-over-70-years/

Background: During the period of hospitalization patients can develop functional decline. The main aim of our study was to assess the natural trajectory of each Activity of Daily Living (ADL) and to assess how in-hospital exercise could influence short-term trajectory of ADLs. Methods: Acutely hospitalized patients (n=297, 56.5% women) were random...

Acute medical illness and subsequent hospitalization are associated with several negative health consequences in older adults, even when the acute disease that caused the hospital admission is successfully treated. Loss of function in activities of daily living following hospitalization increases the risk of new disabilities, hospital readmissions,...

Due to the dramatic impact of the COVID-19 pandemic, Spain underwent a strict lockdown (March–May 2020). How the lockdown modified older adults’ physical activity (PA) has been poorly described. This research assesses the effect of the lockdown on PA levels and identifies predictors of sufficient/insufficient PA in frail older community-dwellers. C...

The purpose of this systematic review and meta-analysis was to appraise the acute effects of exercise training on inflammatory parameters in hospitalized older adults. We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Web of Science, Medline and PubMed were searched for studies...

El objetivo de este estudio fue examinar los efectos de un programa de actividad física AF) de andar en la función muscular en pacientes con EPOC (Enfermedad Pulmonar bstructiva Crónica), con un seguimiento de 12 meses. Se reclutaron 44 hombres (70,3 ± 6,7 años) diagnosticados de EPOC moderado-severo. El grupo intervención realizó un programa de a...

Introduction: Clinically viable screening tools for detecting individuals at heightened risk for mobility limitations is warranted. However, it remains unclear in acutely hospitalized patients (> 75 years) whether handgrip strength might be a good predictor for "proxy" muscle strength. Objective: To examine the reliability and validity of handgrip...

Background: Physical function is an independent predictor of numerous chronic diseases, but its association with all-cause mortality in older adults diagnosed with cancer has received little attention. Objective: The aim of this study was to conduct a systematic review and meta-analysis on the prospective association between physical function and a...

Background Physical function is an independent predictor of numerous chronic diseases, but its association with all-cause mortality in older adults diagnosed with cancer has received little attention. Objective The aim of this study was to conduct a systematic review and meta-analysis on the prospective association between physical function and al...

Valoración Funcional para el programa multicomponente VIVIFRAIL https://www.youtube.com/watch?v=pHa3c49NbgI&feature=youtu.be

Programa multicomponente VIVIFRAIL para personas con Limitación grave (No pueden levantarse de la silla https://www.youtube.com/watch?v=hYSzR-FJ0zc&feature=youtu.be

Entrenamiento para realizar en la calle Programa multicomponente VIVIFRAIL para personas mayores de 70 años que puedan caminar y subir escaleras https://www.youtube.com/watch?v=9-JSxU264Wo&feature=youtu.be

Programa multicomponente VIVIFRAIL para personas con limitación leve (dificultad para levantarse 5 veces de la silla) [Vídeo] https://www.youtube.com/watch?v=MJG3NVJw_PA&feature=youtu.be

Programa multicomponente VIVIFRAIL para personas Robustas https://www.youtube.com/watch?v=G-xXnK99nJM&feature=youtu.be

Programa multicomponente VIVIFRAIL para personas mayores de 70 años que puedan caminar y subir escaleras [Vídeo] https://www.youtube.com/watch?v=MOciUVK8N8c&feature=youtu.be

Entrenamiento para realizar en casa Programa multicomponente VIVIFRAIL para personas con Limitaciones para caminar y levantarse de la silla https://www.youtube.com/watch?v=I_tWOFY8sJ0&feature=youtu.be

OBJECTIVE To analyze the effects of a tailored exercise intervention in acutely hospitalized oldest old diabetic patients. RESEARCH DESIGN AND METHODS This is an ancillary analysis of a randomized controlled trial. 103 acutely hospitalized older adults (mean age ~87 years) with type II diabetes were randomized to an intervention (exercise, n=54) or...

The aim of this article is to present the research protocol for a study that will evaluate the feasibility of implementation of Health Arcade prototype multidomain intervention based on physical and cognitive training using gamification technologies at improving care for older people hospitalized with an acute illness. A total of 40 older people wi...

Objectives: To examine the effectiveness of game-based interventions compared with usual care on health-related outcomes for acutely hospitalized older patients. Design: Systematic review of randomized controlled trials (RCT) and nonrandomized trials. Setting and Participants: Adults aged 65 years or older admitted to an Acute Care for Elderly uni...

Objectives: An individualized, multicomponent exercise program is effective to reverse the functional and cognitive decline that frequently occur during acute care hospitalization in old patients. The aim was to determine whether improvements in cognition mediate improvements in physical function in acutely hospitalized older patients. Design: A s...

Background: Aging-related traits, including gradual loss of skeletal muscle mass and chronic inflammation, are linked to altered body composition and impaired physical functionality, which are important contributing factors to the disabling process. We sought to explore the potential relationship between lower-body muscle strength decline and infla...

Exercise rehabilitation programs have proven to increase exercise capacity and quality of life (QoL) in hospitalized patients with COPD. However, controversy exists as to the actual safety and effectiveness of this type of intervention We assessed the effects of an individualized exercise program on the functional capacity of acutely hospitalized o...

Exercise rehabilitation programs have proven to increase exercise capacity and quality of life (QoL) in hospitalised patients with COPD. However, controversy exists as to the actual safety and effectiveness of this type of intervention We assessed the effects of an individualised exercise program on the functional capacity of acutely hospitalised o...

Background Physical exercise is beneficial to reduce the risk of several conditions associated with advanced age, but to our knowledge, no previous study has examined the association of long-term exercise interventions (≥ 1 year) with the occurrence of dropouts due to health issues and mortality, or the effectiveness of physical exercise versus usu...

The adverse effects of fat mass on functional dependence might be attenuated or worsened, depending on the level of muscular strength. The aim of this study was to determine (i) the detrimental effect of excess adiposity on dependence in activities of daily living (ADL), and (ii) whether relative handgrip strength (HGS) moderates the adverse effect...

Background A classic consequence of short‐term bed rest in older adults is the significant loss in skeletal muscle mass and muscle strength that underlies the accelerated physical performance deficits. Structured exercise programmes applied during acute hospitalization can prevent muscle function deterioration. Methods A single‐blind randomized cl...

Background: The short physical performance battery (SPPB) is a physical performance test of lower extremity function designed for non-disabled older adults. We aimed to establish reference values for community-dwelling Colombian adults aged 60 years or older in terms of (1) the total score; (2) the three subtest scores (walking speed, standing bala...