Fabricio Ferreira de Oliveira

Fabricio Ferreira de Oliveira
Universidade Federal de São Paulo | UNIFESP · Departamento de Neurologia e Neurocirurgia

MD, BBA, MSc, PhD
Executive Medical Director at the ELYSIAN® Clinic in São Paulo, Brazil

About

154
Publications
31,681
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Introduction
Fabricio Ferreira de Oliveira MD BBA MSc PhD is the Executive Medical Director of the ELYSIAN® Clinic in São Paulo, Medical Researcher of the Department of Neurology and Neurosurgery of the Federal University of São Paulo - UNIFESP, Internist and Mentor at the A. C. Camargo Cancer Center, expert in Internal Medicine and Neurology, Member of the International Subcommittee of the American Academy of Neurology and of the Community of Experts of the European Science Foundation.
Additional affiliations
July 2020 - present
Hospital A. C. Camargo
Position
  • Mentor
October 2018 - present
ELYSIAN® Clinic
Position
  • Managing Director
February 2016 - February 2019
Universidade Federal de São Paulo
Position
  • Affiliate Professor
Education
September 2015 - August 2018
October 2010 - October 2014
Universidade Federal de São Paulo
Field of study
  • Neurology/Neurosciences
March 2007 - June 2009
University of Campinas
Field of study
  • Medical Sciences (Neurology)

Publications

Publications (154)
Article
Background: More than 95% of right-handed individuals, as well as almost 80% of left-handed individuals, have left hemisphere dominance for language. The perisylvian networks of the dominant hemisphere tend to be the most important language systems in human brains, usually connected by bidirectional fibres originated from the superior longitudinal...
Article
Lifetime risk factors for cognitive and functional decline in Alzheimer’s disease (AD) are not fully understood, and were prospectively evaluated in patients with low mean schooling from São Paulo, Brazil. Consecutive outpatients with late-onset AD were assessed for APOE haplotypes and the following potential baseline predictors: gender, schooling,...
Article
Background: Pharmacogenetic effects of statins on clinical changes in Alzheimer's disease (AD) could be mediated by epistatic interactions among relevant genetic variants involved in cholesterol metabolism. Objective: To investigate associations of HMGCR (rs3846662), NR1H2 (rs2695121), or CETP (rs5882&rs708272) with cognitive and functional chan...
Article
Psychotic phenomena are among the most severe and disruptive symptoms of dementias and appear in 30% to 50% of patients. They are associated with a worse evolution and great suffering to patients and caregivers. Their current treatments obtain limited results and are not free of adverse effects, which are sometimes serious. It is therefore crucial...
Article
Full-text available
Frontotemporal dementia (FTD) covers a spectrum of neurodegenerative disorders with different phenotypes, genetic backgrounds, and pathological states. Its clinicopathological diversity challenges the diagnostic process and the execution of clinical trials, calling for specific diagnostic biomarkers of pathologic FTD types. There is also a need for...
Article
Full-text available
The field of vascular contributions to cognitive impairment and dementia (VCID) is evolving rapidly. Research in VCID encompasses topics aiming to understand, prevent, and treat the detrimental effects of vascular disease burden in the human brain. In this perspective piece, early career researchers (ECRs) in the field provide an overview of VCID,...
Chapter
In Alzheimer’s disease, amyloid-β biomarkers become abnormal decades before cognition starts to decline and also before detectable biomarkers of neurodegeneration. Reduced levels of acetylcholine receptors and loss of cholinergic neurons are among the major neuropathological events, usually precipitated by the accumulation of extracellular amyloid-...
Article
Objective: Neuropsychiatric syndromes have been associated with memory dysfunction and risk of and earlier onset of dementia, but how psychotropic drugs affect clinical changes in Alzheimer’s disease is not entirely clear. This study aimed to assess the prospective effects of psychotropic drugs on cognitive and functional changes in Alzheimer’s dis...
Article
Full-text available
Introduction: Harmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts. Methods: To harmonize the assessment of mild cognitive impairment in Europe, a workshop (Geneva, May 2018) convened stakeho...
Conference Paper
Full-text available
Background/purpose: Sleep disorders (SD) have a complex etiology and socioeconomic status (SES) as determined by income and education plays an important role in their development. SES also influences allostatic load caused by chronic accumulation of stress throughout life. Environmental and psychological stressors have a direct effect on SD, and th...
Article
Introduction: The inherited risk of late-onset Alzheimer’s disease (AD) is genetically determined. We aimed to examine associations of genetic variants of APOE and ACE with age at AD onset and with neuropsychiatric symptoms according to each dementia stage. Methods: Consecutive outpatients with AD were assessed for demographic features, Clinical De...
Article
Background: Behavioral features may reflect proteinopathies predicting pathophysiology in neurodegenerative diseases. Objective: We aimed to investigate associations of cerebrospinal fluid biomarkers of amyloidogenesis and neurodegeneration with neuropsychiatric features in dementia with Lewy bodies (DLB) compared with late-onset Alzheimer's dis...
Conference Paper
Objective: To study associations of cerebrospinal fluid biomarkers with cognition and functionality in dementia with Lewy bodies (DLB) compared with Alzheimer’s dementia (AD) and cognitively healthy people. Background: Amyloidosis and neurodegeneration may correlate with cognition and functionality, reflecting degrees of neuropathology in dementia...
Article
Full-text available
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean...
Article
Full-text available
Background: Swallowing and feeding problems may occur with the progression of behavioral variant frontotemporal dementia (bvFTD) and can impair the anticipatory and oral preparatory phases of swallowing. Objective: To characterize swallowing problems and the feeding situation of patients with bvFTD and to correlate the swallowing problems with fun...
Article
Full-text available
The SARS-CoV-2 global pandemic will disproportionately impact countries with weak economies and vulnerable populations including people with dementia. Latin American and Caribbean countries (LACs) are burdened with unstable economic development, fragile health systems, massive economic disparities, and a high prevalence of dementia. Here, we unders...
Article
Full-text available
Effects of statins over clinical changes in Alzheimer’s disease (AD) are usually non-significant, but epistatic interactions between genetic variants involved in cholesterol metabolism could be important for such effects. We aimed to investigate whether LDLR single-nucleotide polymorphisms rs11669576 (LDLR8), rs5930 (LDLR10), and rs5925 (LDLR13) ar...
Article
Full-text available
To identify knowledge gaps regarding new‐onset agitation and impulsivity prior to onset of cognitive impairment or dementia the International Society to Advance Alzheimer's Research and Treatment Neuropsychiatric Syndromes (NPS) Professional Interest Area conducted a scoping review. Extending a series of reviews exploring the pre‐dementia risk synd...
Conference Paper
Full-text available
Background Klüver‐Bucy syndrome (KBS) comprises: 1) hyperorality, 2) hypermetamorphosis, 3) hypersexuality, 4) eating disorder, 5) placidity, 6) visual agnosia (psychic blindness) and 7) amnesia (at least three components are described as partial KBS). The classic description involves bilateral injuries to the anterior temporal lobes, but it has be...
Conference Paper
Full-text available
Background Anatomical studies in animals have described multiple striatal circuits and suggested that sub‐components of the striatum project to distinct cortical areas. Researchers that reconstructed tracts of the left and right putamen have shown ipsilateral projections to the primary motor area, primary somatosensory area, supplementary motor are...
Article
Objective Differential diagnosis between Parkinson’s disease (PD) dementia and dementia with Lewy bodies (DLB) is difficult due to common features, whereas management decisions and research endpoints depend upon knowledge of dementia severity. We aimed to assess risk factors for age at dementia onset, as well as which neuropsychiatric features are...
Article
Full-text available
Background Lewy body dementia (LBD) impairs performance in daily activities and affects motor, language and visuospatial tasks. Objective We aimed to correlate neuropsychiatric and motor assessments with language and visual organization tests in LBD. Methods Twenty-two patients with dementia with Lewy bodies and ten patients with Parkinson’s dise...
Conference Paper
Background: Neurofibrillary tangles are usually ubiquitinated, whereas Lewy bodies might decrease cerebrospinal fluid concentrations of ubiquitin; thus, tau isoforms and ubiquitin in the cerebrospinal fluid might correlate with behavioral dysfunction in dementia syndromes. Methods: Consecutive outpatients with probable dementia with Lewy bodies (D...
Article
Full-text available
Background & objectives: Neurodegeneration affects blood pressure variations, while renal function and cerebral perfusion are impaired by vascular risk factors. This study was aimed to estimate variations of measures of cardiovascular risk in Alzheimer's dementia by pharmacogenetic analyses of the effects of angiotensin-converting enzyme (ACE) inhi...
Conference Paper
Full-text available
Background: Pharmacologically treatable behavioral features may reflect underlying amyloidogenesis and neurodegeneration in dementia syndromes. Methods: Consecutive outpatients with probable dementia with Lewy bodies (DLB) were paired with outpatients with late-onset Alzheimer’s dementia (AD) by sex, Clinical Dementia Rating (CDR) and Mini-Mental...
Conference Paper
Full-text available
Background: Given some of the current limitations in implementing gait assessment for mild cognitive impairment (MCI), we aimed to investigate how much Montreal Cognitive Assessment (MoCA) score was correlated with step height (SH) changes during a repetitive stepping-in-place (SIP) task in patients with MCI. Methods: Whilst Montreal Cognitive Ass...
Conference Paper
Full-text available
Background: Earlier evidence showed that Memantine antagonizes the N-methyl-D-aspartate (NMDA) type of glutamate receptor leading to possible behavioral improvement and a synergistic effect with cholinesterase inhibitors over slower functional and cognitive decline in Alzheimer’s dementia (AD). Variations in some receptor genes can contribute to AD...
Conference Paper
Full-text available
Background: Amyloidogenesis may cause earlier onset of dementia with Lewy bodies (DLB) as well as Alzheimer’s dementia (AD), whereas the angiotensin-converting enzyme (ACE-1) is an amyloid-β-degrading enzyme. Methods: Consecutive outpatients with probable DLB (fourth consensus report of the DLB Consortium) were paired with outpatients with late-on...
Conference Paper
Full-text available
Background: Primary Progressive Aphasia (PPA) is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Among the three recognized variants of PPA, we would like to share an interesting case that resembles an animated episode of Dungeons and Dragons written by Steve Gerber and released i...
Preprint
Influence of socioeconomic status-stress induced on sleep quality: a systematic review. Preprints 2018 SUMMARY Sleep disorders (SD) have a complex aetiology, and socioeconomic status (SES) as determined by social class, household income, ethnicity and education plays an important role in their development. As SD are associated with cognitive impair...
Conference Paper
Full-text available
Objective: To assess whether angiotensin-converting enzyme (ACE) inhibitors modulate associations of biofluid concentrations and activity of ACE with motor and non-motor experiences in dementia with Lewy bodies (DLB) compared with Alzheimer’s dementia (AD) and cognitively healthy people. Background: Amyloidogenesis is pathogenically important in D...
Conference Paper
Full-text available
Objective: To study associations of cerebrospinal fluid (CSF) amino acids and monoamine metabolites with motor and non-motor features in dementia with Lewy bodies (DLB) compared with Alzheimer’s dementia (AD) and healthy controls. Background: Motor and non-motor aspects of daily experiences may reflect amino acid and monoamine metabolism in dement...
Conference Paper
Full-text available
Objective: To study associations of cerebrospinal fluid biomarkers of amyloidogenesis and neurodegeneration with motor and non-motor aspects of daily experiences in dementia with Lewy bodies (DLB) compared with Alzheimer’s dementia (AD) and cognitively healthy people. Background: Motor and non-motor aspects of daily experiences may reflect amyloid...
Conference Paper
Full-text available
Background: Illiteracy, midlife cerebrovascular risk and copies of APOE-e4 are risk factors for Alzheimer's dementia (AD). This study aimed to explore the impacts of risk factors for progression of AD in São Paulo, Brazil. Methods: Outpatients with late-onset AD were assessed for APOE haplotypes (rs7412&rs429358 genotyped by TaqMan® Real-Time PCR t...
Conference Paper
Full-text available
Background: Neuropsychiatric syndromes have been associated with risk and earlier onset of dementia, but it is unclear whether neuropsychiatric treatment may affect clinical changes in Alzheimer's disease dementia (AD). This study aimed to investigate whether psychotropics may affect cognitive or functional changes in AD. Methods: Consecutive outpa...
Conference Paper
Full-text available
Background: Brain monoamine activity and aminoacid concentrations may correlate with cognition, reflecting their metabolism in dementia. Methods: Consecutive outpatients with probable dementia with Lewy bodies (DLB, fourth consensus report of the DLB Consortium) were paired with outpatients with late-onset Alzheimer's dementia (AD, NIA-AA workgroup...
Conference Paper
Full-text available
Background: The angiotensin-converting enzyme is an amyloid-ß-degrading enzyme; therefore, angiotensin-converting enzyme inhibitors (ACEis) may increase amyloid-ß concentrations. Contrariwise, ACEis may improve cognitive function by affecting the angiotensin-II-mediated inhibition of acetylcholine release, and also by increasing brain substance P (...
Article
Background: Illiteracy, high cerebrovascular risk and copies of APOE-ϵ4 are risk factors for Alzheimer's disease dementia (AD). We aimed to investigate the impacts of gender, education, coronary heart disease (CHD) risk and creatinine clearance variations, body mass index (BMI) and APOE haplotypes over the rates of cognitive and functional decline...
Conference Paper
Objective: To study associations of cerebrospinal fluid aminoacids and monoamine metabolites with behavior in dementia with Lewy bodies (DLB) compared with Alzheimer’s dementia (AD) and cognitively healthy people. Background: Brain monoamine activity and aminoacid concentrations may correlate with behavioral features, reflecting their metabolism i...
Article
Background: While the angiotensin-converting enzyme degrades amyloid-β, angiotensin-converting enzyme inhibitors (ACEis) may slow cognitive decline by way of cholinergic effects, by increasing brain substance P and boosting the activity of neprilysin, and by modulating glucose homeostasis and augmenting the secretion of adipokines to enhance insul...
Conference Paper
Background and aims: The angiotensin-converting enzyme is an amyloid-β-degrading enzyme. Angiotensin receptor blockers have been implicated in the modulation of glucose homeostasis and in the boosted secretion of adipocytokines, thus improving insulin sensitivity and potentially slowing cognitive decline in patients with dementia due to Alzheimer’s...
Conference Paper
Background and aims: Associations of the insertion allele of an Alu repeat insertion/deletion (I/D) polymorphism in intron 16 of ACE with dementia due to Alzheimer’s disease (AD) are not consistent in all studies. We sought to examine associations of APOE haplotypes and the ACE I/D polymorphism with neuropsychiatric symptoms according to each stage...
Conference Paper
Background and aims: Lewy body dementia syndromes present motor impairment and neuropsychiatric symptoms among their main manifestations. It is unclear how motor experiences are associated with behaviour in these patients. Methods: Participants with Parkinson’s disease dementia (PDD) or dementia with Lewy bodies (DLB) were screened with the Movemen...
Conference Paper
Background: When in combination with other cerebrovascular risk factors, midlife hypercholesterolemia is usually associated with earlier onset of Alzheimer’s disease dementia, particularly regarding higher levels of LDL-cholesterol inducing cortical amyloid-β deposition. Contrariwise, late life hypercholesterolemia might slow cognitive decline, pos...
Article
Hypercholesterolemia and statin use have been unevenly associated with clinical change in Alzheimer's disease dementia. In this longitudinal study, 192 consecutive outpatients with late-onset Alzheimer's disease dementia were stratified according to APOE haplotypes, and followed for one year to investigate associations of lipid profile variations a...
Article
Full-text available
Objective:: To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer's disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Methods:: Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores accord...
Conference Paper
Full-text available
Transtornos do sono são frequentes em pacientes com demências por corpos de Lewy, em particular o distúrbio comportamental do sono REM (RBD), com valor prognóstico nas sinucleinopatias. OBJETIVO: Analisar padrões qualitativos e quantitativos do sono nas demências por corpos de Lewy. MÉTODO: Pacientes consecutivos com demência com corpos de Lewy (DC...
Article
Little is known on how risk factors for Alzheimer disease (AD) dementia affect disease progression, much less for populations with low mean schooling, whereas the transcription of APOE may be regulated by nongenetic factors. In this 44-month cohort study, 214 consecutive outpatients with late-onset AD were assessed for rates of cognitive and functi...
Article
Background: Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. Methods: Consecutive outpatients with late-onset Alzheimer's disease (AD) at various stages and their respective caregivers were assessed for score variations in 1 year of tests assessing caregiver burden,...
Conference Paper
Background: Lewy body dementia syndromes present motor impairment and neuropsychiatric symptoms among their main manifestations. It is unclear how motor signs are associated with behavioural and functional status in these patients. Methods:Participants with Parkinson’s disease dementia (PDD) or dementia with Lewy bodies (DLB) were screened with the...
Conference Paper
Background: Low schooling, high cerebrovascular risk and APOE4+ haplotypes are risk factors for Alzheimer’s disease dementia (AD). We aimed to investigate the impacts of gender, education, coronary heart disease (CHD) risk and creatinine clearance variations, body mass index (BMI) and APOE haplotypes over the rates of cognitive and functional decli...
Conference Paper
Background: Earlier evidence showed that Memantine antagonises the N-methyl-D-aspartate (NMDA) type of glutamate receptor leading to possible behavioural improvement and a synergistic effect with cholinesterase inhibitors over slower cognitive and functional decline in Alzheimer’s disease dementia (AD). Variations in some receptor genes can contrib...
Article
Full-text available
Antecedentes: El deterioro de la función renal depende de la edad y los factores vasculares. La literatura sobre los efectos de fármacos antihipertensivos mediada genéticamente en la función renal es pobre. Objetivo: Estimar las variaciones de urea y creatinina a través del análisis farmacogenético de los efectos antihipertensivos de los inhibidore...
Article
Full-text available
Background: Renal function declines according to age and vascular risk factors, whereas few data are available regarding genetically-mediated effects of anti-hypertensives over renal function. Objective: To estimate urea and creatinine variations in dementia due to Alzheimer disease (AD) by way of a pharmacogenetic analysis of the anti-hypertens...
Article
Full-text available
Objectives: To assess correlations among gait apraxia, balance impairment and cognitive performance in mild (AD1, n = 30) and moderate (AD2, n = 30) AD. Method: The following evaluations were undertaken: gait apraxia (Assessment Walking Skills); balance performance (Berg Balance Scale); Clinical Dementia Rating and Mini-mental State Examination...
Article
Background: Few studies have described characteristics of swallowing in primary progressive aphasia (PPA) and its variants. Objective: To describe and characterize swallowing and eating behaviors of patients with PPA, as well as their correlates with neuropsychiatric symptoms and patterns of communication. Methods: We studied 16 patients with...
Conference Paper
Background: Genotypes of LDLR and CETP have been associated with risk of Alzheimer’s disease dementia (AD). Regardless of APOE haplotypes, it is unknown whether these genes may modify the age at onset of AD. Objectives: To investigate the effects of APOE haplotypes and polymorphisms of LDLR and CETP over the age at onset of AD. Methods: Participant...
Article
Midlife cerebrovascular risk, low cognitive reserve and APOE4+ haplotypes are risk factors for Alzheimer's disease dementia (AD). We prospectively searched for factors that might be associated with yearly changes in caregiver burden, cognition, basic and instrumental functionality in 193 consecutive outpatients with late-onset AD, namely gender, AP...
Article
Introduction: Neuropsychiatric and epidemiological patterns may compensate for insufficient specificity of diagnostic criteria of Lewy body dementia (LBD) syndromes in differential analysis with Alzheimer disease (AD) dementia. We aimed to compare and distinguish demographic and neuropsychiatric features between LBD and APOE-ε3/ε3 late-onset AD. Me...
Article
Primarily, we sought to verify correlations among assessments for cognition, behaviour and functional independence in a sample of patients with dementia due to Alzheimer's disease (AD). Secondarily, impacts of education, APOE haplotypes, length of dementia, age and alcohol use over the neuropsychiatric assessment were estimated. Patients with AD we...
Article
IntroductionThere are three recognized subtypes of primary progressive aphasia syndromes [1]: the logopenic variant, the agrammatic (or non-fluent) variant, and semantic dementia. The logopenic variant of primary progressive aphasia, with hesitant anomic speech, word retrieval and sentence repetition deficits, features left posterior perisylvian or...
Article
Full-text available
The aims of this study were to investigate risk factors for cognitive and functional decline among 193 patients with Alzheimer's disease dementia (AD), and to conduct pharmacogenetic analysis on cerebrovascular metabolism modulators, taking into account APOE haplotypes and the genotypes of ACE, CETP, LDLR and the LXR-β gene. For all patients, later...
Conference Paper
Full-text available
Aims: Due to insufficient specificity of current diagnostic criteria for Lewy body dementia (LBD) syndromes, we sought to compare clinical and epidemiological features between LBD and dementia due to Alzheimer's disease (AD). Methods: According to gender and Mini-Mental State Examination scores, 39 consecutive patients with diagnoses of dementia wi...
Article
Sleep length and architecture are potential markers of progressive cognitive impairment, while neuropsychiatric symptoms and APOE4− haplotypes have been associated with more sleep complaints in patients with dementia due to Alzheimer’s disease (AD). In this cross-sectional study, we sought to investigate which factors might be related to sleep sati...
Article
Full-text available
Objective: Besides significant cognitive decline, patients in later stages of Alzheimer's disease (AD) also present global functional impairment, usually reported by their caregivers. This study searched for preserved activities of daily living by investigating correlations among specific instruments for severe dementia with a performance-based fu...
Article
Full-text available
Pharmacological treatment has mild effects for patients with Alzheimer's disease dementia (AD); therefore, the search for modifiable risk factors is an important challenge. Though risk factors for AD are widely recognized, elements that influence the time of dementia onset have not been comprehensively reported. We aimed to investigate which risk f...