Fabrice MAMBU Mbika

• Doctor of Medicine
• biologist doctor at University of Kinshasa

Background: During the 2018–20 Ebola virus disease outbreak in the Democratic Republic of the Congo, thousands of patients received unprecedented vaccination, monoclonal antibody (mAb) therapy, or both, leading to a large number of survivors. We aimed to report the clinical, virological, viral genomic, and immunological features of two previously v...

Polio-associated paralysis is one of the diseases under national surveillance in the Democratic Republic of the Congo (DRC). Although it has become relatively rare due to control measures, non-polio paralysis cases are still reported and constitute a real problem, especially for etiological diagnosis, which is necessary for better management and re...

Summary Background The Democratic Republic of the Congo has had 15 Ebola virus disease (EVD) outbreaks, from 1976 to 2023. On June 1, 2020, the Democratic Republic of the Congo declared an outbreak of EVD in the western Équateur Province (11th outbreak), proximal to the 2018 Tumba and Bikoro outbreak and concurrent with an outbreak in the eastern N...

Summary Background The Democratic Republic of the Congo has had 15 Ebola virus disease (EVD) outbreaks, from 1976 to 2023. On June 1, 2020, the Democratic Republic of the Congo declared an outbreak of EVD in the western Équateur Province (11th outbreak), proximal to the 2018 Tumba and Bikoro outbreak and concurrent with an outbreak in the eastern N...

Background Ebola virus disease (EVD) outbreaks have emerged in Central and West Africa. EVD diagnosis relies principally on RT-PCR testing with GeneXpert ® , which has logistical and cost restrictions at the peripheral level of the health system. Rapid diagnostic tests (RDTs) would offer a valuable alternative at the point-of-care to reduce the tur...

Background: Ebola virus disease (EVD) outbreaks have emerged in Central and West Africa. EVD diagnosis relies principally on RT-PCR testing with GeneXpert®, which has logistical and cost restrictions at the peripheral level of the health system. Rapid diagnostic tests (RDTs) would offer a valuable alternative at the point-of-care to reduce the tur...

Background Ebola virus disease (EVD) outbreaks have emerged in Central and West Africa. EVD diagnosis relies principally on RT-PCR testing with GeneXpert ® , which has logistical and cost restrictions at the peripheral level of the health system. Rapid diagnostic tests (RDTs) would offer a valuable alternative at the point-of-care to reduce the tur...

During the 10th outbreak of Ebola virus disease in the Democratic Republic of the Congo, the Institut National de Recherche Biomédicale strategically positioned 13 decentralized field laboratories with dedicated equipment to quickly detect cases as the outbreak evolved. The laboratories were operated by national staff, who quickly handed over compe...

During the 10th outbreak of Ebola virus disease in the Democratic Republic of the Congo, the Institut National de Recherche Biomédicale strategically positioned 13 decentralized field laboratories with dedicated equipment to quickly detect cases as the outbreak evolved. The laboratories were operated by national staff, who quickly handed over compe...

Background: As mortality remains high for patients with Ebola virus disease (EVD) despite new treatment options, the ability to level up the provided supportive care and to predict the risk of death is of major importance. This analysis of the EVISTA cohort aims to describe advanced supportive care provided to EVD patients in the Democratic Republ...

Background A paucity of data is available on virologic and biochemical characteristics of paediatric Ebolavirus disease (EVD), compared to adults. Methods We conducted a retrospective chart review of children (<16 years old) and a comparator group of young adults (16−44 years) from two treatment centres during the 2018−2020 EVD epidemic in Eastern...

Background A paucity of data is available on virologic and biochemical characteristics of paediatric Ebolavirus disease (EVD), compared to adults. Methods We conducted a retrospective chart review of children (<16 years old) and a comparator group of young adults (16–44 years) from two treatment centres during the 2018–2020 EVD epidemic in Eastern...

Human Immunodeficiency Virus (HIV) is a deadly sex-transmitted infection (STI) that remains a worldwide public health concern. Despite the progress recorded in the HIV prevention, we still observe high HIV prevalence especially among Men who have sex with Men (MSM). Within this latter group, the prevalence of HIV is reported to be higher and can th...

Human Immunodeficiency Virus (HIV) is a deadly sex-transmitted infection (STI) that remains a worldwide public health concern. Despite the progress recorded in the HIV prevention, we still observe high HIV prevalence especially among Men who have sex with Men (MSM). Within this latter group, the prevalence of HIV is reported to be higher and can th...

We assessed the level of preparedness of health care personnel at Evangelical Vanga Hospital to deal with the pandemic with the specific objectives of measuring the level of knowledge of health care personnel about Covid-19, determining the attitudes of HEV health care personnel toward Covid-19, and describing the practices of health care personnel...

Le test rapide Oraquick® Ebola peut être utilisé comme une alternative d’orientation diagnostique pour les décès. Sa performance au laboratoire a été améliorée après intervention sur terrain dans la surveillance des décès communautaires mais aussi grâce à La formation des équipes locales et l’engagement de la communauté .

Background. Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence. Methods. Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests...

Background The Democratic Republic of the Congo has confronted 13 outbreaks of Ebola virus disease since 1976. Rapid diagnostic tests (RDTs) detecting viral antigens have been developed to circumvent difficulties encountered with RT-PCR for diagnosis in remote low-resource settings, but there is still uncertainty about their performance characteris...

Clinically suspect EVD patients could be missing EVD cases and thereby being involved in EBOV resurgence. Thus, surveillance during and after outbreaks should be extended to EBOV household contacts, and to suspects discharged as negative with an accurate serological assay. Abstract Survivors from Ebola virus disease (EVD) may be at the origin of EV...

Background: Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence. Methods: Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1-4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tes...

Context: Infection with the hepatitis B virus is a lifelong danger to healthcare workers. The transmission is associated with daily handling in hospital and make it an occupational disease with disastrous consequences. Vaccination remains the best protection, although it is insufficiently recommended and carried out in current practice in our setti...

Introduction: The year 2019 ended with the emergence of a viral disease called Covid-19, which is affecting the decade 2020 by overturning the health, economic, financial and social aspects of humanity. Covid-19 is caused by the coronavirus associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV2), which has been declared a publi...

Background: The irrational use of antibiotics remains a challenge in both urban and rural areas. There are very different antibiotics prescription methods in the Democratic Republic of Congo and our study describes one of them. Methods: That was a descriptive and documentary study carried out in the Internal Medicine department of the Hopital Bon B...

On 1 August 2018, the Democratic Republic of the Congo (DRC) declared its tenth Ebola virus disease (EVD) outbreak. To aid the epidemiologic response, the Institut National de Recherche Biomédicale (INRB) implemented an end-to-end genomic surveillance system, including sequencing, bioinformatic analysis and dissemination of genomic epidemiologic re...

On 1 August 2018, the Democratic Republic of the Congo (DRC) declared its tenth Ebola virus disease (EVD) outbreak. To aid the epidemiologic response, the Institut National de Recherche Biomédicale (INRB) implemented an end-to-end genomic surveillance system, including sequencing, bioinformatic analysis and dissemination of genomic epidemiologic re...

On 1 August 2018, the Democratic Republic of the Congo (DRC) declared its tenth Ebola virus disease (EVD) outbreak. To aid the epidemiologic response, the Institut National de Recherche Biomédicale (INRB) implemented an end-to-end genomic sur�veillance system, including sequencing, bioinformatic analysis and dissemination of genomic epidemiologic...

The Democratic Republic of the Congo declared its tenth Ebola virus disease outbreak in July 2018, which has circulated primarily in the Nord Kivu province. In addition to standard epidemiologic surveillance and response efforts, the Institut National de Recherche Biomédicale implemented an end-to-end genomic surveillance system, including sequenci...

During the 2018-2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus-based vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) (Merck). His treatment included an Ebola virus (EBOV)-specific monoclonal antibody (...

Context: The study describes the causes of death in DRC by referring to the causes of death at the hospital IME/KIMPESE. The lack of reliable data on the causes of death in the DRC motivated the initiation of the study. Knowing the causes of death and the frequency of death makes it possible to assess the effectiveness of the health system in a cou...

The Democratic Republic of the Congo declared its tenth Ebola virus disease outbreak in July 2018, which has circulated primarily in the Nord Kivu province. In addition to standard epidemiologic surveillance and response efforts, the Institut National de Recherche Biom&eacutedicale implemented an end-to-end genomic surveillance system, including se...