Fabrice Fekam Boyom

• ScD, Biochemistry
• Head of Department at University of Yaoundé I

Infectious diseases cause over 13 million deaths worldwide annually as a result of the spread of microbial resistance. The use of medicinal plants in the treatment of infectious diseases is well documented. One such plant includes Combretum rhodanthum Engl.& Diels. (C. rhodanthum), which is traditionally used to treat skin and diarrheal infections,...

Background: Malaria is a parasitic disease that affects many parts of the globe, especially sub-Saharan Africa. Over time, malaria parasites have become resistant to most antimalarial drugs, including artemisinin. Medicinal plants, which are used in the traditional treatment of malaria can afford effective drugs against this notorious disease. One...

Figures' captions. - Kinetics of ribose-induced BSA glycation. The bovine serum albumin (10 mg/mL BSA, pH 7.4) was incubated at 37 °C for 9 days in the dark, using ribose as the glycation agent. - Chromatograms of Treculia africana methanol (A) and dichloromethane (B) leaf extracts injected at 0.5 mg/mL and detected at 254 nm (red) and 340 nm (blac...

Objective This research studied two extracts from Treculia africana leaves for their potential against hyperglycaemia-related disorders. Methods The influence of the extracts on α-glucosidase activity and albumin glycation was investigated, and cell viability was estimated in HT-29 human colorectal cells. Phenolic and flavonoid contents and antira...

A series of known tetrazine derivatives, containing benzothiazole scaffold, were prepared during the coupling reactions of selected diazotized 2-aminobenzo[d]thiazole derivatives with p-acetaminophen. The as-prepared compounds were characterized based on NMR and MS spectrometry. The antibacterial and anti-biofilm activities of the synthesized compo...

Epidemiological evidence associates Toxoplasma gondii latent infection with the development of neuropsychiatric disorders, and various immunological and environmental factors play key pathophysiological roles through host immune response alterations. We investigated the cognitive and motor alterations occurring in the terminal stage of T. gondii in...

Background: Malaria is a parasitic disease that affects many parts of the globe, especially sub-Saharan Africa. Over time, malaria parasites have become resistant to most antimalarial drugs, including artemisinin. Medicinal plants, which are used in the traditional treatment of malaria can afford effective drugs against this notorious disease. One...

Objective Study the impact of fermentation time on the phytochemical properties, antioxidant and antileishmanial activities. Materials and methods The preparation of Kombucha tea by fermentation was performed under aseptic conditions and symbiotic culture of bacteria and yeast (SCOBY) layer was maintained in culture for continuous growth in a wate...

Background Tropical diseases have a tremendous impact on human health, especially in the developing world. Among these maladies are malaria, leishmaniasis and human African trypanosomiasis that accounted for over 233 million cases with 234 000 deaths in 2022. The eradication of these diseases has been hampered by the emergence and spread of drug re...

Diarrhea remains one of the leading causes of mortality worldwide, especially among children. Accumulated evidence has shown that Shigella species are the most prevalent bacteria responsible for diarrhea in developing countries. Antimicrobial therapy is necessary for Shigella infections; however, the development of resistance against current drugs...

Diarrhea remains one of the leading causes of mortality worldwide, especially among children. Accumulated evidence has shown that Shigella species are the most prevalent bacteria responsible for diarrhea in developing countries. Antimicrobial therapy is necessary for Shigella infections; however, the development of resistance against current drugs...

Phytochemical investigation of the methanol extract from the fruits of Macaranga monandra (Euphorbiaceae Muell. et Arg.) afforded one new geranylated 1’,2’‐dihydrophenanthrene and two new flavonoid derivatives, named macamondrin ( 1 ), macamondrione A ( 2 ) and B ( 3 ) respectively. The structures of these compounds were elucidated mainly by NMR, m...

The serendipitous discovery of antiparasitic drugs, such as quinine and artemisinin from plant origin reveals that the search for new chemical pharmacophores from medicinal plants is valua-ble. The present study sought to explore the antiplasmodial, antileishmanial, and antitrypano-somal activities of extracts from Lippia adoensis. Crude extracts o...

The development of drug resistance by Shigella species justify the pressing need to search for alternative therapies against Shigella-causing diarrhoea. This study sought to investigate the antimicrobial activity of 70% hydroethanol (ethanol: water; 70:30) extract of Diospyros gilletii stem bark in immunodepressed mice challenged with an oral dose...

Diarrhea remains one of the leading causes of mortality worldwide, especially among children. Recent epidemiological studies conducted in developing countries identified Shigella species as the most predominant pathogenic bacteria responsible for diarrhea. Antimicrobial therapy is necessary for Shigella infections; however, the rapid emergence of r...

Plasmodium falciparum aminoacyl tRNA synthetases (PfaaRSs) are potent antimalarial targets essential for proteome fidelity and overall parasite survival in every stage of the parasite's life cycle. So far, some of these proteins have been singly targeted yielding inhibitor compounds that have been limited by incidences of resistance which can be ov...

Due to the spreading resistance to antimalarial drugs, new therapeutics are urgently needed, preferably with novel modes of action. Extracts from Terminalia ivorensis have previously been shown to possess activity in vitro against multidrug-resistant and drug-sensitive strains of Plasmodium falciparum. However, to the best of our knowledge, no scie...

Caused by pathogenic microorganisms, infectious diseases are known to cause high mortality rates, severe burdens of disability, and serious worldwide aftermaths. Drug-resistant pathogens have reduced the efficacy of available therapies against these diseases, thus accentuating the need to search for effective antimicrobials. Medicinal plants have s...

Shigellosis is a pathological condition that affects the digestive system and possibly causes diarrhoea. Shigella species, which are responsible for this disease, are highly contagious and spread through contaminated food and water. The increasing development of resistance by Shigella species necessitates the urgent need to search for new therapies...

Malaria, leishmaniasis, and African trypanosomiasis are protozoan diseases that constitute major global health problems, especially in developing countries; however, the development of drug resistance coupled with the toxicity of current treatments has hindered their management. The involvement of certain enzymes (dihydrofolate reductase [DHFR]) or...

Caused by pathogenic microorganisms, such as bacteria, parasites, fungi, among others, infec-tious diseases can spread directly or from one individual to another. According to the World Health Organization, these diseases are known to cause high mortality rates, severe burdens of disability and serious worldwide aftermaths. The inappropriate use of...

Malaria, leishmaniasis, and African trypanosomiasis are protozoan diseases that constitute a major global health problem, especially in developing countries; however the development of drug resistance coupled with the toxicity of current treatments have hindered their management. The implication of certain enzymes (dihydrofolate reductase, DHFR) or...

Shigellosis is a pathological condition that affects the digestive system to possibly cause diarrhoea. Shigella species, which are responsible for this disease, are highly contagious and spread through contaminated food and water. The increasing development of resistance by Shigella species necessitate the urgent need to search for new therapies ag...

The development of antimicrobial resistance has increased the prevalence of infectious diseases causing a global health problem that accounts for over 4.95 million deaths worldwide annually. The side effects associated with current antibiotics prompt a crucial need to search for effective and safe antimicrobial agents. In this study, silver nanopar...

BACKGROUND Fusarium maize ear and root rot disease caused by Fusarium verticillioides has become one of the most serious fungal diseases associated with maize production. Due to their abilities to promote plant development and manage diseases, bacterial endophytes provide a more promising approach for treating this vascular disease. RESULTS This w...

Shigellosis is a disease condition caused by various species of the genus Shigella. Drug resistant Shigella has been identified as a pathogen for which there is a priority to develop antimicrobials. Cardiospermum grandiflorum and Blighia welwitschii are plants that have been used in ethnomedicine to treat diarrheal conditions. Scientific validation...

Climate change has resulted in a steady and irreversible shift in the global climate, and occurrences like salinity, drought, temperature rises, high luminous intensity, and ultraviolet radiations are getting more intense and extended over time. The aforementioned spells have subjected agricultural crops to perpetual and unprecedented stress, as ev...

Three new lignan glucosides, namely, justisecundosides A (1), B (2a), and C (2b), were isolated from the whole plant of Justicia secunda together with seven known compounds (3−9). Their structures were established based on a comprehensive analysis of HR-ESI-MS, IR, UV, and CD, in conjunction with their 1D and 2D-NMR data. A putative biogenetic path...

In this study, we report the antibacterial mechanisms of action of uniform silver nanoparticles (AgNPs) and decorated activated carbon nanocomposite (CAC-AgNPs) obtained using a green synthesis approach. The nanomaterials were characterized by ultraviolet-visible (UV-vis) absorption spectra and Fourier transform infrared (FTIR) spectra. The antibac...

Citation: Amang à Ngnoung, G.A.; Nganso Ditchou, Y.O.; Leutcha, P.B.; Dize, D.; Tatsimo, S.J.N.; Tchokouaha, L.R.Y.; Kowa, T.K.; Tembeni, B.; Mamoudou, H.; Poka, M.; et al. Antiplasmodial and Antileishmanial Activities of a New Limonoid and Other Constituents from the Stem Bark of Khaya senegalensis. Molecules 2023, 28, 7227. https://doi. Abstract:...

Plants belonging to the genus Irvingia are widespread across the African and Southeast Asian regions of the world. Irvingia gabonensis, Irvingia malayana, and Irvingia grandifolia are among the commonly used species in ethnomedicine, especially in Africa. Fever, scabies, toothache, inflammation, and liver and gastrointestinal disorders are among th...

Plants belonging to the genus Irvingia are widespread across the African and Southeast Asian regions of the world. Irvingia gabonensis, Irvingia malayana, and Irvingia grandifolia are among the commonly used species in ethnomedicine, especially in Africa. Fever, scabies, toothache, inflammation, and liver and gastrointestinal disorders are among th...

Trypanosomatids are mainly responsible for leishmaniasis, sleeping sickness, and Chagas disease, which are the most challenging among the neglected tropical diseases due to the problem of drug resistance. Although problems of target deconvolution and polypharmacology are encountered, a target-based approach is a rational method for screening drug c...

The emergence of multidrug bacterial resistance poses a great public health problem and requires a constant search for new antibacterial agents. However, Niger’s flora possesses several medicinal plants used in traditional medicine to cure infectious diseases and can be used as sources of bioactive ingredients. This current study was designed to ev...

Fungal infections and other diseases associated with free radical generation and inflammation are currently a critical public health issue that needs innovative control measures. This study aimed to evaluate the antifungal, anti-inflammatory and anti-radical properties of extracts from Croton zambesicus, Mallotus oppositifolius, Drypetes gossweiler...

Introduction: Hepatitis B infection is a serious global health problem worldwide. In Cameroon, this infection shows a great variability in prevalence in the country and even within different population groups. However, the prevalence of HBV in the southwestern region is not yet known. Objectives: This study was conducted to determine the prevale...

Background Dacryodes edulis is a plant that belongs to the Burseraceae family. It is widely used traditionally alone or in association with other plants in Cameroonian folk medicine to cure wounds, fever, headaches, and malaria. The aim of this work was to investigate the leaves and stem bark of D. edulis with an emphasis on the antiplasmodial and...

Background: Human African trypanosomiasis (HAT) is a parasitic infection that may lead to death if left untreated. This disease is caused by a protozoan parasite of the genus Trypanosoma and is transmitted to humans through tsetse fly bites. The disease is widespread across Sub-Saharan Africa, with 70% of cases in recent reports in the Democratic R...

Lemongrass Essential oil (Eos) is a plant extract with known antifungal properties potentially important for the bio-control of dry products in store. This study focuses on the capacity of lemongrass Eos to reduce the growth and mycelial biomass production, amylase and cellulase activities, and control of the aflatoxins production of Aspergillus sp...

Background Treatment of Candida infections have become increasingly difficult due to antifungal drug resistance, which has drawn attention toward the search for innovative and effective drugs. This study aimed to assess the activity of essential oils (EOs) from Pentadiplandra brazzeana Baillon (PB) root and Drypetes gossweileri S. Moore (DG) stem b...

The phytochemical investigation of the MeOH and CH2Cl2-MeOH (1:1) extracts from the flowers and twigs of Helichrysum foetidum (L.) Moench (Asteraceae), which showed antileishmanial and antiplasmodial activities during the preliminary screening, led to the isolation of four undescribed compounds, including two ent-beyer-15-ene-type diterpenoids, foe...

The contamination of agricultural soil represents an environmental and human health risk factor. Arbuscular mycorrhizal (AM) fungi have shown great potentials as toxic metal bioalleviator in agricultural settings. Nonetheless, the field response of AM fungi-mediated toxic metal tolerance in important agricultural crops has been jeopardized owing to...

This study aimed to assess the in vitro antiplasmodial and cytotoxic activities of ethanol extracts from the root barks, leaves and stem barks of seven medicinal plant species growing in Tanzania. The antiplasmodial activities of extracts against chloroquine-sensitive (3D7) and multidrug-resistant (Dd2) strains of Plasmodium falciparum were determi...

Staphylococcus aureus, the causative agent of many infectious diseases has developed resistance to many antibiotics, even chloramphenicol which was the essential antibiotic recommended for the treatment of bacterial infection. Thus, other alternatives to fight against S. aureus infections are necessary; and combinatory therapy of antibiotics with n...

Antrocaryon klaineanum is traditionally used for the treatment of back pain, malaria, female sterility, chlamydiae infections, liver diseases, wounds, and hemorrhoid. This work aimed at investigating the bioactive compounds with antileishmanial and antiplasmodial activities from A. klaineanum. An unreported glucocerebroside antroklaicerebroside (1)...

The chemical investigation of the n-hexane fraction from the methanol extract of the stem bark of Symphonia globulifera Linn f., which displayed good in vitro activity against Leishmania donovani NR-48822 promastigotes (IC 50 43.11 µg/mL), led to the isolation of three previously unreported polyprenylated benzophenones, guttiferone U (1), V (2)/W (...

The chemical investigation of the n-hexane fraction from the methanol extract of the stem bark of Symphonia globulifera Linn f., which displayed good in vitro activity against Leishmania donovani NR-48822 promastigotes (IC 50 43.11 µg/mL), led to the isolation of three previously unreported polyprenylated benzophenones, guttiferone U (1), V (2)/W (...

Background: Third-generation cephalosporins (3GC) are among the most prescribed antibiotics worldwide. Antibiotic resistance, usually due to misuse and overuse, is a feared complication of public health concern. However, there are limited data in Cameroon concerning the knowledge and use of 3GC in our health services. The aim of this study was to...

Ethnopharmacological relevance: Detarium microcarpum is used to treat typhoid fever, a major public health problem, by indigenous population in Africa. Though its preventive activities have been documented, the curative effect is still to be confirmed. Aim of the study: This study aimed at evaluating the curative effects of the hydroethanolic ex...

The present study was carried out to investigate the anti-inflammatory activity of a methanolic extract and fractions of Uvaria comperei stems. The crude extract was obtained by maceration of the powder in methanol and fractions by vacuum chromatography from the methanolic extract. To study the anti-inflammatory activity in vitro, red blood cell ly...

The search for antileishmanial plants used in traditional medicine led to the choice of CH 2 Cl 2-MeOH (1:1) crude extract of the fruits and stem bark of Pentadesma butyracea Sabine (Clusiaceae) which displayed good activity in vitro against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes during preliminary screening with IC 50 values 5.96 and...

Background The liver is one of the crucial organs in humans and is responsible for the regulation of diverse processes, including metabolism, secretion, and detoxification. Ingestion of alcohol and drugs, environmental pollutants, and irradiation are among the risk factors accountable for oxidative stress in the liver. Plant flavonoids have the pot...

Background: Parasitic infections are diseases transmitted by parasites usually found in contaminated food, water or insect bites. Generally classified as neglected tropical diseases, malaria and trypanosomiases are some of the most prominent parasitic diseases that cause significant loss of life annually. In 2020, there were an estimated 241 millio...

Background Native to the Southern Mediterranean region, Laurus nobilis L. (Family Lauraceae) is an evergreen shrub or tree found in warm climate regions with high rainfall. The leaves and essential oil of this plant have been widely used as condiments, spices, and flavoring agents in the culinary and food industries. The whole plant is also used fo...

Cervical cancer is one of the most life-threatening malignancies worldwide, despite intensive research for more efficacious chemotherapeutic agents. Recent efforts geared towards eradicating the scourge of cancer have embodied a major surge of interest in natural products as promising lead molecules in pharmaceutical development and therapeutic tra...

Background Bacterial wilt caused by Ralstonia solanacearum (syn. Pseudomonas solanacearum ) is the most devastating bacterial disease of tomato ( Solanum lycopersicum L.) occurring in tropical zones with consequential substantial yield losses in production fields. Currently, microbial technology in cropping systems has directed investigations towar...

Background: The aim of this work was to study the cytotoxicity of leaves essential oils and their identified constituents of Aeollanthus heliotropioides and Ocimum urticaefolium (Lamiaceae) from Cameroon. Materials and Methods: Leaves essential oils were obtained by hydrodistillation and were analysed by gas chromatography (GC) and GC/mass spectrom...

Background Dacryodes edulis is a plant that belongs to the Burseraceae family. It is widely used traditionally alone or in association with other plants in Cameroonian folk medicine to cure wounds, fever, headaches, and malaria. The aim of this work was to investigate the leaves and stem bark of D. edulis with an emphasis on the antiplasmodial and...

New drugs are urgently needed for the treatment of human African trypanosomiasis (HAT). In line with our quest for novel inhibitors of trypanosomes, a small library of analogs of the antitrypanosomal hit (MMV675968) available at MMV as solid materials was screened for antitrypanosomal activity. In silico exploration of two potent antitrypanosomal s...

A promising strategy for dissolving, mobilizing and enhancing the utilization of the complexed form of phosphorus (P) in soil-plant systems is the use of effective phosphate solubilizing microorganisms. In the present study, six strains of Trichoderma spp. previously obtained from the common bean rhizosphere were investigated for their ability to s...

Widespread antibiotic resistance has led to the urgent need for the identification of new antimicrobials. Plants are considered a valuable potential resource for new effective antimicrobial compounds. Therefore, in the present study, we focused on the antimicrobial activity of Polyalthia longifolia plants harvested from Cameroon using the minimum i...

The bio guided fractionation of the dichloromethane/methanol (1:1) crude extract of the air-dried whole plant of C. aegyptiaca led to the isolation of one new flavone derivative designated conyflavone (1) and one new clerodane diterpene type designated conyclerodane (2) along with five known compounds including two flavonoids Gardenin C (3), chryso...

The aim of the present research was to identify and analyse the biocontrol capacity of nine local Trichoderma spp. isolates against Lasiodiplodia theobromae. The isolates were identified as T. asperellum (3), T. harzianum (5) and T. koningiospsis (1). These fungi significantly slowed L. theobromae mycelial development in vitro, with maximum reducti...

In our ongoing research program on the proapoptotic function of saponins, two previously undescribed saponins, named zygiaosides E (1) and F (2), were isolated from the leaves of Albizia zygia. Their structures were established based on extensive analysis of 1D and 2D NMR data, HR-ESI-MS analysis, and by chemical degradation. The proapoptotic effec...

The absence of novel, safe, and effective bactericide is an urgent concern worldwide and remains a challenge in scientific communities. The unique proprieties of silver nanoparticles (SNPs) synthesized from plant extracts make them a suitable candidate to overcome these limitations. Herein, we synthesized SNPs from Bersama engleriana fruit (BEfr) e...

Ripe figs, barks, and wood of Ficus vallis-choudae are used in traditional medicine against several conditions including nausea and malaria. However, its use is still to be scientifically documented and validated. Hence, the aim of the present work was to evaluate the antiplasmodial activity of the dichloromethane-methanol (DCM-MeOH (1:1)) crude ex...

Ethnopharmacological significance Medicinal plants from the Terminalia genus are widely used as remedies against many infectious diseases, including malaria. As such, Terminalia ivorensis A. Chev. and Terminalia brownii Fresen. are famous due to their usefulness in traditional medicines to treat malaria and yellow fever. However, further informatio...

Introduction and Objective. Skin mycoses is a neglected condition with low quality of life and morbidity that primarily affects school-aged children in developing nations. Current treatment options have considerable limits, emphasizing the critical need for alternative therapies. The purpose of this clinical trial was to evaluate the potential bene...

Introduction and objective Skin mycoses is a neglected condition with low quality of life and morbidity that primarily affects school-aged children in developing nations. Current treatment options have considerable limits, emphasizing the critical need for alternative therapies. The purpose of this clinical trial was to evaluate the potential benef...

Background: Candida tropicalis is a human pathogenic yeast frequently isolated in Latin America and Asian-Pacific regions, although recent studies showed that it is also becoming increasingly widespread throughout several African and south-European countries. Nevertheless, relatively little is known about its global patterns of genetic variation a...

Fungal plant pathology is a huge concern to the agricultural industry across the globe. Fusarium verticillioides is recognized as the most widespread and severe pathogenic fungus associated with maize production. This study aimed to investigate the antagonistic potential of twenty-seven (27) endophytic bacteria from the Desert spurge (Euphorbia ant...

New drugs are urgently needed for the treatment of human African trypanosomiasis (HAT). In line with our quest for dihydrofolate reductase (DHFR) inhibitors in trypanosomes, a small library of analogs of the antitrypanosomal hit ( MMV675968 ) available at MMV as solid materials was screened for antitrypanosomal activity. In silico confirmation of t...

Urinary tract infections (UTIs) are common bacterial infections. The global emergence of multidrug-resistant uropathogens in the last decade underlines the need to search for new antibiotics with novel mechanisms of action. In this regard, exploring endophytic fungi inhabiting medicinal plants used locally against urinary tract infections could be...

Currently, the disease burden from pneumonia remains a major public health problem. In this regard, exploring endophytic fungal extracts from traditionally used plants could be a promising approach in this light. Therefore, this work was conceived with the aim of evaluating the antibacterial and antioxidant activities of two endophytic extracts of...

Antimalarial drug discovery has been facilitated by the development of various in vitro drug susceptibility testing methods suitable for medium-throughput or high-throughput campaigns. Among many, the Plasmodium falciparum lactate dehydrogenase (PfLDH) assay has acceptable demand on equipment, labour, technical skills and affordability and offers a...

Currently, the disease burden from pneumonia remains a major public health problem. In this regard, exploring endophytic fungal extracts from traditionally used plants could be a promising approach in this light. Therefore, this work was conceived with the aim of evaluating the antibacterial and antioxidant activities of two endophytic extracts of...

As part of our search for new secondary metabolites from Macaranga hurifolia Beille, a phytochemical investigation was carried out on the fruits that led to the isolation and characterization of two new prenylated flavonol derivatives named macafolias A (1) and B (2), along with five known compounds. Their chemical structures were established on th...